Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor beta 1 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor beta 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0106 | 0.0987 | 0.5 |
Leishmania major | fatty acid desaturase, putative | 0.0106 | 0.0987 | 0.0987 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0106 | 0.0987 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.0369 | 0.0422 |
Brugia malayi | acyl-CoA desaturase | 0.0747 | 0.8725 | 1 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0106 | 0.0987 | 0.5 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0106 | 0.0987 | 0.5 |
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0106 | 0.0987 | 0.0987 |
Onchocerca volvulus | 0.0853 | 1 | 1 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0747 | 0.8725 | 0.8725 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0106 | 0.0987 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0853 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0747 | 0.8725 | 0.8725 |
Leishmania major | delta-4 fatty acid desaturase | 0.0106 | 0.0987 | 0.0987 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0106 | 0.0987 | 0.0987 |
Leishmania major | delta-6 fatty acid desaturase | 0.0106 | 0.0987 | 0.0987 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0106 | 0.0987 | 0.0987 |
Onchocerca volvulus | 0.0853 | 1 | 1 | |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0106 | 0.0987 | 0.0987 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0106 | 0.0987 | 0.1131 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0106 | 0.0987 | 1 |
Leishmania major | delta-5 fatty acid desaturase | 0.0106 | 0.0987 | 0.0987 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0987 | 0.1131 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0853 | 1 | 1 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0106 | 0.0987 | 0.0987 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0106 | 0.0987 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0747 | 0.8725 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0106 | 0.0987 | 0.5 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0106 | 0.0987 | 0.1131 |
Schistosoma mansoni | fatty acid desaturase | 0.0106 | 0.0987 | 0.5 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0106 | 0.0987 | 0.0987 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0106 | 0.0987 | 0.0987 |
Trypanosoma cruzi | cytochrome b5-dependent oleate desaturase | 0.0106 | 0.0987 | 0.0987 |
Leishmania major | fatty acid desaturase, putative | 0.0106 | 0.0987 | 0.0987 |
Leishmania major | fatty-acid desaturase, putative | 0.0853 | 1 | 1 |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0106 | 0.0987 | 0.0987 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.0369 | 0.0422 |
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0106 | 0.0987 | 0.0987 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0747 | 0.8725 | 0.5 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0106 | 0.0987 | 1 |
Loa Loa (eye worm) | FAT-3 protein | 0.0106 | 0.0987 | 0.1131 |
Brugia malayi | Fatty acid desaturase family protein | 0.0106 | 0.0987 | 0.1131 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0106 | 0.0987 | 1 |
Leishmania major | delta-12 fatty acid desaturase | 0.0106 | 0.0987 | 0.0987 |
Brugia malayi | Fatty acid desaturase family protein | 0.0106 | 0.0987 | 0.1131 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0106 | 0.0987 | 0.0987 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0106 | 0.0987 | 0.0987 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0106 | 0.0987 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0106 | 0.0987 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0106 | 0.0987 | 1 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0106 | 0.0987 | 0.1131 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0106 | 0.0987 | 0.0987 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0106 | 0.0987 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0106 | 0.0987 | 1 |
Trypanosoma cruzi | sphingolipid delta 4 desaturase, putative | 0.0106 | 0.0987 | 0.0987 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0747 | 0.8725 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0106 | 0.0987 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.49 uM | Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay | ChEMBL. | 19232786 |
EC50 (functional) | = 0.55 uM | Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay | ChEMBL. | 19232786 |
EC50 (functional) | > 100 uM | Agonist activity at human cloned adrenergic beta2 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay | ChEMBL. | 19232786 |
Intrinsic activity (binding) | = 0.28 | Intrinsic activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay relative to isoproterenol | ChEMBL. | 19232786 |
Intrinsic activity (binding) | = 1.01 | Intrinsic activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay relative to isoproterenol | ChEMBL. | 19232786 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.