TDR Targets

Basic information

Technical information

TDR Targets ID: 105856
Name: 6-[(2-amino-1H-imidazol-3-ium-3-yl)methyl]-5- bromo-1H-pyrimidine-2,4-dione chloride
MW: 322.546 | Formula: C8H9BrClN5O2
H donors: 4 H acceptors: 2 LogP: 0.26 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=c1[nH]c(=O)c(c([nH]1)C[n+]1cc[nH]c1N)Br.[Cl-]
InChi: 1S/C8H8BrN5O2.ClH/c9-5-4(12-8(16)13-6(5)15)3-14-2-1-11-7(14)10;/h1-2H,3H2,(H4,10,11,12,13,15,16);1H
InChiKey: CJSYUYZFCFZAKC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[(2-azanyl-1H-imidazol-3-ium-3-yl)methyl]-5-bromo-1H-pyrimidine-2,4-dione chloride
6-[(2-amino-1H-imidazol-3-ium-3-yl)methyl]-5-bromo-uracil chloride
6-[(2-amino-3H-imidazol-1-ium-1-yl)methyl]-5-bromo-1H-pyrimidine-2,4-dione chloride
6-[(2-amino-3H-imidazol-1-ium-1-yl)methyl]-5-bromo-uracil chloride

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	thymidine phosphorylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	Get druggable targets OG5_131632	All targets in OG5_131632
Echinococcus granulosus	thymidine phosphorylase	Get druggable targets OG5_131632	All targets in OG5_131632
Mycobacterium ulcerans	thymidine phosphorylase	Get druggable targets OG5_131632	All targets in OG5_131632
Echinococcus multilocularis	thymidine phosphorylase	Get druggable targets OG5_131632	All targets in OG5_131632

