Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0028 | 0.2833 | 1 |
Onchocerca volvulus | 0.0033 | 0.3615 | 0.5 | |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0019 | 0.1545 | 0.0631 |
Schistosoma mansoni | lamin | 0.0033 | 0.3615 | 0.3577 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0028 | 0.2833 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.1545 | 0.1262 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1246 | 0.3339 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0019 | 0.1545 | 0.5359 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0019 | 0.1545 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.3615 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.3615 | 0.2925 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0882 | 0.2315 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0028 | 0.2833 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0882 | 0.2315 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0019 | 0.1545 | 0.418 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.2833 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0019 | 0.1545 | 0.1495 |
Echinococcus multilocularis | musashi | 0.0033 | 0.3615 | 0.2925 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0028 | 0.2833 | 0.2058 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0028 | 0.2833 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0059 | 0.0208 |
Onchocerca volvulus | 0.0033 | 0.3615 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0059 | 0.0000000035153 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.2833 | 0.279 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3522 | 0.9738 |
Entamoeba histolytica | recQ family helicase, putative | 0.0019 | 0.1545 | 0.5455 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0059 | 0.0059 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0028 | 0.2833 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0976 | 0.2578 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0019 | 0.1545 | 0.0631 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0028 | 0.2833 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0019 | 0.1545 | 0.418 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.3615 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0019 | 0.1545 | 0.0631 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0028 | 0.2833 | 0.1523 |
Treponema pallidum | ATP-dependent DNA helicase | 0.001 | 0.0059 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.3615 | 0.3577 |
Echinococcus granulosus | bloom syndrome protein | 0.0019 | 0.1545 | 0.0631 |
Echinococcus multilocularis | lamin | 0.0033 | 0.3615 | 0.2925 |
Schistosoma mansoni | lamin | 0.0033 | 0.3615 | 0.3577 |
Giardia lamblia | Rrm3p helicase | 0.0028 | 0.2833 | 1 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0028 | 0.2833 | 1 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0028 | 0.2833 | 0.1523 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.3615 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0028 | 0.2833 | 0.2058 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3615 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.3615 | 0.2925 |
Echinococcus granulosus | lamin | 0.0033 | 0.3615 | 0.2925 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.1545 | 0.1262 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0059 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0019 | 0.1545 | 0.1495 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.1545 | 0.1545 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.1545 | 0.1545 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.3615 | 0.2925 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0019 | 0.1545 | 0.0631 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0019 | 0.1545 | 0.0631 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.3615 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0019 | 0.1545 | 0.5 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0019 | 0.1545 | 0.1262 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1545 | 0.418 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.