TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 367.312 | Formula: C16H19FN3O4P
H donors: 3 H acceptors: 4 LogP: 1.75 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCC(n1c(nc2c1ccc(c2N)F)c1ccc(o1)P(=O)(O)O)CC
InChi: 1S/C16H19FN3O4P/c1-3-9(4-2)20-11-6-5-10(17)14(18)15(11)19-16(20)12-7-8-13(24-12)25(21,22)23/h5-9H,3-4,18H2,1-2H3,(H2,21,22,23)
InChiKey: ZFKDVPHSRBHRBJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Fructose-1,6-bisphosphatase	Starlite/ChEMBL	References
Homo sapiens	fructose-1,6-bisphosphatase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania major		Get druggable targets OG5_127400	All targets in OG5_127400
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Echinococcus granulosus	fructose 16 bisphosphatase 1	Get druggable targets OG5_127400	All targets in OG5_127400
Schistosoma mansoni	fructose-16-bisphosphatase-related	Get druggable targets OG5_127400	All targets in OG5_127400
Toxoplasma gondii	fructose-bisphospatase II	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania mexicana	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania donovani	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma congolense	fructose-1,6-bisphosphate, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma brucei	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania braziliensis	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania infantum	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma brucei gambiense	fructose-1,6-bisphosphate, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Schistosoma japonicum	ko:K03841 fructose-1,6-bisphosphatase I, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Brugia malayi	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Candida albicans	similar to S. cerevisiae FBP1 (YLR377C) Fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Neospora caninum	Fructose-1 6-biphosphatase, related	Get druggable targets OG5_127400	All targets in OG5_127400

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Neospora caninum	fructose-1,6-bisphosphatase, putative	Fructose-1,6-bisphosphatase	363 aa	298 aa	32.5 %
Toxoplasma gondii	fructose-bisphospatase I	Fructose-1,6-bisphosphatase	363 aa	326 aa	31.3 %
Toxoplasma gondii	fructose-bisphospatase I	fructose-1,6-bisphosphatase 1	338 aa	326 aa	31.0 %
Onchocerca volvulus	CES-1 homolog	Fructose-1,6-bisphosphatase	363 aa	319 aa	60.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0029	0.0073	0.001
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0285	0.0253
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1453	0.5
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0333	0.229
Echinococcus granulosus	ubiquitin specific protease 41	0.0037	0.0285	0.0253
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0037	0.029	0.0259
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0037	0.029	0.0229
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0037	0.029	0.0074
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.069	0.1171
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.6388	0.8709
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0063	0.0063
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.0141	0.3239	0.3239
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0139	0.319	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0433	0.2976
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.733	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Schistosoma mansoni	importin beta-1	0.0034	0.0218	0.0156
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0617	0.0557
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.6388	0.8709
Brugia malayi	jmjC domain containing protein	0.0036	0.0249	0.0188
Leishmania major	mitochondrial DNA polymerase beta	0.0298	0.7714	0.7707
Loa Loa (eye worm)	acetyltransferase	0.0143	0.3305	0.3263
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0037	0.029	0.0259
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.069	0.2162
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0285	0.0254
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0368	0.9714	0.9712
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1453	0.14
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1453	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0143	0.3305	0.3263
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0401	0.034
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.1453	0.4556
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0139	0.319	0.85
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0063	0.0031
Onchocerca volvulus		0.0149	0.3478	0.5957
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0037	0.029	0.0299
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3929	0.5339
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.6388	0.8709
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0433	0.0549
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1453	0.5
Loa Loa (eye worm)	hypothetical protein	0.0149	0.3478	0.3437
Trichomonas vaginalis	set domain proteins, putative	0.023	0.5796	0.7898
Entamoeba histolytica	hypothetical protein	0.0071	0.1253	0.1673
Plasmodium vivax	SET domain protein, putative	0.0029	0.0063	0.0432
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0285	0.0069
Plasmodium vivax	importin-beta 2, putative	0.0034	0.0218	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0617	0.0557
Plasmodium falciparum	importin beta, putative	0.0034	0.0218	0.1496
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0037	0.0285	0.0292
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0428	0.0398
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0073	0.0503
Entamoeba histolytica	hypothetical protein	0.0071	0.1253	0.1673
