TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 409.481 | Formula: C20H15N3O3S2
H donors: 2 H acceptors: 3 LogP: 4.68 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1O)/C=C\1/S/C(=N/c2scc(n2)c2ccccc2)/NC1=O
InChi: 1S/C20H15N3O3S2/c1-26-16-9-12(7-8-15(16)24)10-17-18(25)22-20(28-17)23-19-21-14(11-27-19)13-5-3-2-4-6-13/h2-11,24H,1H3,(H,21,22,23,25)/b17-10+
InChiKey: CCOLFOIXXZQFDW-LICLKQGHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0039	0.0326	0.043
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0098	0.0129
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0326	0.043
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0262	0.2905	0.3827
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0117	0.1225	0.1613
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0173	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0277	0.3076	0.4053
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0129	0.0171
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.0668	0.0668
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0129	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1218	0.1605
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.001	0.0014
Echinococcus granulosus	survival motor neuron protein 1	0.0256	0.2829	0.3727
Brugia malayi	thymidylate kinase	0.0668	0.7591	1
Brugia malayi	TAR-binding protein	0.0068	0.0668	0.088
Schistosoma mansoni	hypothetical protein	0.0052	0.0479	0.0631
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0173	0.0228
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0701	0.0924
Schistosoma mansoni	hypothetical protein	0.0039	0.0326	0.043
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0098	0.0129
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0129	0.0171
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0236	0.0311
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.0129	0.0171
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0098	0.0129
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0098	0.0129
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0116	0.1218	0.1605
Trichomonas vaginalis	thymidylate kinase, putative	0.0668	0.7591	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.0014
Brugia malayi	photoreceptor-specific nuclear receptor	0.0277	0.3076	0.4053
Echinococcus granulosus	thymidylate kinase	0.0668	0.7591	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0129	0.0171
Trichomonas vaginalis	replication factor C large subunit, putative	0.0011	0.00000034704	0.00000045719
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0129	0.0171
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.001	0.0014
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0173	0.0228
Trypanosoma brucei	thymidylate kinase, putative	0.0668	0.7591	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0173	0.0228
Treponema pallidum	thymidylate kinase (tmk)	0.0668	0.7591	1
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0071	0.0701	0.0701
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0129	0.0171
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.0668	0.088
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0129	0.0171
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0129	0.0171
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0129	0.0171
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.025	0.0329
Trypanosoma cruzi	thymidylate kinase, putative	0.0668	0.7591	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0326	0.043
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0129	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0129	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0228
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0129	0.0171
Echinococcus multilocularis	survival motor neuron protein 1	0.0256	0.2829	0.2829
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0129	0.0129
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.001	0.0014
Entamoeba histolytica	Thymidylate kinase, putative	0.0668	0.7591	1
Brugia malayi	ecdysteroid receptor	0.0022	0.0129	0.0171
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0129	0.0171
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0011	0.00000034704	0.00000045719
Leishmania major	hypothetical protein, conserved	0.0262	0.2905	0.3682
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0326	0.0326
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0071	0.0701	0.0924
Giardia lamblia	CDC8	0.0668	0.7591	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0098	0.0129
Trypanosoma cruzi	thymidylate kinase, putative	0.0668	0.7591	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0129	0.0171
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.001	0.0014
Entamoeba histolytica	hypothetical protein	0.0039	0.0326	0.043
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0129	0.0171
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0129	0.0171
Trichomonas vaginalis	set domain proteins, putative	0.0256	0.2834	0.3734
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0225	0.2475	0.3261
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0173	0.0228
Echinococcus granulosus	transcription factor eb	0.0117	0.1225	0.1613
Toxoplasma gondii	ATPase, AAA family protein	0.0011	0.00000034704	0.00000045719
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0173	0.0228
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0129	0.0171
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0173	0.0228
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0129	0.0171
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0129	0.0171
Echinococcus multilocularis	thymidylate kinase	0.0668	0.7591	0.7591
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0129	0.0129
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0668	0.088
Loa Loa (eye worm)	hypothetical protein	0.0032	0.025	0.0329
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0129	0.0129
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0071	0.0701	0.0924
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0173	0.0228
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	0.0668	0.7591	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0129	0.0171
Echinococcus granulosus	tar DNA binding protein	0.0068	0.0668	0.088
Mycobacterium leprae	probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)	0.0668	0.7591	1
Mycobacterium ulcerans	thymidylate kinase	0.0668	0.7591	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.0129	0.0171
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0479	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0129	0.0171
Echinococcus multilocularis	geminin	0.0183	0.1992	0.1992
Brugia malayi	Pre-SET motif family protein	0.0225	0.2475	0.3261
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0479	0.0631
Brugia malayi	Pre-SET motif family protein	0.0032	0.025	0.0329
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.025	0.025
Toxoplasma gondii	thymidylate kinase	0.0668	0.7591	1
Echinococcus granulosus	replication factor c subunit 1	0.0011	0.00000034704	0.00000045719
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.0668	0.088
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0129	0.0171
Onchocerca volvulus		0.0026	0.0173	0.0228
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0129	0.0171
Brugia malayi	steroid hormone receptor	0.0022	0.0129	0.0171
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0173	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0098	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0129	0.0171
