TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.177 | Formula: C11H17Cl2N3O3
H donors: 3 H acceptors: 5 LogP: 2.46 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OCCC1CCN(CC1)c1nc(O)nc(c1Cl)O.Cl
InChi: 1S/C11H16ClN3O3.ClH/c12-8-9(13-11(18)14-10(8)17)15-4-1-7(2-5-15)3-6-16;/h7,16H,1-6H2,(H2,13,14,17,18);1H
InChiKey: CRQFGYQFQOYTFD-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	thymidine phosphorylase	Starlite/ChEMBL	References
Homo sapiens	thymidine phosphorylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	thymidine phosphorylase	Get druggable targets OG5_131632	All targets in OG5_131632
Echinococcus granulosus	thymidine phosphorylase	Get druggable targets OG5_131632	All targets in OG5_131632
Mycobacterium ulcerans	thymidine phosphorylase	Get druggable targets OG5_131632	All targets in OG5_131632
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	Get druggable targets OG5_131632	All targets in OG5_131632

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	G-protein coupled receptor	0.0144	0.077	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0038	0.0116
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0144	0.077	0.077
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0144	0.077	0.1663
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0144	0.077	0.2365
Echinococcus granulosus	neuropeptide receptor	0.0144	0.077	0.077
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0144	0.077	0.2365
Schistosoma mansoni	growth hormone secretagogue receptor	0.0144	0.077	0.1663
Echinococcus granulosus	rhodopsin orphan GPCR	0.0144	0.077	0.077
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0166	0.0166
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0144	0.077	0.1663
Brugia malayi	Melatonin receptor type 1A	0.0144	0.077	0.2365
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0144	0.077	0.077
Schistosoma mansoni	neuropeptide receptor	0.0144	0.077	0.1663
Echinococcus granulosus	g protein coupled receptor	0.0144	0.077	0.077
Echinococcus granulosus	g protein coupled receptor	0.0144	0.077	0.077
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.01	0.0475	0.0301
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0123	0.0377
Onchocerca volvulus		0.0144	0.077	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0144	0.077	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0231	0.135	0.4147
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0056	0.0184	0.0566
Schistosoma mansoni	amine GPCR	0.0144	0.077	0.1663
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0055	0.018	0.018
Echinococcus granulosus	biogenic amine 5HT receptor	0.0144	0.077	0.077
Echinococcus multilocularis	neuropeptide receptor	0.0144	0.077	0.077
Mycobacterium tuberculosis	Probable anthranilate phosphoribosyltransferase TrpD	0.0432	0.2688	0.2554
Onchocerca volvulus		0.0144	0.077	0.2066
Echinococcus multilocularis	serotonin receptor	0.0144	0.077	0.077
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0166	0.0509
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0144	0.077	0.077
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0166	0.0166
Schistosoma mansoni	hypothetical protein	0.0144	0.077	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Schistosoma mansoni	hypothetical protein	0.0034	0.0038	0.0081
Brugia malayi	putative neuropeptide receptor	0.0144	0.077	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus granulosus	thioredoxin glutathione reductase	0.0055	0.018	0.018
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0144	0.077	0.1663
Plasmodium vivax	thioredoxin reductase, putative	0.0055	0.018	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0111	0.0553	0.5
Onchocerca volvulus		0.0144	0.077	0.2066
Loa Loa (eye worm)	TYRA-2 protein	0.0144	0.077	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus multilocularis	somatostatin receptor	0.0144	0.077	0.077
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.014	0.0745	0.1216
Brugia malayi	TAR-binding protein	0.0066	0.0255	0.0783
Schistosoma mansoni	hypothetical protein	0.0047	0.0126	0.0272
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0144	0.077	0.2066
Brugia malayi	hypothetical protein	0.0144	0.077	0.2365
Brugia malayi	Dopamine receptor protein 1	0.0144	0.077	0.2365
Echinococcus granulosus	G protein coupled receptor 139	0.0144	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0107	0.0524	0.161
Mycobacterium ulcerans	anthranilate phosphoribosyltransferase	0.0432	0.2688	0.226
Echinococcus multilocularis	muscleblind protein	0.0147	0.0793	0.0793
Schistosoma mansoni	hypothetical protein	0.0144	0.077	0.1663
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0144	0.077	0.1663
Onchocerca volvulus		0.008	0.0342	0.0699
Onchocerca volvulus		0.0144	0.077	0.2066
Schistosoma mansoni	amine GPCR	0.0144	0.077	0.1663
Echinococcus granulosus	sex peptide receptor	0.0144	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0183	0.0561
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.008	0.0343	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0111	0.0553	0.5
