Detailed information for compound 1005115

Basic information

Technical information
  • TDR Targets ID: 1005115
  • Name: [(2S)-2-[[(1S)-1-(2,3-dihydro-1H-inden-2-yl)- 2-[(1R,2S,5S)-2-[[1,2-dioxo-1-(prop-2-enylami no)hexan-3-yl]carbamoyl]-6,6-dimethyl-3-azabi cyclo[3.1.0]hexan-3-yl]-2-oxoethyl]carbamoyla mino]-3,3-dimethylbutyl] N-ethylcarbamate
  • MW: 708.887 | Formula: C38H56N6O7
  • H donors: 5 H acceptors: 6 LogP: 4.84 Rotable bonds: 23
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=CCNC(=O)C(=O)C(NC(=O)[C@H]1N(C[C@H]2[C@@H]1C2(C)C)C(=O)[C@H](C1Cc2c(C1)cccc2)NC(=O)N[C@@H](C(C)(C)C)COC(=O)NCC)CCC
  • InChi: 1S/C38H56N6O7/c1-9-14-26(31(45)33(47)40-17-10-2)41-32(46)30-28-25(38(28,7)8)20-44(30)34(48)29(24-18-22-15-12-13-16-23(22)19-24)43-35(49)42-27(37(4,5)6)21-51-36(50)39-11-3/h10,12-13,15-16,24-30H,2,9,11,14,17-21H2,1,3-8H3,(H,39,50)(H,40,47)(H,41,46)(H2,42,43,49)/t25-,26?,27+,28-,29-,30-/m0/s1
  • InChiKey: USEJQIGPEBWPGB-QJLCYWBWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2S)-2-[[(1S)-2-[(1R,2S,5S)-2-[1-[2-(allylamino)-2-oxo-acetyl]butylcarbamoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-3-yl]-1-indan-2-yl-2-oxo-ethyl]carbamoylamino]-3,3-dimethyl-butyl] N-ethylcarbamate
  • N-ethylcarbamic acid [(2S)-2-[[[[(1S)-2-[(1R,2S,5S)-2-[[1-[2-(allylamino)-1,2-dioxoethyl]butylamino]-oxomethyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2-indanyl)-2-oxoethyl]amino]-oxomethyl]amino]-3,3-dimethylbutyl] ester
  • N-ethylcarbamic acid [(2S)-2-[[(1S)-2-[(1R,2S,5S)-2-[1-[2-(allylamino)-2-keto-acetyl]butylcarbamoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-3-yl]-1-indan-2-yl-2-keto-ethyl]carbamoylamino]-3,3-dimethyl-butyl] ester
  • [(2S)-2-[[(1S)-1-(2,3-dihydro-1H-inden-2-yl)-2-[(1R,2S,5S)-2-[[1,2-dioxo-1-(prop-2-enylamino)hexan-3-yl]carbamoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-3-yl]-2-oxo-ethyl]carbamoylamino]-3,3-dimethyl-butyl] N-ethylcarbamate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0039 0.0172
Plasmodium vivax SET domain protein, putative 0.003 0.0181 0.08
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0083 0.0215
Loa Loa (eye worm) Smad1 0.0032 0.021 0.0303
Schistosoma mansoni smad1 5 8 and 0.0032 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0107 0.1364 0.1974
Loa Loa (eye worm) hypothetical protein 0.0296 0.4278 0.6193
Schistosoma mansoni tar DNA-binding protein 0.0187 0.2607 0.2607
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.1339 0.5938
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0157 0.0407
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0 0.0001
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0051 0.0513 0.0513
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.1339 0.5938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0394 0.1019
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0727 0.3223
Brugia malayi 6-phosphofructokinase 0.0105 0.1339 0.1938
Schistosoma mansoni tar DNA-binding protein 0.0187 0.2607 0.2607
Schistosoma mansoni smad1 5 8 and 0.0032 0.021 0.021
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0157 0.0697
Brugia malayi MH1 domain containing protein 0.0032 0.021 0.0303
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0157 0.0407
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0394 0.1747
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.021 0.0303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0221 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0123 0.0317
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0394 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0221 0.0572
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0157 0.0697
Loa Loa (eye worm) latrophilin receptor protein 2 0.0094 0.1162 0.1682
Echinococcus multilocularis GPCR, family 2 0.0094 0.1162 0.1162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.0217
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.006 0.0651 0.2885
Brugia malayi Smad1 0.0032 0.021 0.0303
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0157 0.0697
Loa Loa (eye worm) hypothetical protein 0.0164 0.2255 0.3264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.0217
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.1339 0.3464
Brugia malayi cytoplasmic intermediate filament protein 0.0057 0.0601 0.0869
Schistosoma mansoni tar DNA-binding protein 0.0187 0.2607 0.2607
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0157 0.0697
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.1339 0.5938
Schistosoma mansoni hypothetical protein 0.0094 0.1162 0.1162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0119 0.0307
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0394 0.0394
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.1339 0.5938
Loa Loa (eye worm) hypothetical protein 0.0094 0.1162 0.1682
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0727 0.0727
Echinococcus multilocularis microtubule associated protein 2 0.0667 1 1
Trichomonas vaginalis glutaminase, putative 0.0269 0.3865 1
Brugia malayi Intermediate filament tail domain containing protein 0.0107 0.1364 0.1974
Echinococcus multilocularis tar DNA binding protein 0.0187 0.2607 0.2607
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0157 0.0407
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0164 0.2255 1
Giardia lamblia GTOR 0.0044 0.0394 0.1747
Trypanosoma cruzi phosphoglycerate kinase, putative 0.006 0.0651 0.2885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0123 0.0317
Schistosoma mansoni hypothetical protein 0.0094 0.1162 0.1162
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0164 0.2255 0.5835
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.021 0.021
Loa Loa (eye worm) TAR-binding protein 0.0187 0.2607 0.3774
