Detailed information for compound 101643

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 843.939 | Formula: C44H54FN7O9
  • H donors: 8 H acceptors: 8 LogP: 3.78 Rotable bonds: 29
    Rule of 5 violations (Lipinski): 3
  • SMILES: O=C(CCc1ccc(cc1)F)NCCCC[C@H](C(=O)NC(C(=O)NC(C(=O)N)Cc1ccccc1)CC(=O)O)NC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)OC(C)(C)C
  • InChi: 1S/C44H54FN7O9/c1-44(2,3)61-43(60)52-35(24-29-26-48-32-14-8-7-13-31(29)32)41(58)49-33(15-9-10-22-47-37(53)21-18-27-16-19-30(45)20-17-27)40(57)51-36(25-38(54)55)42(59)50-34(39(46)56)23-28-11-5-4-6-12-28/h4-8,11-14,16-17,19-20,26,33-36,48H,9-10,15,18,21-25H2,1-3H3,(H2,46,56)(H,47,53)(H,49,58)(H,50,59)(H,51,57)(H,52,60)(H,54,55)/t33-,34?,35?,36?/m0/s1
  • InChiKey: WIOLZBJHNBDQLE-QTNFWPTDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0021 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0012 0.0212
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0 0.5
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0008 0.0008
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0036 0.0029 1
Schistosoma mansoni dihydrofolate reductase 0.0053 0.0047 0.0047
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0018 0.0569
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0012 0.0357
Echinococcus multilocularis lamin dm0 0.0028 0.0021 0.0021
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0012 0.0901
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0012 0.0212
Echinococcus granulosus lamin 0.0028 0.0021 0.0021
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0062 0.0056 0.2746
Brugia malayi sulfakinin receptor protein 0.0264 0.0271 0.027
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0012 0.0012
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0056 0.2718
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0056 0.0056
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0003 0.0003
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0018 0.0569
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0012 0.0012
Schistosoma mansoni lamin 0.0028 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0246 0.0252 0.0251
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0008 0.0148
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Giardia lamblia DINP protein human, muc B family 0.0019 0.0012 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0029 0.0029
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0264 0.0271 0.027
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0018 0.0569
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0056 0.0056
Schistosoma mansoni cpg binding protein 0.0029 0.0022 0.0022
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0012 0.0901
Echinococcus granulosus microtubule associated protein 2 0.0696 0.0729 0.0729
Schistosoma mansoni hypothetical protein 0.0036 0.0029 0.0029
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.009 0.009
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0029 0.0029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.9436 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.0029 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0012 0.0357
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.0185 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.009 0.009
Onchocerca volvulus 0.005 0.0044 0.2149
Echinococcus multilocularis lamin 0.0028 0.0021 0.0021
Onchocerca volvulus 0.005 0.0044 0.2173
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0018 0.0569
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0053 0.0047 0.366
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.005 0.0044 0.0043
Echinococcus granulosus tumor protein p63 0.0341 0.0353 0.0353
Mycobacterium ulcerans thymidylate synthase 0.013 0.0129 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0056 0.4349
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0012 0.0901
Loa Loa (eye worm) dihydrofolate reductase 0.0053 0.0047 0.0047
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0012 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0008
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0008 0.0609
Brugia malayi thymidylate synthase 0.013 0.0129 0.0128
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0021 0.002
Echinococcus granulosus lamin dm0 0.0028 0.0021 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0357
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0012 0.0011
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.0129 0.0129
Echinococcus multilocularis neuropeptide receptor A26 0.0471 0.0491 0.0491
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0012 0.0212
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0056 0.2718
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.009 0.009
Chlamydia trachomatis dihydrofolate reductase 0.0053 0.0047 0.5
Echinococcus granulosus intermediate filament protein 0.0028 0.0021 0.0021
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0053 0.0047 0.366
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0357
Schistosoma mansoni DNA polymerase eta 0.0019 0.0012 0.0012
Schistosoma mansoni cpg binding protein 0.0031 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0025 0.0018 0.0017
Brugia malayi CXXC zinc finger family protein 0.0029 0.0022 0.0021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0049 0.2336
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0012 0.0212
Echinococcus multilocularis tumor protein p63 0.0341 0.0353 0.0353
Echinococcus multilocularis thymidylate synthase 0.013 0.0129 0.0129
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.9436 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0056 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.009 0.009
Schistosoma mansoni cpg binding protein 0.0031 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.0036 0.0029 1
Echinococcus multilocularis microtubule associated protein 2 0.0696 0.0729 0.0729
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0018 0.0709
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0007 0.0006
Onchocerca volvulus 0.013 0.0129 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0008 0.0008
