Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Homo sapiens | cyclin-dependent kinase 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 4 | 303 aa | 312 aa | 29.8 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.4858 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1997 | 0.3232 | 0.3117 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.3757 | 0.7394 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.4858 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.4858 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1997 | 0.3232 | 0.3117 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.2018 | 0.3282 | 0.3299 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.3757 | 0.7394 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.2018 | 0.3282 | 0.32 |
Echinococcus granulosus | epidermal growth factor receptor | 0.3757 | 0.7394 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.2018 | 0.3282 | 0.32 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0631 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.3757 | 0.7394 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0631 | 0 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.2018 | 0.3282 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.1997 | 0.3232 | 0.3117 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.4858 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2018 | 0.3282 | 0.32 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.4858 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0631 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0631 | 0 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.4858 | 1 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.12 | 0.1347 | 0.0145 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.12 | 0.1347 | 0.0145 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0631 | 0 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.4858 | 1 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.3757 | 0.7394 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.014 uM | Inhibition of CDK2 | ChEMBL. | 18815031 |
IC50 (binding) | = 0.49 uM | Inhibition of CDK4 | ChEMBL. | 18815031 |
IC50 (functional) | = 0.69 uM | Antiproliferative activity against human LoVo cells assessed as BrdU incorporation after 48 hrs | ChEMBL. | 18815031 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18815031 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.