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0221 0.0572
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0257 0.1138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0172 0.0445
Trypanosoma brucei phosphoglycerate kinase, putative 0.006 0.0651 0.2885
Giardia lamblia Phosphoglycerate kinase 0.0164 0.2255 1
Echinococcus granulosus lamin 0.0107 0.1364 0.1364
Echinococcus multilocularis lamin 0.0107 0.1364 0.1364
Brugia malayi glutaminase DH11.1 0.0269 0.3865 0.5595
Loa Loa (eye worm) hypothetical protein 0.0105 0.1334 0.1931
Echinococcus granulosus Smad4 0.0032 0.021 0.021
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0181 0.018
Echinococcus granulosus GPCR family 2 0.0094 0.1162 0.1162
Schistosoma mansoni hypothetical protein 0.0094 0.1162 0.1162
Trypanosoma brucei phosphoglycerate kinase 0.0164 0.2255 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.0217
Brugia malayi 6-phosphofructokinase 0.0105 0.1339 0.1938
Echinococcus multilocularis lamin dm0 0.0107 0.1364 0.1364
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0727 0.3223
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.006 0.0651 0.2885
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0157 0.0697
Brugia malayi Phosphoglycerate kinase 0.0164 0.2255 0.3264
Loa Loa (eye worm) intermediate filament protein 0.0107 0.1364 0.1974
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1339 0.3464
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.1339 0.1938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0158 0.0407
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.1339 0.1339
Echinococcus granulosus phosphoglycerate kinase 1 0.0164 0.2255 0.2255
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0157 0.0407
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0727 0.3223
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0164 0.2255 1
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.1339 0.5938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0221 0.0572
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0394 0.057
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0164 0.2255 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0394 0.1747
Schistosoma mansoni tar DNA-binding protein 0.0187 0.2607 0.2607
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0094 0.1162 0.1682
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0094 0.1162 0.1162
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0051 0.0513 0.0513
Schistosoma mansoni hypothetical protein 0.0202 0.2836 0.2836
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0394 0.1747
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0157 0.0697
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0157 0.0697
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0296 0.4278 0.6193
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0394 0.0394
Brugia malayi Phosphoglycerate kinase 0.006 0.0651 0.0942
Brugia malayi MH2 domain containing protein 0.0032 0.021 0.0303
Entamoeba histolytica phosphoglycerate kinase, putative 0.0164 0.2255 1
Schistosoma mansoni intermediate filament proteins 0.0107 0.1364 0.1364
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0394 0.1747
Echinococcus multilocularis smad 0.0032 0.021 0.021
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0051 0.0513 0.0743
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0181 0.018
Echinococcus granulosus intermediate filament protein 0.0107 0.1364 0.1364
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0181 0.08
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0181 0.018
Onchocerca volvulus 0.0107 0.1364 0.3705
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.1339 0.5938
Plasmodium vivax phosphoglycerate kinase, putative 0.0164 0.2255 1
Plasmodium falciparum phosphoglycerate kinase 0.0164 0.2255 1
Schistosoma mansoni Smad4 0.0032 0.021 0.021
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.2931 0.4242
Schistosoma mansoni smad 0.0032 0.021 0.021
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.021 0.021
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0221 0.0981
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0257 0.1138
Loa Loa (eye worm) glutaminase 0.0269 0.3865 0.5595
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0094 0.1162 0.1162
Echinococcus multilocularis phosphoglycerate kinase 1 0.0164 0.2255 0.2255
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0164 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.0217
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0094 0.1162 0.1162
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.1339 0.1339
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0727 0.0727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0221 0.0572
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0187 0.2607 0.3774
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0394 0.1747
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0221 0.0572
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0157 0.0697
Schistosoma mansoni lamin 0.0107 0.1364 0.1364
Loa Loa (eye worm) RNA binding protein 0.0187 0.2607 0.3774
Loa Loa (eye worm) transcription factor SMAD2 0.0466 0.6909 1
Chlamydia trachomatis phosphoglycerate kinase 0.0164 0.2255 1
Trichomonas vaginalis set domain proteins, putative 0.0237 0.3375 0.8731
Schistosoma mansoni phosphoglycerate kinase 0.0164 0.2255 0.2255
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.1339 0.5938
Schistosoma mansoni smad1 5 8 and 0.0032 0.021 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0256 0.0662
Leishmania major phosphoglycerate kinase B, cytosolic 0.0164 0.2255 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0094 0.1162 0.1162
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.021 0.021
