Detailed information for compound 602813

Basic information

Technical information
  • TDR Targets ID: 602813
  • Name: 3-phenyl-4,5-dihydrothiophene 1,1-dioxide
  • MW: 194.25 | Formula: C10H10O2S
  • H donors: 0 H acceptors: 2 LogP: 1.24 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=S1(=O)CCC(=C1)c1ccccc1
  • InChi: 1S/C10H10O2S/c11-13(12)7-6-10(8-13)9-4-2-1-3-5-9/h1-5,8H,6-7H2
  • InChiKey: OYADUSJXUNXFQD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0024 0.5
Echinococcus multilocularis lamin dm0 0.0166 0.0174 0.0174
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0002 0.0002
Echinococcus granulosus intermediate filament protein 0.0166 0.0174 0.0174
Schistosoma mansoni microtubule-associated protein tau 0.8438 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0103
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0019 0.5669
Brugia malayi beta-lactamase family protein 0.0039 0.0024 0.1391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0021 0.6542
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0002 0.013
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0024 0.0024
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0021 0.6556
Onchocerca volvulus 0.0166 0.0174 0.7894
Brugia malayi cytoplasmic intermediate filament protein 0.0089 0.0083 0.4755
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0002 0.0002
Schistosoma mansoni coup transcription factor 0.0021 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0033 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0019 0.5669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0033 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0021 0.6542
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0002 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0007 0.2211
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0021 0.6556
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0015 0.0881
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0033 0.1878
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0089 0.0083 0.3764
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0024 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.0171 0.7752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0007 0.2224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0007 0.2224
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0021 0.6556
Mycobacterium ulcerans hypothetical protein 0.0039 0.0024 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0002 0.013
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0002 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0103
Toxoplasma gondii ABC1 family protein 0.0039 0.0024 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0103
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0024 0.7407
Schistosoma mansoni thyroid hormone receptor 0.0282 0.0312 0.0312
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0015 0.0698
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0002 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0015 0.0015
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0002 0.013
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0261 0.0287 0.0287
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0024 0.0876
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0033 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0024 0.7407
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0033 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0097 0.5587
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0698
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0002 0.0002
Brugia malayi steroid hormone receptor 0.0021 0.0002 0.013
Onchocerca volvulus 0.0039 0.0024 0.1008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0019 0.5669
Giardia lamblia GTOR 0.0047 0.0033 1
Echinococcus multilocularis tumor protein p63 0.1397 0.1637 0.1637
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0002 0.013
Loa Loa (eye worm) hypothetical protein 0.008 0.0072 0.3289
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0069 0.0059 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.001 0.3097
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0024 0.7407
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0024 0.0876
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0024 0.7407
Echinococcus multilocularis musashi 0.0166 0.0174 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0019 0.5669
Echinococcus granulosus cytoplasmic intermediate filament protein 0.008 0.0072 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0002 0.013
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0021 0.6542
Brugia malayi beta-lactamase family protein 0.0039 0.0024 0.1391
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.1101
Mycobacterium ulcerans beta-lactamase 0.0039 0.0024 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0033 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0002 0.0002
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0004 0.1091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0103
Echinococcus multilocularis lamin 0.0166 0.0174 0.0174
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0101 0.0097 0.4422
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.1101
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0033 1
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0024 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0002 0.0002
Brugia malayi Intermediate filament tail domain containing protein 0.0166 0.0174 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0002 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0015 0.4435
Loa Loa (eye worm) hypothetical protein 0.0069 0.0059 0.2698
Onchocerca volvulus 0.0039 0.0024 0.1008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0103
Mycobacterium tuberculosis Conserved protein 0.0039 0.0024 0.0876
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0002 0.013
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0033 0.1487
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0002 0.0002
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0024 0.0876
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0015 0.0881
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0103
Brugia malayi nuclear receptor NHR-88 0.0021 0.0002 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0007 0.2224
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0252 0.0277 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0024 1
Brugia malayi intermediate filament protein 0.0166 0.0174 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0002 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0007 0.2211
Loa Loa (eye worm) hypothetical protein 0.0077 0.0069 0.3125
Brugia malayi ecdysteroid receptor 0.0021 0.0002 0.013
Echinococcus multilocularis GPCR, family 2 0.0032 0.0015 0.0015
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0002 0.0103
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0024 0.7407
Mycobacterium tuberculosis Conserved protein 0.0039 0.0024 0.0876