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0144	0.077	0.077
Echinococcus granulosus	neuropeptide receptor	0.0144	0.077	0.077
Schistosoma mansoni	hypothetical protein	0.0034	0.0038	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Onchocerca volvulus		0.0144	0.077	0.2066
Brugia malayi	hypothetical protein	0.008	0.0342	0.1049
Loa Loa (eye worm)	melatonin receptor type 1A	0.0144	0.077	0.2365
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0126	0.0651	0.048
Echinococcus granulosus	rhodopsin orphan GPCR	0.0144	0.077	0.077
Echinococcus multilocularis	neuropeptide Y receptor	0.0144	0.077	0.077
Schistosoma mansoni	amine GPCR	0.0144	0.077	0.1663
Echinococcus granulosus	7tm_1 domain containing protein	0.0144	0.077	0.077
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0126	0.0651	0.0794
Echinococcus granulosus	rhodopsin orphan GPCR	0.0144	0.077	0.077
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0111	0.0553	0.5
Brugia malayi	hypothetical protein	0.0144	0.077	0.2365
Brugia malayi	larval opioid receptor	0.0144	0.077	0.2365
Echinococcus granulosus	neuropeptide FF receptor 2	0.0144	0.077	0.077
Brugia malayi	mbt repeat family protein	0.0047	0.0123	0.0377
Onchocerca volvulus		0.0144	0.077	0.2066
Echinococcus multilocularis	fmrfamide receptor	0.0144	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0793	0.2435
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.0299	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus granulosus	neuropeptide Y receptor	0.0144	0.077	0.077
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0144	0.077	0.2365
Echinococcus granulosus	tm gpcr rhodopsin	0.0144	0.077	0.077
Mycobacterium tuberculosis	Probable reductase	0.0126	0.0651	0.048
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0144	0.077	0.1663
Onchocerca volvulus		0.0144	0.077	0.2066
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0144	0.077	0.077
Schistosoma mansoni	neuropeptide F-like receptor	0.0144	0.077	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0144	0.077	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0144	0.077	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Schistosoma mansoni	opsin-like receptor	0.0144	0.077	0.1663
Echinococcus granulosus	muscleblind protein	0.0147	0.0793	0.0793
Echinococcus granulosus	fmrfamide receptor	0.0144	0.077	0.077
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0144	0.077	0.077
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0255	0.055
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0144	0.077	0.1663
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0144	0.077	0.077
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0144	0.077	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0183	0.0561
Mycobacterium tuberculosis	Probable oxidoreductase	0.014	0.0745	0.0575
Schistosoma mansoni	inositol monophosphatase	0.0111	0.0553	0.1194
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0144	0.077	0.077
Echinococcus multilocularis	neuropeptides capa receptor	0.0144	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0144	0.077	0.077
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0111	0.0553	0.5
Schistosoma mansoni	hypothetical protein	0.0034	0.0038	0.0081
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0144	0.077	0.1663
Loa Loa (eye worm)	MBCTL1	0.0053	0.0166	0.0509
Trypanosoma brucei	trypanothione reductase	0.0055	0.018	0.3256
Echinococcus multilocularis	serotonin receptor	0.0144	0.077	0.077
Onchocerca volvulus		0.0144	0.077	0.2066
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0144	0.077	0.2365
Onchocerca volvulus		0.0144	0.077	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus granulosus	rhodopsin orphan GPCR	0.0144	0.077	0.077
Echinococcus granulosus	neuropeptide Y receptor	0.0144	0.077	0.077
Schistosoma mansoni	lozenge	0.0065	0.0244	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0166	0.0509
Schistosoma mansoni	amine GPCR	0.0144	0.077	0.1663
Plasmodium falciparum	thioredoxin reductase	0.0055	0.018	1
Echinococcus granulosus	neuropeptide receptor A26	0.153	0.9993	0.9993
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	0.1531	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0144	0.077	0.077
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0144	0.077	0.2365
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0144	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0144	0.077	0.2365
Brugia malayi	hypothetical protein	0.0144	0.077	0.2365
Schistosoma mansoni	hypothetical protein	0.0034	0.0038	0.0081
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0144	0.077	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Brugia malayi	hypothetical protein	0.0144	0.077	0.2365
Brugia malayi	hypothetical protein	0.0144	0.077	0.2365
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0144	0.077	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0255	0.055
Echinococcus granulosus	neuropeptides capa receptor	0.0144	0.077	0.077
