Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0035 | 0.0326 | 0.1566 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0089 | 0.0989 | 0.1557 |
Echinococcus multilocularis | pyruvate kinase | 0.0018 | 0.0115 | 0.0115 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0024 | 0.0115 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0024 | 0.0115 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0024 | 0.0038 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.0472 | 0.2273 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0024 | 0.0115 |
Onchocerca volvulus | Huntingtin homolog | 0.0093 | 0.104 | 0.5003 |
Leishmania major | pyruvate kinase | 0.0035 | 0.0327 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0024 | 0.0038 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0326 | 0.1566 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0024 | 0.0115 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.0581 | 0.7024 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0106 | 0.12 | 0.1306 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0326 | 0.1566 |
Echinococcus granulosus | pyruvate kinase | 0.0018 | 0.0115 | 0.0115 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0024 | 0.0038 |
Echinococcus granulosus | pyruvate kinase | 0.0018 | 0.0115 | 0.0115 |
Onchocerca volvulus | 0.0011 | 0.0024 | 0.0115 | |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0024 | 0.0115 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0024 | 0.0115 |
Mycobacterium ulcerans | molybdopterin-guanine dinucleotide biosynthesis protein A | 0.0106 | 0.12 | 0.1306 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0178 | 0.2078 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0089 | 0.0989 | 0.0989 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0035 | 0.0327 | 0.1571 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.266 | 0.3485 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0024 | 0.0115 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0024 | 0.0024 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0327 | 0.1571 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0024 | 0.0115 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0024 | 0.0038 |
Mycobacterium ulcerans | pyruvate kinase | 0.0035 | 0.0327 | 0.0001 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0326 | 0.1566 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0024 | 0.0038 |
Onchocerca volvulus | Huntingtin homolog | 0.0093 | 0.104 | 0.5003 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0024 | 0.0038 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0326 | 0.1566 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0024 | 0.0115 |
Brugia malayi | N-terminal motif family protein | 0.0178 | 0.2078 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0106 | 0.12 | 0.1306 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0035 | 0.0327 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0024 | 0.0115 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1725 | 0.8301 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0149 | 0.1725 | 0.8301 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0024 | 0.0115 |
Treponema pallidum | licC protein (licC) | 0.0106 | 0.12 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0035 | 0.0327 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0024 | 0.0115 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0024 | 0.0115 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0089 | 0.0989 | 0.0989 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0024 | 0.0024 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0089 | 0.0989 | 0.1557 |
Echinococcus granulosus | pyruvate kinase | 0.0035 | 0.0327 | 0.0327 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0024 | 0.0115 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0526 | 0.6355 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0035 | 0.0327 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0106 | 0.12 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0326 | 0.1566 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0089 | 0.0989 | 0.0989 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0472 | 0.0472 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0024 | 0.0024 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.0024 | 0.0115 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0089 | 0.0989 | 0.476 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0024 | 0.0115 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0024 | 0.0038 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0472 | 0.0472 |
Chlamydia trachomatis | pyruvate kinase | 0.0035 | 0.0327 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0024 | 0.0038 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0024 | 0.0038 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0024 | 0.0024 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0024 | 0.0115 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0472 | 0.0743 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0089 | 0.0989 | 0.1557 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0024 | 0.0115 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0472 | 0.0472 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.0327 | 0.0327 |
Schistosoma mansoni | hypothetical protein | 0.0507 | 0.6122 | 0.9633 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.0472 | 0.2273 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0526 | 0.6355 | 0.6355 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.0472 | 0.0472 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0326 | 0.9953 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0024 | 0.0115 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0102 | 0.1145 | 0.551 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0327 | 0.1571 |
Echinococcus granulosus | geminin | 0.0507 | 0.6122 | 0.6122 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0024 | 0.0024 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0024 | 0.0024 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0035 | 0.0327 | 0.0001 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0024 | 0.0038 |
Giardia lamblia | Pyruvate kinase | 0.0035 | 0.0327 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0024 | 0.0115 |