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0166 0.0174 0.7916
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0097 0.4422
Echinococcus multilocularis microtubule associated protein 2 0.8438 1 1
Schistosoma mansoni lamin 0.0166 0.0174 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0019 0.5669
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0024 0.0876
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0024 0.0876
Loa Loa (eye worm) hypothetical protein 0.0204 0.022 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0002 0.0002
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0033 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0032 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0002 0.013
Brugia malayi beta-lactamase 0.0039 0.0024 0.1391
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0002 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0019 0.5669
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0002 0.013
Leishmania major hypothetical protein, conserved 0.0039 0.0024 0.7407
Schistosoma mansoni cellular tumor antigen P53 0.0204 0.022 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.001 0.3197
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0033 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.1101
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0097 0.5587
Loa Loa (eye worm) beta-lactamase 0.0039 0.0024 0.1101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.001 0.3197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0002 0.0103
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0015 0.0015
Mycobacterium ulcerans lipase LipD 0.0039 0.0024 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0024 0.7407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0002 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.001 0.3197
Mycobacterium leprae Probable lipase LipE 0.0039 0.0024 0.5
Schistosoma mansoni intermediate filament proteins 0.0166 0.0174 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0021 0.6542
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0002 0.013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0032 0.0015 0.0015
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0033 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.001 0.3097
Loa Loa (eye worm) hypothetical protein 0.0166 0.0174 0.7916
Echinococcus granulosus lamin dm0 0.0166 0.0174 0.0174
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0002 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0002 0.0002
Trichomonas vaginalis esterase, putative 0.0039 0.0024 0.7407
Loa Loa (eye worm) hypothetical protein 0.0077 0.0069 0.3125
Onchocerca volvulus 0.0039 0.0024 0.1008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0024 0.0876
Brugia malayi nuclear hormone receptor 0.0021 0.0002 0.013
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0002 0.0002
Echinococcus granulosus GPCR family 2 0.0032 0.0015 0.0015
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0024 0.7407
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0002 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0013 0.407
Echinococcus multilocularis thyroid hormone receptor alpha 0.0282 0.0312 0.0312
Echinococcus granulosus tumor protein p63 0.1397 0.1637 0.1637
Loa Loa (eye worm) intermediate filament protein 0.0166 0.0174 0.7916
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.1101
Onchocerca volvulus 0.0204 0.022 1
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0002 0.0002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0033 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.1101
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0059 0.3409
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0002 0.013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0002 0.0103
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0024 0.0876
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0033 1
Schistosoma mansoni hypothetical protein 0.0032 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0002 0.0103
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0033 0.0033
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0024 0.7407
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0002 0.0002
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0 0.0118
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.1101
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0024 0.1101
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0002 0.0002
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0261 0.0287 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0007 0.2211
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0103
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0261 0.0287 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0025 0.7529
Schistosoma mansoni lamin 0.0166 0.0174 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0002 0.013
Echinococcus granulosus lamin 0.0166 0.0174 0.0174
Schistosoma mansoni thyroid hormone receptor 0.0282 0.0312 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0007 0.2224
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.008 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0103
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0002 0.0002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0002 0.0002
Mycobacterium tuberculosis Conserved protein 0.0039 0.0024 0.0876
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0033 0.0033
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0024 0.0024
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0033 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0032 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0019 0.5669
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0002 0.013
Onchocerca volvulus 0.0166 0.0174 0.7894
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0002 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0021 0.6542
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0024 0.1391
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0002 0.0103
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0002 0.0002

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 1.23 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 1.28 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 1.41 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 44 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 57 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 97 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 2.21 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -1 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 44 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 57 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 97 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.69 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.20492 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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