Echinococcus granulosus	hypothetical protein	0.0144	0.077	0.077
Mycobacterium ulcerans	thymidine phosphorylase	0.1531	1	1
Echinococcus granulosus	inositol monophosphatase 1	0.0111	0.0553	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0144	0.077	0.077
Brugia malayi	Muscleblind-like protein	0.0147	0.0793	0.2435
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0126	0.0651	0.048
Echinococcus granulosus	rhodopsin orphan GPCR	0.0144	0.077	0.077
Echinococcus granulosus	7TM GPCR rhodopsin	0.0144	0.077	0.077
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0111	0.0553	0.5
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0123	0.0123
Echinococcus granulosus	g protein coupled receptor	0.0144	0.077	0.077
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0038	0.0038
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0126	0.0272
Schistosoma mansoni	inositol monophosphatase	0.0111	0.0553	0.1194
Brugia malayi	hypothetical protein	0.0056	0.0184	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0144	0.077	0.077
Onchocerca volvulus		0.0144	0.077	0.2066
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0144	0.077	0.2365
Onchocerca volvulus		0.0144	0.077	0.2066
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0144	0.077	0.1663
Echinococcus granulosus	microtubule associated protein 2	0.0724	0.4631	0.4631
Schistosoma mansoni	neuropeptide receptor	0.0144	0.077	0.1663
Echinococcus granulosus	serotonin receptor	0.0144	0.077	0.077
Echinococcus multilocularis	neuropeptides capa receptor	0.0144	0.077	0.077
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0111	0.0553	1
Brugia malayi	Dopamine receptor protein 2	0.0144	0.077	0.2365
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0038	0.0038
Echinococcus multilocularis	allatostatin A receptor	0.0144	0.077	0.077
Brugia malayi	neuropeptide F receptor	0.0144	0.077	0.2365
Mycobacterium tuberculosis	Probable dehydrogenase	0.0126	0.0651	0.048
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0144	0.077	0.2365
Onchocerca volvulus		0.0144	0.077	0.2066
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0144	0.077	0.077
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0255	0.055
Onchocerca volvulus		0.0144	0.077	0.2066
Echinococcus multilocularis	fmrfamide receptor	0.0144	0.077	0.077
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0301	0.1814	0.5572
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0144	0.077	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Loa Loa (eye worm)	G-protein coupled receptor	0.0144	0.077	0.2365
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0038	0.0116
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0126	0.0387
Echinococcus multilocularis	microtubule associated protein 2	0.0724	0.4631	0.4631
Echinococcus granulosus	allatostatin A receptor	0.0144	0.077	0.077
Onchocerca volvulus		0.0144	0.077	0.2066
Schistosoma mansoni	opsin-like receptor	0.0144	0.077	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Brugia malayi	Dopamine receptor	0.0144	0.077	0.2365
Brugia malayi	RE15519p	0.0144	0.077	0.2365
Echinococcus multilocularis	neuropeptide s receptor	0.153	0.9993	0.9993
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0144	0.077	0.1663
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0166	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0517	0.3256	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0144	0.077	0.077
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0144	0.077	0.077
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0144	0.077	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus granulosus	tar DNA binding protein	0.0066	0.0255	0.0255
Brugia malayi	hypothetical protein	0.0144	0.077	0.2365
Brugia malayi	G-protein coupled receptor	0.0144	0.077	0.2365
Brugia malayi	hypothetical protein	0.0056	0.0183	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0524	0.161
Brugia malayi	G-protein coupled receptor	0.0144	0.077	0.2365
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0144	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0183	0.0561
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0144	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0183	0.0561
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0144	0.077	0.1663
Schistosoma mansoni	hypothetical protein	0.0288	0.1728	0.3731
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0144	0.077	0.077
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0144	0.077	0.1663
Schistosoma mansoni	aryl hydrocarbon receptor nuclear translocator homolog (darnt)	0.0056	0.0184	0.0398
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0144	0.077	0.2365
Brugia malayi	follicle stimulating hormone receptor	0.0144	0.077	0.2365
Brugia malayi	RNA, U transporter 1	0.008	0.0346	0.1062
Brugia malayi	GnHR receptor homolog	0.0144	0.077	0.2365
Brugia malayi	mbt repeat family protein	0.0047	0.0123	0.0377
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0123	0.0265
Schistosoma mansoni	biogenic amine receptor	0.0144	0.077	0.1663
