TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 281.223 | Formula: C14H7N3O4
H donors: 0 H acceptors: 4 LogP: 2.84 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N#C/C(=C\c1ccc(o1)[N+](=O)[O-])/c1nc2c(o1)cccc2
InChi: 1S/C14H7N3O4/c15-8-9(7-10-5-6-13(20-10)17(18)19)14-16-11-3-1-2-4-12(11)21-14/h1-7H/b9-7+
InChiKey: ZYTRJXROMQJXNJ-VQHVLOKHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0039	0.0136	0.0861
Plasmodium falciparum	basic transcription factor 3b, putative	0.0076	0.0648	0.1663
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0144	0.1585	0.1548
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0346	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0066	0.0147
Onchocerca volvulus		0.0259	0.3166	1
Brugia malayi	nuclear receptor NHR-88	0.0034	0.0066	0.0147
Echinococcus granulosus	neutral alpha glucosidase AB	0.0079	0.0684	0.0659
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0034	0.0066	0.0022
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0773	0.0521
Brugia malayi	Steroid receptor seven-up type 2	0.0034	0.0066	0.0147
Echinococcus multilocularis	chromobox protein 1	0.0076	0.0645	0.0603
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0034	0.0066	0.0022
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0034	0.0066	0.0022
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0601	0.0575
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0056	0.0367	0.0941
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0034	0.0066	0.0147
Trypanosoma cruzi	transcription factor btf3, putative	0.0076	0.0648	0.4091
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0183	0.0406
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0356	0.4508	0.4483
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0034	0.0066	0.0039
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0045	0.0216	0.0173
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0356	0.4508	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0034	0.0066	0.0022
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0144	0.1585	1
Loa Loa (eye worm)	heterochromatin protein 1	0.0076	0.0645	0.143
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0034	0.0066	0.021
Echinococcus granulosus	chromobox protein 1	0.0076	0.0645	0.0619
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0601	0.056
Entamoeba histolytica	hypothetical protein	0.0076	0.0648	0.4091
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0356	0.4508	0.4483
Echinococcus multilocularis	transcription factor btf3	0.0076	0.0648	0.0607
Echinococcus granulosus	ecdysone induced protein 78C	0.0034	0.0066	0.0039
Trichomonas vaginalis	alpha-glucosidase, putative	0.0079	0.0684	0.2161
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0066	0.0147
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0773	0.5
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0066	0.0147
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0601	0.7777
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0144	0.1585	1
Schistosoma mansoni	chromobox protein	0.0076	0.0645	0.0603
Trichomonas vaginalis	chromobox protein, putative	0.0046	0.0228	0.0719
Schistosoma mansoni	alpha-glucosidase	0.0306	0.3823	0.3796
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0356	0.4508	1
Loa Loa (eye worm)	ICD-1 protein	0.0076	0.0648	0.1438
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0079	0.0684	0.2161
Brugia malayi	Probable ClpP-like protease	0.0085	0.0773	0.1715
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0034	0.0066	0.0147
Schistosoma mansoni	RAR-like nuclear receptor	0.0034	0.0066	0.0022
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0034	0.0066	0.0039
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0034	0.0066	0.0147
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0066	0.0039
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0034	0.0066	0.0147
Schistosoma mansoni	hypothetical protein	0.0037	0.0108	0.0064
Brugia malayi	Heterochromatin protein 1	0.0076	0.0645	0.143
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0034	0.0066	0.0022
Onchocerca volvulus		0.0045	0.0216	0.0682
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0136	0.0109
Trypanosoma cruzi	hypothetical protein, conserved	0.0079	0.0684	0.4318
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0034	0.0066	0.0022
Schistosoma mansoni	chromobox protein	0.0076	0.0645	0.0603
Entamoeba histolytica	hypothetical protein	0.0039	0.0136	0.0861
Trichomonas vaginalis	alpha-glucosidase, putative	0.0079	0.0684	0.2161
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0034	0.0066	0.0147
Trichomonas vaginalis	chromobox protein, putative	0.0076	0.0645	0.2036
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0144	0.1585	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0034	0.0066	0.0022
Brugia malayi	photoreceptor-specific nuclear receptor	0.0034	0.0066	0.0147
Echinococcus granulosus	lysosomal alpha glucosidase	0.0356	0.4508	0.4492
Brugia malayi	hypothetical protein	0.0039	0.0136	0.0303
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0601	0.3794
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0085	0.0773	0.0732
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0034	0.0066	0.0147
Echinococcus multilocularis	ecdysone induced protein 78C	0.0034	0.0066	0.0022
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0227	0.2732	0.6062
Brugia malayi	beta-NAC-like protein	0.0076	0.0648	0.1438
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0034	0.0066	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0108	0.0239
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0773	0.0521
