Detailed information for compound 1296381

Basic information

Technical information
  • TDR Targets ID: 1296381
  • Name: N-(3,5-dimethylphenyl)-7H-purin-6-amine
  • MW: 239.276 | Formula: C13H13N5
  • H donors: 2 H acceptors: 3 LogP: 2.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(cc(c1)C)Nc1[nH]cnc2c1ncn2
  • InChi: 1S/C13H13N5/c1-8-3-9(2)5-10(4-8)18-13-11-12(15-6-14-11)16-7-17-13/h3-7H,1-2H3,(H2,14,15,16,17,18)
  • InChiKey: OWQMQPYAUSWQDX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3,5-dimethylphenyl)-(7H-purin-6-yl)amine
  • Oprea1_729016
  • MLS000419159
  • SMR000319850
  • ZINC04059874

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.001 0.001
Onchocerca volvulus 0.0096 0.5553 1
Echinococcus multilocularis cathepsin L 0.0009 0.001 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0536 0.2949
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0438 0.0438
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.2568 0.2568
Loa Loa (eye worm) hypothetical protein 0.0017 0.0536 0.0529
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.1792 1
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0536 0.0667
Schistosoma mansoni hypothetical protein 0.0016 0.0438 0.0502
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0536 0.2949
Leishmania major cathepsin L-like protease 0.0065 0.3582 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0323 0.1422
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0731 0.2018
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0731 0.1251
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.1792 0.5423
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0536 0.2949
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0177 0.0759
Schistosoma mansoni alpha glucosidase 0.0037 0.1792 0.2092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0536 0.2949
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0536 0.7292
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0323 0.0877
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.4315 0.4311
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0536 0.0529
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0731 0.5
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0731 0.0731
Onchocerca volvulus 0.0017 0.0536 0.0667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3582 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0438 0.0431
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0323 0.0877
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.1582 0.1582
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4315 0.5052
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.1792 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.1792 0.499
Schistosoma mansoni hypothetical protein 0.0043 0.2214 0.2586
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0731 0.0724
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0536 0.2949
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0536 0.0529
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.1792 0.1786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0536 0.2949
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.1792 0.499
Echinococcus multilocularis cpg binding protein 0.003 0.1349 0.1343
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0731 0.2018
Entamoeba histolytica hypothetical protein 0.0043 0.2214 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0177 0.0177
Echinococcus multilocularis cysteine protease 0.0017 0.0536 0.0529
Brugia malayi Cathepsin L-like precursor 0.0017 0.0536 0.0536
Schistosoma mansoni hypothetical protein 0.0016 0.0438 0.0502
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3582 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0536 0.2949
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0536 0.2949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3582 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.1792 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0536 0.0529
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.3224 0.8997
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0323 0.1758
Plasmodium vivax vivapain-2 0.0017 0.0536 0.7292
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.1247 0.1241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0536 0.2949
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0731 0.0724
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0536 0.0529
Brugia malayi CXXC zinc finger family protein 0.0028 0.1247 0.1247
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0731 0.4045
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0731 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0177 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3582 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0536 0.0529
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3582 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.1792 1
Brugia malayi Muscleblind-like protein 0.0152 0.9123 0.9123
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4315 0.5052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3582 1
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0177 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0536 0.2949
Brugia malayi Cathepsin L-like precursor 0.0017 0.0536 0.0536
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0536 0.0667
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0731 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0177 0.017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0536 0.2949
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.2568 0.2563
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0438 0.0431
Echinococcus granulosus cathepsin L 0.0009 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0034 0.1582 0.1576
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0536 0.0529
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3582 1
Schistosoma mansoni cpg binding protein 0.0028 0.1247 0.1452
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0536 0.2949
Onchocerca volvulus 0.0017 0.0536 0.0667
Schistosoma mansoni hypothetical protein 0.0016 0.0438 0.0502
Echinococcus granulosus cysteine protease 0.0009 0.001 0.0003
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0536 0.2385
Leishmania major cathepsin L-like protease 0.0017 0.0536 0.0651
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.001 0.0003
Leishmania major cathepsin L-like protease 0.0017 0.0536 0.0651
Leishmania major cathepsin L-like protease 0.0017 0.0536 0.0651
Loa Loa (eye worm) hypothetical protein 0.0011 0.0177 0.017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0323 0.1758
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0536 0.2949
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.1792 0.1792
Schistosoma mansoni hypothetical protein 0.0016 0.0438 0.0502
Brugia malayi cathepsin L-like precursor 0.0011 0.0177 0.0177
Leishmania major cathepsin L-like protease 0.0065 0.3582 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0731 0.0724
Schistosoma mansoni alpha-glucosidase 0.0143 0.8531 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4315 0.5052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.2568 0.2568
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.326 0.3814
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0731 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.2214 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0731 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0536 0.2949