Loa Loa (eye worm)	RNA binding protein	0.0066	0.0255	0.0783
Loa Loa (eye worm)	thioredoxin reductase	0.0055	0.018	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Brugia malayi	hypothetical protein	0.0144	0.077	0.2365
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0144	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0299	0.0918
Schistosoma mansoni	myosin xvIII	0.0144	0.077	0.1663
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0111	0.0553	1
Schistosoma mansoni	amine GPCR	0.0317	0.1924	0.4155
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0144	0.077	0.1663
Onchocerca volvulus		0.0144	0.077	0.2066
Schistosoma mansoni	hypothetical protein	0.0073	0.0299	0.0646
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0188	0.1064	0.1064
Echinococcus multilocularis	inositol monophosphatase 1	0.0111	0.0553	0.0553
Echinococcus granulosus	g-protein coupled receptor	0.0144	0.077	0.077
Schistosoma mansoni	hypothetical protein	0.0301	0.1814	0.3918
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0038	0.0038
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0038	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus multilocularis	sex peptide receptor	0.0144	0.077	0.077
Schistosoma mansoni	biogenic amine receptor	0.0144	0.077	0.1663
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0111	0.0553	1
Mycobacterium leprae	Probable anthranilate phosphoribosyltransferase TrpD	0.0432	0.2688	1
Brugia malayi	AKH receptor	0.0144	0.077	0.2365
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0144	0.077	0.077
Loa Loa (eye worm)	neuropeptide F receptor	0.0144	0.077	0.2365
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0038	0.0038
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0144	0.077	0.077
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.014	0.0745	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0144	0.077	0.077
Schistosoma mansoni	neuropeptide receptor	0.0144	0.077	0.1663
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0144	0.077	0.077
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0123	0.0265
Onchocerca volvulus		0.0517	0.3256	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0144	0.077	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0123	0.0377
Brugia malayi	glutathione reductase	0.0055	0.018	0.0553
Echinococcus multilocularis	neuropeptide receptor	0.0144	0.077	0.077
Schistosoma mansoni	neuropeptide f receptor 76f	0.0144	0.077	0.1663
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0056	0.0183	0.0561
Loa Loa (eye worm)	hypothetical protein	0.008	0.0342	0.1049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0144	0.077	0.1663
Onchocerca volvulus		0.0047	0.0126	0.0011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0144	0.077	0.1663
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0126	0.0651	0.048
Loa Loa (eye worm)	inositol-1	0.0111	0.0553	0.1698
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Brugia malayi	hypothetical protein	0.0144	0.077	0.2365
Echinococcus multilocularis	g-protein coupled receptor	0.0144	0.077	0.077
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0255	0.055
Echinococcus granulosus	biogenic amine 5HT receptor	0.0144	0.077	0.077
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.0255	0.0783
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0126	0.0651	0.048
Brugia malayi	Inositol-1	0.0111	0.0553	0.1698
Onchocerca volvulus	Protein cycle homolog	0.0056	0.0184	0.0197
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0056	0.0184	0.0566
Echinococcus multilocularis	aryl hydrocarbon receptor	0.008	0.0343	0.0343
Brugia malayi	neuropeptide F receptor	0.0144	0.077	0.2365
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0144	0.077	0.077
Echinococcus granulosus	neuropeptides capa receptor	0.0144	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0517	0.3256	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0144	0.077	0.077
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0144	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0793	0.2435
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0107	0.0524	0.161
Brugia malayi	G protein-coupled receptor	0.0144	0.077	0.2365
Echinococcus granulosus	snurportin 1	0.0301	0.1814	0.1814
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0144	0.077	0.1663
Brugia malayi	hypothetical protein	0.0144	0.077	0.2365
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0144	0.077	0.1663
Loa Loa (eye worm)	glutathione reductase	0.0055	0.018	0.0553
Echinococcus granulosus	neuropeptide s receptor	0.153	0.9993	0.9993
Echinococcus multilocularis	muscleblind protein 1	0.0147	0.0793	0.0793
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0255	0.055
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Schistosoma mansoni	neuropeptide F-like receptor	0.0144	0.077	0.1663
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0111	0.0553	1
Plasmodium falciparum	glutathione reductase	0.0055	0.018	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0144	0.077	0.077
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0144	0.077	0.077