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0079	0.0684	0.4318
Onchocerca volvulus	Protein ultraspiracle homolog	0.0034	0.0066	0.021
Trypanosoma brucei	transcription factor BTF3, putative	0.0076	0.0648	0.4091
Schistosoma mansoni	hypothetical protein	0.0039	0.0136	0.0093
Brugia malayi	Pre-SET motif family protein	0.0033	0.0044	0.0098
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0079	0.0684	0.2161
Brugia malayi	Nuclear hormone receptor-like 1	0.0034	0.0066	0.0147
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0066	0.0147
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0144	0.1585	0.3516
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0034	0.0066	0.0147
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0034	0.0066	0.0039
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0085	0.0773	0.1984
Trichomonas vaginalis	alpha-glucosidase, putative	0.0079	0.0684	0.2161
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0773	0.1984
Echinococcus multilocularis	geminin	0.037	0.4704	0.4681
Plasmodium vivax	basic transcription factor 3b, putative	0.0076	0.0648	0.1663
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0034	0.0066	0.0147
Toxoplasma gondii	NAC domain-containing protein	0.0076	0.0648	0.8386
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0066	0.0147
Schistosoma mansoni	hypothetical protein	0.0314	0.3938	0.3912
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0056	0.0123
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0108	0.0239
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0066	0.0039
Schistosoma mansoni	peptidase Clp (S14 family)	0.0085	0.0773	0.0732
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0011	0.0034
Brugia malayi	nuclear hormone receptor	0.0034	0.0066	0.0147
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0034	0.0066	0.0147
Trichomonas vaginalis	conserved hypothetical protein	0.0076	0.0648	0.2048
Trypanosoma cruzi	transcription factor btf3, putative	0.0076	0.0648	0.4091
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0079	0.0684	0.2161
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0144	0.1585	0.3516
Schistosoma mansoni	coup transcription factor	0.0034	0.0066	0.0022
Leishmania major	alpha glucosidase II subunit, putative	0.0079	0.0684	0.4318
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0136	0.0093
Schistosoma mansoni	microtubule-associated protein tau	0.0753	1	1
Onchocerca volvulus	Bile acid receptor homolog	0.0034	0.0066	0.021
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0773	0.1715
Treponema pallidum	hypothetical protein	0.0311	0.3897	1
Brugia malayi	MH2 domain containing protein	0.0143	0.1575	0.3493
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0311	0.3897	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0136	0.0861
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0034	0.0066	0.0147
Trypanosoma cruzi	hypothetical protein, conserved	0.0079	0.0684	0.4318
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0044	0.0568
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0144	0.1585	0.1562
Trichomonas vaginalis	alpha-glucosidase, putative	0.0079	0.0684	0.2161
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0311	0.3897	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0034	0.0066	0.0147
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0044	0.0017
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0085	0.0773	0.0748
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0034	0.0066	0.0147
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0085	0.0773	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0079	0.0684	0.1518
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0311	0.3897	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0079	0.0684	0.4318
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0346	0.0767
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0773	0.5
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0066	0.0147
Schistosoma mansoni	alpha glucosidase	0.0079	0.0684	0.0643
Echinococcus granulosus	transcription factor Dp 1	0.0083	0.0746	0.0721
Echinococcus granulosus	neuropeptide receptor A26	0.0505	0.6567	0.6558
Trichomonas vaginalis	chromobox protein, putative	0.0046	0.0228	0.0719
Brugia malayi	chromobox protein homolog 3	0.0043	0.0183	0.0406
Entamoeba histolytica	hypothetical protein	0.0039	0.0136	0.0861
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0066	0.0022
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0034	0.0066	0.0147
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0346	0.0767
Leishmania major	basic transcription factor 3a, putative	0.0076	0.0648	0.4091
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0144	0.1585	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0066	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0346	0.0767
Onchocerca volvulus		0.0033	0.0056	0.0176
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0079	0.0684	0.1518
Trypanosoma brucei	glucosidase, putative	0.0079	0.0684	0.4318
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0183	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0066	0.0147
Loa Loa (eye worm)	transcription factor SMAD2	0.0143	0.1575	0.3493
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0066	0.0022
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0034	0.0066	0.0039
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0079	0.0684	0.885
Echinococcus granulosus	transcription factor btf3	0.0076	0.0648	0.0623
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0011	0.0034
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0601	0.056
