TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 457.996 | Formula: C24H32ClN5O2
H donors: 0 H acceptors: 1 LogP: 5.71 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COCC1(CCN(CC1)CCc1ccc(cc1)N=[N+]=[N-])N(c1ccccc1)C(=O)CC.Cl
InChi: 1S/C24H31N5O2.ClH/c1-3-23(30)29(22-7-5-4-6-8-22)24(19-31-2)14-17-28(18-15-24)16-13-20-9-11-21(12-10-20)26-27-25;/h4-12H,3,13-19H2,1-2H3;1H
InChiKey: KYNGZQGCBHEUIH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Opioid receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	allatostatin A receptor	Opioid receptor	372 aa	302 aa	28.5 %
Onchocerca volvulus		Opioid receptor	372 aa	386 aa	22.8 %
Onchocerca volvulus		Opioid receptor	372 aa	353 aa	21.0 %
Echinococcus granulosus	tm gpcr rhodopsin	Opioid receptor	372 aa	334 aa	22.5 %
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Opioid receptor	372 aa	331 aa	21.4 %
Onchocerca volvulus		Opioid receptor	372 aa	344 aa	22.1 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Opioid receptor	372 aa	320 aa	25.6 %
Loa Loa (eye worm)	neuropeptide F receptor	Opioid receptor	372 aa	317 aa	23.3 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Opioid receptor	372 aa	366 aa	22.7 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Opioid receptor	372 aa	353 aa	29.2 %
Brugia malayi	GnHR receptor homolog	Opioid receptor	372 aa	313 aa	18.5 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Opioid receptor	372 aa	330 aa	24.2 %
Echinococcus granulosus	allatostatin A receptor	Opioid receptor	372 aa	302 aa	27.8 %
Brugia malayi	ORL1-like opioid receptor	Opioid receptor	372 aa	300 aa	24.7 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Opioid receptor	372 aa	315 aa	28.6 %
Onchocerca volvulus		Opioid receptor	372 aa	349 aa	22.1 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Opioid receptor	372 aa	330 aa	24.5 %
Onchocerca volvulus		Opioid receptor	372 aa	316 aa	26.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	microtubule associated protein 2	0.1439	0.3819	1
Schistosoma mansoni	hypothetical protein	0.0401	0.0961	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0065	0.0065
Onchocerca volvulus		0.0075	0.0065	0.0065
Leishmania major	C-8 sterol isomerase-like protein	0.0217	0.0457	0.1686
Loa Loa (eye worm)	PAN domain-containing protein	0.0075	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0008	0.0008
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0401	0.0961	0.0961
Onchocerca volvulus		0.0075	0.0065	0.0065
Echinococcus granulosus	tissue type plasminogen activator	0.0931	0.2423	0.6343
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0401	0.0961	0.0967
Trypanosoma cruzi	prolyl endopeptidase	0.0391	0.0936	0.3038
Mycobacterium ulcerans	acyl-CoA synthetase	0.0073	0.0059	0.053
Brugia malayi	AMP-binding enzyme family protein	0.0073	0.0059	0.0059
Trypanosoma brucei	prolyl endopeptidase	0.0391	0.0936	1
Brugia malayi	Trypsin-like protease protein 5	0.0401	0.0961	0.0967
Echinococcus multilocularis	sterol regulatory element binding protein	0.0084	0.0089	0.0231
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0054	0.0008	0.0099
Echinococcus granulosus	Niemann Pick C1 protein	0.0278	0.0625	0.1634
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0401	0.0961	0.0961
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0195	0.0395	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.0123	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0391	0.0936	0.0942
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0156	0.0287	0.3489
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0059	0.0059
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0156	0.0287	0.2928
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0395	0.0397
Onchocerca volvulus		0.0063	0.0033	0.0033
Onchocerca volvulus		0.0075	0.0065	0.0065
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0217	0.0457	0.2621
Onchocerca volvulus		0.0401	0.0961	0.0967
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0931	0.2423	1
Brugia malayi	PAN domain containing protein	0.0075	0.0065	0.0065
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0096	0.0123	0.0124
