Detailed information for compound 1071516

Basic information

Technical information
  • TDR Targets ID: 1071516
  • Name: 2-[[4-[(4-fluorophenyl)sulfamoyl]phenyl]carba moyl]benzoic acid
  • MW: 414.407 | Formula: C20H15FN2O5S
  • H donors: 3 H acceptors: 5 LogP: 2.91 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)NS(=O)(=O)c1ccc(cc1)NC(=O)c1ccccc1C(=O)O
  • InChi: 1S/C20H15FN2O5S/c21-13-5-7-15(8-6-13)23-29(27,28)16-11-9-14(10-12-16)22-19(24)17-3-1-2-4-18(17)20(25)26/h1-12,23H,(H,22,24)(H,25,26)
  • InChiKey: DEDQDAITDQHFIE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[[4-[(4-fluorophenyl)sulfamoyl]phenyl]amino]-oxomethyl]benzoic acid
  • AN-329/15332020
  • ST040793
  • ARONIS022603

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0324 0.406 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0101 0.0357
Echinococcus multilocularis dnaJ subfamily B 0.0464 0.5875 0.5874
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0324 0.406 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0603 0.3605
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0048 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0131 0.0777
Loa Loa (eye worm) heat shock protein 90 0.0037 0.0348 0.2079
Echinococcus granulosus phd:f box containing protein 0.0018 0.0101 0.01
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.0598
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0324 0.406 1
Echinococcus granulosus hexokinase 0.009 0.104 0.1039
Brugia malayi hexokinase type II 0.0029 0.0243 0.1455
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0759 0.0714
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0324 0.406 1
Onchocerca volvulus 0.009 0.104 0.6075
Trypanosoma brucei heat shock protein, putative 0.0037 0.0348 0.2892
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0606
Echinococcus multilocularis heat shock protein 90 0.0029 0.0251 0.025
Onchocerca volvulus 0.009 0.104 0.6075
Schistosoma mansoni hypothetical protein 0.0464 0.5875 0.5855
Treponema pallidum hexokinase (hxk) 0.009 0.104 0.2072
Echinococcus multilocularis hexokinase 0.009 0.104 0.1039
Onchocerca volvulus 0.009 0.104 0.6075
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0265 0.2037
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Plasmodium vivax JmjC domain containing protein 0.0018 0.0101 0.0087
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0384 0.3263
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0103 0.0606
Trypanosoma cruzi hexokinase, putative 0.009 0.104 1
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0251 0.5805
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0101 0.0357
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0101 0.01
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0219 0.0224
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0219 0.0259
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.0598
Schistosoma mansoni hypothetical protein 0.0018 0.0103 0.0055
Brugia malayi Hsp90 protein 0.0015 0.0067 0.04
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0029 0.0251 0.0083
Schistosoma mansoni endoplasmin 0.0037 0.0348 0.0302
Echinococcus multilocularis heat shock protein 90 0.0037 0.0348 0.0347
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0103 0.0616
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0101 0.0357
Treponema pallidum hypothetical protein 0.0324 0.406 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0103 0.0101
Trypanosoma brucei Heat shock protein 83, putative 0.0037 0.0348 0.2892
Brugia malayi heat shock protein 90 0.0037 0.0348 0.2086
Brugia malayi Hexokinase family protein 0.0057 0.0605 0.3622
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0603 0.3605
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.067 0.6195
Loa Loa (eye worm) hexokinase 0.0057 0.0605 0.3616
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0759 0.0714
Loa Loa (eye worm) hypothetical protein 0.0029 0.0243 0.1447
Leishmania major hexokinase, putative 0.009 0.104 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0265 0.2037
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0101 0.01
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0603 0.3612
Leishmania major hexokinase, putative 0.009 0.104 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0384 1
Schistosoma mansoni cpg binding protein 0.0034 0.0317 0.027
Loa Loa (eye worm) hexokinase 0.009 0.104 0.6228
Brugia malayi Hexokinase family protein 0.009 0.104 0.6232
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0125 0.0124
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0101 0.01
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0251 0.1894
Trypanosoma brucei hexokinase, putative 0.009 0.104 1
Trypanosoma brucei heat shock protein, putative 0.0037 0.0348 0.2892
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0219 0.0224
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0103 0.0101
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.0598
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.0348 0.2892
Plasmodium falciparum hexokinase 0.009 0.104 0.2438
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0101 0.0598
Onchocerca volvulus 0.0033 0.0293 0.141
Entamoeba histolytica hexokinase 2 0.009 0.104 1
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0348 0.2892
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0219 0.1566
Giardia lamblia Heat shock protein HSP 90-alpha 0.0037 0.0348 1
Trypanosoma brucei hexokinase 0.009 0.104 1
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0384 0.3263
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0101 0.0598
