Detailed information for compound 1022982

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 463.443 | Formula: C23H21N5O6
  • H donors: 5 H acceptors: 6 LogP: 1.03 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CNC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)Cn1c(=O)[nH]c2c(c1=O)cccc2
  • InChi: 1S/C23H21N5O6/c29-19(12-28-22(33)15-6-2-4-8-17(15)27-23(28)34)26-18(21(32)25-11-20(30)31)9-13-10-24-16-7-3-1-5-14(13)16/h1-8,10,18,24H,9,11-12H2,(H,25,32)(H,26,29)(H,27,34)(H,30,31)/t18-/m0/s1
  • InChiKey: RLFBNCPBYQGXQI-SFHVURJKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0067 0.0066
Loa Loa (eye worm) hypothetical protein 0.0179 0.1971 0.3996
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0067 0.0088
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0013 0.0039 0.0076
Toxoplasma gondii thioredoxin reductase 0.0047 0.0426 0.5211
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0067 0.038
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0067 0.038
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0163 0.1669
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0076
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0071 0.0439
Onchocerca volvulus Glucosylceramidase homolog 0.0191 0.2112 0.4632
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.328 0.9283
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0191 0.0436
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0071 0.0085
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0707 0.1434
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0067 0.0136
Brugia malayi Matrixin family protein 0.0179 0.1971 0.3998
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0781 1
Brugia malayi RNA, U transporter 1 0.0093 0.0962 0.1951
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.353 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0781 1
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.328 0.9283
Loa Loa (eye worm) hypothetical protein 0.0179 0.1971 0.3996
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0067 0.038
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.037 0.0863
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.1258 0.1056
Schistosoma mansoni sphingosine kinase A B 0.0342 0.3869 0.8338
Schistosoma mansoni cpg binding protein 0.0029 0.0217 0.0388
Mycobacterium tuberculosis Conserved protein 0.0342 0.3869 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0163 0.1669
Plasmodium falciparum importin beta, putative 0.0033 0.0263 0.3018
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.037 0.0493
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.037 0.0948
Leishmania major trypanothione reductase 0.0047 0.0426 0.5211
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.4633 0.4632
Mycobacterium ulcerans hydrolase 0.0218 0.2426 0.6233
Trypanosoma brucei trypanothione reductase 0.0047 0.0426 0.5211
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0707 0.9007
Brugia malayi hypothetical protein 0.0037 0.0312 0.0634
Echinococcus granulosus ceramide kinase 0.0013 0.0039 0.005
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.037 0.0369
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.328 0.9283
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0191 0.0436
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0781 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0707 0.1455
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0118 0.107
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0426 0.1009
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0292 0.328 0.665
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0284 0.0282
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0163 0.1669
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0022 0.0044
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0071 0.0439
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0707 0.9007
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.112 0.2822
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.353 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.112 0.2822
Loa Loa (eye worm) hypothetical protein 0.0042 0.037 0.0748
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0426 0.0861
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0707 0.1745
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0071 0.0439
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0067 0.0066
Schistosoma mansoni cpg binding protein 0.003 0.0236 0.0429
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0118 0.0207
Loa Loa (eye worm) hypothetical protein 0.0034 0.0284 0.0572
Echinococcus multilocularis Diacylglycerol kinase theta 0.0013 0.0039 0.0038
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0118 0.0207
Plasmodium falciparum thioredoxin reductase 0.0016 0.0071 0.0439
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0217 0.0438
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.353 1
Echinococcus multilocularis geminin 0.0342 0.3871 0.387
Brugia malayi MH2 domain containing protein 0.0119 0.127 0.2575
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.328 0.9283
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0781 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0218 0.2426 0.6233
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0284 0.0532
Brugia malayi Ceramide kinase 0.0013 0.0039 0.0079
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0153 0.1665 0.4245
Loa Loa (eye worm) matrixin family protein 0.0434 0.4931 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0118 0.107