Brugia malayi	PAN domain containing protein	0.0075	0.0065	0.0065
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0123	0.0123
Onchocerca volvulus		0.3661	0.9936	1
Echinococcus multilocularis	protein patched	0.0084	0.0089	0.0231
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.0315	0.486
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0401	0.0961	0.0961
Loa Loa (eye worm)	PAN domain-containing protein	0.0075	0.0065	0.0065
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0401	0.0961	0.2516
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0401	0.0961	0.0967
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.0554	1
Brugia malayi	CHE-14 protein	0.0084	0.0089	0.0089
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0008	0.0008
Toxoplasma gondii	PAN domain-containing protein	0.1164	0.3063	1
Onchocerca volvulus		0.0931	0.2423	0.2438
Echinococcus multilocularis	enteropeptidase	0.0401	0.0961	0.2516
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0457	0.046
Onchocerca volvulus		0.0075	0.0065	0.0065
Brugia malayi	Niemann-Pick C1 protein precursor	0.0195	0.0395	0.0397
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0391	0.0936	0.0935
Mycobacterium ulcerans	hypothetical protein	0.0073	0.0059	0.053
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.0339	0.5388
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0033	0.0033
Schistosoma mansoni	hypothetical protein	0.0081	0.0081	0.008
Onchocerca volvulus		0.0091	0.011	0.011
Brugia malayi	AMP-binding enzyme family protein	0.0073	0.0059	0.0059
Toxoplasma gondii	kringle domain-containing protein	0.0931	0.2423	0.7864
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.0123	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0065	0.0065
Onchocerca volvulus		0.0075	0.0065	0.0065
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0412	0.0994	0.0993
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.0554	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0401	0.0961	0.0961
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0123	0.0123
Echinococcus granulosus	enteropeptidase	0.0401	0.0961	0.2516
Loa Loa (eye worm)	hypothetical protein	0.0401	0.0961	0.0967
Brugia malayi	PAN domain containing protein	0.0075	0.0065	0.0065
Schistosoma mansoni	cercarial elastase (S01 family)	0.0401	0.0961	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0065	0.0065
Onchocerca volvulus		0.0401	0.0961	0.0967
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0008	0.0008
Echinococcus multilocularis	tissue type plasminogen activator	0.0931	0.2423	0.6343
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.0554	1
Onchocerca volvulus		0.0073	0.0059	0.0059
Mycobacterium ulcerans	hypothetical protein	0.0401	0.0961	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0073	0.0059	0.0713
Schistosoma mansoni	cercarial elastase (S01 family)	0.0401	0.0961	0.0961
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.035	0.0823	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0008	0.0008
Echinococcus granulosus	glycoprotein Antigen 5	0.0401	0.0961	0.2516
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0073	0.0059	0.053
Brugia malayi	AMP-binding enzyme family protein	0.0073	0.0059	0.0059
Onchocerca volvulus		0.0075	0.0065	0.0065
Onchocerca volvulus		0.0075	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0001	0.0001
Leishmania major	oligopeptidase b	0.0156	0.0287	0.0967
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.0315	0.486
Toxoplasma gondii	PAN domain-containing protein	0.1164	0.3063	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0931	0.2423	0.2438
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0008	0.0008
Brugia malayi	hypothetical protein	0.0401	0.0961	0.0967
Echinococcus granulosus	microtubule associated protein 2	0.1439	0.3819	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0073	0.0059	0.0713
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.0554	1
Echinococcus multilocularis	expressed conserved protein	0.0183	0.0362	0.0947
Onchocerca volvulus		0.0075	0.0065	0.0065
Brugia malayi	PAN domain containing protein	0.0075	0.0065	0.0065
