Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0542 | 0.5 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0106 | 0.0114 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.5534 | 0.6936 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0542 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0542 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0542 | 0.0585 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0947 | 0.1188 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.736 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.7978 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.5534 | 0.7519 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.5534 | 0.7519 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3258 | 0.4427 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0542 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0542 | 0.068 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0435 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3679 | 0.3972 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0435 | 0.0546 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0542 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.5534 | 0.5278 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0947 | 0.1287 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0435 | 0.0592 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0542 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0618 | 0.0774 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.3667 | 0.3303 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0542 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.1356 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4087 | 0.4413 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.736 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0542 | 0.0737 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0542 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0542 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.5534 | 0.7519 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0542 | 0.068 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0542 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0947 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.9262 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.5534 | 0.6936 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0542 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.5534 | 0.7519 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3258 | 0.4427 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4417 | 0.4769 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0542 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.5534 | 0.6936 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0542 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.5534 | 0.5975 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0618 | 0.0667 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0542 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0542 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0542 | 0.0737 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 8.8 uM | Cytotoxicity against human Bel7402 cells after 24 hrs by MTT assay | ChEMBL. | 19245261 |
IC50 (functional) | > 10 uM | Cytotoxicity against human A549 cells after 24 hrs by MTT assay | ChEMBL. | 19245261 |
IC50 (functional) | > 10 uM | Cytotoxicity against human HCT8 cells after 24 hrs by MTT assay | ChEMBL. | 19245261 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 19245261 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.