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0129	0.0171
Schistosoma mansoni	thymidylate kinase	0.0668	0.7591	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.0014
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0098	0.0129
Brugia malayi	hypothetical protein	0.0012	0.001	0.0014
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0129	0.0171
Entamoeba histolytica	hypothetical protein	0.0039	0.0326	0.043
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0173	0.0228
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.025	0.0329
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.025	0.0329
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0668	0.088
Leishmania major	thymidylate kinase-like protein	0.0668	0.7591	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.025	0.025
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0129	0.0171
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0129	0.0171
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0262	0.2905	0.3827
Onchocerca volvulus		0.0032	0.025	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0129	0.0171
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0071	0.0701	0.0924
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0701	0.0924
Trypanosoma brucei	thymidylate kinase, putative	0.0668	0.7591	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.0014
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0129	0.0171
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0129	0.0129
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0668	0.088
Onchocerca volvulus	Putative thymidylate kinase	0.0668	0.7591	1
Loa Loa (eye worm)	hypothetical protein	0.0256	0.2829	0.3727
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.001	0.0014
Echinococcus granulosus	transcription factor Dp 1	0.0041	0.0354	0.0466
Echinococcus granulosus	geminin	0.0183	0.1992	0.2625
Echinococcus multilocularis	replication factor c subunit 1	0.0011	0.00000034704	0.00000034704
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0228
Schistosoma mansoni	chromosome transmission fidelity factor	0.0011	0.00000034704	0.00000045719
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0129	0.0171
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0701	0.0924
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0098	0.0129
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0173	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0129	0.0171
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0129	0.0129
Plasmodium vivax	SET domain protein, putative	0.0032	0.025	0.0329
Brugia malayi	hypothetical protein	0.0012	0.001	0.0014
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0071	0.0701	0.0924
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0129	0.0171
Entamoeba histolytica	hypothetical protein	0.0039	0.0326	0.043
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0129	0.0171
Brugia malayi	hypothetical protein	0.0256	0.2829	0.3727
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0129	0.0129
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0129	0.0171
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.001	0.001
Onchocerca volvulus		0.0022	0.0129	0.0171
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0129	0.0171
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.025	0.0329
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0173	0.0228
Loa Loa (eye worm)	thymidylate kinase	0.0668	0.7591	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.0014
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0173	0.0228
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.025	0.0329
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0173	0.0228
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0173	0.0116
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0129	0.0129
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0129	0.0129
Schistosoma mansoni	thymidylate kinase	0.0668	0.7591	1
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0071	0.0701	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0129	0.0171
Schistosoma mansoni	hypothetical protein	0.0668	0.7591	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.00000034704	0.00000045719
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0129	0.0171
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0173	0.0116
Onchocerca volvulus		0.0052	0.0479	0.0631
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0129	0.0171
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.025	0.0329
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.0014
Chlamydia trachomatis	thymidylate kinase	0.0668	0.7591	1
Echinococcus multilocularis	transcription factor Dp 1	0.0041	0.0354	0.0354
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.0668	0.088
Schistosoma mansoni	hypothetical protein	0.0183	0.1992	0.2625
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0129	0.0171
Plasmodium falciparum	thymidylate kinase	0.0668	0.7591	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0129	0.0171
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0129	0.0171
Schistosoma mansoni	hypothetical protein	0.0183	0.1992	0.2625
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0129	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0228
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0129	0.0171
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0129	0.0171
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0129	0.0171
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0129	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0129	0.0171
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0129	0.0171
Echinococcus multilocularis	transcription factor eb	0.0117	0.1225	0.1225
Plasmodium vivax	thymidylate kinase, putative	0.0668	0.7591	1
Brugia malayi	hypothetical protein	0.0039	0.0326	0.043
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.001	0.0014
Brugia malayi	nuclear receptor RXR	0.0012	0.001	0.0014
Schistosoma mansoni	coup transcription factor	0.0022	0.0129	0.0171
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0668	0.088
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.00000034704	0.00000045719
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.0129	0.0171
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0173	0.0228
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0129	0.0171
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0071	0.0701	0.0712
Loa Loa (eye worm)	RNA binding protein	0.0068	0.0668	0.088
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0173	0.0228
Trichomonas vaginalis	thymidylate kinase, putative	0.0668	0.7591	1
Brugia malayi	RNA binding protein	0.0068	0.0668	0.088
Brugia malayi	nuclear hormone receptor	0.0022	0.0129	0.0171
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0098	0.0016
Onchocerca volvulus		0.0256	0.2834	0.3734
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0668	0.088
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0098	0.0129
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0129	0.0171
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)	0.0668	0.7591	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0129	0.0171

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 103.2 uM	Inhibition of human recombinant GST-fused SHP2 using p-nitrophenyl phosphate as substrate	ChEMBL.	18702480

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL519399

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1018757