TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 360.795 | Formula: C17H17ClN4O3
H donors: 2 H acceptors: 4 LogP: 2.5 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: N#CCNC(=O)[C@@H](NC(=O)c1nc(oc1C)C)Cc1cccc(c1)Cl
InChi: 1S/C17H17ClN4O3/c1-10-15(21-11(2)25-10)17(24)22-14(16(23)20-7-6-19)9-12-4-3-5-13(18)8-12/h3-5,8,14H,7,9H2,1-2H3,(H,20,23)(H,22,24)/t14-/m0/s1
InChiKey: YIVHEIDCCXKPDU-AWEZNQCLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin V	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin V	334 aa	357 aa	29.7 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0297	1	1
Echinococcus multilocularis	cathepsin b	0.0186	0.5	0.3962
Echinococcus granulosus	orexin receptor type 2	0.0297	1	1
Schistosoma mansoni	opsin-like receptor	0.0297	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Brugia malayi	hypothetical protein	0.0297	1	1
Echinococcus multilocularis	orexin receptor type 2	0.0297	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1718	1
Echinococcus granulosus	neuropeptide Y receptor	0.0297	1	1
Echinococcus granulosus	g protein coupled receptor	0.0297	1	1
Schistosoma mansoni	hypothetical protein	0.0297	1	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1718	1
Onchocerca volvulus		0.0297	1	1
Onchocerca volvulus		0.0113	0.1718	0.1623
Echinococcus granulosus	neuropeptide receptor	0.0297	1	1
Onchocerca volvulus		0.0297	1	1
Onchocerca volvulus		0.0113	0.1718	0.1623
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0297	1	1
Brugia malayi	AKH receptor	0.0297	1	1
Echinococcus granulosus	g protein coupled receptor	0.0297	1	1
Leishmania major	cathepsin L-like protease	0.0113	0.1718	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0297	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.1718	0.3437
Schistosoma mansoni	histamine h1 receptor	0.0297	1	1
Schistosoma mansoni	hypothetical protein	0.0297	1	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0297	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Brugia malayi	Melatonin receptor type 1A	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.1718	0.3437
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1718	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0297	1	1
Echinococcus granulosus	fmrfamide receptor	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.5	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1718	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0297	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0297	1	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0297	1	1
Onchocerca volvulus		0.0297	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0297	1	1
Echinococcus multilocularis	serotonin receptor	0.0297	1	1
Leishmania major	cathepsin L-like protease	0.0113	0.1718	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1718	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0297	1	1
Echinococcus granulosus	sex peptide receptor	0.0297	1	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0297	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0297	1	1
Echinococcus multilocularis	somatostatin receptor	0.0297	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0297	1	1
Leishmania major	cathepsin L-like protease	0.0113	0.1718	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0297	1	1
Onchocerca volvulus		0.0297	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0113	0.1718	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0113	0.1718	1
Leishmania major	cathepsin L-like protease	0.0113	0.1718	1
Brugia malayi	Papain family cysteine protease containing protein	0.0113	0.1718	0.1623
Schistosoma mansoni	adenoreceptor	0.0297	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Schistosoma mansoni	biogenic amine receptor	0.0297	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0297	1	1
Schistosoma mansoni	myosin xvIII	0.0297	1	1
Brugia malayi	Serotonin receptor	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1718	1
Schistosoma mansoni	amine GPCR	0.0297	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0297	1	1
Echinococcus multilocularis	cathepsin b	0.0186	0.5	0.3962
Schistosoma mansoni	amine GPCR	0.0297	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0297	1	1
Echinococcus granulosus	cathepsin l1	0.0113	0.1718	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Brugia malayi	hypothetical protein	0.0297	1	1
Schistosoma mansoni	amine GPCR	0.0297	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0297	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0297	1	1
Schistosoma mansoni	neuropeptide receptor	0.0297	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0297	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0297	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0297	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Brugia malayi	G protein-coupled receptor	0.0297	1	1
Onchocerca volvulus		0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1718	1
Brugia malayi	Cathepsin L-like precursor	0.0113	0.1718	0.1623
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1718	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0297	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0113	0.1718	0.3437
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0114	0.0114
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0297	1	1
Onchocerca volvulus		0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1718	1
Brugia malayi	Dopamine receptor	0.0297	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1718	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	0.0114	0.0664
Schistosoma mansoni	neuropeptide receptor	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Leishmania major	cathepsin L-like protease	0.0113	0.1718	1
Onchocerca volvulus	Cathepsin L homolog	0.0113	0.1718	0.1623
Plasmodium vivax	vivapain-2	0.0113	0.1718	0.5
Brugia malayi	Cathepsin L-like precursor	0.0113	0.1718	0.1623
