TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 381.88 | Formula: C16H20ClN5O2S
H donors: 2 H acceptors: 3 LogP: 1.94 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N(C)C)CSc1nnc(o1)[C@H](Cc1c[nH]c2c1cccc2)N.Cl
InChi: 1S/C16H19N5O2S.ClH/c1-21(2)14(22)9-24-16-20-19-15(23-16)12(17)7-10-8-18-13-6-4-3-5-11(10)13;/h3-6,8,12,18H,7,9,17H2,1-2H3;1H/t12-;/m0./s1
InChiKey: LXJVQDBDORPBIC-YDALLXLXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cathepsin l1	0.0022	0.0155	0.0269
Loa Loa (eye worm)	cysteine protease	0.0031	0.0486	0.0833
Echinococcus granulosus	lysine specific histone demethylase 1A	0.002	0.0077	0.0133
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0486	0.3853
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0148	0.4815	1
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0267	0.9248	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.002	0.0077	0.0133
Brugia malayi	MH2 domain containing protein	0.0122	0.3849	0.772
Brugia malayi	Blistered cuticle protein 3	0.0039	0.0761	0.1526
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0287	1	1
Brugia malayi	Animal haem peroxidase family protein	0.0039	0.0761	0.1526
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0031	0.0486	1
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0155	0.031
Schistosoma mansoni	hypothetical protein	0.0173	0.5746	1
Brugia malayi	Papain family cysteine protease containing protein	0.0031	0.0486	0.0974
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0486	0.3853
Echinococcus multilocularis	geminin	0.0173	0.5746	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0486	0.3853
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0486	0.3853
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0148	0.4815	0.838
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0031	0.0486	0.0845
Onchocerca volvulus		0.0022	0.0155	0.1138
Onchocerca volvulus	Cathepsin L homolog	0.0031	0.0486	0.5977
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.3849	0.7685
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1058	0.1842
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0486	0.3853
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0486	0.3853
Trypanosoma cruzi	cruzipain precursor, putative	0.0031	0.0486	0.1009
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.1058	0.2
Leishmania major	cathepsin L-like protease	0.0031	0.0486	0.3455
Loa Loa (eye worm)	animal heme peroxidase	0.0039	0.0761	0.1394
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0155	0.1226
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0155	0.1226
Loa Loa (eye worm)	animal heme peroxidase	0.0039	0.0761	0.1394
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0486	0.3853
Echinococcus multilocularis	cathepsin b	0.0148	0.4815	0.838
Echinococcus multilocularis	cathepsin L cysteine protease	0.0031	0.0486	0.0845
Chlamydia trachomatis	protoporphyrinogen oxidase	0.002	0.0077	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0486	0.3853
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0486	0.3853
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0031	0.0486	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0486	0.3853
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0486	0.3853
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0031	0.0486	0.0833
Echinococcus granulosus	peroxidasin	0.0039	0.0761	0.1324
Brugia malayi	Animal haem peroxidase family protein	0.0039	0.0761	0.1526
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0486	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1058	0.1842
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.002	0.0077	0.1579
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0031	0.0486	0.0845
Leishmania major	cathepsin L-like protease	0.0031	0.0486	0.3455
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0052	0.126	0.2618
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0031	0.0486	1
Onchocerca volvulus	Peroxidase homolog	0.0039	0.0761	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0052	0.126	1
Plasmodium vivax	hypothetical protein, conserved	0.002	0.0077	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0155	0.0159
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0052	0.126	0.2194
Onchocerca volvulus		0.0031	0.0486	0.5977
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0486	0.3853
Onchocerca volvulus		0.0039	0.0761	1
Loa Loa (eye worm)	cathepsin B	0.0052	0.126	0.2412
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0031	0.0486	0.3853
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0486	0.3853
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1058	0.1842
Onchocerca volvulus		0.0039	0.0761	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0486	0.3853
