TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 355.431 | Formula: C20H25N3O3
H donors: 2 H acceptors: 1 LogP: 2.48 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccccc1)Nc1ccc(cc1)OCCCN1CCOCC1
InChi: 1S/C20H25N3O3/c24-20(21-17-5-2-1-3-6-17)22-18-7-9-19(10-8-18)26-14-4-11-23-12-15-25-16-13-23/h1-3,5-10H,4,11-16H2,(H2,21,22,24)
InChiKey: HTAZKQMMJVVVSK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epoxide hydrolase 2, cytoplasmic	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	Get druggable targets OG5_129061	All targets in OG5_129061
Mycobacterium ulcerans	epoxide hydrolase EphA	Get druggable targets OG5_129061	All targets in OG5_129061

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0697	0.0697
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0181	0.2988	0.5958
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0164	0.0812
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0297	0.5015	1
Entamoeba histolytica	hypothetical protein	0.0023	0.0227	0.2141
Loa Loa (eye worm)	hypothetical protein	0.0023	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.001	0.0001	0.0001
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0297	0.5015	1
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0042	0.0565	0.1887
Loa Loa (eye worm)	delta-1-pyrroline-5-carboxylate dehydrogenase	0.001	0.0001	0.0001
Echinococcus multilocularis	RUN	0.0019	0.0164	0.0164
Echinococcus granulosus	Aminotransferase class III	0.0042	0.0565	0.0565
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0081	0.1246	0.1246
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0697	0.0697
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0042	0.0565	0.1124
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0081	0.1246	0.1246
Mycobacterium leprae	conserved hypothetical protein	0.0023	0.0227	0.0449
Echinococcus multilocularis	succinate semialdehyde dehydrogenase	0.001	0.0001	0.0001
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0181	0.2988	0.5958
Echinococcus granulosus	aldehyde dehydrogenase family 3 member B1	0.001	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.0019	0.0164	0.0549
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.023	0.0456
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.023	0.0766
Echinococcus multilocularis	succinate semialdehyde dehydrogenase	0.001	0.0001	0.0001
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.023	0.2177
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0164	0.0164
Schistosoma mansoni	hypothetical protein	0.007	0.1053	0.3522
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.0227	0.0753
Onchocerca volvulus	Aldehyde dehydrogenase homolog	0.001	0.0001	0.0012
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0042	0.0565	0.1124
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0115	0.184	0.184
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0164	0.0164
Brugia malayi	MAP kinase sur-1	0.005	0.0697	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0129	0.0129
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0697	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0697	0.0697
Echinococcus multilocularis	Fatty aldehyde dehydrogenase	0.001	0.0001	0.0001
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.023	0.0766
Echinococcus granulosus	L aminoadipate semialdehyde	0.0081	0.1246	0.1246
Echinococcus granulosus	betaine aldehyde dehydrogenase	0.001	0.0001	0.0001
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.023	0.023
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.023	0.0456
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0697	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0181	0.2988	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0129	0.0253
Schistosoma mansoni	lipoxygenase	0.0115	0.184	0.6157
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0697	0.0697
Echinococcus granulosus	Fatty aldehyde dehydrogenase	0.001	0.0001	0.0001
Brugia malayi	aldehyde dehydrogenase	0.001	0.0001	0.0001
Echinococcus multilocularis	betaine aldehyde dehydrogenase	0.001	0.0001	0.0001
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0181	0.2988	0.2988
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.023	0.0456
Mycobacterium leprae	PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT)	0.0042	0.0565	0.1124
Schistosoma mansoni	aldehyde dehydrogenase	0.0181	0.2988	1
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0697	0.1387
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0042	0.0565	0.1124
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0042	0.0565	0.1124
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0023	0.0227	0.0449
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.1388	0.4646
Onchocerca volvulus		0.0019	0.0164	0.1316
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.023	0.0456
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0042	0.0565	0.1891
Toxoplasma gondii	aldehyde dehydrogenase	0.0181	0.2988	1
Schistosoma mansoni	transcription factor LCR-F1	0.007	0.1053	0.3522
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.023	0.2177
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0697	0.1387
Schistosoma mansoni	loxhd1	0.0019	0.0164	0.0549
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.023	0.2177
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.1388	0.1388
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0181	0.2988	0.5958
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0697	1
Schistosoma mansoni	lipoxygenase	0.008	0.1234	0.413
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0042	0.0565	0.1124
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.023	0.0456
Onchocerca volvulus		0.0023	0.023	0.1848
Schistosoma mansoni	aldehyde dehydrogenase	0.001	0.0001	0.0005
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0023	0.0227	0.0449
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0164	0.0164
Loa Loa (eye worm)	hypothetical protein	0.001	0.0001	0.0001
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.007	0.1053	0.1053
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0697	0.2332
Loa Loa (eye worm)	aldehyde dehydrogenase 4	0.001	0.0001	0.0001
Mycobacterium leprae	Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM	0.0042	0.0565	0.1124
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.1388	0.4646
Echinococcus multilocularis	ornithine aminotransferase	0.0042	0.0565	0.0565
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0164	0.0164
Brugia malayi	Aldehyde dehydrogenase protein 4	0.001	0.0001	0.0001
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0164	0.0164
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0112	0.0221
Schistosoma mansoni	rab6-interacting	0.0019	0.0164	0.0549
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0197	0.3279	0.6538
Plasmodium falciparum	ornithine aminotransferase	0.0042	0.0565	1
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0227	0.3236
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0042	0.0565	0.1124
