TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 256.253 | Formula: C15H12O4
H donors: 0 H acceptors: 3 LogP: 2.43 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: C/C=C/C1=C(OC(=O)C)C(=O)c2c(C1=O)cccc2
InChi: 1S/C15H12O4/c1-3-6-12-13(17)10-7-4-5-8-11(10)14(18)15(12)19-9(2)16/h3-8H,1-2H3/b6-3+
InChiKey: IJCZNWLTVXCYGF-ZZXKWVIFSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0322	0.2287	0.6912
Leishmania major	glucose transporter/membrane transporter D2, putative	0.01	0.0647	0.8731
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1366	1	1
Echinococcus granulosus	General substrate transporter	0.0277	0.1953	0.5882
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Trypanosoma cruzi	glucose transporter, putative	0.0045	0.0244	0.3296
Toxoplasma gondii	sugar transporter ST1	0.0045	0.0244	0.0327
Plasmodium vivax	hexose transporter	0.0322	0.2287	0.2253
Echinococcus granulosus	solute carrier family 22	0.0045	0.0244	0.0618
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0173	0.0927
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0097	0.0623	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0072	0.0441	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Brugia malayi	hypothetical protein	0.0045	0.0244	0.1068
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Brugia malayi	Major Facilitator Superfamily protein	0.0045	0.0244	0.1068
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0322	0.2287	0.6912
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0028	0.0642
Trypanosoma cruzi	hexose transporter, putative	0.0055	0.0313	0.4223
Trypanosoma cruzi	hexose transporter, putative	0.0045	0.0244	0.3296
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.052	0.3752	0.3724
Onchocerca volvulus		0.0045	0.0244	1
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0173	0.3931
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Onchocerca volvulus		0.0045	0.0244	1
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0045	0.0244	1
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0018	0.0044	0.0591
Giardia lamblia	Sugar-proton symporter	0.0045	0.0244	0.346
Schistosoma mansoni	sugar transporter	0.0045	0.0244	0.0894
Schistosoma mansoni	glucose transport protein	0.0322	0.2287	1
Mycobacterium ulcerans	lipase LipD	0.0036	0.0173	0.3931
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0173	0.3931
Trichomonas vaginalis	sugar transporter, putative	0.01	0.0647	0.274
Toxoplasma gondii	sugar transporter ST3	0.0045	0.0244	0.0327
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0173	0.0927
Schistosoma mansoni	serine/threonine protein kinase	0.0099	0.0638	0.2648
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0099	0.0638	0.1831
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0173	0.0757
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0099	0.0638	0.1831
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0173	0.2336
Onchocerca volvulus		0.0045	0.0244	1
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0244	0.0956
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0173	0.013
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0099	0.0638	0.0597
Entamoeba histolytica	protein kinase, putative	0.0099	0.0638	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0097	0.0623	0.2725
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0099	0.0638	0.0597
Brugia malayi	major facilitator superfamily protein	0.0045	0.0244	0.1068
Plasmodium vivax	lysine--tRNA ligase, putative	0.0072	0.0441	0.0399
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0322	0.2287	0.6912
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0099	0.0638	0.1831
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0045	0.0244	0.1383
Brugia malayi	hypothetical protein	0.0045	0.0244	0.1068
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0322	0.2287	0.6912
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0173	0.2436
Schistosoma mansoni	glucose transporter	0.0045	0.0244	0.0894
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.004	0.0203	0.0887
Onchocerca volvulus		0.0045	0.0244	1
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0099	0.0638	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0063	0.0375	0.1536
Giardia lamblia	Prolyl-tRNA synthetase	0.0097	0.0623	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0028	0.0381
Toxoplasma gondii	sugar transporter ST2	0.0045	0.0244	0.0327
Chlamydia trachomatis	proline--tRNA ligase	0.0034	0.0162	0.2978
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0045	0.0244	0.0618
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0173	0.0642
Trichomonas vaginalis	glucose transporter, putative	0.01	0.0647	0.274
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Trypanosoma brucei	glucose transporter, putative	0.01	0.0647	0.8731
Trypanosoma brucei	glucose transporter, putative	0.01	0.0647	0.8731
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0173	0.0399
Echinococcus granulosus	solute carrier family 22	0.0045	0.0244	0.0618
Loa Loa (eye worm)	sugar transporter	0.0045	0.0244	0.1068
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.01	0.0647	0.274
Brugia malayi	lysyl-tRNA synthetase	0.0072	0.0441	0.1927
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0638	0.2699
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0097	0.0623	0.1785
