Detailed information for compound 1009543

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 541.3 | Formula: C15H21N5O13P2
  • H donors: 7 H acceptors: 10 LogP: -5.68 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 3
  • SMILES: O[C@@H]1[C@H]2COP(=O)([O-])OP(=O)(O)OC[C@H]3O[C@@H](n4c5nc[n+]([C@@H]([C@@H]1O)O2)c(N)c5nc4)[C@@H]([C@@H]3O)O
  • InChi: 1S/C15H21N5O13P2/c16-12-7-13-18-4-19(12)14-10(23)8(21)5(31-14)1-29-34(25,26)33-35(27,28)30-2-6-9(22)11(24)15(32-6)20(13)3-17-7/h3-6,8-11,14-16,21-24H,1-2H2,(H2,25,26,27,28)/t5-,6-,8-,9-,10-,11-,14-,15-/m1/s1
  • InChiKey: RSEFDAKYCYLNIE-KEOHHSTQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glutathione reductase 0.0038 0.035 0.0312
Trichomonas vaginalis set domain proteins, putative 0.0242 0.3388 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0047 0.0491 0.1519
Brugia malayi acetyltransferase, GNAT family protein 0.0167 0.2272 0.7668
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0167 0.2272 0.2241
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0135 0.0243
Entamoeba histolytica hypothetical protein 0.0083 0.1028 1
Trichomonas vaginalis importin beta-1, putative 0.0052 0.0562 0.1476
Leishmania major DNA polymerase kappa, putative 0.0021 0.0096 0.0081
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.1216 0.4058
Brugia malayi Integrin alpha pat-2 precursor 0.0055 0.0604 0.1937
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0241 0.0201
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.1072 0.3552
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0096 0.0056
Plasmodium falciparum importin beta, putative 0.0064 0.0743 0.2438
Trypanosoma brucei importin beta-1 subunit, putative 0.0064 0.0743 0.2565
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0073 0.1025
Leishmania major trypanothione reductase 0.0038 0.035 0.0981
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0521 0.0483
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0095 0.1204 0.4019
Echinococcus granulosus histone acetyltransferase KAT2B 0.0162 0.2203 0.2171
Loa Loa (eye worm) hypothetical protein 0.0048 0.0504 0.0466
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0073 0.0033
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0209 0.2899 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0518 0.1573
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.2951 0.2923
Brugia malayi Importin beta-1 subunit 0.0064 0.0743 0.2417
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.0331
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0096 0.0081
Brugia malayi glutathione reductase 0.0038 0.035 0.1066
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.1072 0.3552
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.0504 0.174
Plasmodium falciparum thioredoxin reductase 0.0038 0.035 0.1008
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0209 0.2899 1
Trypanosoma cruzi GMP reductase 0.0209 0.2899 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0096 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0241 0.0201
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0521 0.0483
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0241 0.0201
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0096 0.0081
Entamoeba histolytica hypothetical protein 0.0083 0.1028 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0096 0.0056
Echinococcus granulosus GTP binding nuclear protein Ran 0.0047 0.0491 0.0453
Schistosoma mansoni hypothetical protein 0.0083 0.1028 0.0992
Echinococcus granulosus dna polymerase kappa 0.0021 0.0096 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.0331
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0521 0.1652
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.1025 0.3385
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0491 0.1478
Trypanosoma brucei GMP reductase 0.0209 0.2899 1
Leishmania major GTP-binding protein, putative 0.0047 0.0491 0.1478
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0521 0.0483
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0518 0.1341
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0358 0.0319
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.1216 0.4058
Loa Loa (eye worm) hypothetical protein 0.003 0.0241 0.0201
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.035 0.1003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0241 0.0201
Echinococcus multilocularis integrin alpha ps 0.0026 0.0178 0.0139
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0135 0.0219
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.0331
Toxoplasma gondii HEAT repeat-containing protein 0.0064 0.0743 0.2372
Trypanosoma cruzi GMP reductase 0.0209 0.2899 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0173
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0209 0.2899 1
Echinococcus multilocularis importin subunit beta 1 0.0064 0.0743 0.0706
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0295
Echinococcus granulosus integrin alpha ps 0.0055 0.0604 0.0566
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.0331
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0135 0.0219
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0209 0.2899 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0457 0.4018
Entamoeba histolytica hypothetical protein 0.0052 0.0562 0.5125
Entamoeba histolytica hypothetical protein 0.0083 0.1028 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0073 0.0025
Schistosoma mansoni hypothetical protein 0.0368 0.5274 0.5255
Entamoeba histolytica hypothetical protein 0.0023 0.0135 0.0648
