TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 524.577 | Formula: C29H31F3N4O2
H donors: 1 H acceptors: 2 LogP: 5.02 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: O=C(N1CCC[C@@H]1CN1CCCC1)c1ccc(cc1)c1cnc(c(c1)OCc1ccccc1C(F)(F)F)N
InChi: 1S/C29H31F3N4O2/c30-29(31,32)25-8-2-1-6-22(25)19-38-26-16-23(17-34-27(26)33)20-9-11-21(12-10-20)28(37)36-15-5-7-24(36)18-35-13-3-4-14-35/h1-2,6,8-12,16-17,24H,3-5,7,13-15,18-19H2,(H2,33,34)/t24-/m1/s1
InChiKey: VBZNTJZERXQKQT-XMMPIXPASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	MET proto-oncogene, receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0156	0.1043	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0156	0.1043	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.0279	0.2529	1
Loa Loa (eye worm)	hypothetical protein	0.0279	0.2529	0.2529
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0279	0.2529	0.8104
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0125	0.0675	0.0647
Entamoeba histolytica	cysteine protease, putative	0.0156	0.1043	0.4054
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0072	0.003	0.003
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0117	0.0573	0.0544
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0125	0.0675	0.2582
Entamoeba histolytica	cysteine proteinase, putative	0.0156	0.1043	0.4054
Onchocerca volvulus		0.0279	0.2529	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0279	0.2529	0.2529
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0112	0.0511	0.0483
Trypanosoma cruzi	cysteine peptidase, putative	0.0279	0.2529	0.2506
Loa Loa (eye worm)	hypothetical protein	0.0072	0.003	0.003
Entamoeba histolytica	cysteine protease, putative	0.0156	0.1043	0.4054
Echinococcus multilocularis	cathepsin b	0.0896	1	1
Brugia malayi	Trypsin family protein	0.0145	0.091	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0154	0.0154
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0279	0.2529	0.8104
Loa Loa (eye worm)	hypothetical protein	0.0195	0.1516	0.1516
Trypanosoma cruzi	cysteine peptidase, putative	0.0279	0.2529	0.2506
Loa Loa (eye worm)	hypothetical protein	0.0334	0.3203	0.3203
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0072	0.003	0.003
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0279	0.2529	0.8104
Onchocerca volvulus		0.0279	0.2529	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.003	0.003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.1516	0.4818
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0125	0.0675	0.0647
Entamoeba histolytica	cysteine protease, putative	0.0156	0.1043	0.4054
Leishmania major	cathepsin L-like protease	0.0279	0.2529	0.7602
Entamoeba histolytica	cysteine proteinase, putative	0.0279	0.2529	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0279	0.2529	0.7602
Brugia malayi	Papain family cysteine protease containing protein	0.0279	0.2529	0.2506
Leishmania major	cysteine peptidase A (CPA)	0.0279	0.2529	0.7602
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0279	0.2529	0.2529
Toxoplasma gondii	cathepsin B	0.0327	0.3113	1
Brugia malayi	calpain family protein 1	0.0112	0.0511	0.0483
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0125	0.0675	0.267
Leishmania major	cathepsin L-like protease	0.0279	0.2529	0.7602
Schistosoma mansoni	cathepsin s	0.0084	0.0169	0.014
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0084	0.0169	0.0169
Echinococcus granulosus	cathepsin b	0.0896	1	1
Treponema pallidum	ATP-dependent RNA helicase	0.0125	0.0675	0.5
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0156	0.1043	0.1016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1043	0.3285
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0279	0.2529	0.8104
Onchocerca volvulus	Cathepsin L homolog	0.0279	0.2529	1
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0125	0.0675	0.5
Echinococcus granulosus	cathepsin L cysteine protease	0.0156	0.1043	0.1016
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0327	0.3113	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0279	0.2529	0.2506
Leishmania major	cathepsin L-like protease	0.0279	0.2529	0.7602
Brugia malayi	Cathepsin L-like precursor	0.0279	0.2529	0.2506
Onchocerca volvulus		0.0279	0.2529	1
Plasmodium vivax	vivapain-3	0.0156	0.1043	0.4054
Onchocerca volvulus	Cathepsin F homolog	0.0279	0.2529	1
Giardia lamblia	Cathepsin B precursor	0.0327	0.3113	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.091	0.091
Entamoeba histolytica	cysteine proteinase, putative	0.0279	0.2529	1
Echinococcus granulosus	cathepsin b	0.0896	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0279	0.2529	0.7602
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0125	0.0675	0.2093
Brugia malayi	Cathepsin L-like precursor	0.0279	0.2529	0.2506
Onchocerca volvulus		0.0279	0.2529	1
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0125	0.0675	0.0647
Onchocerca volvulus	Cathepsin L homolog	0.0072	0.003	0.0118
Entamoeba histolytica	cysteine protease, putative	0.0156	0.1043	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0511	0.0511
Giardia lamblia	Cathepsin B precursor	0.0327	0.3113	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0156	0.1043	0.1508
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0156	0.1043	0.1016
Loa Loa (eye worm)	calpain family protein 1	0.0082	0.0154	0.0154
Brugia malayi	Cathepsin L-like precursor	0.0279	0.2529	0.2506
Onchocerca volvulus		0.0092	0.0272	0.1074