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0173	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0322	0.2287	0.6912
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Echinococcus granulosus	solute carrier family 22	0.0045	0.0244	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0173	0.0757
Onchocerca volvulus		0.0045	0.0244	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0072	0.0441	0.5944
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0441	0.1927
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Trichomonas vaginalis	esterase, putative	0.0036	0.0173	0.0642
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0322	0.2287	0.6912
Treponema pallidum	prolyl-tRNA synthetase	0.0034	0.0162	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Trypanosoma brucei	sugar transporter, putative	0.0045	0.0244	0.3296
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0045	0.0244	0.5545
Echinococcus multilocularis	neuropeptide receptor A26	0.0457	0.329	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0099	0.0638	0.1831
Plasmodium falciparum	mitogen-activated protein kinase 2	0.052	0.3752	0.3724
Echinococcus multilocularis	General substrate transporter	0.0277	0.1953	0.5882
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0173	0.0577
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0099	0.0638	0.1831
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Mycobacterium ulcerans	sugar transporter	0.0045	0.0244	0.5545
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0099	0.0638	0.1831
Toxoplasma gondii	glycyl-tRNA synthetase	0.0018	0.0044	0.0024
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0028	0.0381
Toxoplasma gondii	protein kinase, putative	0.0909	0.6627	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0113	0.0741	0.1081
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0244	0.0618
Leishmania major	myo-inositol/proton symporter (MIT)	0.0045	0.0244	0.3296
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0045	0.0244	0.1068
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0099	0.0638	0.0597
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0018	0.0044	0.0591
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0173	0.3931
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0028	0.0381
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.052	0.3752	0.5643
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0018	0.0044	0.0591
Trypanosoma brucei	glucose transporter 2A	0.01	0.0647	0.8731
Plasmodium falciparum	proline--tRNA ligase	0.0113	0.0741	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0638	0.2789
Onchocerca volvulus	Putative transporter	0.0045	0.0244	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Schistosoma mansoni	lysyl-tRNA synthetase	0.0072	0.0441	0.1769
Trichomonas vaginalis	sugar transport protein, putative	0.0045	0.0244	0.0956
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0099	0.0638	0.2789
Brugia malayi	beta-lactamase family protein	0.0036	0.0173	0.0757
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0173	0.0927
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0018	0.0044	0.0192
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0099	0.0638	0.0925
Echinococcus granulosus	synaptic vesicle 2 protein	0.0045	0.0244	0.0618
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0173	0.0642
Schistosoma mansoni	glucose transport protein	0.0322	0.2287	1
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0028	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0113	0.0741	1
Trichomonas vaginalis	glucose transporter, putative	0.01	0.0647	0.274
Chlamydia trachomatis	lysine--tRNA ligase	0.0072	0.0441	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0113	0.0741	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0173	0.0927
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0072	0.0441	0.5944
Entamoeba histolytica	hypothetical protein	0.0072	0.0441	0.6679
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0018	0.0044	0.0995
Schistosoma mansoni	protein kinase	0.0099	0.0638	0.2648
Schistosoma mansoni	hypothetical protein	0.0169	0.1157	0.4962
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0173	0.2436
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0244	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Onchocerca volvulus		0.0045	0.0244	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0078	0.049	0.214
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0113	0.0741	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0244	0.0618
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0018	0.0044	0.0192
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0173	0.0927
Brugia malayi	Sugar transporter family protein	0.0045	0.0244	0.1068
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0623	0.2725
Leishmania major	glucose transporter, lmgt1	0.01	0.0647	0.8731
Onchocerca volvulus		0.0045	0.0244	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.01	0.0647	0.8731
Echinococcus multilocularis	lysyl tRNA synthetase	0.0072	0.0441	0.1223
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0173	0.0757
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0018	0.0044	0.0995
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0173	0.0577
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0072	0.0441	0.1826