Echinococcus granulosus	rhodopsin orphan GPCR	0.0297	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0114	0.0114
Onchocerca volvulus		0.0297	1	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0297	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0297	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0297	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.1718	0.3437
Loa Loa (eye worm)	neuropeptide F receptor	0.0297	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0297	1	1
Brugia malayi	hypothetical protein	0.0297	1	1
Giardia lamblia	Cathepsin B precursor	0.0075	0	0.5
Brugia malayi	hypothetical protein	0.0297	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1718	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Onchocerca volvulus		0.0297	1	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0297	1	1
Onchocerca volvulus		0.0297	1	1
Echinococcus granulosus	hypothetical protein	0.0297	1	1
Echinococcus granulosus	allatostatin A receptor	0.0297	1	1
Echinococcus granulosus	neuropeptide receptor	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Brugia malayi	Serotonin receptor	0.0297	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0186	0.5	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0297	1	1
Brugia malayi	hypothetical protein	0.0297	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0297	1	1
Brugia malayi	larval opioid receptor	0.0297	1	1
Brugia malayi	G-protein coupled receptor	0.0297	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0113	0.1718	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0077	0.0114	0.0114
Entamoeba histolytica	cysteine protease, putative	0.0113	0.1718	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0297	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0297	1	1
Schistosoma mansoni	neuropeptide receptor	0.0297	1	1
Echinococcus granulosus	serotonin receptor	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0297	1	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0297	1	1
Echinococcus granulosus	cathepsin b	0.0186	0.5	0.4942
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0297	1	1
Onchocerca volvulus		0.0297	1	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0297	1	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0297	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0297	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1718	1
Schistosoma mansoni	opsin-like receptor	0.0297	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0297	1	1
Schistosoma mansoni	neuropeptide receptor	0.0297	1	1
Brugia malayi	neuropeptide F receptor	0.0297	1	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0297	1	1
Brugia malayi	Cathepsin L-like precursor	0.0113	0.1718	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.1718	0.3437
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0113	0.1718	0.1623
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0297	1	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0186	0.5	0.4942
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0297	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1718	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0297	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0113	0.1718	0.1623
Schistosoma mansoni	growth hormone secretagogue receptor	0.0297	1	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0297	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0297	1	1
Brugia malayi	hypothetical protein	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0297	1	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0297	1	1
Brugia malayi	hypothetical protein	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1718	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0297	1	1
Loa Loa (eye worm)	fibroinase	0.0113	0.1718	0.1718
Onchocerca volvulus	Cathepsin L homolog	0.0113	0.1718	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Schistosoma mansoni	biogenic amine receptor	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1718	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0297	1	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0297	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0297	1	1
Brugia malayi	neuropeptide F receptor	0.0297	1	1
Schistosoma mansoni	amine GPCR	0.0297	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.5	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1718	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Toxoplasma gondii	cathepsin CPL	0.0113	0.1718	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0297	1	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0297	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0297	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0297	1	1
Echinococcus multilocularis	g-protein coupled receptor	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Schistosoma mansoni	opsin-like receptor	0.0297	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1718	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Echinococcus granulosus	somatostatin receptor	0.0297	1	1
Onchocerca volvulus		0.0297	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0297	1	1
Brugia malayi	Cathepsin L-like precursor	0.0113	0.1718	0.1623
Giardia lamblia	Cathepsin B precursor	0.0075	0	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1718	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1718	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0114	0.0114
Echinococcus granulosus	cathepsin b	0.0186	0.5	0.4942
Brugia malayi	GnHR receptor homolog	0.0297	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0297	1	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0297	1	1
Echinococcus multilocularis	sex peptide receptor	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	0.0114	0.0664
Giardia lamblia	Cathepsin B precursor	0.0075	0	0.5
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0113	0.1718	0.1623
Echinococcus granulosus	G protein coupled receptor 139	0.0297	1	1
