TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 695.592 | Formula: C30H25F4N3O10S
H donors: 4 H acceptors: 9 LogP: 5.29 Rotable bonds: 17
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)CN(c1ccc(cc1OCCOc1cc(F)ccc1N(CC(=O)O)CC(=O)O)c1nc2c(s1)ccc(c2)C(F)(F)F)CC(=O)O
InChi: 1S/C30H25F4N3O10S/c31-18-3-5-21(37(14-27(42)43)15-28(44)45)23(11-18)47-8-7-46-22-9-16(1-4-20(22)36(12-25(38)39)13-26(40)41)29-35-19-10-17(30(32,33)34)2-6-24(19)48-29/h1-6,9-11H,7-8,12-15H2,(H,38,39)(H,40,41)(H,42,43)(H,44,45)
InChiKey: LCSQCWVASNHECE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0117	0.0204
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0032	0.0856	0.0386
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.3615	0.3287
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0186	0.0466
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0856	0.0386
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0025	0.0648	0.0172
Brugia malayi	nuclear hormone receptor	0.0011	0.0186	0.0466
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0186	0.0324
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0027	0.0686	0.0208
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0025	0.0648	0.0172
Echinococcus granulosus	Smad4	0.0009	0.0117	0.0204
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0311	0.9759	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Brugia malayi	hypothetical protein	0.0006	0.002	0.005
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0025	0.0648	0.0167
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0186	0.0324
Schistosoma mansoni	coup transcription factor	0.0011	0.0186	0.0324
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0118	0.3615	0.4635
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0686	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0006	0.002	0.005
Brugia malayi	6-phosphofructokinase	0.0118	0.3615	0.9067
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0186	0.0324
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0488	0.1225
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0186	0.0466
Loa Loa (eye worm)	6-phosphofructokinase	0.0118	0.3615	0.9067
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0117	0.0204
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0118	0.3615	0.4635
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0856	0.0386
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.002	0.005
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0118	0.3615	0.3372
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0186	0.0466
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0186	0.0324
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0856	0.0386
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0311	0.9759	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0186	0.0324
Leishmania major	ATP-dependent phosphofructokinase	0.0118	0.3615	0.4635
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0186	0.0466
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0488	0.0853
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0117	0.0204
Echinococcus granulosus	smad	0.0009	0.0117	0.0204
Loa Loa (eye worm)	MH2 domain-containing protein	0.013	0.3987	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0186	0.0466
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0027	0.0686	0.0214
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0186	0.0324
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0186	0.0324
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0118	0.3615	0.3257
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0032	0.0856	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0186	0.0466
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0186	0.0324
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.002	0.0035
Schistosoma mansoni	ap endonuclease	0.002	0.0488	0.0853
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0186	0.0466
Brugia malayi	MH1 domain containing protein	0.0009	0.0117	0.0294
Toxoplasma gondii	phosphofructokinase PFKII	0.0032	0.0856	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0186	0.0324
Schistosoma mansoni	ap endonuclease	0.002	0.0488	0.0853
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.002	0.0035
Echinococcus multilocularis	Smad4	0.0009	0.0117	0.0204
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0186	0.0324
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0032	0.0856	1
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0186	0.0324
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0186	0.0324
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0117	0.0204
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0186	0.0324
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0091	0.2726	0.4759
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0488	0.0853
Loa Loa (eye worm)	phosphofructokinase	0.0118	0.3615	0.9067
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.002	0.005
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0156	0.48	0.4651
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0648	0.0236
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0311	0.9759	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0186	0.0681
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0025	0.0648	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0117	0.0294
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.0027	0.0686	0.0214
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0186	0.0324
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0027	0.0686	0.0214
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0311	0.9759	1
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0686	0.0214
Echinococcus granulosus	L aminoadipate semialdehyde	0.0091	0.2726	0.4759
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0186	0.0466
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0027	0.0686	0.0294
Echinococcus multilocularis	smad	0.0009	0.0117	0.0204
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0186	0.0466
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0186	0.0681
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0311	0.9759	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0186	0.0466
Echinococcus granulosus	6 phosphofructokinase	0.0118	0.3615	0.6311
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0025	0.0648	0.0172
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0186	0.0324
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0117	0.0294
Brugia malayi	MH2 domain containing protein	0.0009	0.0117	0.0294
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0025	0.0648	0.4335
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0186	0.0466
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0186	0.0324
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0186	0.0466
Brugia malayi	ecdysteroid receptor	0.0011	0.0186	0.0466
Entamoeba histolytica	phosphofructokinase, putative	0.0118	0.3615	0.3287
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0186	0.0466
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0488	0.1225
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0186	0.0466
Brugia malayi	6-phosphofructokinase	0.0118	0.3615	0.9067