Brugia malayi Matrixin family protein 0.0179 0.1971 0.3998
Mycobacterium tuberculosis Probable reductase 0.0106 0.112 0.2822
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0071 0.0439
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0071 0.0439
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0284 0.0532
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0067 0.0066
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0071 0.0439
Onchocerca volvulus 0.0179 0.1971 0.4318
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0118 1
Toxoplasma gondii exonuclease III APE 0.002 0.0118 0.107
Schistosoma mansoni hypothetical protein 0.0016 0.0067 0.0061
Schistosoma mansoni ran 0.0024 0.0163 0.027
Loa Loa (eye worm) hypothetical protein 0.005 0.0463 0.0936
Entamoeba histolytica hypothetical protein 0.0037 0.0312 0.0714
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0071 0.0439
Loa Loa (eye worm) hypothetical protein 0.0179 0.1971 0.3996
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0118 0.0117
Schistosoma mansoni hypothetical protein 0.0254 0.2844 0.6106
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2112 0.5938
Onchocerca volvulus 0.0034 0.0284 0.0547
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0781 1
Brugia malayi Matrixin family protein 0.0179 0.1971 0.3998
Schistosoma mansoni sphingoid long chain base kinase 0.0342 0.3869 0.8338
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0071 0.0439
Schistosoma mansoni ap endonuclease 0.002 0.0118 0.0173
Entamoeba histolytica Ran family GTPase 0.0024 0.0163 0.0323
Echinococcus granulosus Diacylglycerol kinase theta 0.0013 0.0039 0.005
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0312 0.0595
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.353 1
Onchocerca volvulus 0.0268 0.3006 0.663
Schistosoma mansoni hypothetical protein 0.0348 0.3931 0.8473
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0426 0.5211
Schistosoma mansoni hypothetical protein 0.0035 0.0286 0.0538
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0071 0.0093
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.1258 0.3182
Brugia malayi Hemopexin family protein 0.0254 0.2844 0.5767
Plasmodium falciparum glutathione reductase 0.0047 0.0426 0.5211
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0067 0.0134
Onchocerca volvulus 0.0029 0.0217 0.0398
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.353 1
Loa Loa (eye worm) ceramide kinase 0.0013 0.0039 0.0076
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0067 0.0066
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0071 0.0439
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.127 0.2573
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0163 0.0264
Echinococcus multilocularis sphingosine kinase 1 0.0342 0.3869 0.3868
Plasmodium vivax importin-beta 2, putative 0.0033 0.0263 0.3018
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0067 0.038
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0163 0.0216
Onchocerca volvulus Matrix metalloproteinase homolog 0.0398 0.4514 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0067 0.038
Echinococcus granulosus snurportin 1 0.0348 0.3931 0.5259
Loa Loa (eye worm) hypothetical protein 0.0016 0.0067 0.0133
Brugia malayi Pre-SET motif family protein 0.0034 0.0284 0.0575
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0071 0.007
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0463 0.0938
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.037 0.0721
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.053 0.6617
Schistosoma mansoni importin beta-1 0.0033 0.0263 0.0487
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0153 0.1665 0.4172
Loa Loa (eye worm) hypothetical protein 0.0033 0.0263 0.0531
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0279 0.0567
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2112 0.5938
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0071 0.0439
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0781 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0071 0.0071
Brugia malayi Eye-specific diacylglycerol kinase 0.0013 0.0039 0.0079
Loa Loa (eye worm) matrixin family protein 0.0398 0.4514 0.9153
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0067 0.0066
Entamoeba histolytica hypothetical protein 0.0037 0.0312 0.0714
Leishmania major GTP-binding protein, putative 0.0024 0.0163 0.1669
Echinococcus granulosus importin subunit beta 1 0.0033 0.0263 0.035
Entamoeba histolytica hypothetical protein 0.0026 0.0191 0.0397
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0781 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0067 0.0136
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0076
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.037 0.0493
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0071 0.0085
Brugia malayi hypothetical protein 0.0013 0.0039 0.0079
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0163 0.1669
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0118 0.0135
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0071 0.0439
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2112 0.5938
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0348 0.3931 0.7972
Brugia malayi Thioredoxin reductase 0.0047 0.0426 0.0863
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0013 0.0039 0.0038
Leishmania major hypothetical protein, conserved 0.0077 0.0781 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0118 0.0207
Entamoeba histolytica hypothetical protein 0.0037 0.0312 0.0714
