TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 493.659 | Formula: C29H40FN5O
H donors: 2 H acceptors: 1 LogP: 4.48 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: C[C@@H]1CN(C[C@@H](N1)C)Cc1ccc(cc1)N1CCCC1C(=O)N1CCC(CC1)Nc1cccc(c1)F
InChi: 1S/C29H40FN5O/c1-21-18-33(19-22(2)31-21)20-23-8-10-27(11-9-23)35-14-4-7-28(35)29(36)34-15-12-25(13-16-34)32-26-6-3-5-24(30)17-26/h3,5-6,8-11,17,21-22,25,28,31-32H,4,7,12-16,18-20H2,1-2H3/t21-,22+,28?
InChiKey: HAVGWTMIBHZYEA-UXCHGGSFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	motilin receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.084	0.0479
Onchocerca volvulus	Methionine aminopeptidase 2 homolog	0.0046	0.0614	0.7307
Onchocerca volvulus		0.0016	0.0072	0.0853
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0124	0.1471
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0894	1
Leishmania major	hypothetical protein, conserved	0.0016	0.0071	0.0794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0072	0.1168
Trypanosoma brucei	methionine aminopeptidase 2, putative	0.0046	0.0614	0.6594
Schistosoma mansoni	hypothetical protein	0.0035	0.0416	0.4477
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.084	1
Schistosoma mansoni	single-minded	0.0047	0.0629	0.7255
Schistosoma mansoni	polycystin 1-related	0.0019	0.0124	0.0676
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0072	0.0853
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0055	0.0782	0.0418
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0072	0.1168
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0046	0.0614	1
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0033	0.038	0.4009
Schistosoma mansoni	lipoxygenase	0.0019	0.0124	0.0676
Mycobacterium tuberculosis	Probable methyltransferase	0.0059	0.084	0.0538
Entamoeba histolytica	hypothetical protein	0.0035	0.0416	0.6349
Toxoplasma gondii	cathepsin CPL	0.0016	0.0072	0.0009
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.0033	0.038	0.4522
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0072	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0124	0.047
Leishmania major	cathepsin L-like protease	0.0062	0.0894	1
Mycobacterium ulcerans	putative regulatory protein	0.0035	0.0408	0.003
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0072	0.1168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0072	0.1168
Chlamydia trachomatis	methionine aminopeptidase	0.0033	0.038	1
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0055	0.0782	0.8743
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0072	0.1168
Loa Loa (eye worm)	cysteine protease	0.0016	0.0072	0.0272
Onchocerca volvulus		0.0016	0.0072	0.0853
Schistosoma mansoni	rab6-interacting	0.0019	0.0124	0.0676
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0049	0.0672	0.7994
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0072	0.1168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0072	0.1168
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0072	0.0272
Echinococcus multilocularis	transfer RNA-Lys	0.0035	0.0408	0.4859
Brugia malayi	Doublecortin family protein	0.0019	0.0124	0.0203
Schistosoma mansoni	lipoxygenase	0.0053	0.0744	0.8746
Echinococcus granulosus	methionyl aminopeptidase 2	0.0046	0.0614	0.7303
Toxoplasma gondii	methionine aminopeptidase 2, putative	0.0046	0.0614	0.7055
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0894	1
Leishmania major	cathepsin L-like protease	0.0016	0.0072	0.0802
Loa Loa (eye worm)	initiation factor 2-associated protein	0.0046	0.0614	0.2332
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0072	0.1168
Echinococcus multilocularis	RUN	0.0019	0.0124	0.1471
Plasmodium vivax	methionine aminopeptidase 2, putative	0.0046	0.0614	0.9034
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0046	0.0614	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0894	1
Schistosoma mansoni	o-methyltransferase	0.0059	0.084	0.9995
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0072	0.1168
Brugia malayi	hypothetical protein	0.0035	0.0416	0.1344
Brugia malayi	O-methyltransferase family protein	0.0059	0.084	0.3001
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0072	0.0853
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.084	0.0538
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0072	0.0272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0072	0.1168
Entamoeba histolytica	hypothetical protein	0.0035	0.0416	0.6349
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0416	0.4948
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0056	0.0797	0.8918
Echinococcus granulosus	RUN	0.0019	0.0124	0.1471
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0894	1
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0049	0.0672	0.7994
Leishmania major	cathepsin L-like protease	0.0016	0.0072	0.0802
