Detailed information for compound 540694

Basic information

Technical information
  • TDR Targets ID: 540694
  • Name: (3aR,4R,5S,6S,6aS)-4-(hydroxymethyl)-2-[[(2S, 3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethy l)tetrahydropyran-2-yl]amino]-3a,5,6,6a-tetra hydrocyclopenta[d]oxazole-4,5,6-triol
  • MW: 366.321 | Formula: C13H22N2O10
  • H donors: 9 H acceptors: 8 LogP: -4.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]1O[C@H](NC2=N[C@@H]3[C@H](O2)[C@@H](O)[C@@H]([C@]3(O)CO)O)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C13H22N2O10/c16-1-3-4(18)5(19)6(20)11(24-3)15-12-14-9-8(25-12)7(21)10(22)13(9,23)2-17/h3-11,16-23H,1-2H2,(H,14,15)/t3-,4-,5+,6-,7-,8-,9-,10+,11+,13+/m1/s1
  • InChiKey: NRKVPNOUINUNKY-UXTOMXPUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3aR,4R,5S,6S,6aS)-4-(hydroxymethyl)-2-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]amino]-3a,5,6,6a-tetrahydrocyclopenta[d]oxazole-4,5,6-triol
  • (3aR,4R,5S,6S,6aS)-4-(hydroxymethyl)-2-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]amino]-3a,5,6,6a-tetrahydrocyclopenta[d][1,3]oxazole-4,5,6-triol
  • (3aR,4R,5S,6S,6aS)-4-methylol-2-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]amino]-3a,5,6,6a-tetrahydrocyclopenta[d]oxazole-4,5,6-triol
  • trehazolin
  • 132729-37-4
  • Trehalostatin

