Target list

Search results for query: PLoS NTD Query 3 (L. major, w/ essentiality)

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #98 (Mtb no TM domain (now searched on lma)): 20
  • Score for genes in query #102 (Mtb any genetic validation (now searched on lma)): 50
  • Score for genes in query #104 (Mtb dindex >=0.6 (now searched on lma)): 35
  • Score for genes in query #110 (Lma in Tbr and Tcr): 25
  • Score for genes in query #103 (Mtb any essentiality evidence (now searched on lma)): 50
  • Score for genes in query #107 (Mtb all proteins (now searched on lma)): 1
  • Score for genes in query #97 (Mtb mwt <100kDa (now searched on lma)): 20
  • Score for genes in query #105 (Mtb Compd desirability >0.3 (now searched on lma)): 35
  • Score for genes in query #99 (Mtb PDB (now searched on lma)): 50
  • Score for genes in query #95 (Mtb enz (EC + func. Categ.) (now searched on lma)): 100
  • Score for genes in query #106 (Mtb assayable (now searched on lma)): 35
  • Score for genes in query #100 (Mtb modbase (now searched on lma)): 30
  • Score for genes in query #101 (Mtb not in humans (now searched on lma)): 25
  • Score for genes in query #96 (Mtb Pubmed (now searched on lma)): 35

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

8243 records found | Showing page 2 of 330 (records 26-50) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
L. major   LmjF.26.0140   OG5_127379   adenine phosphoribosyltransferase 366
L. major   LmjF.21.1080   OG5_126712   cell division protein kinase 2,cdc2-related kinase 366
L. major   LmjF.12.0530   OG5_126980   glucose-6-phosphate isomerase 366
L. major   LmjF.35.0020   OG5_126685   pyruvate kinase 366
L. major   LmjF.16.1540   OG5_128177   DNA polymerase I alpha catalytic subunit, putative 366
L. major   LmjF.30.3520   OG5_126734   S-adenosylmethionine synthetase 351
L. major   LmjF.21.0240   OG5_126743   hexokinase, putative 351
L. major   LmjF.22.1360   OG5_127590   farnesyl pyrophosphate synthase 351
L. major   LmjF.18.1080   OG5_126748   protein kinase A catalytic subunit 351
L. major   LmjF.31.2940   OG5_129470   squalene synthase, putative 351
L. major   LmjF.28.0690   OG5_126821   serine/threonine protein phosphatase catalytic subunit, putative 351
L. major   LmjF.06.0370   OG5_127569   glutamine synthetase, putative 351
L. major   LmjF.28.2430   OG5_127061   vacuolar ATP synthase subunit b, putative 351
L. major   LmjF.07.1030   OG5_128367   peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 351
L. major   LmjF.19.1530   OG5_126727   peptidylprolyl isomerase-like protein 351
L. major   LmjF.12.0220   OG5_127291   hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 351
L. major   LmjF.11.1100   OG5_129288   lanosterol 14-alpha-demethylase, putative 351
L. major   LmjF.21.1210   OG5_129576   thymidine kinase, putative 351
L. major   LmjF.34.0110   OG5_126762   adenylate kinase, putative 351
L. major   LmjF.13.1190   OG5_127011   adenylosuccinate synthetase, putative 351
L. major   LmjF.20.0110   OG5_126776   phosphoglycerate kinase B, cytosolic 351
L. major   LmjF.27.1870   OG5_134306   trypanothione synthetase, putative 341
L. major   LmjF.03.0910   OG5_128875   inorganic pyrophosphatase, putative 341
L. major   LmjF.08.0100   OG5_141243   dual-specificity protein phosphatase, putative 341
L. major   LmjF.36.6650   OG5_129051   2,3-bisphosphoglycerate-independent phosphoglycerate mutase 341

Showing page 2 (records 26-50) of 330