Echinococcus multilocularis cpg binding protein 0.0034 0.0317 0.0315
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0219 0.1313
Schistosoma mansoni heat shock protein 0.0015 0.0067 0.0019
Loa Loa (eye worm) hexokinase 0.009 0.104 0.6228
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0348 0.2892
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0384 0.3263
Schistosoma mansoni heat shock protein 0.0037 0.0348 0.0302
Leishmania major hypothetical protein, conserved 0.003 0.0265 0.2037
Entamoeba histolytica hexokinase 1 0.009 0.104 1
Trichomonas vaginalis endoplasmin, putative 0.0023 0.0164 0.3058
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0125 0.0124
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0324 0.406 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0103 0.0101
Schistosoma mansoni jumonji domain containing protein 0.0067 0.0734 0.069
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0219 0.0224
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0101 0.0357
Echinococcus granulosus GPCR family 2 0.0018 0.0103 0.0101
Echinococcus multilocularis hexokinase type 2 0.009 0.104 0.1039
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0015 0.0067 0.0065
Trypanosoma brucei heat shock protein, putative 0.0037 0.0348 0.2892
Echinococcus multilocularis lysine specific demethylase 5A 0.0067 0.0734 0.0733
Entamoeba histolytica hypothetical protein 0.004 0.0384 0.3263
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0101 0.0054
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0371 0.2225
Schistosoma mansoni hypothetical protein 0.0018 0.0103 0.0055
Schistosoma mansoni heat shock protein 0.0037 0.0348 0.0302
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0219 0.0224
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Echinococcus multilocularis heat shock protein 0.0037 0.0348 0.0347
Loa Loa (eye worm) hypothetical protein 0.003 0.0265 0.1579
Schistosoma mansoni cpg binding protein 0.0034 0.0317 0.027
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0067 0.0734 0.0733
Schistosoma mansoni hypothetical protein 0.0039 0.0371 0.0325
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0131 0.0162
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0384 0.3263
Schistosoma mansoni hexokinase 0.009 0.104 0.0997
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0293 0.1746
Brugia malayi hypothetical protein 0.002 0.0126 0.0752
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0101 0.0054
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0101 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0219 0.1313
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0384 0.0796
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0265 0.0497
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0131 0.0162
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Leishmania major basic transcription factor 3a, putative 0.004 0.0384 0.3263
Schistosoma mansoni endoplasmin 0.0037 0.0348 0.0302
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0103 0.0101
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0131 0.0036
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0029 0.0251 0.025
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0265 0.0497
Brugia malayi Endoplasmin precursor 0.0037 0.0348 0.2086
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0101 0.01
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0219 0.0224
Trypanosoma cruzi Heat shock protein 83, putative 0.0037 0.0348 0.2892
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0603 0.3612
Onchocerca volvulus Hexokinase homolog 0.0057 0.0605 0.3357
Echinococcus multilocularis endoplasmin 0.0029 0.0251 0.025
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0348 0.2892
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0348 0.2892
Brugia malayi jmjC domain containing protein 0.0018 0.0101 0.0608
Echinococcus granulosus hexokinase type 2 0.009 0.104 0.1039
Brugia malayi jmjC domain containing protein 0.0069 0.0759 0.4544
Plasmodium falciparum heat shock protein 90 0.0037 0.0348 0.0705
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Plasmodium falciparum endoplasmin, putative 0.0023 0.0164 0.0243
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0101 0.01
Loa Loa (eye worm) hypothetical protein 0.0139 0.1669 1
Echinococcus granulosus hexokinase 0.009 0.104 0.1039
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0067 0.0734 0.0733
Loa Loa (eye worm) hypothetical protein 0.002 0.0131 0.0777
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0029 0.0251 0.1894
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0251 0.1894
Loa Loa (eye worm) hypothetical protein 0.0027 0.0219 0.1305
Plasmodium vivax hexokinase, putative 0.009 0.104 0.2438
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Loa Loa (eye worm) hypothetical protein 0.002 0.0131 0.0777
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0219 0.1566
Loa Loa (eye worm) hypothetical protein 0.0027 0.0219 0.1305
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Brugia malayi hypothetical protein 0.003 0.0265 0.1588
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0219 0.1313
Schistosoma mansoni transcription factor btf3 0.004 0.0384 0.0338
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0131 0.5
Brugia malayi jmjC domain containing protein 0.0018 0.0101 0.0608
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0765 0.0721
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0384 1
Toxoplasma gondii hexokinase 0.009 0.104 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0101 0.0357
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0265 0.2037