Trypanosoma cruzi	cruzipain precursor, putative	0.0084	0.0169	0.014
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0117	0.0573	0.0544
Brugia malayi	calpain family protein 1	0.0112	0.0511	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0072	0.003	0.003
Echinococcus granulosus	cysteine protease	0.0156	0.1043	0.1016
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0279	0.2529	0.2506
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0156	0.1043	0.1016
Trypanosoma cruzi	cysteine peptidase, putative	0.0084	0.0169	0.014
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0279	0.2529	0.8104
Toxoplasma gondii	cathepsin CPL	0.0279	0.2529	0.8104
Trypanosoma cruzi	cysteine protease, putative	0.0156	0.1043	0.1016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0279	0.2529	0.8104
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0125	0.0675	0.0647
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0117	0.0573	0.0544
Echinococcus multilocularis	cysteine protease	0.0279	0.2529	0.2506
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0334	0.3203	0.3183
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0117	0.0573	0.0544
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0125	0.0675	0.0647
Brugia malayi	Cathepsin L-like precursor	0.0195	0.1516	0.149
Loa Loa (eye worm)	hypothetical protein	0.0072	0.003	0.003
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0279	0.2529	0.8104
Entamoeba histolytica	cysteine proteinase 1, putative	0.0156	0.1043	0.4054
Onchocerca volvulus		0.0279	0.2529	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0279	0.2529	0.8104
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0279	0.2529	0.7602
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0896	1	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0327	0.3113	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0279	0.2529	0.2506
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0327	0.3113	0.3093
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0125	0.0675	0.2093
Brugia malayi	Cathepsin L-like precursor	0.0195	0.1516	0.149
Echinococcus multilocularis	calpain A	0.0117	0.0573	0.0544
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0279	0.2529	0.2506
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0156	0.1043	0.1016
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0896	1	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0145	0.091	0.0883
Onchocerca volvulus		0.0279	0.2529	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0195	0.1516	0.4818
Onchocerca volvulus		0.0072	0.003	0.0118
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0195	0.1516	0.149
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0896	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0279	0.2529	0.8104
Echinococcus granulosus	calpain A	0.0117	0.0573	0.0544
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0279	0.2529	0.7602
Loa Loa (eye worm)	hypothetical protein	0.0195	0.1516	0.1516
Loa Loa (eye worm)	hypothetical protein	0.0072	0.003	0.003
Entamoeba histolytica	cysteine protease, putative	0.0156	0.1043	0.4054
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0084	0.0169	0.014
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0125	0.0675	0.2093
Entamoeba histolytica	cysteine protease, putative	0.0156	0.1043	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0156	0.1043	0.1016
Trypanosoma cruzi	cysteine peptidase, putative	0.0279	0.2529	0.2506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0279	0.2529	0.8104
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0327	0.3113	0.3093
Brugia malayi	Cathepsin L-like precursor	0.0279	0.2529	0.2506
Plasmodium vivax	vivapain-2	0.0279	0.2529	1
Onchocerca volvulus		0.0195	0.1516	0.5994
Entamoeba histolytica	cysteine proteinase, putative	0.0156	0.1043	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0279	0.2529	0.7602
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0279	0.2529	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0279	0.2529	0.7602
Echinococcus multilocularis	cathepsin L	0.0156	0.1043	0.1016
Brugia malayi	cathepsin F-like cysteine proteinase	0.0084	0.0169	0.014
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0279	0.2529	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0279	0.2529	0.8104
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0279	0.2529	0.8104
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0195	0.1516	0.149
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0279	0.2529	0.8104
Echinococcus granulosus	cathepsin l1	0.0279	0.2529	0.2506
Onchocerca volvulus		0.0145	0.091	0.3599
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0279	0.2529	0.2506
Brugia malayi	eukaryotic initiation factor 4A	0.0125	0.0675	0.0647
Schistosoma mansoni	cathepsin F (C01 family)	0.0279	0.2529	0.2506
Echinococcus multilocularis	cathepsin L cysteine protease	0.0279	0.2529	0.2506
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0279	0.2529	0.8104
Brugia malayi	Cathepsin L-like precursor	0.0279	0.2529	0.2506
Echinococcus multilocularis	calpain family protein 1, d	0.0082	0.0154	0.0124
Trypanosoma cruzi	cysteine peptidase, putative	0.0156	0.1043	0.1016
Plasmodium vivax	vivapain-2	0.0279	0.2529	1
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0125	0.0675	0.0647
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0334	0.3203	0.3203
Plasmodium vivax	unspecified product	0.0156	0.1043	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0156	0.1043	0.1508