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0027	0.0686	0.0294
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.002	0.0035
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0186	0.0466
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0156	0.48	0.4557
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0186	0.0324
Toxoplasma gondii	6-phosphofructokinase	0.0032	0.0856	1
Trypanosoma brucei	hypothetical protein, conserved	0.0232	0.7234	1
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0027	0.0686	0.1198
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0186	0.0324
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0186	0.0466
Echinococcus multilocularis	6 phosphofructokinase	0.0118	0.3615	0.6311
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0032	0.0856	0.0396
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0117	0.0204
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0186	0.0466
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0156	0.48	0.4651
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0186	0.0466
Trypanosoma cruzi	hypothetical protein, conserved	0.0232	0.7234	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0186	0.0324
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0186	0.0324
Brugia malayi	phosphofructokinase	0.0118	0.3615	0.9067
Brugia malayi	hypothetical protein	0.0006	0.002	0.005
Schistosoma mansoni	hypothetical protein	0.0185	0.5728	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0117	0.0204
Leishmania major	phosphopantetheinyl transferase-like protein	0.0025	0.0648	0.0236
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0117	0.0204
Schistosoma mansoni	smad	0.0009	0.0117	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0006	0.002	0.005
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0117	0.0204
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0186	0.0681
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0186	0.0324
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0186	0.0324
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.002	0.0035
Brugia malayi	MH1 domain containing protein	0.0009	0.0117	0.0294
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0856	0.0386
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0186	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0006	0.002	0.005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.002	0.005
Brugia malayi	steroid hormone receptor	0.0011	0.0186	0.0466
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0186	0.0324
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0186	0.0324
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0186	0.0466
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0025	0.0648	0.4335
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0186	0.0466
Treponema pallidum	hypothetical protein	0.0311	0.9759	0.9747
Treponema pallidum	fructose-bisphosphate aldolase	0.0319	1	1
Schistosoma mansoni	6-phosphofructokinase	0.0118	0.3615	0.6311
Mycobacterium ulcerans	6-phosphofructokinase	0.0118	0.3615	0.3372
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0027	0.0686	0.0294
Brugia malayi	MH2 domain containing protein	0.0009	0.0117	0.0294
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0032	0.0856	0.0386
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0025	0.0648	0.0172
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0186	0.0324
Onchocerca volvulus		0.0091	0.2726	1
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0027	0.0686	0.0214
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0186	0.0466
Brugia malayi	MH2 domain containing protein	0.013	0.3987	1
Mycobacterium tuberculosis	Conserved protein	0.0027	0.0686	0.0214
Echinococcus multilocularis	geminin	0.0185	0.5728	1
Entamoeba histolytica	phosphofructokinase, putative	0.0118	0.3615	0.3287
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Entamoeba histolytica	phosphofructokinase, putative	0.0118	0.3615	0.3287
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0186	0.0466
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0186	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0186	0.0466
Loa Loa (eye worm)	transcription factor SMAD2	0.013	0.3987	1
Echinococcus granulosus	citrate lyase subunit beta protein	0.0027	0.0686	0.1198
Schistosoma mansoni	6-phosphofructokinase	0.0118	0.3615	0.6311
Entamoeba histolytica	hypothetical protein	0.0025	0.0648	0.0167
Brugia malayi	Smad1	0.0009	0.0117	0.0294
Loa Loa (eye worm)	Smad1	0.0009	0.0117	0.0294
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0856	0.0386
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0032	0.0856	0.0386
Plasmodium vivax	6-phosphofructokinase, putative	0.0032	0.0856	0.0396
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0186	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0186	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0186	0.0466
Schistosoma mansoni	Smad4	0.0009	0.0117	0.0204
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0025	0.0648	0.0172
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0186	0.0466
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0118	0.3615	0.3287
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0186	0.0466
Onchocerca volvulus		0.0011	0.0186	0.0681
Giardia lamblia	Fructose-bisphosphate aldolase	0.0319	1	1
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0186	0.0466
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0186	0.0324
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0186	0.0466
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0186	0.0324
Plasmodium vivax	6-phosphofructokinase, putative	0.0032	0.0856	0.0396
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.002	0.005
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0032	0.0856	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2726	0.6838
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0091	0.2726	0.6838
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0032	0.0856	1
Schistosoma mansoni	hypothetical protein	0.0185	0.5728	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.3615	0.3287
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0856	0.0386
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0186	0.0466
Brugia malayi	nuclear receptor RXR	0.0006	0.002	0.005
Trypanosoma cruzi	hypothetical protein, conserved	0.0232	0.7234	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0118	0.3615	0.9067
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0186	0.0324
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0091	0.2726	0.4759
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0319	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0186	0.0466
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0032	0.0856	0.0396
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.3615	0.3287
Loa Loa (eye worm)	hypothetical protein	0.0006	0.002	0.005
Echinococcus granulosus	geminin	0.0185	0.5728	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.3615	0.3287
Leishmania major	hypothetical protein, conserved	0.0232	0.7234	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0186	0.0466

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1206630

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1031676