Brugia malayi diacylglycerol kinase 0.0013 0.0039 0.0079
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0013 0.0039 0.0038
Plasmodium falciparum glutathione reductase 0.0016 0.0071 0.0439
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0067 0.0133
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2112 0.5938
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.037 0.0864
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0071 0.0085
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0286 0.0381
Onchocerca volvulus 0.0254 0.2844 0.6268
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0652 0.7474 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0067 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.037 0.0948
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0067 0.038
Plasmodium falciparum thioredoxin reductase 0.0047 0.0426 0.5211
Echinococcus granulosus dnaJ subfamily B 0.0408 0.4633 0.6198
Schistosoma mansoni hypothetical protein 0.0016 0.0067 0.0061
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0426 0.5211
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0218 0.2426 0.492
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0118 0.024
Brugia malayi Matrixin family protein 0.0434 0.4931 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0071 0.0439
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.037 0.0493
Echinococcus multilocularis cpg binding protein 0.003 0.0236 0.0235
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.2232 0.6282
Echinococcus granulosus Diacylglycerol kinase zeta 0.0013 0.0039 0.005
Schistosoma mansoni hypothetical protein 0.0016 0.0067 0.0061
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.037 0.0948
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0118 0.0157
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0312 0.0416
Leishmania major importin beta-1 subunit, putative 0.0026 0.0191 0.2052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.353 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0067 0.0136
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.037 0.4462
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0312 0.0311
Schistosoma mansoni hypothetical protein 0.0408 0.4633 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0426 0.0568
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0284 0.0532
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.036 0.0359
Loa Loa (eye worm) matrix metalloproteinase 0.0179 0.1971 0.3996
Brugia malayi glutathione reductase 0.0047 0.0426 0.0863
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0292 0.328 0.6651
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0071 0.0439
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.2232 0.6282
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0153 0.1665 0.4245
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0263 0.3018
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0067 0.038
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0067 0.038
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0118 0.107
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0071 0.0439
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0605 0.1233
Trichomonas vaginalis set domain proteins, putative 0.0268 0.3006 0.8498
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.037 0.0369
Echinococcus granulosus geminin 0.0342 0.3871 0.5178
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0071 0.0439
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0071 0.0439
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0163 0.1669
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0263 0.0262
Brugia malayi diacylglycerol kinase 0.0013 0.0039 0.0079
Mycobacterium ulcerans hypothetical protein 0.0342 0.3869 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.037 0.075
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0067 0.0066
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.1258 0.3182
Echinococcus granulosus sphingosine kinase 1 0.0342 0.3869 0.5176
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0284 0.0282
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0122 0.13 0.2746
Plasmodium vivax SET domain protein, putative 0.0034 0.0284 0.3296
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.037 0.0369
Trichomonas vaginalis ran, putative 0.0024 0.0163 0.0355
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0707 0.1432
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0071 0.0439
Schistosoma mansoni cpg binding protein 0.003 0.0236 0.0429
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2112 0.5938
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.037 0.0721
Schistosoma mansoni hypothetical protein 0.0342 0.3871 0.8341
Brugia malayi Pre-SET motif family protein 0.0236 0.2628 0.5329
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0071 0.0439
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.037 0.4462
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0067 0.0088
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0463 0.0938
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0118 0.107
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.2628 0.5327
Echinococcus multilocularis GPCR, family 2 0.0016 0.0067 0.0066
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0118 0.0135
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0652 0.7474 0.7473
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0191 0.0436
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0071 0.0439
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0707 0.9007