Echinococcus granulosus dnaJ subfamily B 0.0464 0.5875 0.5874
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0101 0.01
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0048 0.0046
Brugia malayi hexokinase 0.009 0.104 0.6232
Plasmodium vivax endoplasmin, putative 0.0037 0.0348 0.0705
Brugia malayi jmjC domain containing protein 0.0018 0.0101 0.0608
Toxoplasma gondii heat shock protein 90, putative 0.0037 0.0348 0.2892
Loa Loa (eye worm) hypothetical protein 0.0039 0.0371 0.2217
Loa Loa (eye worm) hexokinase type II 0.009 0.104 0.6228
Loa Loa (eye worm) ICD-1 protein 0.004 0.0384 0.2295
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0219 0.1566
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0101 0.0054
Brugia malayi beta-NAC-like protein 0.004 0.0384 0.2303
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0384 1
Schistosoma mansoni hypothetical protein 0.0018 0.0103 0.0055
Toxoplasma gondii heat shock protein HSP90 0.0037 0.0348 0.2892
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0251 0.5805
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0219 0.0224
Brugia malayi jmjC domain containing protein 0.0018 0.0101 0.0608
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Brugia malayi jmjC domain containing protein 0.0067 0.0734 0.44
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0101 0.0087
Echinococcus granulosus endoplasmin 0.0029 0.0251 0.025
Echinococcus granulosus transcription factor btf3 0.004 0.0384 0.0383
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0759 0.0757
Trypanosoma brucei heat shock protein, putative 0.0037 0.0348 0.2892
Trypanosoma brucei heat shock protein, putative 0.0037 0.0348 0.2892
Trichomonas vaginalis heat shock protein, putative 0.0023 0.0164 0.3058
Echinococcus granulosus hexokinase 0.009 0.104 0.1039
Mycobacterium ulcerans heat shock protein 90 0.0029 0.0251 0.0305
Echinococcus granulosus heat shock protein 90 0.0029 0.0251 0.025
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0029 0.0251 0.5
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0015 0.0067 0.0065
Plasmodium vivax heat shock protein 86, putative 0.0037 0.0348 0.0705
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0103 0.0616
Schistosoma mansoni hypothetical protein 0.0018 0.0103 0.0055
Toxoplasma gondii NAC domain-containing protein 0.004 0.0384 0.3263
Echinococcus granulosus heat shock protein 0.0037 0.0348 0.0347
Echinococcus multilocularis transcription factor btf3 0.004 0.0384 0.0383
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0219 0.0259
Echinococcus granulosus cpg binding protein 0.0034 0.0317 0.0315
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0029 0.0251 0.034
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0348 0.2892
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0103 0.0101
Echinococcus granulosus heat shock protein 90 0.0037 0.0348 0.0347
Schistosoma mansoni cpg binding protein 0.0033 0.0293 0.0246
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0265 0.0497
Loa Loa (eye worm) hypothetical protein 0.002 0.0131 0.0777
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0101 0.01
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0384 0.0796
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0759 0.4538
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0219 0.1566
Loa Loa (eye worm) hypothetical protein 0.002 0.0131 0.0777
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0219 0.0224
Brugia malayi hypothetical protein 0.0139 0.1669 1
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0348 0.2892
Loa Loa (eye worm) hexokinase 0.0028 0.0233 0.1387
Loa Loa (eye worm) hypothetical protein 0.0029 0.0243 0.1447
Echinococcus multilocularis hexokinase 0.009 0.104 0.1039
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Onchocerca volvulus 0.0027 0.0219 0.0952
Loa Loa (eye worm) hypothetical protein 0.0139 0.1669 1
Leishmania major heat shock protein 83-1 0.0037 0.0348 0.2892
Loa Loa (eye worm) heat shock protein 75 0.0015 0.0067 0.039
Leishmania major hypothetical protein, conserved 0.0018 0.0101 0.0357
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0265 0.2037
Loa Loa (eye worm) endoplasmin 0.0037 0.0348 0.2079
Trypanosoma brucei heat shock protein, putative 0.0037 0.0348 0.2892
Trypanosoma brucei hexokinase 0.009 0.104 1
Brugia malayi CXXC zinc finger family protein 0.0033 0.0293 0.1754
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0251 0.5805
Trypanosoma brucei heat shock protein, putative 0.0037 0.0348 0.2892
Mycobacterium ulcerans hypothetical protein 0.0027 0.0219 0.0224
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0101 0.0054
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0219 0.1566
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0153 0.0884
Loa Loa (eye worm) hypothetical protein 0.0027 0.0219 0.1305
Loa Loa (eye worm) hypothetical protein 0.0062 0.0669 0.3999
Trypanosoma brucei heat shock protein, putative 0.0037 0.0348 0.2892
Echinococcus multilocularis hexokinase 0.009 0.104 0.1039
Onchocerca volvulus Huntingtin homolog 0.0139 0.1669 1
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0348 0.8863
Trypanosoma cruzi hexokinase, putative 0.009 0.104 1
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0348 0.2892
Brugia malayi Hexokinase family protein 0.0028 0.0233 0.1396
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0219 0.1566
Onchocerca volvulus Huntingtin homolog 0.0139 0.1669 1
Onchocerca volvulus 0.0057 0.0605 0.3357
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0101 0.0598

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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