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bombyx mori Trehalase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127877 All targets in OG5_127877
Trichomonas vaginalis trehalase, putative Get druggable targets OG5_127877 All targets in OG5_127877
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127877 All targets in OG5_127877
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127877 All targets in OG5_127877
Brugia malayi Trehalase family protein Get druggable targets OG5_127877 All targets in OG5_127877
Onchocerca volvulus Get druggable targets OG5_127877 All targets in OG5_127877
Loa Loa (eye worm) TRE-1 protein Get druggable targets OG5_127877 All targets in OG5_127877
Brugia malayi Trehalase family protein Get druggable targets OG5_127877 All targets in OG5_127877
Onchocerca volvulus Get druggable targets OG5_127877 All targets in OG5_127877
Loa Loa (eye worm) trehalase Get druggable targets OG5_127877 All targets in OG5_127877
Loa Loa (eye worm) trehalase Get druggable targets OG5_127877 All targets in OG5_127877
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127877 All targets in OG5_127877
Onchocerca volvulus Get druggable targets OG5_127877 All targets in OG5_127877
Onchocerca volvulus Get druggable targets OG5_127877 All targets in OG5_127877
Loa Loa (eye worm) trehalase Get druggable targets OG5_127877 All targets in OG5_127877
Brugia malayi Trehalase family protein Get druggable targets OG5_127877 All targets in OG5_127877
Candida albicans neutral trehalase similar to S. cerevisiae NTH1 (YDR001C) involved in stress response Get druggable targets OG5_127877 All targets in OG5_127877
Brugia malayi hypothetical protein Get druggable targets OG5_127877 All targets in OG5_127877
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127877 All targets in OG5_127877
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127877 All targets in OG5_127877
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127877 All targets in OG5_127877
Onchocerca volvulus Trehalase homolog Get druggable targets OG5_127877 All targets in OG5_127877
Loa Loa (eye worm) TRE-2 protein Get druggable targets OG5_127877 All targets in OG5_127877
Onchocerca volvulus Get druggable targets OG5_127877 All targets in OG5_127877
Brugia malayi Trehalase family protein Get druggable targets OG5_127877 All targets in OG5_127877
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Trehalase   579 aa 526 aa 36.5 %
Onchocerca volvulus Trehalase   579 aa 543 aa 36.5 %
Loa Loa (eye worm) trehalase Trehalase   579 aa 568 aa 33.3 %
Brugia malayi Trehalase family protein Trehalase   579 aa 576 aa 33.7 %
Onchocerca volvulus Trehalase   579 aa 535 aa 37.9 %
Onchocerca volvulus Trehalase   579 aa 573 aa 33.2 %
Onchocerca volvulus NF-kappa-B inhibitor-interacting Ras-like protein homolog Trehalase   579 aa 546 aa 30.8 %
Onchocerca volvulus Trehalase   579 aa 534 aa 36.0 %
Loa Loa (eye worm) hypothetical protein Trehalase   579 aa 570 aa 35.1 %
Onchocerca volvulus Trehalase   579 aa 541 aa 34.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.1896 0.1896
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0058 0.0096
Brugia malayi glutathione reductase 0.0093 0.1758 0.5486
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.1769 0.1769
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0163 0.3205 0.5334
Toxoplasma gondii thioredoxin reductase 0.0093 0.1758 0.6826
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0817 0.4645
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0132 0.2576 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0734 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0493 0.1914
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0493 0.2803
Plasmodium falciparum glutathione reductase 0.0093 0.1758 1
Loa Loa (eye worm) trehalase 0.0055 0.0966 0.3013
Brugia malayi Trehalase family protein 0.0159 0.3124 0.9748
Brugia malayi Trehalase family protein 0.0055 0.0966 0.3013
Brugia malayi Trehalase family protein 0.0159 0.3124 0.9748
Loa Loa (eye worm) hypothetical protein 0.0159 0.3124 0.9748
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0284 0.1618
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0132 0.2576 0.5443
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0315 0.0982
Mycobacterium tuberculosis Probable dehydrogenase 0.0212 0.4239 0.8958
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0284 0.0911
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0493 0.2803
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0315 0.0982
Leishmania major trypanothione reductase 0.0093 0.1758 0.6826
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0236 0.4731 1
Loa Loa (eye worm) glutathione reductase 0.0093 0.1758 0.5486
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0493 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0493 0.2803
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0104 0.198 0.6179
Mycobacterium tuberculosis Probable oxidoreductase 0.0236 0.4731 1
Onchocerca volvulus 0.0159 0.3124 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0058 0.0328
Echinococcus granulosus bloom syndrome protein 0.0022 0.0284 0.0284
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0493 0.2803
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0817 0.0817
Brugia malayi Thioredoxin reductase 0.0093 0.1758 0.5486
Loa Loa (eye worm) RecQ helicase 0.0022 0.0284 0.0888
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.1758 1
Brugia malayi Trehalase family protein 0.0159 0.3124 0.9748
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0284 0.0911
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0284 0.0284
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0734 0.4174
Brugia malayi trehalase I 0.0055 0.0966 0.3013
Schistosoma mansoni DNA helicase recq1 0.0022 0.0284 0.0474
Onchocerca volvulus 0.0159 0.3124 1
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.1758 0.5486
Brugia malayi hypothetical protein 0.0055 0.0966 0.3013
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0212 0.4239 0.8958
Onchocerca volvulus 0.0159 0.3124 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.2576 1
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0493 0.1914
Brugia malayi hypothetical protein 0.0055 0.0966 0.3013
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0058 0.0328
Plasmodium vivax glutathione reductase, putative 0.0093 0.1758 1
Brugia malayi Trehalase family protein 0.0055 0.0966 0.3013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.1896 0.1896
Brugia malayi hypothetical protein 0.0159 0.3124 0.9748
Loa Loa (eye worm) hypothetical protein 0.0159 0.3124 0.9748
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0493 0.1578
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0284 0.1105
Brugia malayi Trehalase protein 5 0.0055 0.0966 0.3013
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0493 0.082
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0284 0.0911
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0284 0.1618
Loa Loa (eye worm) hypothetical protein 0.0159 0.3124 0.9748
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0212 0.4239 0.8958
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0163 0.3205 0.3205
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0284 0.0888