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Echinococcus multilocularis	geminin	0.0169	0.1157	0.343
Trypanosoma cruzi	sugar transporter, putative	0.0045	0.0244	0.3296
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Leishmania major	glucose transporter, lmgt2	0.01	0.0647	0.8731
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Plasmodium vivax	sugar transporter, putative	0.0045	0.0244	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0173	0.0757
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Toxoplasma gondii	ABC1 family protein	0.0036	0.0173	0.022
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0173	0.0927
Brugia malayi	beta-lactamase	0.0036	0.0173	0.0757
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0244	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0072	0.0441	1
Trypanosoma brucei	glucose transporter, putative	0.01	0.0647	0.8731
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Onchocerca volvulus		0.0045	0.0244	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Toxoplasma gondii	lysine-tRNA ligase	0.0072	0.0441	0.0625
Giardia lamblia	Hexose transporter	0.0045	0.0244	0.346
Schistosoma mansoni	protein kinase	0.0099	0.0638	0.2648
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0018	0.0044	0.0024
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0045	0.0244	0.0201
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0045	0.0244	0.3296
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0322	0.2287	0.6912
Plasmodium vivax	proline--tRNA ligase, putative	0.0113	0.0741	0.0701
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0097	0.0623	0.2583
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0173	0.2336
Trypanosoma cruzi	hexose transporter, putative	0.01	0.0647	0.8731
Onchocerca volvulus		0.0045	0.0244	1
Trypanosoma brucei	glucose transporter, putative	0.01	0.0647	0.8731
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0061	0.0361	0.2127
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0097	0.0623	0.2634
Onchocerca volvulus		0.0045	0.0244	1
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0099	0.0638	0.0597
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0173	0.0927
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0097	0.0623	0.2583
Leishmania major	threonyl-tRNA synthetase, putative	0.0018	0.0044	0.0591
Schistosoma mansoni	lysyl-tRNA synthetase	0.0072	0.0441	0.1769
Giardia lamblia	Lysyl-tRNA synthetase	0.0072	0.0441	0.6849
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0173	0.0757
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0173	0.3931
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0072	0.0441	0.6932
Leishmania major	protein kinase, putative	0.0099	0.0638	0.8605
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0045	0.0244	0.0618
Trichomonas vaginalis	glucose transporter, putative	0.0045	0.0244	0.0956
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0034	0.0162	0.3676
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0018	0.0044	0.0192
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0244	0.0956
Leishmania major	glucose transporter, lmgt3	0.01	0.0647	0.8731
Trypanosoma brucei	glucose transporter, putative	0.01	0.0647	0.8731
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Schistosoma mansoni	sugar transporter	0.0045	0.0244	0.0894
Onchocerca volvulus		0.0045	0.0244	1
Brugia malayi	major facilitator superfamily protein	0.0045	0.0244	0.1068
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0244	0.0956
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0099	0.0638	0.8605
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0173	0.2336
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0099	0.0638	0.0925
Leishmania major	hypothetical protein, conserved	0.0045	0.0244	0.3296
Onchocerca volvulus		0.0045	0.0244	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0045	0.0244	0.0618
Toxoplasma gondii	facilitative glucose transporter GT1	0.0322	0.2287	0.3424
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0099	0.0638	0.1831
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0099	0.0638	0.0925
Brugia malayi	Major Facilitator Superfamily protein	0.0045	0.0244	0.1068
Trichomonas vaginalis	myo-inositol transporter, putative	0.0045	0.0244	0.0956
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0173	0.0757
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0097	0.0623	0.1785
Schistosoma mansoni	glucose transport protein	0.0322	0.2287	1
Trypanosoma brucei	glucose transporter, putative	0.01	0.0647	0.8731
Brugia malayi	glycyl-tRNA synthetase	0.0018	0.0044	0.0192
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0045	0.0244	0.5545
Echinococcus granulosus	solute carrier family 22	0.0045	0.0244	0.0618
Leishmania major	hypothetical protein, conserved	0.0036	0.0173	0.2336
Plasmodium falciparum	lysine--tRNA ligase	0.0072	0.0441	0.0399
Schistosoma mansoni	hypothetical protein	0.0169	0.1157	0.4962
Trypanosoma brucei	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0028	0.0381
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0173	0.0757
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0113	0.0741	1
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0244	0.0618
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Trypanosoma brucei	THT1 - hexose transporter, putative	0.01	0.0647	0.8731
