Target list

Search results for query: PLoS NTD Query 3 (L. major, w/ essentiality)

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #104 (Mtb dindex >=0.6 (now searched on lma)): 35
  • Score for genes in query #98 (Mtb no TM domain (now searched on lma)): 20
  • Score for genes in query #105 (Mtb Compd desirability >0.3 (now searched on lma)): 35
  • Score for genes in query #97 (Mtb mwt <100kDa (now searched on lma)): 20
  • Score for genes in query #99 (Mtb PDB (now searched on lma)): 50
  • Score for genes in query #102 (Mtb any genetic validation (now searched on lma)): 50
  • Score for genes in query #110 (Lma in Tbr and Tcr): 25
  • Score for genes in query #101 (Mtb not in humans (now searched on lma)): 25
  • Score for genes in query #103 (Mtb any essentiality evidence (now searched on lma)): 50
  • Score for genes in query #95 (Mtb enz (EC + func. Categ.) (now searched on lma)): 100
  • Score for genes in query #107 (Mtb all proteins (now searched on lma)): 1
  • Score for genes in query #106 (Mtb assayable (now searched on lma)): 35
  • Score for genes in query #100 (Mtb modbase (now searched on lma)): 30
  • Score for genes in query #96 (Mtb Pubmed (now searched on lma)): 35

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

8243 records found | Showing page 3 of 330 (records 51-75) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
L. major   LmjF.06.0560   OG5_143192   deoxyuridine triphosphatase, putative,dUTP diphosphatase 341
L. major   LmjF.16.0540   OG5_128535   aspartate carbamoyltransferase, putative 341
L. major   LmjF.04.1160   OG5_127400   336
L. major   LmjF.10.0890   OG5_128118   FKBP-type peptidyl-prolyl cis-trans isomerase, putative 336
L. major   LmjF.23.0950   OG5_127293   cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 336
L. major   LmjF.32.0080   OG5_127597   N-myristoyl transferase, putative 331
L. major   LmjF.23.0110   OG5_127109   GDP-mannose pyrophosphorylase 331
L. major   LmjF.31.0560   OG5_128331   mevalonate kinase, putative 331
L. major   LmjF.18.0200   OG5_133772   UDP-galactopyranose mutase 331
L. major   LmjF.36.2390   OG5_129172   sterol 24-c-methyltransferase, putative 326
L. major   LmjF.36.2380   OG5_129172   sterol 24-c-methyltransferase, putative 326
L. major   LmjF.15.1290   OG5_128755   mitochondrial DNA topoisomerase II 321
L. major   LmjF.30.3500   OG5_126734   S-adenosylmethionine synthetase 321
L. major   LmjF.32.1820   OG5_126676   iron superoxide dismutase, putative 316
L. major   LmjF.05.0980   OG5_127601   NADH-ubiquinone oxidoreductase, mitochondrial, putative 316
L. major   LmjF.18.0510   OG5_126691   aconitase, putative 316
L. major   LmjF.26.0810   OG5_126711   type II (glutathione peroxidase-like) tryparedoxin peroxidase 316
L. major   LmjF.34.0890   OG5_127345   DNA-directed RNA polymerase subunit, putative 316
L. major   LmjF.36.6940   OG5_126843   protein disulfide isomerase 316
L. major   LmjF.19.1560   OG5_126887   inosine-5-monophosphate dehydrogenase 316
L. major   LmjF.22.0110   OG5_127152   GMP synthase, putative,glutamine amidotransferase, putative 316
L. major   LmjF.33.1930   OG5_126730   phosphoribosylpyrophosphate synthetase, putative,phosphoribosyl transferase, put ... 316
L. major   LmjF.32.2950   OG5_126708   nucleoside diphosphate kinase b 316
L. major   LmjF.18.1220   OG5_127154   prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putativ ... 316
L. major   LmjF.06.0610   OG5_127503   carbonic anhydrase family protein, putative 316

Showing page 3 (records 51-75) of 330