Loa Loa (eye worm) GMP reductase 0.009 0.1128 0.1092
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0047 0.0491 0.1693
Loa Loa (eye worm) integrin alpha pat-2 0.0121 0.1591 0.1557
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0139
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0096 0.0331
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0096 0.0081
Leishmania major inosine-5-monophosphate dehydrogenase 0.0209 0.2899 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0521 0.0483
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.1072 0.3552
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0135 0.0243
Onchocerca volvulus 0.0083 0.1025 0.2493
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0518 0.1617
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0047 0.0491 0.0453
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0096 0.0069
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0095 0.1204 0.3869
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0334 0.1009
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0135 0.0466
Schistosoma mansoni transcription factor LCR-F1 0.0083 0.1028 0.0992
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0073 0.0025
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.1216 0.391
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0073 0.0033
Entamoeba histolytica hypothetical protein 0.0083 0.1028 1
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.035 0.0312
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0587 0.1879
Entamoeba histolytica Ran family GTPase 0.0047 0.0491 0.4375
Onchocerca volvulus 0.0242 0.3388 1
Echinococcus multilocularis geminin 0.0368 0.5274 0.5255
Echinococcus multilocularis integrin alpha 3 0.0026 0.0178 0.0139
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0291 0.0771
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0096 0.0106
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0052 0.0562 0.1476
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0096 0.0081
Plasmodium vivax SET domain protein, putative 0.003 0.0241 0.0609
Brugia malayi Pre-SET motif family protein 0.0212 0.2951 1
Onchocerca volvulus Putative GMP reductase 0.009 0.1128 0.2818
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0096 0.0056
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0358 0.0319
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0209 0.2899 1
Brugia malayi RNA, U transporter 1 0.0183 0.2507 0.8476
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.1072 0.3552
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0073 0.0114
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0047 0.0491 0.1549
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0073 0.0252
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0518 0.1341
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0096 0.0056
Echinococcus granulosus geminin 0.0368 0.5274 0.5255
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.0331
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0241 0.0201
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.035 0.1008
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0491 0.1478
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.1072 0.3552
Loa Loa (eye worm) hypothetical protein 0.0083 0.1025 0.0989
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0204 0.2822 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.1025 0.0989
Leishmania major importin beta-1 subunit, putative 0.0052 0.0562 0.1732
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0204 0.2822 1
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0209 0.2899 0.287
Trypanosoma brucei importin beta-1 subunit, putative 0.0064 0.0743 0.2565
Brugia malayi GMP reductase 0.009 0.1128 0.3737
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0047 0.0491 1
Echinococcus multilocularis dna polymerase eta 0.0048 0.0504 0.0466
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.0331
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.009 0.1128 0.3737
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0518 0.048
Loa Loa (eye worm) hypothetical protein 0.0163 0.2212 0.2181
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0096 0.0069
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0135 0.0219
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0241 0.0201
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0093 0.1165 0.3866
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0209 0.2899 1
Echinococcus granulosus integrin alpha 3 0.0026 0.0178 0.0139
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0521 0.0483
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0096 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.0331
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.0331
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0135 0.0225
Leishmania major DNA polymerase eta, putative 0.0034 0.0291 0.0771
Trypanosoma brucei trypanothione reductase 0.0038 0.035 0.1208
Schistosoma mansoni hypothetical protein 0.0026 0.0178 0.0139
Echinococcus multilocularis integrin alpha ps 0.0055 0.0604 0.0566
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.035 0.0981
Schistosoma mansoni ap endonuclease 0.0019 0.0073 0.0033
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0083 0.1028 0.0992
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0114 0.1481 0.4995
Loa Loa (eye worm) hypothetical protein 0.0054 0.0587 0.0549
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0587 0.0549
Toxoplasma gondii thioredoxin reductase 0.0038 0.035 0.0981