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0013	0.0094	0.034
Loa Loa (eye worm)	MH1 domain-containing protein	0.0015	0.0109	0.0345
Echinococcus multilocularis	GPCR, family 2	0.0012	0.0068	0.0068
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0036	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0094	0.0295
Schistosoma mansoni	cpg binding protein	0.0029	0.0294	0.0927
Brugia malayi	MH1 domain containing protein	0.0015	0.0109	0.0398
Brugia malayi	MH1 domain containing protein	0.0008	0.0023	0.0084
Brugia malayi	mothers against decapentaplegic homolog 3	0.0007	0.0003	0.001
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0013	0.0094	0.0094
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0013	0.0094	0.0094
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0013	0.0094	0.034
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0015	0.0109	0.0109
Schistosoma mansoni	ran	0.0017	0.0141	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0007	0.001	0.0032
Brugia malayi	photoreceptor-specific nuclear receptor	0.0013	0.0094	0.034
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0094	0.0295
Onchocerca volvulus	Protein ultraspiracle homolog	0.0013	0.0094	0.3181
Entamoeba histolytica	hypothetical protein	0.0036	0.039	1
Echinococcus granulosus	snurportin 1	0.0247	0.3173	0.3173
Schistosoma mansoni	thyroid hormone receptor	0.0013	0.0094	0.0295
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0013	0.0094	0.0094
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0013	0.0094	0.0094
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0033	0.0033
Brugia malayi	Nuclear hormone receptor-like 1	0.0013	0.0094	0.034
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0017	0.0141	0.0513
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0013	0.0094	0.0295
Toxoplasma gondii	HEAT repeat-containing protein	0.0023	0.0222	0.164
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0017	0.0141	0.0141
Entamoeba histolytica	hypothetical protein	0.0019	0.0164	0.0919
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.001	0.001
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0017	0.0141	0.0141
Schistosoma mansoni	hypothetical protein	0.0012	0.0068	0.0216
Schistosoma mansoni	hypothetical protein	0.0025	0.0245	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0007	0.001	0.0032
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0013	0.0094	0.0295
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0036	0.0397	0.1443
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0017	0.0141	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.039	0.1228
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0245	0.0772
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0013	0.0094	0.0094
Echinococcus multilocularis	thymidine phosphorylase	0.0765	1	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0019	0.0164	1
Schistosoma mansoni	hypothetical protein	0.0036	0.039	0.1228
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0036	0.0397	0.1443
Echinococcus granulosus	FTZ F1 alpha	0.0013	0.0094	0.0094
Onchocerca volvulus		0.0029	0.0294	1
Schistosoma mansoni	Smad4	0.0007	0.0003	0.0009
Echinococcus multilocularis	cpg binding protein	0.003	0.0316	0.0316
Trichomonas vaginalis	ran, putative	0.0017	0.0141	0.8588
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0013	0.0094	0.034
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0015	0.0109	0.0345
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0036	0.0389	0.0389
Schistosoma mansoni	importin beta-1	0.0023	0.0222	0.0698
Echinococcus granulosus	Smad4	0.0015	0.0109	0.0109
Schistosoma mansoni	nuclear hormone receptor	0.0013	0.0094	0.0295
Loa Loa (eye worm)	MH2 domain-containing protein	0.0215	0.275	0.8665
Brugia malayi	hypothetical protein	0.0036	0.039	0.1417
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0013	0.0094	0.0295
Loa Loa (eye worm)	MH2 domain-containing protein	0.0007	0.0003	0.0009
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0012	0.0068	0.0068
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0036	0.0389	0.0389
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0007	0.0003	0.0003
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0036	0.0389	0.1414
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0009
Trypanosoma brucei	importin beta-1 subunit, putative	0.0023	0.0222	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0013	0.0094	0.0094
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0013	0.0094	0.0094
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0007	0.001	0.0032
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.001	0.001
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0013	0.0094	0.0094
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.001	0.0032
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0073
Brugia malayi	MH2 domain containing protein	0.0007	0.0003	0.001
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0013	0.0094	0.0094
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0012	0.0068	0.0249
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0013	0.0094	0.0295
Echinococcus multilocularis	snurportin 1	0.0247	0.3173	0.3173
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.001	0.001
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0012	0.0068	0.0068
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0019	0.0164	1
Mycobacterium leprae	Probable anthranilate phosphoribosyltransferase TrpD	0.0216	0.2763	0.5
Mycobacterium ulcerans	thymidine phosphorylase	0.0765	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0013	0.0094	0.0295
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0013	0.0094	0.0094
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0007	0.001	0.0032
Onchocerca volvulus	Bile acid receptor homolog	0.0013	0.0094	0.3181
Loa Loa (eye worm)	transcription factor SMAD2	0.0215	0.275	0.8665
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0013	0.0094	0.0295
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0013	0.0094	0.0094
Schistosoma mansoni	hypothetical protein	0.0012	0.0068	0.0216
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0036	0.0389	0.1225
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0015	0.0109	0.0109
Brugia malayi	latrophilin 2 splice variant baaae	0.0025	0.0245	0.0891
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0247	0.3173	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0036	0.0389	0.0389
Brugia malayi	nuclear receptor NHR-88	0.0013	0.0094	0.034
Trichomonas vaginalis	importin beta-1, putative	0.0019	0.0164	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.001	0.0032
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0012	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0397	0.1251
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0015	0.0109	0.0109
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0013	0.0094	0.0094
Leishmania major	importin beta-1 subunit, putative	0.0019	0.0164	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0294	0.0927
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	0.0765	1	1
Schistosoma mansoni	Smad4	0.0015	0.0109	0.0345
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0036	0.0389	0.1225
Entamoeba histolytica	hypothetical protein	0.0036	0.039	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.001	0.0032
Brugia malayi	Nuclear hormone receptor-like 1	0.0007	0.001	0.0036