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0012 0.2053
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.013 0.0129 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0357
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.009 0.009
Echinococcus granulosus dna polymerase kappa 0.0019 0.0012 0.0012
Echinococcus granulosus neuropeptide s receptor 0.0471 0.0491 0.0491
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.009 0.009
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Echinococcus multilocularis cpg binding protein 0.0031 0.0023 0.0023
Echinococcus granulosus dihydrofolate reductase 0.0053 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.002
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0183 0.0185 1
Brugia malayi hypothetical protein 0.0025 0.0018 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0357
Brugia malayi hypothetical protein 0.0016 0.0008 0.0008
Schistosoma mansoni lamin 0.0028 0.0021 0.0021
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0183 0.0185 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0012 0.0901
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0056 0.4349
Brugia malayi hypothetical protein 0.0246 0.0252 0.0251
Echinococcus multilocularis musashi 0.0028 0.0021 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0056 0.4349
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0357
Echinococcus multilocularis dna polymerase eta 0.0019 0.0012 0.0012
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0018 0.0569
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0012 0.0012
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.013 0.0129 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0018 0.0569
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0021 0.002
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0183 0.0185 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0357
Mycobacterium tuberculosis Hypothetical protein 0.0062 0.0056 0.4387
Schistosoma mansoni microtubule-associated protein tau 0.0696 0.0729 0.0729
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.9436 1 1
Brugia malayi hypothetical protein 0.0062 0.0056 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0012 0.0212
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.9436 1 1
Schistosoma mansoni hypothetical protein 0.005 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0011
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0003
Echinococcus granulosus neuropeptide receptor A26 0.0471 0.0491 0.0491
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0357
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0012 0.0357
Leishmania major DNA polymerase kappa, putative 0.0019 0.0012 0.0212
Schistosoma mansoni intermediate filament proteins 0.0028 0.0021 0.0021
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0012 0.2053
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.0252 0.0252
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.009 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0357
Echinococcus granulosus cpg binding protein 0.0031 0.0023 0.0023
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0357
Brugia malayi dihydrofolate reductase family protein 0.0053 0.0047 0.0047
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0003 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0012 0.0357
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0029 0.0029
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0056 1
Brugia malayi intermediate filament protein 0.0028 0.0021 0.002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0008 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0012 0.0212
Echinococcus granulosus thymidylate synthase 0.013 0.0129 0.0129
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0012 0.0012
Onchocerca volvulus 0.0029 0.0022 0.0092
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0056 0.0056
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.0252 0.0252
Echinococcus multilocularis neuropeptide s receptor 0.0471 0.0491 0.0491
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0056 0.4349
Brugia malayi hypothetical protein 0.0036 0.0029 0.0029
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0053 0.0047 0.366
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0022 0.0021
Echinococcus granulosus dna polymerase eta 0.0019 0.0012 0.0012
Brugia malayi isocitrate dehydrogenase 0.0016 0.0008 0.0008
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0183 0.0185 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0012 0.0212
Echinococcus multilocularis dihydrofolate reductase 0.0053 0.0047 0.0047
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0012 0.0012
Treponema pallidum bacterioferrin (TpF1) 0.0009 0 0.5
Schistosoma mansoni survival motor neuron protein 0.005 0.0044 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0357
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.009 0.009
Loa Loa (eye worm) thymidylate synthase 0.013 0.0129 0.0128
Brugia malayi Dihydrofolate reductase 0.0053 0.0047 0.0047
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.0185 1
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0044 0.0044
Leishmania major hypothetical protein, conserved 0.0025 0.0018 0.0569
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0007 0.0007
Trypanosoma brucei unspecified product 0.0019 0.0012 0.0357
Brugia malayi hypothetical protein 0.0264 0.0271 0.027
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0036 0.0029 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0008 0.0148

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 450 nM Stimulation of amylase release in guinea pig pancreas ChEMBL. 1375964
IC50 (binding) = 250 nm Inhibition of specific binding of [125I]-BH-CCK-8 in guinea pig pancreas. ChEMBL. 1375964
IC50 (binding) = 9900 nm Inhibition of specific binding of [125I]-BH-CCK-8 in guinea pig cortex ChEMBL. 1375964
Max (functional) = 68 % Hydrolysis of phosphoinositide (PI) relative to maximal response elicited by CCK-8 in guinea pig pancreas. ChEMBL. 1375964

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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