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0023	0.0227	0.3993
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0164	0.0164
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.023	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0023	0.023	0.023
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0112	0.0221
Echinococcus multilocularis	muscleblind protein 1	0.0582	1	1
Schistosoma mansoni	polycystin 1-related	0.0019	0.0164	0.0549
Brugia malayi	Doublecortin family protein	0.0019	0.0164	0.0164
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.1388	0.1388
Schistosoma mansoni	aldehyde dehydrogenase	0.0181	0.2988	1
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0197	0.3279	0.6538
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0089	0.1388	0.1388
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0697	0.0697
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0042	0.0565	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0129	0.0129
Mycobacterium ulcerans	L-lysine aminotransferase	0.0042	0.0565	0.1124
Echinococcus multilocularis	aldehyde dehydrogenase family 3 member B1	0.001	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0129	0.0129
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0081	0.1246	0.417
Onchocerca volvulus		0.0081	0.1246	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.007	0.1053	0.1053
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0129	0.0129
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.023	0.0456
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0042	0.0565	0.0565
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0164	0.0164
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0697	0.2328
Schistosoma mansoni	aldehyde dehydrogenase	0.001	0.0001	0.0005
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.0227	0.0753
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0181	0.2988	0.5958
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0023	0.0227	0.0449
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0129	0.0253
Echinococcus granulosus	muscleblind protein	0.0582	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.023	0.023
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0697	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0164	0.0164
Mycobacterium ulcerans	hypothetical protein	0.0297	0.5015	1
Loa Loa (eye worm)	hypothetical protein	0.0582	1	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0697	0.2328
Echinococcus multilocularis	ornithine aminotransferase	0.0042	0.0565	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1246	0.1246
Entamoeba histolytica	hypothetical protein	0.007	0.1053	1
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0023	0.0227	1
Echinococcus granulosus	ornithine aminotransferase	0.0042	0.0565	0.0565
Schistosoma mansoni	aldehyde dehydrogenase	0.001	0.0001	0.0005
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0697	0.1387
Echinococcus multilocularis	muscleblind protein	0.0582	1	1
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0042	0.0565	0.1124
Plasmodium vivax	ornithine aminotransferase, putative	0.0042	0.0565	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.023	0.0456
Schistosoma mansoni	hypothetical protein	0.001	0.0001	0.0005
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0112	0.0221
Echinococcus granulosus	RUN	0.0019	0.0164	0.0164
Mycobacterium ulcerans	hypothetical protein	0.0023	0.023	0.0456
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0112	0.0221
Brugia malayi	hypothetical protein	0.0019	0.0164	0.0164
Schistosoma mansoni	succinate semialdehyde dehydrogenase	0.001	0.0001	0.0005
Mycobacterium leprae	Probable Acetylornithine aminotransferase ArgD	0.0042	0.0565	0.1124
Entamoeba histolytica	hypothetical protein	0.007	0.1053	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.1388	0.1388
Schistosoma mansoni	aldehyde dehydrogenase	0.001	0.0001	0.0005
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0042	0.0565	0.1124
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0227	0.0753
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0089	0.1388	0.1388
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.1388	0.1388
Entamoeba histolytica	hypothetical protein	0.007	0.1053	1
Schistosoma mansoni	rab6-interacting	0.0019	0.0164	0.0549
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0697	1
Schistosoma mansoni	aldehyde dehydrogenase	0.001	0.0001	0.0005
Echinococcus multilocularis	Aminotransferase class III	0.0042	0.0565	0.0565
Echinococcus granulosus	succinate semialdehyde dehydrogenase	0.001	0.0001	0.0001
Brugia malayi	hypothetical protein	0.007	0.1053	0.1053
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.023	0.0766
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0697	0.1387
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0697	0.2328
Loa Loa (eye worm)	hypothetical protein	0.0582	1	1
Brugia malayi	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor	0.001	0.0001	0.0001
Onchocerca volvulus		0.0019	0.0164	0.1316
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.023	0.0456
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0023	0.0227	0.2246
Entamoeba histolytica	hypothetical protein	0.007	0.1053	1
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0297	0.5015	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0129	0.0129
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0297	0.5015	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.1388	0.4646
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.023	0.023
Schistosoma mansoni	delta 1-pyrroline-5-carboxylate synthetase	0.001	0.0001	0.0005
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0181	0.2988	0.2988
Mycobacterium tuberculosis	Probable aminotransferase	0.0297	0.5015	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.023	0.0456
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.0697	1
Brugia malayi	Succinate semialdehyde dehydrogenase, mitochondrial precursor	0.001	0.0001	0.0001
Trypanosoma brucei	protein kinase, putative	0.005	0.0697	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0115	0.184	0.184
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0042	0.0565	1
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0227	0.2246
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0164	0.0164
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0227	0.2246
Brugia malayi	hypothetical protein	0.0019	0.0164	0.0164
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.023	0.0456
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0164	0.0812
Loa Loa (eye worm)	aldehyde dehydrogenase	0.001	0.0001	0.0001
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0042	0.0565	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 39 nM	Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay	ChEMBL.	19520575

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL561382

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1054839