Schistosoma mansoni	hypothetical protein	0.0401	0.0961	0.0961
Echinococcus granulosus	Protein patched homolog 1	0.0084	0.0089	0.0231
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.0554	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0401	0.0961	0.0961
Schistosoma mansoni	hypothetical protein	0.0081	0.0081	0.008
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0252	0.0554	0.0557
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.0339	0.5388
Leishmania major	hypothetical protein, conserved	0.0931	0.2423	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.0123	0.0321
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0054	0.0008	0.5
Loa Loa (eye worm)	hypothetical protein	0.0401	0.0961	0.0967
Brugia malayi	PAN domain containing protein	0.0075	0.0065	0.0065
Mycobacterium ulcerans	acyl-CoA synthetase	0.0073	0.0059	0.053
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0052	0.0001	0.0001
Schistosoma mansoni	cercarial elastase (S01 family)	0.0401	0.0961	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0032	0.0033
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.0315	0.486
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0198	0.0403	0.0402
Echinococcus multilocularis	prolyl endopeptidase	0.0391	0.0936	0.2449
Echinococcus granulosus	Mastin	0.0401	0.0961	0.2516
Echinococcus granulosus	Niemann Pick C1 protein	0.0195	0.0395	0.1032
Mycobacterium ulcerans	acyl-CoA synthetase	0.0073	0.0059	0.053
Loa Loa (eye worm)	hypothetical protein	0.0091	0.011	0.011
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0401	0.0961	0.0961
Onchocerca volvulus	Glucosylceramidase homolog	0.0166	0.0315	0.0317
Brugia malayi	SEA domain containing protein	0.0063	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0008	0.0008
Schistosoma mansoni	hypothetical protein	0.0931	0.2423	0.2422
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0391	0.0936	0.0935
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0065	0.0065
Brugia malayi	PAN domain containing protein	0.0075	0.0065	0.0065
Echinococcus multilocularis	Niemann Pick C1 protein	0.0278	0.0625	0.1634
Loa Loa (eye worm)	MH2 domain-containing protein	0.013	0.0215	0.0217
Echinococcus granulosus	expressed conserved protein	0.0183	0.0362	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0931	0.2423	0.2438
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0059	0.0059
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0084	0.0089	0.0089
Schistosoma mansoni	cercarial elastase (S01 family)	0.0401	0.0961	0.0961
Loa Loa (eye worm)	PAN domain-containing protein	0.0075	0.0065	0.0065
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0156	0.0287	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.0554	1
Loa Loa (eye worm)	hypothetical protein	0.0401	0.0961	0.0967
Loa Loa (eye worm)	hypothetical protein	0.3661	0.9936	1
Brugia malayi	Trypsin family protein	0.0401	0.0961	0.0967
Onchocerca volvulus		0.0075	0.0065	0.0065
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0793	0.2041	0.5343
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0391	0.0936	0.3711
Schistosoma mansoni	cercarial elastase (S01 family)	0.0401	0.0961	0.0961
Brugia malayi	PAN domain containing protein	0.0075	0.0065	0.0065
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0391	0.0936	0.0942
Onchocerca volvulus		0.0063	0.0033	0.0033
Loa Loa (eye worm)	trypsin family protein	0.0401	0.0961	0.0967
Brugia malayi	Trypsin family protein	0.0401	0.0961	0.0967
Loa Loa (eye worm)	hypothetical protein	0.0401	0.0961	0.0967
Schistosoma mansoni	cercarial elastase (S01 family)	0.0401	0.0961	0.0961
Loa Loa (eye worm)	transcription factor SMAD2	0.013	0.0215	0.0217
Toxoplasma gondii	prolyl endopeptidase	0.0391	0.0936	0.2905
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0104	0.0145	0.0144
Plasmodium falciparum	cysteine repeat modular protein 1	0.0931	0.2423	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.0315	0.486
Mycobacterium tuberculosis	Probable peptidase	0.0156	0.0287	0.3489
Onchocerca volvulus		0.0063	0.0033	0.0033
Brugia malayi	PAN domain containing protein	0.0075	0.0065	0.0065