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0055	0.0782	0.0418
Schistosoma mansoni	loxhd1	0.0019	0.0124	0.0676
Trypanosoma cruzi	major cysteine proteinase, putative	0.0048	0.0655	0.7331
Schistosoma mansoni	hypothetical protein	0.0019	0.0124	0.0676
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0416	0.4948
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0072	0.1168
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0124	0.1471
Onchocerca volvulus		0.0019	0.0124	0.1472
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0049	0.0672	0.7513
Brugia malayi	O-methyltransferase family protein	0.0059	0.084	0.3001
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.0072	0.0012
Leishmania major	cathepsin L-like protease	0.0016	0.0072	0.0802
Leishmania major	methionine aminopeptidase 2, putative	0.0046	0.0614	0.6864
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.0072	0.0012
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0046	0.0614	0.6864
Echinococcus multilocularis	cysteine protease	0.0016	0.0072	0.0853
Onchocerca volvulus		0.0035	0.0408	0.4861
Schistosoma mansoni	methionyl aminopeptidase 2 (M24 family)	0.0046	0.0614	0.7052
Brugia malayi	hypothetical protein	0.0019	0.0124	0.0203
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.084	1
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0049	0.0672	0.7299
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0072	0.1168
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0072	0.0853
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0055	0.0782	0.9302
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0049	0.0672	0.2553
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.084	0.0479
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0072	0.1168
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0124	0.1471
Brugia malayi	bHLH-PAS transcription factor	0.0035	0.0408	0.1315
Wolbachia endosymbiont of Brugia malayi	O-methyltransferase	0.0059	0.084	1
Leishmania major	cathepsin L-like protease	0.0016	0.0072	0.0802
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0046	0.0614	1
Plasmodium vivax	vivapain-2	0.0016	0.0072	0.0012
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0055	0.0782	0.9237
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0124	0.0877
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0072	0.1168
Entamoeba histolytica	hypothetical protein	0.0035	0.0416	0.6349
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0894	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0894	1
Loa Loa (eye worm)	fibroinase	0.0016	0.0072	0.0272
Plasmodium falciparum	methionine aminopeptidase 2	0.0046	0.0614	0.9034
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0055	0.0782	0.047
Toxoplasma gondii	methionine aminopeptidase	0.0049	0.0672	0.7809
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0053	0.0744	0.8853
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0072	0.1168
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0049	0.0672	1
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0033	0.038	0.4014
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0124	0.1471
Onchocerca volvulus		0.0016	0.0072	0.0853
Onchocerca volvulus		0.0016	0.0072	0.0853
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0894	1
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0124	0.0877
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0124	0.1471
Onchocerca volvulus		0.0059	0.084	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0894	1
Brugia malayi	hypothetical protein	0.0019	0.0124	0.0203
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0072	0.1168
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0894	1
Brugia malayi	O-methyltransferase family protein	0.0059	0.084	0.3001
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0049	0.0672	0.7513
Plasmodium vivax	vivapain-2	0.0016	0.0072	0.0012
Mycobacterium tuberculosis	Probable catechol-O-methyltransferase	0.0506	0.8939	1
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0055	0.0782	0.9302
Onchocerca volvulus		0.0016	0.0072	0.0853
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.084	0.9399
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0072	0.0853
Leishmania major	cathepsin L-like protease	0.0062	0.0894	1
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0049	0.0672	0.7299
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.084	0.0479
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0894	1
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0049	0.0672	1
Brugia malayi	Methionine aminopeptidase protein type I	0.0049	0.0672	0.2344
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0072	0.1168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0072	0.1168
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0046	0.0614	0.6594
