TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 452.357 | Formula: C19H19Cl2N5O2S
H donors: 1 H acceptors: 5 LogP: 4.28 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CS(=O)(=O)c1ccc2c(c1)c(NCc1ccccc1)nc(n2)n1cncc1.Cl.Cl
InChi: 1S/C19H17N5O2S.2ClH/c1-27(25,26)15-7-8-17-16(11-15)18(21-12-14-5-3-2-4-6-14)23-19(22-17)24-10-9-20-13-24;;/h2-11,13H,12H2,1H3,(H,21,22,23);2*1H
InChiKey: LZDXQGDLZHJYJN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 5A, cGMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Leishmania major	cysteine peptidase A (CPA)	0.0054	0.1367	0.3723
Treponema pallidum	heat shock protein 90	0.0026	0.0343	0.5
Onchocerca volvulus		0.0054	0.1367	1
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0554	0.0554
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Loa Loa (eye worm)	heat shock protein 90	0.0033	0.0589	0.0589
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0032	0.0554	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Toxoplasma gondii	GAF domain-containing protein	0.0023	0.0248	0.0802
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.2102	0.2102
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.2102	0.6796
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.2102	0.2102
Plasmodium vivax	vivapain-1	0.0032	0.0554	0.4054
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0033	0.0582	0.0582
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Schistosoma mansoni	endoplasmin	0.0033	0.0589	0.0589
Plasmodium vivax	vivapain-2	0.0054	0.1367	1
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.003	0.0494	1
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Toxoplasma gondii	cathepsin CPL	0.0054	0.1367	0.4419
Echinococcus multilocularis	cysteine protease	0.0054	0.1367	0.1367
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0813	0.0813
Schistosoma mansoni	cathepsin F (C01 family)	0.0039	0.0813	0.0813
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0554	0.0554
Echinococcus granulosus	cysteine protease	0.0032	0.0554	0.0554
Schistosoma mansoni	endoplasmin	0.0033	0.0589	0.0589
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Onchocerca volvulus		0.0054	0.1367	1
Trichomonas vaginalis	heat shock protein, putative	0.0033	0.0589	0.1904
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Echinococcus granulosus	endoplasmin	0.0026	0.0343	0.0343
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0054	0.1367	0.1367
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0101	0.3093	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Loa Loa (eye worm)	ctsf protein	0.0054	0.1367	0.1367
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0054	0.1367	0.1367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.1367	0.4419
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0288	1	1
Giardia lamblia	Grp94/Hsp90	0.0026	0.0343	0.1109
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0288	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0554	0.4054
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0033	0.0582	0.1883
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Onchocerca volvulus		0.0054	0.1367	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0026	0.0343	0.0343
Mycobacterium ulcerans	heat shock protein 90	0.0026	0.0343	0.3862
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1367	0.1367
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0039	0.0813	0.0813
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0054	0.1367	1
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0054	0.1367	0.1367
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Brugia malayi	Endoplasmin precursor	0.0033	0.0589	0.0589
Giardia lamblia	Cathepsin B precursor	0.0101	0.3093	1
Loa Loa (eye worm)	cysteine protease	0.0054	0.1367	0.1367
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Trypanosoma cruzi	Heat shock protein 83, putative	0.0033	0.0589	0.0589
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.0813	0.5946
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.1367	0.1367
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0101	0.3093	1
Echinococcus granulosus	cathepsin l1	0.0054	0.1367	0.1367
Trypanosoma brucei	heat shock protein 90, putative	0.0033	0.0589	0.0138
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.2102	0.2102
Echinococcus multilocularis	heat shock protein 90	0.0026	0.0343	0.0343
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0033	0.0582	0.1883
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Loa Loa (eye worm)	fibroinase	0.0054	0.1367	0.1367
Onchocerca volvulus	Cathepsin F homolog	0.0054	0.1367	1
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0343	0.1109
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0026	0.0343	0.0343
Trypanosoma brucei	Heat shock protein 83, putative	0.0033	0.0589	0.0138
Entamoeba histolytica	cysteine protease, putative	0.0054	0.1367	1
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Entamoeba histolytica	heat shock protein 90, putative	0.0033	0.0589	0.431
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.1367	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1367	0.1367
Echinococcus multilocularis	heat shock protein	0.0033	0.0589	0.0589
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0248	0.0802
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0032	0.0554	0.0554
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.1367	1
Giardia lamblia	Cathepsin B precursor	0.0101	0.3093	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Onchocerca volvulus		0.0054	0.1367	1
Echinococcus granulosus	heat shock protein 90	0.0026	0.0343	0.0343
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.005	0.1235	0.3994
Entamoeba histolytica	cysteine proteinase 1, putative	0.0032	0.0554	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.1767	0.5715
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0813	0.0813
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0554	0.1791
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.1367	0.1367
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0074	0.2102	0.2102
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0343	0.1109
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0288	1	1
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1367	0.1367
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.1767	0.5715
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0582	0.1883
Echinococcus granulosus	cathepsin b	0.0288	1	1
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0033	0.0582	0.0582
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0033	0.0589	0.1904
Plasmodium falciparum	GAF domain-related protein, putative	0.0023	0.0248	0.1815
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Echinococcus granulosus	cathepsin L	0.0032	0.0554	0.0554
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1367	0.1367
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Trypanosoma cruzi	cysteine proteinase, putative	0.0032	0.0554	0.0554
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.1767	0.5715
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Echinococcus multilocularis	heat shock protein 90	0.0033	0.0589	0.0589
Echinococcus multilocularis	cathepsin b	0.0288	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0554	0.0554
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0033	0.0582	0.0582
Echinococcus granulosus	cathepsin l1	0.0039	0.0813	0.0813
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.1367	0.1367
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0054	0.1367	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0288	1	1