Trypanosoma cruzi	cysteine peptidase, putative	0.0279	0.2529	0.2506
Entamoeba histolytica	cysteine protease, putative	0.0156	0.1043	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0279	0.2529	0.8104
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0675	0.0675
Leishmania major	cathepsin L-like protease	0.0279	0.2529	0.7602
Trypanosoma cruzi	cysteine proteinase, putative	0.0156	0.1043	0.1016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0279	0.2529	0.8104
Brugia malayi	Papain family cysteine protease containing protein	0.0156	0.1043	0.1016
Entamoeba histolytica	cysteine proteinase, putative	0.0156	0.1043	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0072	0.003	0.003
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0125	0.0675	0.2093
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0125	0.0675	0.0647
Plasmodium vivax	RNA helicase-1, putative	0.0125	0.0675	0.2582
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0896	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0279	0.2529	1
Leishmania major	cathepsin L-like protease	0.0279	0.2529	0.7602
Entamoeba histolytica	cysteine protease, putative	0.0156	0.1043	0.4054
Echinococcus multilocularis	cathepsin b	0.0896	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0327	0.3113	1
Echinococcus granulosus	cathepsin l1	0.0195	0.1516	0.149
Leishmania major	cathepsin L-like protease	0.0279	0.2529	0.7602
Loa Loa (eye worm)	hypothetical protein	0.0145	0.091	0.091
Loa Loa (eye worm)	cysteine protease	0.0279	0.2529	0.2529
Leishmania major	cathepsin L-like protease	0.0279	0.2529	0.7602
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0125	0.0675	0.0647
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0279	0.2529	0.8104
Entamoeba histolytica	cysteine protease, putative	0.0279	0.2529	1
Loa Loa (eye worm)	hypothetical protein	0.0896	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0279	0.2529	0.8104
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0279	0.2529	0.7602
Entamoeba histolytica	cysteine proteinase, putative	0.0195	0.1516	0.5946
Brugia malayi	Cathepsin L-like precursor	0.0084	0.0169	0.014
Leishmania major	cathepsin L-like protease	0.0279	0.2529	0.7602
Entamoeba histolytica	cysteine protease, putative	0.0156	0.1043	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0195	0.1516	0.149
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0279	0.2529	0.8104
Loa Loa (eye worm)	fibroinase	0.0279	0.2529	0.2529
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0279	0.2529	0.8104
Echinococcus multilocularis	cysteine protease	0.0279	0.2529	0.2506
Schistosoma mansoni	cathepsin F (C01 family)	0.0279	0.2529	0.2506
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0145	0.091	0.0883
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0279	0.2529	0.8104
Onchocerca volvulus		0.0279	0.2529	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0279	0.2529	0.7602
Entamoeba histolytica	cysteine proteinase 2	0.0156	0.1043	0.4054
Plasmodium vivax	vivapain-1	0.0156	0.1043	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0072	0.003	0.003
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0279	0.2529	0.2506
Giardia lamblia	Cathepsin B precursor	0.0327	0.3113	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0279	0.2529	0.8104
Entamoeba histolytica	cysteine proteinase, putative	0.0156	0.1043	0.4054
Echinococcus granulosus	cathepsin L	0.0156	0.1043	0.1016
Loa Loa (eye worm)	cathepsin B	0.0327	0.3113	0.3113
Loa Loa (eye worm)	hypothetical protein	0.0195	0.1516	0.1516
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0125	0.0675	0.2582
Brugia malayi	Cathepsin L-like precursor	0.0279	0.2529	0.2506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1043	0.3285
Loa Loa (eye worm)	ctsf protein	0.0279	0.2529	0.2529
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0279	0.2529	0.8104
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0279	0.2529	0.7602
Entamoeba histolytica	cysteine protease, putative	0.0156	0.1043	0.4054
Plasmodium vivax	unspecified product	0.0084	0.0169	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0169	0.0169
Loa Loa (eye worm)	calpain family protein 1	0.0112	0.0511	0.0511
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0279	0.2529	0.7602
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0279	0.2529	0.8104
Brugia malayi	cathepsin L-like precursor	0.0195	0.1516	0.149
Entamoeba histolytica	cysteine protease, putative	0.0156	0.1043	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0279	0.2529	0.8104
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0125	0.0675	0.2093
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0358	0.0358
Trypanosoma cruzi	cysteine proteinase, putative	0.0156	0.1043	0.1016
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0896	1	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0169	0.0169
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0279	0.2529	0.7602
Entamoeba histolytica	cysteine protease, putative	0.0156	0.1043	0.4054

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 7.11 uM	Inhibition of human recombinant c-MET kinase expressed in A549 cells assessed as inhibition of HGF-induced autophosphorylation by ELISA method	ChEMBL.	21812414
Ki (binding)	= 2.59 uM	Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay	ChEMBL.	21812414

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1824871

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1042627