TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 412.547 | Formula: C26H24N2OS
H donors: 1 H acceptors: 1 LogP: 6.07 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCc2c(CC1)c(cc(c2)NC(=O)c1cc2c(s1)cccc2)c1ccccc1
InChi: 1S/C26H24N2OS/c1-28-13-11-19-15-21(17-23(22(19)12-14-28)18-7-3-2-4-8-18)27-26(29)25-16-20-9-5-6-10-24(20)30-25/h2-10,15-17H,11-14H2,1H3,(H,27,29)
InChiKey: ASASAVQRRQCNEG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	survival motor neuron protein 1	0.0283	0.2724	1
Plasmodium vivax	vivapain-2	0.0048	0.0207	1
Schistosoma mansoni	calpain-7 (C02 family)	0.0041	0.0127	0.0476
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0207	0.2842
Schistosoma mansoni	aldehyde dehydrogenase	0.0072	0.0465	0.1737
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0066	0.0242
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0076	0.1044
Loa Loa (eye worm)	hypothetical protein	0.0283	0.2724	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0095	0.0357
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1408	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0279	0.2674	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0127	0.0476
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0076	0.1044
Echinococcus multilocularis	calpain	0.0041	0.0127	0.0127
Onchocerca volvulus		0.0048	0.0207	0.4107
Trypanosoma brucei	antigen, putative	0.0041	0.0127	0.0903
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0207	0.2842
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0207	0.2842
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0119	0.0965	0.3544
Brugia malayi	Cathepsin L-like precursor	0.0048	0.0207	0.0761
Echinococcus multilocularis	calpain A	0.0112	0.0897	0.0897
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1408	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0207	0.2842
Brugia malayi	Papain family cysteine protease containing protein	0.0048	0.0207	0.0761
Echinococcus multilocularis	calpain 5	0.0041	0.0127	0.0127
Onchocerca volvulus		0.0048	0.0207	0.4107
Trypanosoma cruzi	cysteine peptidase, putative	0.016	0.1408	0.5267
Brugia malayi	hypothetical protein	0.0283	0.2724	1
Leishmania major	cathepsin L-like protease	0.0048	0.0207	0.0984
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0279	0.2674	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0048	0.0207	0.0775
Leishmania major	cathepsin L-like protease	0.0048	0.0207	0.0984
Schistosoma mansoni	calpain C (C02 family)	0.0041	0.0127	0.0476
Leishmania major	cathepsin L-like protease	0.0048	0.0207	0.0984
Onchocerca volvulus		0.0048	0.0207	0.4107
Trypanosoma cruzi	cysteine peptidase, putative	0.0048	0.0207	0.0775
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0207	0.2842
Trypanosoma cruzi	cruzipain precursor, putative	0.016	0.1408	0.5267
Brugia malayi	calpain family protein 1	0.0108	0.0844	0.31
Onchocerca volvulus	Cathepsin F homolog	0.0048	0.0207	0.4107
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0207	0.2842
Echinococcus granulosus	calpain 7 C02 family	0.0041	0.0127	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0714	0.2438
Plasmodium vivax	calpain, putative	0.0041	0.0127	0.6136
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0127	0.0903
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1408	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0207	0.2842
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0127	0.0476
Brugia malayi	Latrophilin receptor protein 2	0.0038	0.0095	0.035
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0119	0.0965	0.3384
Giardia lamblia	Cathepsin B precursor	0.0097	0.0729	0.5
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0048	0.0207	0.0207
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0311	0.1142
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0207	0.2842
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0076	0.0076
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0036	0.5
Onchocerca volvulus		0.0067	0.041	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0207	0.2842
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1408	1
Brugia malayi	Inositol-1	0.0036	0.0076	0.028
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0207	0.2842
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0207	0.2842
Trypanosoma brucei	calpain-like protein, putative	0.0041	0.0127	0.0903
Leishmania major	cathepsin L-like protease	0.016	0.1408	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0038	0.0095	0.0111
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0076	0.0285
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1408	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0048	0.0207	0.2842
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0072	0.0465	1
Echinococcus granulosus	calpain	0.0041	0.0127	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0965	0.3384
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0097	0.0729	0.5179
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0112	0.0897	0.3353
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0038	0.0095	0.035
Onchocerca volvulus		0.0048	0.0207	0.4107
