Detailed information for compound 1028686

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 437.574 | Formula: C26H35N3O3
  • H donors: 1 H acceptors: 2 LogP: 5.8 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)Oc1ccccc1CNCC1CCN(CC1)CC1CCCCC1
  • InChi: 1S/C26H35N3O3/c30-29(31)24-10-12-25(13-11-24)32-26-9-5-4-8-23(26)19-27-18-21-14-16-28(17-15-21)20-22-6-2-1-3-7-22/h4-5,8-13,21-22,27H,1-3,6-7,14-20H2
  • InChiKey: WCIVWNGTDVORMN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0151 0.0078
Loa Loa (eye worm) sugar transporter 0.0108 0.1898 0.3899
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0244 0.0676
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0074 0.0283
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0425 0.0354
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0244 0.0276
Schistosoma mansoni hypothetical protein 0.0033 0.0419 0.0348
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0084 0.001
Loa Loa (eye worm) hypothetical protein 0.0062 0.0985 0.1987
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.4812 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0074 0.0283
Loa Loa (eye worm) hypothetical protein 0.0053 0.0818 0.1636
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0747 0.0773
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0518 0.6595
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0742 0.0673
Loa Loa (eye worm) hypothetical protein 0.0049 0.0742 0.1477
Trypanosoma brucei glucose transporter 1E 0.0033 0.0433 0.5602
Echinococcus granulosus intermediate filament protein 0.0054 0.0837 0.077
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0518 0.051
Schistosoma mansoni hypothetical protein 0.0071 0.1166 0.11
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1898 0.1838
Loa Loa (eye worm) hypothetical protein 0.0018 0.0126 0.0187
Schistosoma mansoni hypothetical protein 0.0033 0.0419 0.0348
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0244 0.036
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.1639
Echinococcus granulosus tumor protein p63 0.0336 0.6379 0.6352
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.1898 0.1838
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0518 0.0779
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0211 0.0138
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0084 0.0012
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.5561 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0126 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.1639
Brugia malayi follicle stimulating hormone receptor 0.0256 0.4812 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0151 0.0141
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0107 0.013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.1809 0.3663
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0433 0.5602
Trypanosoma brucei glucose transporter, putative 0.0033 0.0433 0.5602
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0492 0.0421
Trypanosoma brucei glucose transporter, putative 0.0033 0.0433 0.5602
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0151 0.1639
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.001
Schistosoma mansoni protein kinase 0.0033 0.0425 0.0354
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0244 0.0172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.5561 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0419 0.0348
Loa Loa (eye worm) hypothetical protein 0.0033 0.0427 0.0818
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.1049 0.0983
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0412 0.0617
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0249 0.0177
Loa Loa (eye worm) hypothetical protein 0.0071 0.1166 0.2365
Onchocerca volvulus 0.0049 0.0742 0.8747
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0249 0.037
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0425 0.5485
Schistosoma mansoni transient receptor potential channel 0.0065 0.1049 0.0983
Echinococcus granulosus lamin dm0 0.0054 0.0837 0.077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.5561 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0084 0.001
Onchocerca volvulus 0.0054 0.0837 1
Trypanosoma brucei unspecified product 0.0019 0.0151 0.1639
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0433 0.0656
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0249 1
Trypanosoma cruzi hexose transporter 0.0033 0.0433 0.5346
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0244 0.0939
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0244 0.0276
Trypanosoma brucei glucose transporter, putative 0.0033 0.0433 0.5602
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0177 0.0411
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0126 0.0206
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.1049 0.0983
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.1898 0.1838
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.5561 1
Plasmodium falciparum protein kinase 7 0.0305 0.5774 0.6542
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0135 0.0912
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0191 0.0213
Brugia malayi hypothetical protein 0.0032 0.0402 0.0694
Schistosoma mansoni glucose transport protein 0.0108 0.1898 0.1838
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0385 0.0314
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0084 0.0693
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0344 0.0644
Schistosoma mansoni hypothetical protein 0.052 1 1
Toxoplasma gondii protein kinase, putative 0.0305 0.5774 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0108 0.1898 0.1838
Echinococcus granulosus transient receptor potential gamma protein 0.0098 0.1702 0.164
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.001
Toxoplasma gondii facilitative glucose transporter GT1 0.0108 0.1898 0.3201
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0249 0.0177
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0074 0.0283
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.1049 0.0983
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.5561 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0492 0.0421
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0084 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.1639
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0425 0.0354
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0433 0.0656
Schistosoma mansoni glucose transport protein 0.0108 0.1898 0.1838
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0074 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0244 0.0435
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0151 0.0141
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0518 0.6782
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0151 0.0141
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0426 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0433 0.0656
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0249 0.0957
Entamoeba histolytica protein kinase, putative 0.0033 0.0425 0.0507
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0412 0.0617
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0244 0.0939
Leishmania major protein kinase, putative 0.0033 0.0425 0.5223
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.5561 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0837 0.1677
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0837 0.1612
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0151 0.1153
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0211 0.0138
Schistosoma mansoni transient receptor potential channel 0.0065 0.1049 0.0983