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0079	0.0684	0.0643
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0034	0.0066	0.0147
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0601	0.056
Brugia malayi	Pre-SET motif family protein	0.0227	0.2732	0.6062
Echinococcus multilocularis	chromobox protein 1	0.0076	0.0645	0.0603
Brugia malayi	ecdysteroid receptor	0.0034	0.0066	0.0147
Onchocerca volvulus		0.0206	0.2436	0.7694
Onchocerca volvulus		0.0034	0.0066	0.021
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0773	0.1984
Loa Loa (eye worm)	MH2 domain-containing protein	0.0143	0.1575	0.3493
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0144	0.1585	0.1548
Trichomonas vaginalis	conserved hypothetical protein	0.0076	0.0648	0.2048
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0311	0.3897	1
Echinococcus multilocularis	neuropeptide s receptor	0.0505	0.6567	0.6552
Echinococcus granulosus	chromobox protein 1	0.0076	0.0645	0.0619
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0085	0.0773	1
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0144	0.1585	1
Echinococcus granulosus	neuropeptide s receptor	0.0505	0.6567	0.6558
Trichomonas vaginalis	alpha-glucosidase, putative	0.0079	0.0684	0.2161
Trichomonas vaginalis	chromobox protein, putative	0.0076	0.0645	0.2036
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0034	0.0066	0.0022
Schistosoma mansoni	transcription factor btf3	0.0076	0.0648	0.0607
Echinococcus granulosus	geminin	0.037	0.4704	0.469
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0056	0.0367	0.0324
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0183	0.0578
Plasmodium vivax	SET domain protein, putative	0.0033	0.0044	0.0113
Echinococcus granulosus	X box binding protein 1	0.0314	0.3938	0.3922
Echinococcus multilocularis	FTZ F1 alpha	0.0034	0.0066	0.0022
Echinococcus multilocularis	neuropeptide receptor A26	0.0505	0.6567	0.6552
Echinococcus multilocularis	transcription factor Dp 1	0.0083	0.0746	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0066	0.0147
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0034	0.0066	0.0022
Echinococcus multilocularis	microtubule associated protein 2	0.0753	1	1
Schistosoma mansoni	hypothetical protein	0.037	0.4704	0.4681
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0066	0.0147
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0601	0.0664
Brugia malayi	steroid hormone receptor	0.0034	0.0066	0.0147
Schistosoma mansoni	nuclear hormone receptor	0.0034	0.0066	0.0022
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0034	0.0066	0.0147
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0034	0.0066	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0044	0.0098
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0046	0.0228	0.0719
Echinococcus granulosus	peptidase Clp S14 family	0.0056	0.0367	0.034
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0066	0.0147
Schistosoma mansoni	alpha-glucosidase	0.0306	0.3823	0.3796
Echinococcus granulosus	FTZ F1 alpha	0.0034	0.0066	0.0039
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0034	0.0066	0.0022
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0034	0.0066	0.0022
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0773	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0066	0.0147
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0034	0.0066	0.0022
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0034	0.0066	0.0147
Entamoeba histolytica	transcription factor BTF3, putative	0.0076	0.0648	0.4091
Schistosoma mansoni	hypothetical protein	0.037	0.4704	0.4681
Trichomonas vaginalis	set domain proteins, putative	0.0259	0.3166	1
Loa Loa (eye worm)	steroid hormone receptor	0.0034	0.0066	0.0147
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0136	0.0093
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0066	0.0022
Echinococcus multilocularis	X box binding protein 1	0.0314	0.3938	0.3912
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0311	0.3897	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0066	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0076	0.0648	0.2048
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0183	0.0578
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0085	0.0773	0.1984
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0079	0.0684	0.2161

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 1.13 uM	Cytotoxicity against human A427 cells after 96 hrs by microtiter assay	ChEMBL.	18187237
IC50 (functional)	= 1.41 uM	Cytotoxicity against human RT112 cells after 96 hrs by microtiter assay	ChEMBL.	18187237
IC50 (functional)	= 1.65 uM	Cytotoxicity against human 5637 cells after 96 hrs by microtiter assay	ChEMBL.	18187237
IC50 (functional)	= 2.86 uM	Cytotoxicity against human YAPC cells after 96 hrs by microtiter assay	ChEMBL.	18187237
IC50 (functional)	= 2.86 uM	Cytotoxicity against human SISO cells after 96 hrs by microtiter assay	ChEMBL.	18187237
IC50 (functional)	= 2.87 uM	Cytotoxicity against human MCF7 cells after 96 hrs by microtiter assay	ChEMBL.	18187237
IC50 (functional)	= 3 uM	Cytotoxicity against human DAN-G cells after 96 hrs by microtiter assay	ChEMBL.	18187237
IC50 (functional)	= 3.98 uM	Cytotoxicity against human RT4 cells after 96 hrs by microtiter assay	ChEMBL.	18187237
IC50 (functional)	= 7 uM	Cytotoxicity against human KYSE510 cells after 96 hrs by microtiter assay	ChEMBL.	18187237

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	18187237

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL503790

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1005650