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0072	0.0465	0.0465
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0207	0.2842
Loa Loa (eye worm)	fibroinase	0.0048	0.0207	0.0532
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0038	0.0095	0.035
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0076	0.3674
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0563	0.1869
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0207	0.2842
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0072	0.0465	0.2915
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0207	0.2842
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0112	0.0897	0.0897
Toxoplasma gondii	cathepsin CPL	0.0048	0.0207	0.2007
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0127	0.0476
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0127	0.0383
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0041	0.0127	0.0476
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0041	0.0127	0.0476
Trypanosoma brucei	calpain-like protein, putative	0.0041	0.0127	0.0903
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0207	0.2842
Schistosoma mansoni	cathepsin F (C01 family)	0.0035	0.0066	0.0247
Loa Loa (eye worm)	inositol-1	0.0036	0.0076	0.0038
Leishmania major	cathepsin L-like protease	0.016	0.1408	1
Brugia malayi	calpain 7	0.0041	0.0127	0.0467
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0097	0.0729	0.4903
Onchocerca volvulus		0.0048	0.0207	0.4107
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0076	0.0285
Echinococcus granulosus	calpain A	0.0112	0.0897	0.3292
Echinococcus multilocularis	cysteine protease	0.0048	0.0207	0.0207
Giardia lamblia	Cathepsin B precursor	0.0097	0.0729	0.5
Schistosoma mansoni	hypothetical protein	0.0038	0.0095	0.0357
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0127	0.0383
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0066	0.0904
Entamoeba histolytica	cysteine proteinase, putative	0.0048	0.0207	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0207	0.2842
Loa Loa (eye worm)	calpain	0.0041	0.0127	0.023
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0076	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0279	0.2674	1
Onchocerca volvulus	Cathepsin L homolog	0.0048	0.0207	0.4107
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1408	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0097	0.0729	0.2728
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0072	0.0465	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0048	0.0207	0.0532
Loa Loa (eye worm)	calpain family protein 1	0.0079	0.0541	0.1786
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1408	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0048	0.0207	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0729	0.2728
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0048	0.0207	0.0761
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0066	0.0242
Brugia malayi	cathepsin B-like cysteine proteinase	0.0279	0.2674	0.9817
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0127	0.0476
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0207	0.2842
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0066	0.0904
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0147	0.1267	0.4739
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1408	1
Leishmania major	cathepsin L-like protease	0.0048	0.0207	0.0984
Brugia malayi	latrophilin 2 splice variant baaae	0.0081	0.0563	0.2066
Loa Loa (eye worm)	cathepsin B	0.0097	0.0729	0.2496
Echinococcus granulosus	cathepsin l1	0.0048	0.0207	0.0761
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0207	0.2842
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0127	0.0383
Schistosoma mansoni	calpain (C02 family)	0.0041	0.0127	0.0476
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0127	0.0476
Echinococcus granulosus	cathepsin b	0.0279	0.2674	0.9817
Brugia malayi	cathepsin L-like precursor	0.0035	0.0066	0.0242
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0279	0.2674	1
Plasmodium vivax	vivapain-2	0.0048	0.0207	1
Entamoeba histolytica	cysteine proteinase, putative	0.0048	0.0207	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0283	0.2724	0.2724
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0127	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0844	0.2929
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0072	0.0465	1
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0311	0.1163
Schistosoma mansoni	hypothetical protein	0.0038	0.0095	0.0357
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0127	0.0476
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0108	0.0844	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0541	0.1786
Loa Loa (eye worm)	cysteine protease	0.0048	0.0207	0.0532
Toxoplasma gondii	aldehyde dehydrogenase	0.0072	0.0465	0.5946
Leishmania major	cathepsin L-like protease	0.0048	0.0207	0.0984
Echinococcus multilocularis	cysteine protease	0.0048	0.0207	0.0207
Echinococcus multilocularis	GPCR, family 2	0.0038	0.0095	0.0095
Echinococcus granulosus	cathepsin l1	0.0035	0.0066	0.0242