Echinococcus multilocularis	Mastin	0.0401	0.0961	0.2516
Loa Loa (eye worm)	DOMON domain-containing protein	0.0063	0.0033	0.0033
Brugia malayi	Trypsin family protein	0.3661	0.9936	1
Loa Loa (eye worm)	hypothetical protein	0.3661	0.9936	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.0123	0.0321
Onchocerca volvulus		0.0401	0.0961	0.0967
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0156	0.0287	0.0967
Schistosoma mansoni	microtubule-associated protein tau	0.1439	0.3819	0.3818
Echinococcus multilocularis	transmembrane protease serine 3	0.0401	0.0961	0.2516
Onchocerca volvulus		0.0063	0.0033	0.0033
Onchocerca volvulus		0.0075	0.0065	0.0065
Schistosoma mansoni	hypothetical protein	0.0081	0.0081	0.008
Brugia malayi	Trypsin family protein	0.0401	0.0961	0.0967
Echinococcus multilocularis	Niemann Pick C1 protein	0.0195	0.0395	0.1032
Schistosoma mansoni	cercarial elastase (S01 family)	0.0401	0.0961	0.0961
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0217	0.0457	0.0796
Schistosoma mansoni	hypothetical protein	0.0063	0.0033	0.0032
Onchocerca volvulus		0.0401	0.0961	0.0967
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.0315	0.486
Onchocerca volvulus		0.0401	0.0961	0.0967
Echinococcus granulosus	sterol regulatory element binding protein	0.0084	0.0089	0.0231
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0401	0.0961	0.2516
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0073	0.0059	0.053
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0008	0.0008
Echinococcus multilocularis	glycoprotein Antigen 5	0.0401	0.0961	0.2516
Brugia malayi	prolyl oligopeptidase family protein	0.0391	0.0936	0.0942
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0073	0.0059	0.053
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0252	0.0554	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0141	0.0141
Trypanosoma cruzi	hypothetical protein, conserved	0.0931	0.2423	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0089	0.0089
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0401	0.0961	0.2516
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0073	0.0059	0.053
Loa Loa (eye worm)	PAN domain-containing protein	0.0075	0.0065	0.0065
Brugia malayi	PAN domain containing protein	0.0075	0.0065	0.0065
Schistosoma mansoni	cercarial elastase (S01 family)	0.0401	0.0961	0.0961
Echinococcus granulosus	prolyl endopeptidase	0.0391	0.0936	0.2449
Echinococcus granulosus	transmembrane protease serine 3	0.0401	0.0961	0.2516
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0401	0.0961	0.0961
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0217	0.0457	0.046
Echinococcus multilocularis	protein dispatched 1	0.0095	0.0121	0.0316
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.3661	0.9936	0.9936
Brugia malayi	PAN domain containing protein	0.0075	0.0065	0.0065
Brugia malayi	MH2 domain containing protein	0.013	0.0215	0.0217
Brugia malayi	Muscle positioning protein 4	0.0091	0.011	0.011
Schistosoma mansoni	cercarial elastase (S01 family)	0.0401	0.0961	0.0961
Brugia malayi	Protein kinase domain containing protein	0.0931	0.2423	0.2438
Loa Loa (eye worm)	PAN domain-containing protein	0.0075	0.0065	0.0065
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.0315	0.486
Onchocerca volvulus		0.0075	0.0065	0.0065
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.0315	0.486
Onchocerca volvulus		0.3261	0.8834	0.889
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0123	0.0123
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0401	0.0961	0.2516
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0096	0.0123	0.0124
Brugia malayi	Kringle domain containing protein	0.0931	0.2423	0.2438
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0065	0.0065
Schistosoma mansoni	patched 1	0.0084	0.0089	0.0088
Schistosoma mansoni	hypothetical protein	0.0081	0.0081	0.008

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 16 nM	Displacement of [3H]-nalotrexone from rat-brain Opioid receptors	ChEMBL.	6288945

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL535806

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1029759