Brugia malayi	cathepsin L-like precursor	0.0039	0.0813	0.0813
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0343	0.1109
Trypanosoma cruzi	heat shock protein 90, putative	0.0019	0.0094	0.0094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Entamoeba histolytica	cysteine proteinase 2	0.0032	0.0554	0.4054
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0074	0.2102	0.6096
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0813	0.0813
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1367	0.1367
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0554	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0554	0.4054
Trichomonas vaginalis	heat shock protein, putative	0.002	0.0122	0.0395
Plasmodium vivax	vivapain-2	0.0054	0.1367	1
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Toxoplasma gondii	cathepsin B	0.0101	0.3093	1
Toxoplasma gondii	heat shock protein 90, putative	0.0033	0.0589	0.1904
Echinococcus granulosus	heat shock protein	0.0033	0.0589	0.0589
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Echinococcus multilocularis	endoplasmin	0.0026	0.0343	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0288	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.1367	0.1367
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0074	0.2102	0.6796
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1367	0.1367
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.1367	0.4419
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Trypanosoma cruzi	cysteine protease, putative	0.0032	0.0554	0.0554
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0026	0.0343	0.1109
Trypanosoma cruzi	cysteine proteinase, putative	0.0032	0.0554	0.0554
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0589	0.0589
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0074	0.2102	0.2102
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0033	0.0582	0.0582
Onchocerca volvulus		0.0054	0.1367	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0813	0.2627
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0554	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0813	0.0813
Plasmodium vivax	heat shock protein 86, putative	0.0033	0.0589	0.431
Brugia malayi	heat shock protein 90	0.0033	0.0589	0.0589
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.1367	1
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Giardia lamblia	Cathepsin B precursor	0.0101	0.3093	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0589	0.0589
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Toxoplasma gondii	hypothetical protein	0.0023	0.0248	0.0802
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0033	0.0582	0.0582
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Echinococcus granulosus	cathepsin L cysteine protease	0.0032	0.0554	0.0554
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Entamoeba histolytica	heat shock protein 90, putative	0.0033	0.0589	0.431
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Trypanosoma cruzi	heat shock protein 85, putative	0.0026	0.0343	0.0343
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0589	0.0589
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0101	0.3093	0.3093
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.1367	0.1367
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0074	0.2102	0.6096
Plasmodium vivax	unspecified product	0.0032	0.0554	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0074	0.2102	0.6796
Loa Loa (eye worm)	endoplasmin	0.0033	0.0589	0.0589
Onchocerca volvulus		0.0054	0.1367	1
Toxoplasma gondii	hypothetical protein	0.0023	0.0248	0.0802
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0101	0.3093	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Echinococcus multilocularis	cathepsin L	0.0032	0.0554	0.0554
Echinococcus multilocularis	cathepsin b	0.0288	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.1367	0.1367
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0288	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1367	0.1367
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0554	0.0554
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.1367	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Plasmodium vivax	endoplasmin, putative	0.0033	0.0589	0.431
Toxoplasma gondii	hypothetical protein	0.0065	0.1767	0.5715
Plasmodium falciparum	heat shock protein 90	0.0033	0.0589	0.431
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.005	0.1235	0.1235
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0039	0.0813	0.0813
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0554	0.1791
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0813	0.0813
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0248
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0582	0.0582
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Toxoplasma gondii	heat shock protein HSP90	0.0033	0.0589	0.1904
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0813	0.2627
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0026	0.0343	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.1367	0.1367
Onchocerca volvulus		0.0039	0.0813	0.5946
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1367	0.1367
Loa Loa (eye worm)	cathepsin B	0.0101	0.3093	0.3093
Onchocerca volvulus		0.0054	0.1367	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Echinococcus granulosus	heat shock protein 90	0.0033	0.0589	0.0589
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1367	0.1367
Schistosoma mansoni	heat shock protein	0.0033	0.0589	0.0589
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Plasmodium vivax	hypothetical protein, conserved	0.0023	0.0248	0.1815
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0554	0.0554
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1367	0.1367
Trypanosoma cruzi	heat shock protein 90, putative	0.0033	0.0589	0.0589
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0101	0.3093	0.3093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0074	0.2102	0.2102
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0054	0.1367	0.1367
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Trypanosoma cruzi	cruzipain precursor, putative	0.0054	0.1367	0.1367
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1367	0.1367
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.005	0.1235	0.3994
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Echinococcus granulosus	cathepsin b	0.0288	1	1
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0026	0.0343	0.5
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.003	0.0494	1
Trichomonas vaginalis	endoplasmin, putative	0.002	0.0122	0.0395
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.003	0.0494	1
Trypanosoma brucei	heat shock protein 90, putative	0.0033	0.0589	0.0138
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Echinococcus multilocularis	cysteine protease	0.0054	0.1367	0.1367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Plasmodium falciparum	endoplasmin, putative	0.002	0.0122	0.0894
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0054	0.1367	1
Schistosoma mansoni	heat shock protein	0.0033	0.0589	0.0589
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Plasmodium vivax	vivapain-3	0.0032	0.0554	0.4054
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0554	0.0554

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.11 uM	Inhibitory activity against phosphodiesterase 5 from human platelets	ChEMBL.	7658441

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL554051

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1048980