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.084	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0046	0.0614	1
Leishmania major	cysteine peptidase A (CPA)	0.0016	0.0072	0.0802
Treponema pallidum	methionine aminopeptidase (map)	0.0033	0.038	0.5
Onchocerca volvulus		0.0059	0.084	1
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.0033	0.038	0.5141
Loa Loa (eye worm)	hypothetical protein	0.0059	0.084	0.3192
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.0033	0.038	0.4522
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0416	0.4477
Loa Loa (eye worm)	ctsf protein	0.0016	0.0072	0.0272
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0124	0.047
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0033	0.038	0.452
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0072	0.0853
Trypanosoma brucei	methionine aminopeptidase, putative	0.0049	0.0672	0.7299
Brugia malayi	PAS domain containing protein	0.0047	0.0629	0.2178
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.0072	0.0012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0894	1
Echinococcus granulosus	single minded 2	0.0035	0.0408	0.4859
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0894	1
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0033	0.038	0.4009
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0124	0.047
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.0033	0.038	0.5141
Echinococcus multilocularis	cysteine protease	0.0016	0.0072	0.0853
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0072	0.0853
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0072	0.0853
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0145	0.241	0.916
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0052	0.0714	0.2714
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0072	0.1168
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0894	1
Loa Loa (eye worm)	hypothetical protein	0.0158	0.2631	1
Schistosoma mansoni	o-methyltransferase	0.0059	0.084	0.9995
Brugia malayi	hypothetical protein	0.0158	0.2631	1
Brugia malayi	initiation factor 2-associated protein.	0.0046	0.0614	0.2117
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.084	1
Mycobacterium ulcerans	methyltransferase	0.0059	0.084	0.0478
Schistosoma mansoni	o-methyltransferase	0.0059	0.084	0.9995
Leishmania major	cathepsin L-like protease	0.0016	0.0072	0.0802
Entamoeba histolytica	methionine aminopeptidase, putative	0.0046	0.0614	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0053	0.0744	0.8853
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0071	0.0794
Entamoeba histolytica	hypothetical protein	0.0035	0.0416	0.6349
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0049	0.0672	0.7513
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0072	0.1168
Giardia lamblia	Methionine aminopeptidase	0.0046	0.0614	0.5
Brugia malayi	O-methyltransferase	0.0059	0.084	0.3001
Brugia malayi	hypoxia-induced factor 1	0.0145	0.241	0.9137
Schistosoma mansoni	o-methyltransferase	0.0059	0.084	0.9995
Onchocerca volvulus		0.0016	0.0072	0.0853
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0894	1
Leishmania major	cathepsin L-like protease	0.0062	0.0894	1
Mycobacterium leprae	PROBABLE METHYLTRANSFERASE	0.0059	0.084	1
Schistosoma mansoni	rab6-interacting	0.0019	0.0124	0.0676
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0072	0.0272
Loa Loa (eye worm)	O-methyltransferase	0.0059	0.084	0.3192
Schistosoma mansoni	aryl hydrocarbon receptor	0.0047	0.0629	0.7255
Onchocerca volvulus		0.0019	0.0124	0.1472
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0072	0.0802
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0046	0.0614	0.6864
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0894	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0072	0.1168
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0071	0.0794
Toxoplasma gondii	methionine aminopeptidase	0.0033	0.038	0.4014
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0124	0.1471
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0072	0.1168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0072	0.1168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0072	0.1168
Echinococcus granulosus	cathepsin l1	0.0016	0.0072	0.0853
Echinococcus multilocularis	methionyl aminopeptidase 2	0.0046	0.0614	0.7303
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0072	0.1168
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.084	1
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0055	0.0782	0.2774
Onchocerca volvulus		0.0016	0.0072	0.0853
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0072	0.0853

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 5.6	Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay	ChEMBL.	19006669

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL518261

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1011693