Schistosoma mansoni DNA polymerase eta 0.0048 0.0504 0.0466
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.1025 0.0989
Trypanosoma cruzi importin beta-1 subunit, putative 0.0052 0.0562 0.1732
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.1072 0.3391
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0096 0.0081
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0135 1
Schistosoma mansoni integrin alpha 0.0055 0.0604 0.0566
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0093 0.1165 0.113
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.0175 0.0136
Onchocerca volvulus 0.0163 0.2212 0.6264
Brugia malayi hypothetical protein 0.0163 0.2212 0.7462
Leishmania major DNA polymerase eta, putative 0.0048 0.0504 0.1526
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0083 0.1028 0.0992
Schistosoma mansoni ap endonuclease 0.0019 0.0073 0.0033
Toxoplasma gondii IMP dehydrogenas 0.0209 0.2899 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0135 0.0243
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0209 0.2899 0.287
Brugia malayi Pre-SET motif family protein 0.003 0.0241 0.0689
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.0331
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0096 0.0331
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.0331
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.0504 0.1596
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0521 0.0483
Giardia lamblia DINP protein human, muc B family 0.0021 0.0096 0.0548
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0096 0.0056
Brugia malayi hypothetical protein 0.0083 0.1028 0.3394
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0204 0.2822 0.9729
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0587 0.1879
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0096 0.0106
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0096 0.0106
Schistosoma mansoni importin beta-1 0.0064 0.0743 0.0706
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0521 0.0483
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.009 0.1128 0.3737
Echinococcus granulosus importin subunit beta 1 0.0064 0.0743 0.0706
Plasmodium vivax glutathione reductase, putative 0.0038 0.035 0.1008
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0167 0.2272 0.2241
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0135 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0291 0.0771
Brugia malayi Thioredoxin reductase 0.0038 0.035 0.1066
Loa Loa (eye worm) IMP dehydrogenase 1 0.0209 0.2899 0.287
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0504 0.1526
Mycobacterium tuberculosis Probable reductase 0.0086 0.1072 0.3552
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.0175 0.0136
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0224 0.0185
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.1216 0.4058
Echinococcus multilocularis integrin alpha ps 0.0055 0.0604 0.0566
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0521 0.0483
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0209 0.2899 0.287
Echinococcus granulosus integrin alpha ps 0.0026 0.0178 0.0139
Plasmodium falciparum glutathione reductase 0.0038 0.035 0.1008
Schistosoma mansoni ran 0.0047 0.0491 0.0453
Plasmodium vivax importin-beta 2, putative 0.0064 0.0743 0.2438
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0457 0.1395
Schistosoma mansoni hypothetical protein 0.0368 0.5274 0.5255
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0047 0.0491 0.0453
Schistosoma mansoni ran 0.0047 0.0491 0.0453
Echinococcus multilocularis snurportin 1 0.0686 1 1
Schistosoma mansoni hypothetical protein 0.0037 0.0334 0.0295
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0457 0.9184
Leishmania major guanosine monophosphate reductase 0.0209 0.2899 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0052 0.0562 0.1476
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0073 0.0033
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0518 0.1573
Schistosoma mansoni integrin alpha-ps 0.0029 0.0212 0.0173
Schistosoma mansoni integrin alpha-ps 0.0055 0.0604 0.0566
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0047 0.0491 0.1519
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0114 0.1481 0.487
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0209 0.2899 1
Loa Loa (eye worm) acetyltransferase 0.0167 0.2272 0.2241
Trichomonas vaginalis ran, putative 0.0047 0.0491 0.126
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0241 0.0592
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0241 0.0201
Echinococcus granulosus dna polymerase eta 0.0048 0.0504 0.0466
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0096 0.0106
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0209 0.2899 0.982
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0096 0.0193
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0686 1 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0135 0.0225
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0209 0.2899 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.1025 0.0989
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.0175 0.0136
Loa Loa (eye worm) hypothetical protein 0.0064 0.0743 0.0706
Schistosoma mansoni hypothetical protein 0.0686 1 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0047 0.0491 0.1478
Trypanosoma brucei unspecified product 0.0021 0.0096 0.0331
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0096 0.0331

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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