Schistosoma mansoni	cathepsin F (C01 family)	0.0048	0.0207	0.0775
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0112	0.0897	0.3292
Schistosoma mansoni	calpain-7 (C02 family)	0.0041	0.0127	0.0476
Leishmania major	cathepsin L-like protease	0.016	0.1408	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0095	0.0357
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0038	0.0095	0.0095
Giardia lamblia	Cathepsin B precursor	0.0097	0.0729	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0072	0.0465	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0048	0.0207	0.0532
Echinococcus multilocularis	cathepsin b	0.0279	0.2674	0.2674
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0038	0.0095	0.035
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0048	0.0207	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1408	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0207	0.2842
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0076	0.1044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0048	0.0207	0.2842
Echinococcus multilocularis	cathepsin b	0.0279	0.2674	0.2674
Echinococcus granulosus	calpain 5	0.0041	0.0127	0.0467
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0041	0.0127	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0095	0.0111
Echinococcus granulosus	calpain A	0.0041	0.0127	0.0467
Trypanosoma cruzi	cysteine peptidase, putative	0.016	0.1408	0.5267
Onchocerca volvulus		0.0058	0.0311	0.7122
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0076	0.028
Brugia malayi	calpain family protein 1	0.0108	0.0844	0.31
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0127	0.0476
Echinococcus multilocularis	calpain 7 (C02 family)	0.0041	0.0127	0.0127
Brugia malayi	Cathepsin L-like precursor	0.0048	0.0207	0.0761
Trypanosoma brucei	calpain-like protein, putative	0.0041	0.0127	0.0903
Onchocerca volvulus	Cathepsin L homolog	0.0048	0.0207	0.4107
Leishmania major	cysteine peptidase A (CPA)	0.0048	0.0207	0.0984
Echinococcus granulosus	cathepsin b	0.0279	0.2674	0.9817
Echinococcus multilocularis	cathepsin L cysteine protease	0.0048	0.0207	0.0207
Brugia malayi	Cathepsin L-like precursor	0.0048	0.0207	0.0761
Echinococcus multilocularis	cathepsin L cysteine protease	0.0048	0.0207	0.0207
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0072	0.0465	0.1706
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0035	0.0066	0.0242
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0076	0.0285
Onchocerca volvulus		0.0048	0.0207	0.4107
Loa Loa (eye worm)	hypothetical protein	0.0067	0.041	0.1294
Echinococcus multilocularis	hypothetical protein	0.0041	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0207	0.0532
Schistosoma mansoni	aldehyde dehydrogenase	0.0072	0.0465	0.1737
Entamoeba histolytica	cysteine proteinase, putative	0.0035	0.0066	0.3182
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0127	0.0476
Onchocerca volvulus		0.0048	0.0207	0.4107
Schistosoma mansoni	hypothetical protein	0.0081	0.0563	0.2104
Trypanosoma cruzi	cysteine peptidase, putative	0.016	0.1408	0.5267
Brugia malayi	Cathepsin L-like precursor	0.0048	0.0207	0.0761
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1408	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0076	0.0541
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0076	0.0285
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0048	0.0207	0.0761
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1408	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0048	0.0207	0.0207
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0207	0.2842
Loa Loa (eye worm)	hypothetical protein	0.0279	0.2674	0.9812
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0207	0.2842
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0097	0.0729	1
Loa Loa (eye worm)	ctsf protein	0.0048	0.0207	0.0532
Brugia malayi	Cathepsin L-like precursor	0.0048	0.0207	0.0761
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0112	0.0897	0.3353
Toxoplasma gondii	cathepsin B	0.0097	0.0729	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0207	0.2842
Trypanosoma brucei	calpain-like protein, putative	0.0041	0.0127	0.0903
Loa Loa (eye worm)	calpain family protein 1	0.0108	0.0844	0.2929
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0207	1
Schistosoma mansoni	hypothetical protein	0.0058	0.0311	0.1163
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0207	0.2842
Echinococcus multilocularis	calpain family protein 1, d	0.0079	0.0541	0.0541
Echinococcus granulosus	GPCR family 2	0.0038	0.0095	0.035
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0038	0.0095	0.0095
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0119	0.0965	0.3544
Trypanosoma cruzi	major cysteine proteinase, putative	0.0128	0.106	0.3964
Brugia malayi	Cathepsin L-like precursor	0.0048	0.0207	0.0761
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0048	0.0207	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0279	0.2674	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL527913

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1021430