TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.819 | Formula: C16H23ClN2O2
H donors: 1 H acceptors: 1 LogP: 2.07 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COC(CCC1(O)c2ccccc2N2C1=NCCC2)C.Cl
InChi: 1S/C16H22N2O2.ClH/c1-12(20-2)8-9-16(19)13-6-3-4-7-14(13)18-11-5-10-17-15(16)18;/h3-4,6-7,12,19H,5,8-11H2,1-2H3;1H
InChiKey: YZMUNKCDJWDZSD-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0009	0.0011
Onchocerca volvulus	Putative nachr subunit	0.0067	0.0891	1
Brugia malayi	excitatory GABA receptor EXP-1A	0.0067	0.0891	0.1868
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0484	1
Entamoeba histolytica	hypothetical protein	0.0023	0.0009	0.0105
Onchocerca volvulus		0.0036	0.0273	0.1438
Onchocerca volvulus		0.0067	0.0891	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Brugia malayi	regulator of G-protein signaling egl-10	0.0023	0.0009	0.0018
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0023	0.0009	0.001
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0036	0.0273	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0067	0.0891	0.1868
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0023	0.0009	0.001
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0891	0.1868
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0067	0.0891	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0273	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0569	0.6933
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0067	0.0891	0.1052
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0023	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Schistosoma mansoni	z-protein (S1r protein)	0.0023	0.0009	0.0029
Onchocerca volvulus		0.0067	0.0891	1
Schistosoma mansoni	axis inhibition protein axin	0.0023	0.0009	0.0029
Schistosoma mansoni	nAChR subunit	0.0067	0.0891	0.2957
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0067	0.0891	0.1052
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0067	0.0891	0.1052
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0036	0.0273	0.0572
Schistosoma mansoni	nAChR subunit	0.0067	0.0891	0.2957
Echinococcus granulosus	Regulator of G protein signaling 20	0.0023	0.0009	0.001
Schistosoma mansoni	regulator of G protein signaling	0.0023	0.0009	0.0029
Echinococcus granulosus	glycine receptor subunit beta	0.0067	0.0891	0.1052
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0031	0.0169	0.0199
Schistosoma mansoni	regulator of G protein signaling	0.0023	0.0009	0.0029
Trypanosoma cruzi	hypothetical protein	0.0523	1	1
Brugia malayi	PXA domain containing protein	0.0023	0.0009	0.0018
Echinococcus multilocularis	regulator of G protein signaling 3	0.0023	0.0009	0.001
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0173	0.3015	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0067	0.0891	0.1052
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0067	0.0891	0.1868
Onchocerca volvulus		0.0067	0.0891	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0067	0.0891	0.1084
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Loa Loa (eye worm)	GABA receptor subunit	0.0036	0.0273	0.0332
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0	0.5
Echinococcus multilocularis	nAChR subunit	0.0036	0.0273	0.0322
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0067	0.0891	0.1868
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0067	0.0891	0.1084
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0891	0.1868
Brugia malayi	hypothetical protein	0.0023	0.0009	0.0018
Brugia malayi	acetyltransferase, GNAT family protein	0.0173	0.3015	0.6317
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0036	0.0273	0.0905
Entamoeba histolytica	hypothetical protein	0.0036	0.0273	0.3323
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0067	0.0891	0.2957
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0067	0.0891	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0009	0.0011
Schistosoma mansoni	regulator of G protein signaling	0.0023	0.0009	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0891	0.1868
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0031	0.0169	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0009	0.0011
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0067	0.0891	0.1052
Onchocerca volvulus		0.0036	0.0273	0.1438
Loa Loa (eye worm)	ACC-1 protein	0.0067	0.0891	0.1084
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0023	0.0009	0.001
Echinococcus multilocularis	glycine receptor subunit beta	0.0067	0.0891	0.1052
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0067	0.0891	0.1084
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0067	0.0891	0.1084
Schistosoma mansoni	nAChR subunit	0.0067	0.0891	0.2957
Echinococcus granulosus	axis inhibition protein axin	0.0023	0.0009	0.001
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0031	0.0169	0.0206
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0067	0.0891	0.1052
Brugia malayi	hypothetical protein	0.0031	0.0169	0.0354
Onchocerca volvulus		0.0067	0.0891	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0067	0.0891	0.1052
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0067	0.0891	0.1052