Mycobacterium leprae | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0581 | 0.7024 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0035 | 0.0327 | 0.0327 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0327 | 0.1571 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.2078 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.0024 | 0.0115 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0526 | 0.6355 | 0.6355 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0024 | 0.0115 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0035 | 0.0327 | 0.1571 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0326 | 0.1566 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.104 | 0.5003 |
Echinococcus multilocularis | pyruvate kinase | 0.0018 | 0.0115 | 0.0115 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0024 | 0.0115 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0035 | 0.0327 | 0.0001 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0024 | 0.0115 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.0024 | 0.0115 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0149 | 0.1725 | 0.8301 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0326 | 0.1566 |
Plasmodium vivax | pyruvate kinase, putative | 0.0035 | 0.0327 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0326 | 0.1566 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0472 | 0.2273 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0089 | 0.0989 | 0.476 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0024 | 0.0038 |
Mycobacterium ulcerans | hypothetical protein | 0.0106 | 0.12 | 0.1306 |
Brugia malayi | hypothetical protein | 0.0093 | 0.104 | 0.5003 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0024 | 0.0024 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.0472 | 0.0472 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0106 | 0.12 | 0.1306 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.0011 | 0.0024 | 0.0114 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0024 | 0.0024 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0326 | 0.2713 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0327 | 0.1571 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0581 | 0.7024 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0581 | 0.7024 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0326 | 0.0326 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0327 | 0.1571 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0024 | 0.0115 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0024 | 0.0115 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0024 | 0.0115 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0472 | 0.0743 |
Leishmania major | pyruvate kinase | 0.0035 | 0.0327 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0089 | 0.0989 | 0.0989 |
Echinococcus multilocularis | geminin | 0.0507 | 0.6122 | 0.6122 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0024 | 0.0024 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0024 | 0.0115 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0035 | 0.0327 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0472 | 0.0743 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0024 | 0.0115 |
Schistosoma mansoni | pyruvate kinase | 0.0018 | 0.0115 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0024 | 0.0115 |
Echinococcus multilocularis | pyruvate kinase | 0.0028 | 0.0235 | 0.0235 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0024 | 0.0038 |
Echinococcus granulosus | pyruvate kinase | 0.0018 | 0.0115 | 0.0115 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0025 | 0.0195 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0035 | 0.0327 | 0.2721 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0035 | 0.0327 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0326 | 0.0326 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0326 | 0.1566 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0024 | 0.0115 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0024 | 0.0024 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0024 | 0.0115 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0024 | 0.0024 |
Onchocerca volvulus | 0.0035 | 0.0326 | 0.1566 | |
Echinococcus multilocularis | pyruvate kinase | 0.0018 | 0.0115 | 0.0115 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0024 | 0.0115 |
Onchocerca volvulus | 0.0035 | 0.0326 | 0.1566 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0326 | 0.1566 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0024 | 0.0038 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0195 | 0.0939 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0149 | 0.1725 | 0.8301 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0024 | 0.0024 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0326 | 0.0512 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.104 | 0.5003 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0327 | 0.1571 |
Plasmodium falciparum | pyruvate kinase | 0.0035 | 0.0327 | 1 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0025 | 0.0195 | 0.0939 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0024 | 0.0024 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0472 | 0.0472 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0326 | 0.0512 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0327 | 0.1571 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0024 | 0.0115 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0326 | 0.1566 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0326 | 0.1566 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0024 | 0.0115 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.0472 | 0.2273 |
Schistosoma mansoni | pyruvate kinase | 0.0035 | 0.0327 | 0.0514 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1145 | 0.551 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0472 | 0.0743 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0024 | 0.0115 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0024 | 0.0024 |
Schistosoma mansoni | hypothetical protein | 0.0507 | 0.6122 | 0.9633 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0024 | 0.0115 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.1145 | 0.1802 |
Schistosoma mansoni | pyruvate kinase | 0.0035 | 0.0327 | 0.0514 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0024 | 0.0115 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0018 | 0.0115 | 0.096 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0035 | 0.0327 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.