Detailed information for compound 1453569

Basic information

Technical information
  • TDR Targets ID: 1453569
  • Name: 2-[[5-(3-bromophenyl)-4-prop-2-enyl-1,2,4-tri azol-3-yl]sulfanyl]acetamide
  • MW: 353.238 | Formula: C13H13BrN4OS
  • H donors: 1 H acceptors: 3 LogP: 2.31 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCn1c(SCC(=O)N)nnc1c1cccc(c1)Br
  • InChi: 1S/C13H13BrN4OS/c1-2-6-18-12(9-4-3-5-10(14)7-9)16-17-13(18)20-8-11(15)19/h2-5,7H,1,6,8H2,(H2,15,19)
  • InChiKey: UVMNPBQHIHVPAG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-allyl-5-(3-bromophenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
  • 2-[[4-allyl-5-(3-bromophenyl)-1,2,4-triazol-3-yl]thio]acetamide
  • 2-[[5-(3-bromophenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]ethanamide
  • MLS000078548
  • SMR000041610
  • ZINC02349229
  • STOCK3S-21577

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis translational activator gcn1 0.0007 0.0057 0.0057
Plasmodium falciparum transportin 0.0007 0.0057 0.0159
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0576 0.159
Brugia malayi CXXC zinc finger family protein 0.0033 0.0784 0.2165
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0471 0.1301
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0576 0.159
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0471 0.1301
Schistosoma mansoni hypothetical protein 0.0018 0.0376 0.0376
Schistosoma mansoni proliferating cell nuclear antigen 0.0138 0.3623 0.3623
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0004 0 0.5
Schistosoma mansoni hypothetical protein 0.0018 0.0376 0.0376
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0471 1
Echinococcus granulosus transportin 1 0.0007 0.0057 0.0057
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0083 0.023
Plasmodium vivax proliferating cell nuclear antigen, putative 0.0138 0.3623 1
Plasmodium falciparum proliferating cell nuclear antigen 2 0.0074 0.1881 0.5192
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0784 0.0784
Schistosoma mansoni importin-beta 2 0.0007 0.0057 0.0057
Trichomonas vaginalis hypothetical protein 0.0007 0.0057 0.0159
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0376 0.0376
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.1321 0.3647
Loa Loa (eye worm) histone methyltransferase 0.001 0.0158 0.0158
Plasmodium vivax importin-beta 2, putative 0.0035 0.0826 0.2281
Leishmania major hypothetical protein, conserved 0.0007 0.0057 0.0159
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0376 0.0376
Echinococcus multilocularis importin 5 0.0007 0.0057 0.0057
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0576 0.159
Toxoplasma gondii proliferating cell nuclear antigen PCNA2 0.0074 0.1881 0.5192
Leishmania major proliferative cell nuclear antigen (PCNA), putative 0.0138 0.3623 1
Trichomonas vaginalis proliferating cell nuclear antigen, putative 0.0138 0.3623 1
Echinococcus multilocularis tar DNA binding protein 0.0073 0.1877 0.1877
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0471 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1321 0.1321
Schistosoma mansoni importin beta-1 0.0035 0.0826 0.0826
Echinococcus granulosus cpg binding protein 0.0035 0.0836 0.0836
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0083 0.023
Mycobacterium leprae Probable oxidoreductase 0.0004 0 0.5
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0004 0 0.5
Entamoeba histolytica proliferating cell nuclear antigen, putative 0.0138 0.3623 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0471 0.0471
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0576 0.0576
Brugia malayi RNA, U transporter 1 0.0099 0.2574 0.7106
Loa Loa (eye worm) hypothetical protein 0.0039 0.0953 0.0953
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0576 0.0576
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0004 0 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.18 0.18
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0471 0.1301
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0471 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.1451 0.1451
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1877 0.1877
Brugia malayi TAR-binding protein 0.0073 0.1877 0.518
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0083 0.023
Trichomonas vaginalis proliferating cell nuclear antigen, putative 0.0138 0.3623 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0647 0.1786
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1321 0.1321
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0576 0.159
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0826 0.2281
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0083 0.023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0376 0.0376
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0471 0.1301
Schistosoma mansoni hypothetical protein 0.0039 0.0953 0.0953
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0155 0.0428
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0376 0.1037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0083 0.023
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0376 0.0376
Toxoplasma gondii exonuclease III APE 0.0022 0.0471 0.1301
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0158 0.0158
Schistosoma mansoni cpg binding protein 0.0035 0.0836 0.0836
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0083 0.023
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0103 0.0103
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0007 0.0057 0.0159
Echinococcus multilocularis GPCR, family 2 0.0018 0.0376 0.0376
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0826 0.2281
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0471 0.1301
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0007 0.0057 0.0159
Plasmodium vivax proliferating cell nuclear antigen, putative 0.0074 0.1881 0.5192
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0083 0.023
Entamoeba histolytica Ran family GTPase 0.0026 0.0576 0.159
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0103 0.0103
Echinococcus multilocularis snurportin 1 0.0372 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0826 0.0826
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0471 0.1301
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0576 0.0576
Schistosoma mansoni proliferating cell nuclear antigen 0.0138 0.3623 0.3623
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0471 0.1301