Schistosoma mansoni aldehyde dehydrogenase 0.0132 0.2576 0.4287
Schistosoma mansoni DNA helicase recq5 0.0022 0.0284 0.0474
Echinococcus multilocularis neuropeptide receptor A26 0.0489 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.3124 0.9748
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0493 0.1914
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0284 0.0284
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0284 0.1618
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0132 0.2576 0.2576
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0493 0.2803
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0058 0.0786
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0817 0.3171
Onchocerca volvulus 0.0159 0.3124 1
Echinococcus multilocularis neuropeptide s receptor 0.0489 1 1
Treponema pallidum ATP-dependent DNA helicase 0.0011 0.0058 0.0597
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0284 0.0888
Brugia malayi hypothetical protein 0.0055 0.0966 0.3013
Loa Loa (eye worm) trehalase 0.0159 0.3124 0.9748
Brugia malayi Trehalase family protein 0.0159 0.3124 0.9748
Brugia malayi trehalase 0.0055 0.0966 0.3013
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0493 0.6716
Plasmodium falciparum glutathione reductase 0.0032 0.0493 0.2803
Onchocerca volvulus 0.0159 0.3124 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0284 0.1618
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0734 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0493 0.2803
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.1896 0.5917
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0493 0.1914
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0493 0.0493
Treponema pallidum NADH oxidase 0.0032 0.0493 0.5104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1896 0.3156
Brugia malayi Cytochrome P450 family protein 0.0025 0.035 0.1092
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0049 0.0081
Loa Loa (eye worm) TRE-2 protein 0.0159 0.3124 0.9748
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1896 0.3156
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0817 0.2614
Loa Loa (eye worm) trehalase 0.0159 0.3124 0.9748
Loa Loa (eye worm) hypothetical protein 0.0055 0.0966 0.3013
Plasmodium falciparum thioredoxin reductase 0.0093 0.1758 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0132 0.2576 0.2576
Loa Loa (eye worm) hypothetical protein 0.0055 0.0966 0.3013
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.035 0.1092
Brugia malayi acetyltransferase, GNAT family protein 0.0163 0.3205 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.311 0.311
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0493 0.2803
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.3124 1
Trichomonas vaginalis trehalase, putative 0.0159 0.3124 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0493 0.2803
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0493 0.2803
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1896 0.3156
Echinococcus granulosus neuropeptide receptor A26 0.0489 1 1
Loa Loa (eye worm) TRE-1 protein 0.0159 0.3124 0.9748
Treponema pallidum hypothetical protein 0.0055 0.0966 1
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0284 0.0888
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0284 0.0284
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.2576 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0493 0.1914
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0236 0.4731 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0817 0.3171
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0236 0.4731 1
Toxoplasma gondii aldehyde dehydrogenase 0.0132 0.2576 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0493 1
Loa Loa (eye worm) trehalase 0.0055 0.0966 0.3013
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0493 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.1896 0.5917
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0493 0.2803
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0284 0.1105
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0493 0.1914
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.1769 0.1769
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0493 0.1914
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0493 0.2803
Plasmodium falciparum thioredoxin reductase 0.0032 0.0493 0.2803
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0284 0.3877
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0493 0.1538
Trypanosoma brucei trypanothione reductase 0.0093 0.1758 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0284 0.3877
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0493 0.1914
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0049 0.0189
Loa Loa (eye worm) trehalase 0.0159 0.3124 0.9748
Loa Loa (eye worm) acetyltransferase 0.0163 0.3205 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0493 0.0493
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.2576 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.018
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0493 0.1578
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0493 0.1914
Mycobacterium tuberculosis Probable reductase 0.0212 0.4239 0.8958
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.1758 0.3716
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0493 0.1042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0493 0.2803
Loa Loa (eye worm) hypothetical protein 0.0055 0.0966 0.3013
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0284 0.0888
Loa Loa (eye worm) hypothetical protein 0.0022 0.0284 0.0888
Loa Loa (eye worm) hypothetical protein 0.0055 0.0966 0.3013
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0049 0.0664
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0493 0.2803
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0493 1
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.1758 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0284 0.0284
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.1896 0.1896
Schistosoma mansoni aldehyde dehydrogenase 0.0132 0.2576 0.4287
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0493 0.2803
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0212 0.4239 0.8958
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0058 0.0328
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0011 0.0049 0.0277
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0817 0.2614
Loa Loa (eye worm) hypothetical protein 0.0159 0.3124 0.9748
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0212 0.4239 0.8958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0493 0.2803
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0284 0.1105
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.1896 0.1896
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0058 0.0224
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.018
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0493 0.2803
Onchocerca volvulus Trehalase homolog 0.0159 0.3124 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0212 0.4239 0.8958

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.9 10'-8M Inhibition of Bombyx mori trehalase ChEMBL. 11714317

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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