Leishmania major	cysteine peptidase A (CPA)	0.0031	0.0486	0.3455
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0486	0.1009
Brugia malayi	Animal haem peroxidase family protein	0.0039	0.0761	0.1526
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0486	0.3853
Onchocerca volvulus	Dual oxidase homolog	0.0039	0.0761	1
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.002	0.0077	0.0133
Plasmodium falciparum	protoporphyrinogen oxidase	0.002	0.0077	0.1579
Onchocerca volvulus	Cathepsin F homolog	0.0031	0.0486	0.5977
Trypanosoma cruzi	UDP-galactopyranose mutase	0.002	0.0077	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0761	0.1394
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1058	0.1842
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0022	0.0155	0.031
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1058	0.1842
Schistosoma mansoni	peroxidasin	0.0039	0.0761	0.1324
Echinococcus multilocularis	cathepsin b	0.0148	0.4815	0.838
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0155	0.0159
Onchocerca volvulus		0.0031	0.0486	0.5977
Plasmodium vivax	hypothetical protein, conserved	0.002	0.0077	0.1579
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0031	0.0486	0.0845
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0486	0.3853
Brugia malayi	cathepsin L-like precursor	0.0022	0.0155	0.031
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0486	0.3853
Echinococcus granulosus	cathepsin l1	0.0031	0.0486	0.0845
Onchocerca volvulus		0.0039	0.0761	1
Toxoplasma gondii	cathepsin B	0.0052	0.126	1
Onchocerca volvulus	Peroxidasin homolog	0.0039	0.0761	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0031	0.0486	0.0845
Giardia lamblia	Cathepsin B precursor	0.0052	0.126	0.5
Onchocerca volvulus		0.0031	0.0486	0.5977
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0148	0.4815	0.838
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0761	0.1394
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0486	0.1009
Leishmania major	cathepsin L-like protease	0.0031	0.0486	0.3455
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.0155	0.3182
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0761	0.1394
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0031	0.0486	0.0845
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1058	0.1842
Brugia malayi	hypothetical protein	0.002	0.0077	0.0154
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0486	0.3853
Echinococcus granulosus	cathepsin b	0.0148	0.4815	0.838
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0052	0.126	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0761	0.1394
Leishmania major	cathepsin L-like protease	0.0031	0.0486	0.3455
Onchocerca volvulus		0.0031	0.0486	0.5977
Schistosoma mansoni	cathepsin F (C01 family)	0.0031	0.0486	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0152	0.4985	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0486	0.3853
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0486	0.0974
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0761	0.1394
Toxoplasma gondii	cathepsin CPL	0.0031	0.0486	0.3455
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0486	0.3853
Loa Loa (eye worm)	hypothetical protein	0.0152	0.4985	1
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0486	0.0974
Echinococcus granulosus	geminin	0.0173	0.5746	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0486	0.3853
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0155	0.031
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0486	0.3853
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0486	0.3853
Brugia malayi	Muscleblind-like protein	0.0152	0.4985	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0761	0.1394
Leishmania major	cathepsin L-like protease	0.0031	0.0486	0.3455
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0486	0.0974
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0022	0.0155	0.0321
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1058	0.1842
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.002	0.0077	0.0133
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0148	0.4815	0.838
Loa Loa (eye worm)	ctsf protein	0.0031	0.0486	0.0833
Brugia malayi	hypothetical protein	0.0039	0.0761	0.1526
Brugia malayi	amine oxidase, flavin-containing family protein	0.002	0.0077	0.0154
Leishmania major	cathepsin L-like protease	0.0031	0.0486	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0486	0.0833
Onchocerca volvulus	Peroxidasin homolog	0.0039	0.0761	1
Loa Loa (eye worm)	animal heme peroxidase	0.0039	0.0761	0.1394
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.002	0.0077	0.1579
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0486	1
Onchocerca volvulus	Peroxidase homolog	0.0039	0.0761	1
