Detailed information for compound 1027844

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 297.352 | Formula: C17H19N3O2
  • H donors: 2 H acceptors: 2 LogP: 2.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)/C=N/NC(=O)c1[nH]c(c(c1C)C(=O)C)C
  • InChi: 1S/C17H19N3O2/c1-10-5-7-14(8-6-10)9-18-20-17(22)16-11(2)15(13(4)21)12(3)19-16/h5-9,19H,1-4H3,(H,20,22)/b18-9+
  • InChiKey: DOWBEDCSRVOFSH-GIJQJNRQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0959 0.4255
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0399 0.6849
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0597 0.2648
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Onchocerca volvulus 0.0015 0.0201 0.5
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0119 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0959 0.4255
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Onchocerca volvulus 0.0015 0.0201 0.5
Schistosoma mansoni protein kinase 0.0032 0.0597 0.2648
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0597 0.2648
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0597 0.0597
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0597 0.2648
Schistosoma mansoni ferritin light chain 0.0009 0.0068 0.0303
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0597 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0582 0.2583
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0606 0.8651
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0201 0.0894
Onchocerca volvulus 0.0015 0.0201 0.5
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus multilocularis expressed protein 0.0009 0.0068 0.0303
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0597 0.2648
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0597 0.2648
Giardia lamblia Hexose transporter 0.0015 0.0201 0.346
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0582 0.8464
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0023 0.0399 0.1769
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0068 0.5753
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Entamoeba histolytica hypothetical protein 0.0036 0.0688 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0688 0.3052
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0606 0.8651
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0399 0.1769
Onchocerca volvulus 0.0015 0.0201 0.5
Onchocerca volvulus 0.0015 0.0201 0.5
Schistosoma mansoni ferritin 0.0009 0.0068 0.0303
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0552 0.2448
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0597 0.0597
Schistosoma mansoni glucose transport protein 0.0105 0.2253 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0894
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0894
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Echinococcus granulosus General substrate transporter 0.009 0.1918 0.851
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0201 0.0894
Schistosoma mansoni ferritin light chain 0.0009 0.0068 0.0303
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0201 0.0894
Loa Loa (eye worm) sugar transporter 0.0105 0.2253 1
Toxoplasma gondii sugar transporter ST3 0.0015 0.0201 0.0305
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0201 0.0894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0959 0.4255
Leishmania major hypothetical protein, conserved 0.0015 0.0201 0.2874
Plasmodium vivax CDK-related protein kinase 6, putative 0.0445 1 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2253 1
Schistosoma mansoni glucose transporter 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0606 0.269
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0068 0.1173
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0597 0.8517
Schistosoma mansoni protein kinase 0.0032 0.0597 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0201 0.0894
Trypanosoma brucei glucose transporter 1E 0.0033 0.0606 0.8651
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0169 0.3724 0.5632
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0399 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0201 0.0894
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0201 0.2874
Brugia malayi hypothetical protein 0.0015 0.0201 0.0894
Mycobacterium ulcerans sugar transporter 0.0015 0.0201 0.5052
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0606 0.8651
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0333 0.1477
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2253 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0201 0.2874
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0701 0.0701
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0688 0.3052
Schistosoma mansoni protein kinase 0.0032 0.0597 0.2648
Plasmodium falciparum mitogen-activated protein kinase 2 0.0169 0.3724 0.3724
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0399 0.5689
Brugia malayi Sugar transporter family protein 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0119 0.2978
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0959 0.4255
Leishmania major protein kinase, putative 0.0032 0.0597 0.8517
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Brugia malayi major facilitator superfamily protein 0.0015 0.0201 0.0894
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0201 0.6328
Trichomonas vaginalis ferritin, putative 0.0009 0.0068 0.0303
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0701 0.106
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0399 0.5689
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0701 1
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0582 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0448 0.1987
Onchocerca volvulus 0.0015 0.0201 0.5
Schistosoma mansoni glucose transport protein 0.0105 0.2253 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus multilocularis General substrate transporter 0.009 0.1918 0.851
Onchocerca volvulus 0.0015 0.0201 0.5
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0169 0.3724 0.3724
Echinococcus granulosus ferritin 0.0009 0.0068 0.0303
Leishmania major glucose transporter, lmgt1 0.0033 0.0606 0.8651
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0959 0.4255
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0597 0.2648
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0068 0.2145
Brugia malayi hypothetical protein 0.0015 0.0201 0.0894
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0399 0.1769
Onchocerca volvulus 0.0015 0.0201 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.2253 1
Echinococcus granulosus expressed protein 0.0009 0.0068 0.0303
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0582 1
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0894
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Toxoplasma gondii protein kinase, putative 0.0296 0.6612 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0597 0.0597
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0399 0.1769
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0894
Onchocerca volvulus 0.0015 0.0201 0.5
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0701 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0582 0.2583
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0399 0.0603
Brugia malayi Sugar transporter family protein 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0597 0.2648
Entamoeba histolytica hypothetical protein 0.0023 0.0399 0.5797
Schistosoma mansoni apoferritin-2 0.0009 0.0068 0.0303
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0399 0.1769
Entamoeba histolytica protein kinase, putative 0.0032 0.0597 0.8679
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0597 0.2648