Loa Loa (eye worm)	steroid hormone receptor	0.0013	0.0094	0.0295
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0013	0.0094	0.0295
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0033	0.0033
Brugia malayi	MH2 domain containing protein	0.0015	0.0109	0.0398
Brugia malayi	Importin beta-1 subunit	0.0023	0.0222	0.0806
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0032	0.0116
Schistosoma mansoni	Smad4	0.0007	0.0003	0.0009
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0012	0.0068	0.0068
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0013	0.0094	0.0295
Echinococcus granulosus	mothers against decapentaplegic 2	0.0007	0.0003	0.0003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0013	0.0094	0.0295
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.039	0.039
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0094	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0094	0.0295
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0632	1
Echinococcus multilocularis	FTZ F1 alpha	0.0013	0.0094	0.0094
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0036	0.0389	0.1225
Schistosoma mansoni	smad1 5 8 and	0.0015	0.0109	0.0345
Brugia malayi	Smad1	0.0015	0.0109	0.0398
Brugia malayi	RNA, U transporter 1	0.0066	0.0784	0.2851
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0012	0.0068	0.0216
Echinococcus granulosus	mothers against decapentaplegic 5	0.0015	0.0109	0.0109
Schistosoma mansoni	smad	0.0007	0.0003	0.0009
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0019	0.0164	1
Brugia malayi	MH1 domain containing protein	0.0015	0.0109	0.0398
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0013	0.0094	0.0295
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0718	0.2262
Echinococcus multilocularis	ecdysone induced protein 78C	0.0013	0.0094	0.0094
Schistosoma mansoni	hypothetical protein	0.0012	0.0068	0.0216
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0007	0.001	0.0032
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0294	0.107
Brugia malayi	ecdysteroid receptor	0.0013	0.0094	0.034
Schistosoma mansoni	hypothetical protein	0.0012	0.0068	0.0216
Brugia malayi	MH1 domain containing protein	0.0008	0.0023	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0007	0.001	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0094	0.0295
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0013	0.0094	0.034
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0013	0.0094	0.034
Brugia malayi	MH2 domain containing protein	0.0215	0.275	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0013	0.0094	0.034
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0013	0.0094	0.034
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0013	0.0094	0.0295
Echinococcus granulosus	cpg binding protein	0.003	0.0316	0.0316
Schistosoma mansoni	retinoic acid receptor RXR	0.0013	0.0094	0.0295
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0013	0.0094	0.0295
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0013	0.0094	0.034
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0013	0.0094	0.034
Loa Loa (eye worm)	Smad1	0.0015	0.0109	0.0345
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0013	0.0094	0.0295
Entamoeba histolytica	hypothetical protein	0.0036	0.039	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.0007	0.0003	0.0009
Brugia malayi	MH2 domain containing protein	0.0015	0.0109	0.0398
Echinococcus multilocularis	importin subunit beta 1	0.0023	0.0222	0.0222
Schistosoma mansoni	cpg binding protein	0.003	0.0316	0.0995
Echinococcus multilocularis	Smad4	0.0015	0.0109	0.0109
Brugia malayi	hypothetical protein	0.0007	0.001	0.0036
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0013	0.0094	0.0094
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0013	0.0094	0.034
Schistosoma mansoni	smad1 5 8 and	0.0015	0.0109	0.0345
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0013	0.0094	0.034
Schistosoma mansoni	smad1 5 8 and	0.0015	0.0109	0.0345
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0013	0.0094	0.3181
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0094	0.0295
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.001	0.001
Schistosoma mansoni	hypothetical protein	0.0247	0.3173	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.039	0.039
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0094	0.0295
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0007	0.001	0.001
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0033	0.0105
Echinococcus granulosus	importin subunit beta 1	0.0023	0.0222	0.0222
Brugia malayi	steroid hormone receptor	0.0013	0.0094	0.034
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0013	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0094	0.0295
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0036	0.0397	0.1251
Schistosoma mansoni	RAR-like nuclear receptor	0.0013	0.0094	0.0295
Brugia malayi	Nuclear hormone receptor-like 1	0.0007	0.001	0.0036
Echinococcus granulosus	smad	0.0015	0.0109	0.0109
Brugia malayi	nuclear receptor RXR	0.0007	0.001	0.0036
Plasmodium vivax	importin-beta 2, putative	0.0023	0.0222	1
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0017	0.0141	0.0444
Plasmodium falciparum	importin beta, putative	0.0023	0.0222	1
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0007	0.0003	0.0093
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0013	0.0094	0.0295
Trypanosoma brucei	importin beta-1 subunit, putative	0.0023	0.0222	1
Schistosoma mansoni	smad	0.0015	0.0109	0.0345
Brugia malayi	Latrophilin receptor protein 2	0.0012	0.0068	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0222	0.0698
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0013	0.0094	0.034
Entamoeba histolytica	hypothetical protein	0.0036	0.039	1
Brugia malayi	Steroid receptor seven-up type 2	0.0013	0.0094	0.034
Brugia malayi	hypothetical protein	0.0007	0.001	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0068	0.0216
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0036	0.0389	0.1225
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0007	0.001	0.001
Onchocerca volvulus		0.0013	0.0094	0.3181
Echinococcus multilocularis	smad	0.0015	0.0109	0.0109
Schistosoma mansoni	cpg binding protein	0.003	0.0316	0.0995
Echinococcus granulosus	GPCR family 2	0.0012	0.0068	0.0068
Echinococcus granulosus	ecdysone induced protein 78C	0.0013	0.0094	0.0094
Schistosoma mansoni	coup transcription factor	0.0013	0.0094	0.0295
Brugia malayi	nuclear hormone receptor	0.0013	0.0094	0.034
Schistosoma mansoni	ran	0.0017	0.0141	0.0444
Loa Loa (eye worm)	MH2 domain-containing protein	0.0015	0.0109	0.0345
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0013	0.0094	0.034
Loa Loa (eye worm)	nuclear factor I	0.0008	0.0023	0.0073
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0013	0.0094	0.0295
Echinococcus granulosus	mothers against decapentaplegic 6	0.0007	0.0003	0.0003

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 20 nM	Inhibition of human recombinant thymidine phosphorylase	ChEMBL.	17870212
IC50 (binding)	= 0.0019 uM	Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine Phosphorylase	ChEMBL.	12519058
IC50 (binding)	= 0.0019 uM	Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine Phosphorylase	ChEMBL.	12519058

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL65986
PubChem: 10087523

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 105856