Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 2 | Starlite/ChEMBL | References |
Mus musculus | solute carrier family 5 (sodium/glucose cotransporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0166 | 0.1946 | 0.1933 |
Echinococcus granulosus | solute carrier family 5 | 0.0363 | 0.447 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0157 | 0.0316 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.027 | 0.0254 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0015 | 0.0017 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0135 | 1 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0093 | 0.1006 | 0.222 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0093 | 0.1006 | 0.0991 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.027 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0135 | 0.1195 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.027 | 0.057 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0157 | 0.0141 |
Onchocerca volvulus | 0.0047 | 0.0424 | 0.1713 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 0.2788 | 0.6222 |
Schistosoma mansoni | sodium/solute symporter | 0.0093 | 0.1006 | 0.222 |
Brugia malayi | Isocitrate dehydrogenase | 0.0015 | 0.0017 | 0.0061 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0135 | 1 |
Onchocerca volvulus | 0.0093 | 0.1006 | 0.5443 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.027 | 0.057 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0445 | 0.1595 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0017 | 0.0001 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0424 | 0.0915 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0157 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0135 | 0.0485 |
Schistosoma mansoni | lamin | 0.0026 | 0.0157 | 0.0316 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0157 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0151 | 0.0542 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0135 | 0.0485 |
Echinococcus granulosus | geminin | 0.0166 | 0.1946 | 0.4333 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.027 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0246 | 0.0884 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1946 | 0.4333 |
Echinococcus granulosus | lamin | 0.0026 | 0.0157 | 0.0316 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0135 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0157 | 0.0564 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.027 | 0.5 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0363 | 0.447 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.0093 | 0.1006 | 0.3607 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0363 | 0.447 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0135 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0246 | 0.0884 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0015 | 0.0017 | 0.0061 |
Brugia malayi | hypothetical protein | 0.0148 | 0.1716 | 0.6155 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0023 | 0.0082 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0157 | 0.0141 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0017 | 0.006 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0445 | 0.1595 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0363 | 0.447 | 0.4461 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0093 | 0.1006 | 0.222 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0157 | 0.0564 |
Schistosoma mansoni | inositol transporter | 0.0363 | 0.447 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0135 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0424 | 0.1522 |
Brugia malayi | hypothetical protein | 0.0035 | 0.027 | 0.097 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0363 | 0.447 | 0.4461 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1716 | 0.6155 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 0.2788 | 0.2776 |
Schistosoma mansoni | inositol transporter | 0.0363 | 0.447 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0017 | 0.006 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0246 | 0.0516 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0135 | 1 |
Brugia malayi | GH02984p | 0.0093 | 0.1006 | 0.3607 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.027 | 0.057 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1006 | 0.3607 |
Onchocerca volvulus | 0.0148 | 0.1716 | 1 | |
Echinococcus multilocularis | musashi | 0.0026 | 0.0157 | 0.0141 |
Schistosoma mansoni | lamin | 0.0026 | 0.0157 | 0.0316 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0015 | 0.0017 | 0.0001 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0017 | 0.006 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0135 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0015 | 0.0017 | 0.0061 |
Schistosoma mansoni | high-affinity choline transporter | 0.0093 | 0.1006 | 0.222 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1946 | 0.4333 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0445 | 0.1595 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0424 | 0.0915 |
Brugia malayi | hypothetical protein | 0.0232 | 0.2788 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.0363 | 0.447 | 0.4461 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0093 | 0.1006 | 0.0991 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0157 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1006 | 0.3607 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0093 | 0.1006 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0017 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2788 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0157 | 0.0564 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0157 | 0.0316 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0445 | 0.1595 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0363 | 0.447 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.027 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.5 nM | Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay | ChEMBL. | 19785435 |
IC50 (binding) | = 36 nM | Inhibition of human SGLT2 expressed in HEK293 cells assessed as inhibition of [14C]alpha-methylglucopyranoside uptake | ChEMBL. | 19785435 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.