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0067 0.0136
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0426 0.0424
Loa Loa (eye worm) hypothetical protein 0.0342 0.3869 0.7846
Loa Loa (eye worm) glutathione reductase 0.0047 0.0426 0.0861
Schistosoma mansoni ran 0.0024 0.0163 0.027
Treponema pallidum fructose-bisphosphate aldolase 0.0313 0.353 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0218 0.2426 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0707 0.0945
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0191 0.2052
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0118 0.0237
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0071 0.0439
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0262 0.0349
Loa Loa (eye worm) hypothetical protein 0.0077 0.0781 0.1581
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0071 0.0085
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0067 0.0088
Echinococcus multilocularis snurportin 1 0.0348 0.3931 0.3931
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2112 0.5938
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0118 0.107
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0284 0.0378
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.353 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0313 0.353 1
Echinococcus granulosus cpg binding protein 0.003 0.0236 0.0314
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0071 0.0439
Schistosoma mansoni hypothetical protein 0.0342 0.3871 0.8341
Schistosoma mansoni hypothetical protein 0.0037 0.0312 0.0595
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.037 0.4462
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.037 0.4462
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0013 0.0039 0.005
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0071 0.0145
Brugia malayi Importin beta-1 subunit 0.0033 0.0263 0.0533
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0263 0.3018
Brugia malayi CXXC zinc finger family protein 0.0029 0.0217 0.044
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0313 0.353 0.9114
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0313 0.353 0.9114
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0163 0.0161
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.112 0.2822
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0286 0.0285
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0707 0.9007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0284 0.3296
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0179 0.1971 0.4206
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0067 0.038
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0067 0.0061
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2112 0.5938
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0263 0.3018
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.112 0.2822
Onchocerca volvulus Matrilysin homolog 0.0398 0.4514 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0022 0.0044
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0163 0.0327
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.127 0.2573
Loa Loa (eye worm) hypothetical protein 0.0218 0.2426 0.4919
Echinococcus granulosus GPCR family 2 0.0016 0.0067 0.0088
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0071 0.0439
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0284 0.0532
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0163 0.033
Entamoeba histolytica hypothetical protein, conserved 0.0342 0.3869 1
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.328 0.9283
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0071 0.0093
Schistosoma mansoni hypothetical protein 0.0034 0.0279 0.0523
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.328 0.9283
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0071 0.0439
Loa Loa (eye worm) hypothetical protein 0.0034 0.0279 0.0564
Brugia malayi hypothetical protein 0.005 0.0463 0.0939
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0163 0.1669
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0463 0.0936
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0118 0.0227
Brugia malayi Matrixin family protein 0.0179 0.1971 0.3998
Brugia malayi hypothetical protein 0.0077 0.0781 0.1584
Brugia malayi Diacylglycerol kinase protein 2 0.0013 0.0039 0.0079
Loa Loa (eye worm) diacylglycerol kinase 2 0.0013 0.0039 0.0076
Plasmodium vivax glutathione reductase, putative 0.0047 0.0426 0.5211
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.1258 0.3182
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.353 1
Schistosoma mansoni ap endonuclease 0.002 0.0118 0.0173
Entamoeba histolytica hypothetical protein 0.0037 0.0312 0.0714
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0076
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0067 0.0074
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0118 0.0227
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0071 0.5
Onchocerca volvulus Matrilysin homolog 0.0179 0.1971 0.4318
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.112 0.2822
Echinococcus multilocularis ceramide kinase 0.0013 0.0039 0.0038
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0118 0.107
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0707 0.0706
Schistosoma mansoni hypothetical protein 0.0016 0.0067 0.0061
Echinococcus granulosus transcription factor Dp 1 0.0041 0.036 0.0481
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0071 0.0094

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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