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0144	0.077	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus multilocularis	g protein coupled receptor	0.0144	0.077	0.077
Echinococcus multilocularis	thymidine phosphorylase	0.1531	1	1
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0056	0.0184	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0123	0.0123
Echinococcus multilocularis	Protein lozenge	0.0065	0.0244	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0144	0.077	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0792	0.5085	0.5085
Echinococcus granulosus	tm gpcr rhodopsin	0.0144	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Brugia malayi	Thioredoxin reductase	0.0055	0.018	0.0553
Echinococcus multilocularis	G protein coupled receptor 139	0.0144	0.077	0.077
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0107	0.0524	0.161
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0144	0.077	0.077
Brugia malayi	hypothetical protein	0.0517	0.3256	1
Onchocerca volvulus		0.0144	0.077	0.2066
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0038	0.0116
Schistosoma mansoni	opsin-like receptor	0.0144	0.077	0.1663
Echinococcus granulosus	aryl hydrocarbon receptor	0.008	0.0343	0.0343
Echinococcus multilocularis	orexin receptor type 2	0.0144	0.077	0.077
Echinococcus multilocularis	g protein coupled receptor	0.0144	0.077	0.077
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0144	0.077	0.077
Echinococcus multilocularis	neuropeptide receptor A26	0.153	0.9993	0.9993
Brugia malayi	G protein-coupled receptor F59B2.13	0.0144	0.077	0.2365
Schistosoma mansoni	histamine h1 receptor	0.0144	0.077	0.1663
Schistosoma mansoni	neuropeptide receptor	0.0144	0.077	0.1663
Onchocerca volvulus		0.0144	0.077	0.2066
Brugia malayi	Serotonin receptor	0.0144	0.077	0.2365
Echinococcus multilocularis	g protein coupled receptor	0.0144	0.077	0.077
Echinococcus granulosus	dro:myosuppressin receptor	0.0144	0.077	0.077
Brugia malayi	putative neuropeptide receptor NPR1	0.0144	0.077	0.2365
Echinococcus granulosus	tm gpcr rhodopsin	0.0144	0.077	0.077
Plasmodium vivax	glutathione reductase, putative	0.0055	0.018	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0144	0.077	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus granulosus	somatostatin receptor	0.0144	0.077	0.077
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.0255	0.0783
Schistosoma mansoni	hypothetical protein	0.0144	0.077	0.1663
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.0255	0.0783
Schistosoma mansoni	adenoreceptor	0.0144	0.077	0.1663
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0144	0.077	0.077
Brugia malayi	hypothetical protein	0.0231	0.135	0.4147
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.0255	0.0255
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0144	0.077	0.077
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0188	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Brugia malayi	Serotonin receptor	0.0144	0.077	0.2365
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.014	0.0745	0.0575
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0123	0.0265
Brugia malayi	sulfakinin receptor protein	0.0144	0.077	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Schistosoma mansoni	biogenic amine receptor	0.0144	0.077	0.1663
Echinococcus granulosus	rhodopsin orphan GPCR	0.0144	0.077	0.077
Brugia malayi	ORL1-like opioid receptor	0.0144	0.077	0.2365
Schistosoma mansoni	hypothetical protein	0.0144	0.077	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.135	0.135
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0144	0.077	0.077
Echinococcus granulosus	orexin receptor type 2	0.0144	0.077	0.077
Brugia malayi	RNA binding protein	0.0066	0.0255	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0144	0.077	0.2365
Loa Loa (eye worm)	runx1	0.0065	0.0244	0.0751
Echinococcus granulosus	GPCR family 2	0.0034	0.0038	0.0038
Toxoplasma gondii	thioredoxin reductase	0.0055	0.018	0.3256
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0123	0.0123
Echinococcus multilocularis	snurportin 1	0.0301	0.1814	0.1814
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0144	0.077	0.1663
Echinococcus multilocularis	neuropeptide Y receptor	0.0144	0.077	0.077
Echinococcus multilocularis	dro:myosuppressin receptor	0.0144	0.077	0.077
Brugia malayi	hypothetical protein	0.0144	0.077	0.2365
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0111	0.0553	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.135	0.135
Schistosoma mansoni	microtubule-associated protein tau	0.0724	0.4631	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.5 uM	Inhibition of Escherichia coli TP	ChEMBL.	16337119
IC50 (binding)	= 7.5 uM	Inhibition of human TP expressed in V79 cells	ChEMBL.	16337119
IC50 (binding)	= 9 uM	Inhibition of human TP purified from placenta	ChEMBL.	16337119

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL559380

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1052535