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0084 0.0152
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0107 0.013
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0433 0.0656
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0249 0.0295
Plasmodium falciparum hexose transporter 0.0108 0.1898 0.2094
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0419 0.0728
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0244 0.2537
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0412 0.0341
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0518 0.051
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0151 0.0078
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0084 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0419 0.0348
Trypanosoma brucei glucose transporter, putative 0.0033 0.0433 0.5602
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0126 0.0483
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0425 0.0354
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0151 0.1153
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0249 0.0177
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0518 0.6595
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0244 0.0939
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0492 0.0882
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0433 0.0656
Leishmania major glucose transporter, lmgt1 0.0033 0.0433 0.5346
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0747 0.1181
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0151 0.1153
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0518 0.6595
Loa Loa (eye worm) hypothetical protein 0.0026 0.0293 0.0536
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0084 0.0693
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0433 0.5346
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0426 0.0617
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0177 0.0411
Echinococcus multilocularis GPCR, family 2 0.0033 0.0419 0.0348
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0425 0.0641
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0249 0.0957
Echinococcus granulosus lamin 0.0054 0.0837 0.077
Schistosoma mansoni hypothetical protein 0.0108 0.1898 0.1838
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0174 0.3206 0.5495
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0426 0.0404
Schistosoma mansoni transient receptor potential channel 0.0098 0.1702 0.164
Schistosoma mansoni protein kinase 0.0033 0.0425 0.0354
Loa Loa (eye worm) hypothetical protein 0.0018 0.0126 0.0187
Loa Loa (eye worm) hypothetical protein 0.0098 0.1702 0.3487
Echinococcus multilocularis transient receptor potential gamma protein 0.0098 0.1702 0.164
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0244 0.2537
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0426 0.0404
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0151 0.0307
Loa Loa (eye worm) hypothetical protein 0.0025 0.0268 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.1639
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0151 0.0078
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0249 0.2605
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0419 0.08
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0433 0.5346
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0151 0.0078
Schistosoma mansoni transient receptor potential channel 4 0.0098 0.1702 0.164
Entamoeba histolytica hypothetical protein 0.0024 0.0249 0.0181
Schistosoma mansoni hypothetical protein 0.0022 0.0211 0.0138
Loa Loa (eye worm) hypothetical protein 0.0018 0.0126 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0433 0.0656
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.1639
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0425 0.0354
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0151 0.1153
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0084 0.0018
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0151 0.0078
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0244 0.0939
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.1898 0.3325
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.001
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0249 0.0177
Trypanosoma brucei glucose transporter, putative 0.0033 0.0433 0.5602
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.1898 0.1838
Loa Loa (eye worm) hypothetical protein 0.0032 0.0412 0.0786
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0412 0.0341
Echinococcus granulosus dna polymerase eta 0.0019 0.0151 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0244 0.036
Trypanosoma brucei glucose transporter, putative 0.0033 0.0433 0.5602
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.1166 0.2305
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0412 0.0341
Loa Loa (eye worm) hypothetical protein 0.0054 0.0837 0.1677
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Brugia malayi hypothetical protein 0.0049 0.0747 0.1421
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.1639
Plasmodium vivax hexose transporter 0.0108 0.1898 0.2094
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.1639
Loa Loa (eye worm) hypothetical protein 0.0024 0.0249 0.0445
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0433 0.5602
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0433 0.5346
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1898 0.1838
Echinococcus multilocularis General substrate transporter 0.0093 0.16 0.1537
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0151 0.1153
Loa Loa (eye worm) hypothetical protein 0.0033 0.0419 0.08
Brugia malayi Sugar transporter family protein 0.0108 0.1898 0.3851
Loa Loa (eye worm) sugar transporter 0.0015 0.0074 0.0078
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0425 0.0814
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0425 0.0354
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0084 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.1639
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0084 0.0152
Echinococcus granulosus dna polymerase kappa 0.0019 0.0151 0.0078
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0244 0.0939
Schistosoma mansoni lamin 0.0054 0.0837 0.077
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0151 0.1639
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.5561 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0074 0.0078
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0426 0.0404
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0084 0.0022
Plasmodium falciparum protein kinase 6 0.0458 0.8787 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1898 0.1838
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.1809 0.3713
Schistosoma mansoni lamin 0.0054 0.0837 0.077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0268 0.0485
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0425 0.0354
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0249 0.0308
Echinococcus multilocularis lamin 0.0054 0.0837 0.077
Brugia malayi Cam kinase protein 1 0.0033 0.0425 0.0742
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0151 0.0581
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0426 0.0404
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0837 0.1677
Brugia malayi isocitrate dehydrogenase 0.0016 0.0084 0.0022
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0126 0.5049
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Schistosoma mansoni hypothetical protein 0.052 1 1
Onchocerca volvulus 0.0054 0.0837 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0084 0.0018