Schistosoma mansoni apoferritin-2 0.0009 0.0068 0.0303
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0597 0.2648
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Onchocerca volvulus 0.0015 0.0201 0.5
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0201 0.5052
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0399 0.1769
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0318 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0068 0.2145
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0597 0.0903
Schistosoma mansoni ferritin 0.0009 0.0068 0.0303
Loa Loa (eye worm) sugar transporter 0.0015 0.0201 0.0894
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0201 0.0305
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0597 0.0597
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0606 0.269
Schistosoma mansoni hypothetical protein 0.0105 0.2253 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0688 0.3052
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0318 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0597 0.0597
Brugia malayi hypothetical protein 0.0015 0.0201 0.0894
Giardia lamblia Sugar-proton symporter 0.0015 0.0201 0.346
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0582 0.2583
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0068 0.1713
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0552 0.2448
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0959 0.4255
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0201 0.0894
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0201 0.0894
Toxoplasma gondii sugar transporter ST1 0.0015 0.0201 0.0305
Onchocerca volvulus 0.0015 0.0201 0.5
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0201 0.5052
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0582 0.2583
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0701 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0201 0.0201
Leishmania major glucose transporter, lmgt3 0.0033 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0031 0.0582 0.2583
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0201 0.2874
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0597 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0399 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0318 0.5469
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0201 0.2874
Schistosoma mansoni hypothetical protein 0.0036 0.0688 0.3052
Onchocerca volvulus Putative transporter 0.0015 0.0201 0.5
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0032 0.0597 0.2648
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0701 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.2253 0.3408
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0068 0.1713
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0201 0.0894
Schistosoma mansoni ferritin 0.0009 0.0068 0.0303
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trypanosoma brucei glucose transporter 2A 0.0033 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0399 0.0399
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0201 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.016 0.0709
Trypanosoma brucei sugar transporter, putative 0.0015 0.0201 0.2874
Plasmodium vivax sugar transporter, putative 0.0015 0.0201 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Entamoeba histolytica hypothetical protein 0.0036 0.0688 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2253 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0597 0.0597
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0582 0.2583
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Entamoeba histolytica hypothetical protein 0.0036 0.0688 1
Brugia malayi Sugar transporter family protein 0.0105 0.2253 1
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0119 0.2978
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.2253 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0068 0.339
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0201 0.5052
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0597 0.0903
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0582 0.2583
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0399 0.1769
Onchocerca volvulus 0.0015 0.0201 0.5
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0959 0.4255
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0201 0.6328
Echinococcus multilocularis ferritin 0.0009 0.0068 0.0303
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0597 0.0597
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0597 0.2648
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2253 1
Leishmania major glucose transporter, lmgt2 0.0033 0.0606 0.8651
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0597 0.0903
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0597 0.2648
Entamoeba histolytica protein kinase, putative 0.0032 0.0597 0.8679
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0606 0.269
Brugia malayi Cam kinase protein 1 0.0032 0.0597 0.2648
Loa Loa (eye worm) hypothetical protein 0.0031 0.0582 0.2583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0959 0.4255
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Plasmodium falciparum hexose transporter 0.0105 0.2253 0.2253
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2253 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0701 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0606 0.269
Onchocerca volvulus 0.0015 0.0201 0.5
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0701 0.0701
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0201 0.0894
Brugia malayi major facilitator superfamily protein 0.0015 0.0201 0.0894
Brugia malayi hypothetical protein 0.0036 0.0688 0.3052
Plasmodium vivax hexose transporter 0.0105 0.2253 0.2253
Plasmodium falciparum protein kinase 7 0.0296 0.6612 0.6612
Entamoeba histolytica hypothetical protein 0.0036 0.0688 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0201 0.2874
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0606 0.8651
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0597 0.2648
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2253 1
Toxoplasma gondii sugar transporter ST2 0.0015 0.0201 0.0305
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0959 0.4255
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0399 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Onchocerca volvulus 0.0015 0.0201 0.5
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0606 0.269
Onchocerca volvulus 0.0015 0.0201 0.5
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0399 0.5689
Schistosoma mansoni glucose transport protein 0.0105 0.2253 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0399 0.6849
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0606 0.269
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0597 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0606 0.269
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2253 1
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0582 0.2583
Trypanosoma cruzi hexose transporter 0.0033 0.0606 0.8651
Schistosoma mansoni ferritin 0.0009 0.0068 0.0303
Trypanosoma cruzi hexose transporter, putative 0.0018 0.027 0.386
Onchocerca volvulus 0.0015 0.0201 0.5

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 92 % Growth inhibition of Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 to 8 days by microplate alamar blue assay ChEMBL. 21752642
MIC99 (functional) < 6.25 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 to 8 days by microplate alamar blue assay ChEMBL. 21752642

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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