Entamoeba histolytica cysteine protease, putative 0.0017 0.0536 0.2385
Onchocerca volvulus 0.0017 0.0536 0.0667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3582 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0536 0.7292
Echinococcus granulosus muscleblind protein 0.0152 0.9123 0.9122
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.3582 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0438 0.0431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0536 0.2949
Brugia malayi TAR-binding protein 0.0076 0.4315 0.4315
Loa Loa (eye worm) TAR-binding protein 0.0076 0.4315 0.4311
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0536 0.2949
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.1792 0.8088
Entamoeba histolytica hypothetical protein 0.0043 0.2214 1
Onchocerca volvulus 0.0017 0.0536 0.0667
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.1792 1
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0536 0.1472
Schistosoma mansoni alpha-glucosidase 0.0143 0.8531 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.1792 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0323 0.1758
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0323 0.0877
Echinococcus multilocularis tar DNA binding protein 0.0076 0.4315 0.4311
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0536 0.0617
Brugia malayi Cathepsin L-like precursor 0.0011 0.0177 0.0177
Echinococcus granulosus cathepsin l1 0.0017 0.0536 0.0529
Onchocerca volvulus 0.0017 0.0536 0.0667
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0731 1
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.3582 1
Brugia malayi RNA binding protein 0.0076 0.4315 0.4315
Schistosoma mansoni cpg binding protein 0.003 0.1349 0.1572
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0536 0.0529
Schistosoma mansoni ap endonuclease 0.002 0.0731 0.0846
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.1792 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0438 0.0431
Schistosoma mansoni cpg binding protein 0.003 0.1349 0.1572
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0536 0.2949
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.2214 0.2586
Onchocerca volvulus 0.0017 0.0536 0.0667
Loa Loa (eye worm) cysteine protease 0.0017 0.0536 0.0529
Echinococcus granulosus cpg binding protein 0.003 0.1349 0.1343
Trypanosoma brucei glucosidase, putative 0.0037 0.1792 0.499
Brugia malayi Cathepsin L-like precursor 0.0017 0.0536 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0177 0.0938
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0536 0.2949
Loa Loa (eye worm) hypothetical protein 0.0152 0.9123 0.9122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0536 0.2949
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0438 0.0438
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0536 0.0667
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.2214 0.2208
Echinococcus multilocularis muscleblind protein 1 0.0152 0.9123 0.9122
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0731 0.2018
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.3582 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0536 0.0536
Onchocerca volvulus 0.0017 0.0536 0.0667
Loa Loa (eye worm) RNA binding protein 0.0076 0.4315 0.4311
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0731 0.3271
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.1792 0.4508
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.001 0.001
Loa Loa (eye worm) ctsf protein 0.0017 0.0536 0.0529
Entamoeba histolytica hypothetical protein 0.0043 0.2214 1
Leishmania major cathepsin L-like protease 0.0065 0.3582 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0536 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0177 0.0938
Echinococcus granulosus tar DNA binding protein 0.0076 0.4315 0.4311
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0536 0.2949
Echinococcus multilocularis GPCR, family 2 0.0016 0.0438 0.0431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0536 0.2949
Echinococcus granulosus GPCR family 2 0.0016 0.0438 0.0431
Onchocerca volvulus 0.0028 0.1247 0.199
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0323 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0536 0.2949
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0536 0.0617
Loa Loa (eye worm) hypothetical protein 0.0014 0.0323 0.0317
Echinococcus multilocularis cysteine protease 0.0017 0.0536 0.0529
Loa Loa (eye worm) hypothetical protein 0.0049 0.2568 0.2563
Brugia malayi Cathepsin L-like precursor 0.0011 0.0177 0.0177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0536 0.2949
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0323 0.1758
Brugia malayi Cathepsin L-like precursor 0.0017 0.0536 0.0536
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.1792 0.1786
Echinococcus multilocularis muscleblind protein 0.0152 0.9123 0.9122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3582 1
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.3582 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.1792 1
Leishmania major cathepsin L-like protease 0.0017 0.0536 0.0651
Echinococcus granulosus cathepsin l1 0.0011 0.0177 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3582 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.9123 0.9122
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.4315 0.4315
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.2698 0.7525
Brugia malayi hypothetical protein 0.0043 0.2214 0.2214
Leishmania major cathepsin L-like protease 0.0017 0.0536 0.0651
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0731 0.4045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0536 0.2949
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0536 0.7292
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4315 0.5052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0438 0.0431
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0536 0.0651
Schistosoma mansoni ap endonuclease 0.002 0.0731 0.0846
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.2214 0.2208
Plasmodium vivax vivapain-2 0.0017 0.0536 0.7292
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4315 0.5052
Schistosoma mansoni hypothetical protein 0.0034 0.1582 0.1845
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0323 0.1758
Toxoplasma gondii exonuclease III APE 0.002 0.0731 0.0842
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0536 0.0529
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3582 1
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0536 0.2385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0536 0.2949
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0323 0.1758
Brugia malayi Cathepsin L-like precursor 0.0017 0.0536 0.0536
Loa Loa (eye worm) fibroinase 0.0017 0.0536 0.0529
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0731 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.1792 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0323 0.1758
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.1792 0.8088
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0323 0.0272
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0323 0.1758
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.1792 0.1786
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.2853 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0438 0.0431

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.082 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 0.2239 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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