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.1451 0.1451
Trypanosoma cruzi proliferative cell nuclear antigen (PCNA), putative 0.0138 0.3623 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0376 0.0376
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1321 0.1321
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Loa Loa (eye worm) importin-beta domain-containing protein 0.0007 0.0057 0.0057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0083 0.023
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.1321 0.1321
Trypanosoma brucei proliferative cell nuclear antigen (PCNA), putative 0.0138 0.3623 1
Echinococcus multilocularis proliferating cell nuclear antigen 0.0138 0.3623 0.3623
Toxoplasma gondii HEAT repeat-containing protein 0.0007 0.0057 0.0159
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0471 0.1301
Plasmodium vivax transportin, putative 0.0007 0.0057 0.0159
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0471 0.1301
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1321 0.1321
Schistosoma mansoni hypothetical protein 0.0018 0.0376 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0083 0.023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.1451 0.4005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0083 0.023
Echinococcus granulosus GPCR family 2 0.0018 0.0376 0.0376
Leishmania major GTP-binding protein, putative 0.0026 0.0576 0.159
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0103 0.0103
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0826 0.0826
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.1877 0.518
Echinococcus granulosus proliferating cell nuclear antigen 0.0138 0.3623 0.3623
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0004 0 0.5
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0576 0.159
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0576 0.159
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0826 0.2281
Brugia malayi RNA binding protein 0.0073 0.1877 0.518
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0083 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0083 0.023
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0083 0.023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0471 0.1301
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0083 0.023
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1595 0.4402
Schistosoma mansoni hypothetical protein 0.0372 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0083 0.023
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1877 0.1877
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0576 0.159
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0103 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1877 0.1877
Schistosoma mansoni ran 0.0026 0.0576 0.0576
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.1877 0.1877
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0083 0.023
Entamoeba histolytica HEAT repeat domain containing protein 0.0007 0.0057 0.0159
Toxoplasma gondii proliferating cell nuclear antigen PCNA1 0.0138 0.3623 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1321 0.1321
Trichomonas vaginalis helicase, putative 0.0008 0.0083 0.023
Plasmodium falciparum importin beta, putative 0.0035 0.0826 0.2281
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0083 0.023
Echinococcus granulosus importin subunit beta 1 0.0035 0.0826 0.0826
Brugia malayi proliferating cell nuclear antigen (PCNA) 0.0138 0.3623 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0376 0.0376
Giardia lamblia PcnA 0.0138 0.3623 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0471 0.0471
Schistosoma mansoni cpg binding protein 0.0033 0.0784 0.0784
Entamoeba histolytica hypothetical protein 0.0028 0.0647 0.1786
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0004 0 0.5
Schistosoma mansoni cpg binding protein 0.0035 0.0836 0.0836
Brugia malayi Importin beta-1 subunit 0.0035 0.0826 0.2281
Echinococcus granulosus tar DNA binding protein 0.0073 0.1877 0.1877
Leishmania major importin beta-1 subunit, putative 0.0028 0.0647 0.1786
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1877 0.1877
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0376 0.1037
Trichomonas vaginalis ran, putative 0.0026 0.0576 0.159
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0647 0.1786
Loa Loa (eye worm) RNA binding protein 0.0073 0.1877 0.1877
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1321 0.1321
Schistosoma mansoni ap endonuclease 0.0022 0.0471 0.0471
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0471 0.0471
Echinococcus multilocularis cpg binding protein 0.0035 0.0836 0.0836
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0576 0.159
Plasmodium falciparum proliferating cell nuclear antigen 1 0.0138 0.3623 1
Schistosoma mansoni hypothetical protein 0.0018 0.0376 0.0376
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1321 0.1321
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.1451 0.4005
Brugia malayi kap beta 3 protein 0.0007 0.0057 0.0159
Schistosoma mansoni ran 0.0026 0.0576 0.0576
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0647 0.1786
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0471 1
Echinococcus multilocularis transportin 1 0.0007 0.0057 0.0057
Toxoplasma gondii HEAT repeat-containing protein 0.0007 0.0057 0.0159
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0953 0.2631
Loa Loa (eye worm) kap beta 3 protein 0.0007 0.0057 0.0057
Loa Loa (eye worm) TAR-binding protein 0.0073 0.1877 0.1877
Loa Loa (eye worm) proliferating cell nuclear antigen 0.0138 0.3623 0.3623
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0158 0.0158
Schistosoma mansoni ap endonuclease 0.0022 0.0471 0.0471
Echinococcus granulosus translational activator gcn1 0.0007 0.0057 0.0057
Trypanosoma cruzi proliferative cell nuclear antigen (PCNA), putative 0.0138 0.3623 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0647 0.1786
Echinococcus granulosus importin 5 0.0007 0.0057 0.0057
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0471 0.1301
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0103 0.0103
Onchocerca volvulus 0.0033 0.0784 1
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1877 0.1877

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.0596 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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