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0569	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0273	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0009	0.0011
Trypanosoma cruzi	hypothetical protein, conserved	0.0523	1	1
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0023	0.0009	0.0029
Brugia malayi	hypothetical protein	0.0023	0.0009	0.0018
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.0484	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0569	1
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0023	0.0009	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0009	0.0009
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0	0.5
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0023	0.0009	0.001
Brugia malayi	regulator of G-protein signaling rgs-7	0.0023	0.0009	0.0018
Brugia malayi	hypothetical protein	0.0031	0.0169	0.0354
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0023	0.0009	0.001
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0067	0.0891	0.2957
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0891	0.1868
Onchocerca volvulus		0.0067	0.0891	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0067	0.0891	0.1052
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0067	0.0891	0.2957
Schistosoma mansoni	nAChR subunit	0.0067	0.0891	0.2957
Trypanosoma cruzi	hypothetical protein, conserved	0.0523	1	1
Schistosoma mansoni	nAChR subunit	0.0067	0.0891	0.2957
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Schistosoma mansoni	axis inhibition protein axin	0.0023	0.0009	0.0029
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0067	0.0891	0.1868
Schistosoma mansoni	nAChR subunit	0.0067	0.0891	0.2957
Echinococcus granulosus	nAChR subunit	0.0067	0.0891	0.1052
Trypanosoma cruzi	hypothetical protein, conserved	0.0523	1	1
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0031	0.0169	0.0199
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0173	0.3015	0.3558
Echinococcus granulosus	expressed protein	0.0446	0.8472	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0067	0.0891	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0009	0.0011
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0023	0.0009	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0273	0.0332
Entamoeba histolytica	hypothetical protein	0.0023	0.0009	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Trypanosoma cruzi	hypothetical protein	0.0523	1	1
Trypanosoma brucei	nucleoside 2-deoxyribosyltransferase	0.0523	1	1
Echinococcus multilocularis	expressed protein	0.0446	0.8472	1
Schistosoma mansoni	regulator of G protein signaling	0.0023	0.0009	0.0029
Loa Loa (eye worm)	ACC-1 protein	0.0067	0.0891	0.1084
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4772	0.5804
Echinococcus granulosus	regulator of G protein signaling 3	0.0023	0.0009	0.001
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0031	0.0169	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0067	0.0891	0.1868
Loa Loa (eye worm)	acetyltransferase	0.0173	0.3015	0.3667
Loa Loa (eye worm)	ectopic membrane ruffles in embryo protein 1	0.0064	0.0821	0.0999
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Schistosoma mansoni	nAChR subunit	0.0067	0.0891	0.2957
Schistosoma mansoni	acetylcholine receptor-related	0.0031	0.0169	0.0561
Echinococcus multilocularis	regulator of G protein signaling 7	0.0023	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0009	0.0009
Brugia malayi	PXA domain containing protein	0.0023	0.0009	0.0018
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0067	0.0891	0.1052
Echinococcus granulosus	nAChR subunit	0.0036	0.0273	0.0322
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0031	0.0169	0.0354
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0067	0.0891	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0484	0.59
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Echinococcus granulosus	axis inhibition protein axin	0.0023	0.0009	0.001
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0036	0.0273	0.0572
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0261	0.4772	1
Loa Loa (eye worm)	acetylcholine receptor protein	0.0031	0.0169	0.0206
Schistosoma mansoni	ubiquitin-activating enzyme E1C	0.0064	0.0821	0.2723
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0067	0.0891	0.1052
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0031	0.0169	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Loa Loa (eye worm)	hypothetical protein	0.023	0.4154	0.5052
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0036	0.0273	0.0572
Schistosoma mansoni	nAChR subunit	0.0031	0.0169	0.0561
Echinococcus granulosus	NEDD8 activating enzyme E1 catalytic subunit	0.0064	0.0821	0.0969
Echinococcus granulosus	regulator of G protein signaling 3	0.0023	0.0009	0.001
Echinococcus multilocularis	axis inhibition protein axin	0.0023	0.0009	0.001
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0067	0.0891	0.1052
Onchocerca volvulus		0.0067	0.0891	1
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0023	0.0009	0.0018
Echinococcus multilocularis	regulator of G protein signaling 3	0.0023	0.0009	0.001
Schistosoma mansoni	neurotransmitter gated ion channel	0.0031	0.0169	0.0561