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.1339 0.1339
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0164 0.2255 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.006 0.0651 0.2885
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0181 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0256 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0394 0.1019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.018
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0394 0.1747
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0157 0.0697
Echinococcus granulosus tar DNA binding protein 0.0187 0.2607 0.2607
Brugia malayi MH2 domain containing protein 0.0466 0.6909 1
Trypanosoma brucei phosphoglycerate kinase 0.0164 0.2255 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0164 0.2255 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0083 0.0215
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0057 0.0601 0.0869
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0157 0.0407
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0107 0.1364 0.1974
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.1339 0.1938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0083 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0187 0.2607 0.2607
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0157 0.0407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0256 0.0662
Schistosoma mansoni hypothetical protein 0.0094 0.1162 0.1162
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.021 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0221 0.0572
Mycobacterium ulcerans glutaminase 0.0269 0.3865 1
Echinococcus granulosus smad 0.0032 0.021 0.021
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0394 0.0394
Trypanosoma brucei phosphoglycerate kinase 0.006 0.0651 0.2885
Leishmania major phosphoglycerate kinase C, glycosomal 0.0164 0.2255 1
Brugia malayi MH1 domain containing protein 0.0032 0.021 0.0303
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0257 0.1138
Echinococcus granulosus lamin dm0 0.0107 0.1364 0.1364
Loa Loa (eye worm) phosphofructokinase 0.0105 0.1339 0.1938
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0164 0.2255 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0296 0.4278 0.6193
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1339 0.3464
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0727 0.0727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0394 0.1019
Brugia malayi MH2 domain containing protein 0.0032 0.021 0.0303
Echinococcus multilocularis Smad4 0.0032 0.021 0.021
Schistosoma mansoni microtubule-associated protein tau 0.0667 1 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0157 0.0407
Brugia malayi latrophilin 2 splice variant baaae 0.0202 0.2836 0.4105
Loa Loa (eye worm) hypothetical protein 0.005 0.0483 0.0699
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0394 0.1747
Treponema pallidum phosphoglycerate kinase 0.0164 0.2255 1
Schistosoma mansoni lamin 0.0107 0.1364 0.1364
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0394 0.1747
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0296 0.4278 0.6193
Echinococcus multilocularis musashi 0.0107 0.1364 0.1364
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0157 0.0697
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0303 0.0303
Brugia malayi Pre-SET motif family protein 0.003 0.0181 0.0261
Schistosoma mansoni glutaminase 0.0269 0.3865 0.3865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0296 0.0764
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0119 0.0307
Loa Loa (eye worm) hypothetical protein 0.003 0.0181 0.0261
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.006 0.0651 0.2885
Brugia malayi phosphofructokinase 0.0105 0.1339 0.1938
Loa Loa (eye worm) hypothetical protein 0.0202 0.2836 0.4105
Brugia malayi RNA binding protein 0.0187 0.2607 0.3774
Loa Loa (eye worm) hypothetical protein 0.005 0.0483 0.0699
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.1339 0.5938
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1339 0.3464
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.021 0.0303
Brugia malayi Latrophilin receptor protein 2 0.0094 0.1162 0.1682
Brugia malayi intermediate filament protein 0.0107 0.1364 0.1974
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0164 0.2255 1
Mycobacterium ulcerans phosphoglycerate kinase 0.0164 0.2255 0.5835
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.1339 0.1339
Schistosoma mansoni phosphoglycerate kinase 0.0164 0.2255 0.2255
Onchocerca volvulus 0.0237 0.3375 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0727 0.1052
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0727 0.3223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0256 0.0662
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1339 0.3464
Brugia malayi Pre-SET motif family protein 0.0208 0.2931 0.4242
Loa Loa (eye worm) glutaminase 2 0.0269 0.3865 0.5595
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0727 0.3224
Brugia malayi TAR-binding protein 0.0187 0.2607 0.3774
Loa Loa (eye worm) MH2 domain-containing protein 0.0466 0.6909 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.021 0.021
Brugia malayi RNA recognition motif domain containing protein 0.0187 0.2607 0.3774
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0256 0.0662
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0727 0.1052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0123 0.0317
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0164 0.2255 0.5835
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.006 0.0651 0.2885
Onchocerca volvulus 0.0107 0.1364 0.3705

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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