Brugia malayi	sulfakinin receptor protein	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1718	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0077	0.0114	0.0228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1718	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1718	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1718	1
Loa Loa (eye worm)	ctsf protein	0.0113	0.1718	0.1718
Onchocerca volvulus		0.0297	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0297	1	1
Onchocerca volvulus		0.0297	1	1
Brugia malayi	hypothetical protein	0.0297	1	1
Leishmania major	cathepsin L-like protease	0.0113	0.1718	1
Onchocerca volvulus		0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1718	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0297	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0297	1	1
Echinococcus granulosus	neuropeptide s receptor	0.0297	1	1
Onchocerca volvulus		0.0113	0.1718	0.1623
Echinococcus granulosus	dro:myosuppressin receptor	0.0297	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1718	1
Leishmania major	cathepsin L-like protease	0.0113	0.1718	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0113	0.1718	0.5
Brugia malayi	hypothetical protein	0.0297	1	1
Brugia malayi	putative neuropeptide receptor	0.0297	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.5	0.5
Onchocerca volvulus		0.0113	0.1718	0.1623
Schistosoma mansoni	cathepsin F (C01 family)	0.0113	0.1718	0.1718
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0297	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0297	1	1
Brugia malayi	ORL1-like opioid receptor	0.0297	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0113	0.1718	0.1718
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1718	0.1718
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Echinococcus granulosus	g protein coupled receptor	0.0297	1	1
Plasmodium vivax	vivapain-2	0.0113	0.1718	0.5
Onchocerca volvulus		0.0113	0.1718	0.1623
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0297	1	1
Brugia malayi	G-protein coupled receptor	0.0297	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0297	1	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0297	1	1
Onchocerca volvulus		0.0297	1	1
Brugia malayi	Cathepsin L-like precursor	0.0113	0.1718	0.1623
Schistosoma mansoni	cathepsin F (C01 family)	0.0113	0.1718	0.1718
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1718	1
Echinococcus multilocularis	allatostatin A receptor	0.0297	1	1
Brugia malayi	Dopamine receptor protein 2	0.0297	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0297	1	1
Echinococcus granulosus	g-protein coupled receptor	0.0297	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0113	0.1718	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0297	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0297	1	1
Brugia malayi	RE15519p	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1718	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0186	0.5	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0297	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0297	1	1
Echinococcus granulosus	neuropeptide receptor A26	0.0297	1	1
Schistosoma mansoni	amine GPCR	0.0297	1	1
Brugia malayi	Cathepsin L-like precursor	0.0113	0.1718	0.1623
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0297	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1718	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1718	1
Brugia malayi	Dopamine receptor protein 1	0.0297	1	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0297	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0113	0.1718	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0297	1	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0297	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.0297	1	1
Loa Loa (eye worm)	cysteine protease	0.0113	0.1718	0.1718
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0297	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1718	1
Onchocerca volvulus		0.0113	0.1718	0.1623
Schistosoma mansoni	hypothetical protein	0.0297	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0297	1	1
Onchocerca volvulus		0.0297	1	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.1718	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.1718	1
Echinococcus multilocularis	serotonin receptor	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1718	1
Echinococcus granulosus	neuropeptide Y receptor	0.0297	1	1
Schistosoma mansoni	biogenic amine receptor	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0297	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0297	1	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0297	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0297	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0113	0.1718	0.1718
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0113	0.1718	0.5
Onchocerca volvulus		0.0297	1	1
Leishmania major	cathepsin L-like protease	0.0113	0.1718	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0297	1	1
Schistosoma mansoni	hypothetical protein	0.0297	1	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0297	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0297	1	1
Onchocerca volvulus		0.0113	0.1718	0.1623
Loa Loa (eye worm)	G-protein coupled receptor	0.0297	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.1718	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0113	0.1718	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0297	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5	Inhibition of cathepsin K	ChEMBL.	19515558
IC50 (binding)	> 5	Inhibition of cathepsin B	ChEMBL.	19515558
IC50 (binding)	= 5.6	Inhibition of cathepsin L2	ChEMBL.	19515558
IC50 (binding)	= 6.1	Inhibition of cathepsin S	ChEMBL.	19515558
IC50 (binding)	= 6.2	Inhibition of cathepsin L	ChEMBL.	19515558

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL563522

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1056463