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0113	0.0741	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0173	0.0757
Echinococcus granulosus	neuropeptide receptor A26	0.0457	0.329	1
Loa Loa (eye worm)	sugar transporter	0.0322	0.2287	1
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0018	0.0044	0.0192
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0045	0.0244	0.1068
Onchocerca volvulus		0.0045	0.0244	1
Trichomonas vaginalis	conserved hypothetical protein	0.01	0.0647	0.274
Trypanosoma brucei	THT1 - hexose transporter, putative	0.01	0.0647	0.8731
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0018	0.0044	0.0591
Plasmodium falciparum	protein kinase 7	0.0909	0.6627	0.6612
Echinococcus granulosus	neuropeptide s receptor	0.0457	0.329	1
Trypanosoma brucei	glucose transporter 1E	0.01	0.0647	0.8731
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0099	0.0638	0.2789
Schistosoma mansoni	hypothetical protein	0.0322	0.2287	1
Trypanosoma cruzi	hexose transporter	0.01	0.0647	0.8731
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0018	0.0044	0.0262
Toxoplasma gondii	transporter, major facilitator family protein	0.0045	0.0244	0.0327
Onchocerca volvulus		0.0045	0.0244	1
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0099	0.0638	0.0597
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0173	0.0927
Echinococcus granulosus	calcium dependent protein kinase	0.0092	0.0593	0.1692
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Brugia malayi	hypothetical protein	0.0045	0.0244	0.1068
Schistosoma mansoni	sugar transporter	0.0045	0.0244	0.0894
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0061	0.0361	0.2127
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0322	0.2287	0.6912
Echinococcus granulosus	lysyl tRNA synthetase	0.0072	0.0441	0.1223
Trypanosoma cruzi	hexose transporter, putative	0.01	0.0647	0.8731
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0244	0.0618
Brugia malayi	Sugar transporter family protein	0.0045	0.0244	0.1068
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0099	0.0638	0.0597
Trypanosoma brucei	glucose transporter, putative	0.01	0.0647	0.8731
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0244	0.1068
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0173	0.0927
Plasmodium falciparum	hexose transporter	0.0322	0.2287	0.2253
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0173	0.0642
Brugia malayi	beta-lactamase family protein	0.0036	0.0173	0.0757
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0018	0.0044	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0322	0.2287	1
Trypanosoma brucei	glucose transporter, putative	0.01	0.0647	0.8731
Onchocerca volvulus		0.0045	0.0244	1
Echinococcus multilocularis	calcium dependent protein kinase	0.0092	0.0593	0.1692
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0173	0.0399
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0072	0.0441	0.5944
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0623	0.2725
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0045	0.0244	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Onchocerca volvulus		0.0045	0.0244	1
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0018	0.0044	0.01
Schistosoma mansoni	sugar transporter	0.0045	0.0244	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0173	0.0642
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0099	0.0638	0.0597
Echinococcus multilocularis	neuropeptide s receptor	0.0457	0.329	1
Trichomonas vaginalis	sugar transporter, putative	0.01	0.0647	0.274
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0244	0.0956
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0099	0.0638	0.0597
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0097	0.0623	0.2725
Brugia malayi	Cam kinase protein 1	0.0099	0.0638	0.2789
Trichomonas vaginalis	sugar transporter, putative	0.01	0.0647	0.274
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0228	0.1591	1
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0097	0.0623	0.9752
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0099	0.0638	0.1831
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0099	0.0638	0.2789
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0173	0.0927
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0173	0.0757
Echinococcus granulosus	geminin	0.0169	0.1157	0.343
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0045	0.0244	0.1383
Leishmania major	hypothetical protein, conserved	0.0016	0.0028	0.0381
Brugia malayi	Major Facilitator Superfamily protein	0.0045	0.0244	0.1068
Mycobacterium ulcerans	integral membrane transport protein	0.0045	0.0244	0.5545
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0061	0.0361	0.5587
Trypanosoma cruzi	hexose transporter, putative	0.01	0.0647	0.8731
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0044	0.0192
Brugia malayi	Sugar transporter family protein	0.0322	0.2287	1
Schistosoma mansoni	protein kinase	0.0099	0.0638	0.2648
Leishmania major	hypothetical protein, conserved	0.0016	0.0028	0.0381
Entamoeba histolytica	protein kinase, putative	0.0099	0.0638	1

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 5.1 ug ml-1	Evaluated for cytotoxicity in the KB cell culture assay	ChEMBL.	3669007
ED50 (functional)	= 5.1 ug ml-1	Evaluated for cytotoxicity in the KB cell culture assay	ChEMBL.	3669007

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 100665