Schistosoma mansoni	neurotransmitter gated ion channel	0.0036	0.0273	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0067	0.0891	0.1084
Schistosoma mansoni	regulator of G protein signaling	0.0023	0.0009	0.0029
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0031	0.0169	0.0354
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0036	0.0273	0.0572
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0009	0.0009
Echinococcus multilocularis	glycine receptor subunit beta	0.0067	0.0891	0.1052
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0067	0.0891	0.1052
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0067	0.0891	0.1868
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0023	0.0009	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0273	0.0332
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0031	0.0169	0.0206
Brugia malayi	hypothetical protein	0.0031	0.0169	0.0354
Echinococcus multilocularis	regulator of G protein signaling 7	0.0023	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0067	0.0891	0.1868
Echinococcus granulosus	glycine receptor subunit beta	0.0067	0.0891	0.1052
Entamoeba histolytica	ubiquitin-activating enzyme, putative	0.0064	0.0821	1
Echinococcus multilocularis	nAChR subunit	0.0067	0.0891	0.1052
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0009	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0273	0.0332
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0009	0.0009
Loa Loa (eye worm)	PXA domain-containing protein	0.0023	0.0009	0.0011
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0031	0.0169	0.0561
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0009	0.0011
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0067	0.0891	0.1868
Brugia malayi	Cation transporter family protein	0.0067	0.0891	0.1868
Loa Loa (eye worm)	RGS-3 protein	0.0023	0.0009	0.0011
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0023	0.0009	0.0018
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0067	0.0891	0.1868
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0067	0.0891	0.1052
Brugia malayi	Cation transporter family protein	0.0067	0.0891	0.1868
Echinococcus multilocularis	NEDD8 activating enzyme E1 catalytic subunit	0.0064	0.0821	0.0969
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0023	0.0009	0.0011
Brugia malayi	Ectopic membrane ruffles in embryo protein 1	0.0064	0.0821	0.172
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0067	0.0891	0.2957
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0009	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0523	1	1
Schistosoma mansoni	nAChR subunit	0.0031	0.0169	0.0561
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0	0.5
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0067	0.0891	0.2957
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0891	0.1868
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0067	0.0891	0.1052
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0023	0.0009	0.0029
Entamoeba histolytica	hypothetical protein	0.0023	0.0009	0.0105
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0067	0.0891	0.1052
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0031	0.0169	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0046	0.0467	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0273	0.0332
Schistosoma mansoni	neurotransmitter gated ion channel	0.0031	0.0169	0.0561
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0023	0.0009	0.0011
Echinococcus multilocularis	axis inhibition protein axin	0.0023	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0067	0.0891	0.1084
Echinococcus multilocularis	regulator of G protein signaling	0.0023	0.0009	0.001
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0031	0.0169	0.0199
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0031	0.0169	0.0354
Echinococcus granulosus	regulator of G protein signaling 7	0.0023	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0169	0.2918	0.3444
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0009	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0434	0.8222	1
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0273	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0273	0.0332
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0067	0.0891	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0891	0.1868
Brugia malayi	Cation transporter family protein	0.0067	0.0891	0.1868
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0031	0.0169	0.0199
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0067	0.0891	0.2957
Loa Loa (eye worm)	LGC-31 protein	0.0067	0.0891	0.1084
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0891	0.1084
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0206
Echinococcus granulosus	regulator of G protein signaling 7	0.0023	0.0009	0.001
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0569	0.6933
Brugia malayi	hypothetical protein	0.0031	0.0169	0.0354
Toxoplasma gondii	NEDD8-activating enzyme E1 catalytic subunit	0.0064	0.0821	1
Brugia malayi	A-kinase anchor protein 10, precursor	0.0023	0.0009	0.0018
Brugia malayi	hypothetical protein	0.0031	0.0169	0.0354

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL555964

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1050564