Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0011 | 0.0647 | 0.0864 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0024 | 0.3971 | 0.3889 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0022 | 0.3337 | 0.4398 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.4383 | 0.5834 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0028 | 0.4773 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0021 | 0.3157 | 0.4155 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0039 | 0.7486 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0026 | 0.4383 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0021 | 0.324 | 0.4329 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1625 | 0.0823 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0028 | 0.4773 | 0.6376 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0028 | 0.4773 | 0.6357 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0025 | 0.4191 | 0.5599 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0008 | 0.0039 | 0.0052 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0028 | 0.4773 | 0.6337 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0008 | 0.0081 | 0.0056 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0047 | 0.9418 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0008 | 0.0039 | 0.0039 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0039 | 0.7486 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0008 | 0.0081 | 0.0108 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0026 | 0.4383 | 0.4383 |
Mycobacterium ulcerans | thioesterase TesA | 0.0022 | 0.3337 | 0.443 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0026 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0039 | 0.7486 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0026 | 0.4383 | 0.5856 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0021 | 0.3157 | 0.4188 |
Mycobacterium ulcerans | thioesterase | 0.0022 | 0.3337 | 0.443 |
Onchocerca volvulus | 0.004 | 0.7722 | 0.6887 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0028 | 0.4773 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0019 | 0.2616 | 0.3495 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0026 | 0.4383 | 0.5856 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0028 | 0.4773 | 0.6376 |
Loa Loa (eye worm) | fatty acid synthase | 0.0026 | 0.43 | 0.4318 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0009 | 0.0267 | 0.0356 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0017 | 0.2258 | 0.2981 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0024 | 0.3971 | 0.5305 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0017 | 0.2258 | 0.2981 |
Mycobacterium ulcerans | polyketide synthase | 0.0028 | 0.4773 | 0.6357 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0015 | 0.1676 | 0.224 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0021 | 0.3157 | 0.4188 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0028 | 0.4773 | 0.6357 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0018 | 0.2576 | 0.3708 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0017 | 0.2258 | 0.2941 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.3971 | 0.3971 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.4383 | 0.5834 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.8648 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0026 | 0.4383 | 0.581 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.4383 | 0.5856 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0028 | 0.4773 | 0.6376 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0028 | 0.4773 | 0.6337 |
Onchocerca volvulus | 0.0045 | 0.9028 | 0.9285 | |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0017 | 0.218 | 0.2574 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0039 | 0.7486 | 1 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0022 | 0.3337 | 0.4459 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0025 | 0.4191 | 0.5599 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.