Loa Loa (eye worm)	animal heme peroxidase	0.0039	0.0761	0.1394
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0761	0.1394
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0486	0.3853
Echinococcus multilocularis		0.002	0.0077	0.0133
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.002	0.0077	0.1579
Giardia lamblia	Cathepsin B precursor	0.0052	0.126	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0486	0.3853
Loa Loa (eye worm)	blistered cuticle protein 3	0.0039	0.0761	0.1394
Echinococcus multilocularis	cysteine protease	0.0031	0.0486	0.0845
Schistosoma mansoni	hypothetical protein	0.0173	0.5746	1
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.002	0.0077	0.5
Schistosoma mansoni	peroxidasin	0.0039	0.0761	0.1324
Onchocerca volvulus		0.0031	0.0486	0.5977
Schistosoma mansoni	cathepsin F (C01 family)	0.0031	0.0486	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0761	0.1394
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0486	0.3853
Plasmodium vivax	vivapain-2	0.0031	0.0486	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0486	0.3853
Trypanosoma cruzi	UDP-galactopyranose mutase	0.002	0.0077	0.0159
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0155	0.0269
Schistosoma mansoni	amine oxidase	0.002	0.0077	0.0133
Brugia malayi	Peroxidasin	0.0039	0.0761	0.1526
Brugia malayi	cathepsin B-like cysteine proteinase	0.0148	0.4815	0.9659
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0155	0.0159
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0486	0.3853
Echinococcus multilocularis	muscleblind protein 1	0.0152	0.4985	0.8676
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0486	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0486	0.3853
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0031	0.0486	0.0833
Plasmodium vivax	vivapain-2	0.0031	0.0486	1
Onchocerca volvulus	Chorion peroxidase homolog	0.0039	0.0761	1
Schistosoma mansoni	amine oxidase	0.002	0.0077	0.0133
Echinococcus multilocularis	peroxidasin	0.0039	0.0761	0.1324
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0486	0.1009
Echinococcus multilocularis	cysteine protease	0.0031	0.0486	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0761	0.1394
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0486	0.0974
Echinococcus granulosus	cathepsin b	0.0148	0.4815	0.838
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0486	0.0974
Loa Loa (eye worm)	fibroinase	0.0031	0.0486	0.0833
Leishmania major	cathepsin L-like protease	0.0031	0.0486	0.3455
Onchocerca volvulus		0.0031	0.0486	0.5977
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0761	0.1394
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.1058	0.2123
Leishmania major	cathepsin L-like protease	0.0031	0.0486	0.3455
Onchocerca volvulus		0.0031	0.0486	0.5977
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.3849	0.7685
Echinococcus granulosus	muscleblind protein	0.0152	0.4985	0.8676
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0486	0.3853
Echinococcus multilocularis	protoporphyrinogen oxidase	0.002	0.0077	0.0133
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.002	0.0077	0.1579
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0486	0.3853
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0486	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0761	0.1394
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4815	0.9654
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0486	0.3853
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0148	0.4815	0.838
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0486	0.3853
Echinococcus multilocularis	muscleblind protein	0.0152	0.4985	0.8676
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0486	0.0974
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0052	0.126	1
Giardia lamblia	Cathepsin B precursor	0.0052	0.126	0.5
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.002	0.0077	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0761	0.1394
Onchocerca volvulus	Cathepsin L homolog	0.0031	0.0486	0.5977
Brugia malayi	SWIRM domain containing protein	0.002	0.0077	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0761	0.1394
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0031	0.0486	0.3853
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0486	0.3853
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0761	0.1394
Brugia malayi	Animal haem peroxidase family protein	0.0039	0.0761	0.1526
Brugia malayi	Animal haem peroxidase family protein	0.0039	0.0761	0.1526

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.17 uM	Inhibition of cathepsin L (unknown origin)	ChEMBL.	18060772

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL558044

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1051504