Schistosoma mansoni glucose transport protein 0.0108 0.1898 0.1838
Echinococcus granulosus GPCR family 2 0.0033 0.0419 0.0348
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0244 0.0172
Loa Loa (eye worm) hypothetical protein 0.0032 0.0412 0.0786
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0107 0.013
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0425 0.0354
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0419 0.0728
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0174 0.3206 0.3595
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0426 0.0404
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.5561 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1898 0.1838
Plasmodium vivax CDK-related protein kinase 6, putative 0.0458 0.8787 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0151 0.1153
Brugia malayi intermediate filament protein 0.0054 0.0837 0.1612
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0747 1
Schistosoma mansoni hypothetical protein 0.0033 0.0419 0.0348
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0151 0.0164
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0425 0.0354
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0344 0.0571
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.5561 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0151 0.1153
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0249 0.0201
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0425 0.0814
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0426 0.0617
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0151 0.1639
Loa Loa (eye worm) hypothetical protein 0.0026 0.0288 0.0526
Schistosoma mansoni protein kinase 0.0033 0.0425 0.0354
Loa Loa (eye worm) hypothetical protein 0.0024 0.0244 0.0435
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0412 0.0714
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0425 0.0742
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0419 0.0348
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.1049 0.0983
Loa Loa (eye worm) hypothetical protein 0.0049 0.0747 0.1487
Trypanosoma brucei glucose transporter 2A 0.0033 0.0433 0.5602
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0151 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0433 0.0656
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0074 0.0078
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0084 0.0041
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0412 0.0967
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0433 0.5602
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0249 0.3011
Entamoeba histolytica protein kinase, putative 0.0033 0.0425 0.0507
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0426 0.0404
Echinococcus granulosus General substrate transporter 0.0093 0.16 0.1537
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0151 0.0581
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0412 0.0714
Trypanosoma brucei glucose transporter, putative 0.0033 0.0433 0.5602
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.1809 0.3663
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0151 0.0164
Loa Loa (eye worm) hypothetical protein 0.0103 0.1809 0.3713
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.2601 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0425 0.0354
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.2601 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0244 0.2537
Echinococcus multilocularis dna polymerase eta 0.0019 0.0151 0.0078
Mycobacterium ulcerans sugar transporter 0.0015 0.0074 0.0283
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0412 0.0482
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0747 0.0773
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0433 0.5346
Echinococcus multilocularis lamin dm0 0.0054 0.0837 0.077
Trypanosoma brucei glucose transporter, putative 0.0033 0.0433 0.5602
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0249 0.032
Schistosoma mansoni DNA polymerase eta 0.0019 0.0151 0.0078
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0426 0.0404
Leishmania major DNA polymerase eta, putative 0.0019 0.0151 0.1153
Loa Loa (eye worm) hypothetical protein 0.0036 0.0492 0.0953
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0747 1
Leishmania major hypothetical protein, conserved 0.0049 0.0747 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0244 0.0939
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0747 0.0773
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0249 0.032
Schistosoma mansoni hypothetical protein 0.0033 0.0419 0.0348
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0107 0.013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.5561 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0126 0.006
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0747 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0151 0.1639
Echinococcus multilocularis musashi 0.0054 0.0837 0.077
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Echinococcus multilocularis transient receptor potential ion channel A 0.0095 0.1637 0.1576
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0244 0.036
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0426 0.0617
Schistosoma mansoni intermediate filament proteins 0.0054 0.0837 0.077
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0126 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.1639
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0419 0.0348
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Echinococcus multilocularis tumor protein p63 0.0336 0.6379 0.6352
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0244 0.0939
Loa Loa (eye worm) hypothetical protein 0.0018 0.0126 0.0187
Leishmania major glucose transporter, lmgt2 0.0033 0.0433 0.5346
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0426 0.0404
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0412 0.0341
Loa Loa (eye worm) hypothetical protein 0.0024 0.0244 0.0435
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0244 0.0676
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0084 0.0099
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0078
Loa Loa (eye worm) hypothetical protein 0.0033 0.0425 0.0814
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0518 0.6595
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0074 0.0549
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0249 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.1639
Loa Loa (eye worm) hypothetical protein 0.0019 0.0151 0.024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0244 0.0172
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0288 0.0216
Trypanosoma brucei sugar transporter, putative 0.0015 0.0074 0.0549
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.5561 1
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0385 0.0314
Plasmodium falciparum mitogen-activated protein kinase 2 0.0174 0.3206 0.3595
Echinococcus granulosus transient receptor potential ion channel A 0.0095 0.1637 0.1576
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0288 0.0216
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.2601 1
Onchocerca volvulus 0.0024 0.0244 0.2236
Leishmania major glucose transporter, lmgt3 0.0033 0.0433 0.5346
Echinococcus multilocularis geminin 0.052 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0151 0.0307
Mycobacterium ulcerans hypothetical protein 0.0024 0.0244 0.0939
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0249 0.2605
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.5561 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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