Brugia malayi	hypothetical protein	0.0071	0.1253	0.1197
Echinococcus granulosus	snurportin 1	0.0368	0.9714	0.9713
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.1453	0.14
Brugia malayi	exodeoxyribonuclease III family protein	0.0037	0.029	0.0229
Schistosoma mansoni	peptidase Clp (S14 family)	0.0078	0.1453	0.14
Onchocerca volvulus	Alhambra homolog	0.0029	0.0073	0.0018
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3929	0.5339
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0157	0.3702	1
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.1453	0.1426
Brugia malayi	jmjC domain containing protein	0.0096	0.1977	0.1927
Schistosoma mansoni	hypothetical protein	0.0368	0.9714	0.9712
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0298	0.7714	0.7664
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.029	0.1996
Toxoplasma gondii	fructose-bisphospatase I	0.0141	0.3239	0.3239
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0617	0.0557
Echinococcus multilocularis	snurportin 1	0.0368	0.9714	0.9712
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0249	0.0188
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0428	0.0398
Schistosoma mansoni	ap endonuclease	0.0037	0.029	0.0229
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0073	0.001
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1453	0.1983
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.029	0.0354
Entamoeba histolytica	hypothetical protein	0.0071	0.1253	0.1673
Toxoplasma gondii	hypothetical protein	0.0048	0.0603	0.0603
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0249	0.0188
Loa Loa (eye worm)	hypothetical protein	0.005	0.0671	0.0612
Mycobacterium ulcerans	hypothetical protein	0.0157	0.3702	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3929	0.5339
Onchocerca volvulus	Glucosylceramidase homolog	0.0165	0.3929	0.6743
Brugia malayi	Importin beta-1 subunit	0.0034	0.0218	0.0156
Schistosoma mansoni	hypothetical protein	0.0033	0.018	0.0118
Schistosoma mansoni	hypothetical protein	0.0071	0.1253	0.1197
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.0249	0.0218
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.5	0.4968
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.3249	0.3227
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0078	0.1453	1
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0251	0.6388	0.6365
Brugia malayi	Pre-SET motif family protein	0.0202	0.5	0.4968
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0037	0.0285	0.0223
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0298	0.7714	0.7707
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0037	0.029	0.0259
Echinococcus granulosus	importin subunit beta 1	0.0034	0.0218	0.0186
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0433	0.0549
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0433	0.0402
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0037	0.0285	0.0346
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0333	0.0358
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.1253	0.1197
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.069	0.1171
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0433	0.0433
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0037	0.029	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0218	0.0156
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0037	0.029	0.0229
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0073	0.0073
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0037	0.0285	0.0254
Schistosoma mansoni	jumonji domain containing protein	0.0076	0.1414	0.136
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.4181	0.5686
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0964	0.0907
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.0141	0.3239	0.3089
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0073	0.0503
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0143	0.3305	0.3263
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0073	0.001
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.069	0.0659
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0285	0.0223
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0428	0.0398
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0285	0.0253
Brugia malayi	Probable ClpP-like protease	0.0078	0.1453	0.14
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3929	0.5339
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0139	0.319	0.85
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.733	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.4181	0.5686
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.029	0.1996
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0037	0.0285	0.0223
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0141	0.3239	0.3217
Echinococcus multilocularis	ubiquitin specific protease 41	0.0037	0.0285	0.0223
Brugia malayi	acetyltransferase, GNAT family protein	0.0143	0.3305	0.3263
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.1253	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0285	0.0223
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0037	0.029	0.0396
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.069	0.0631
Onchocerca volvulus		0.023	0.5796	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.1253	0.1224
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0689	0.0659
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1453	1
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0251	0.6388	0.6365
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1453	0.341
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0433	0.0433
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0034	0.0218	0.0218
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.3249	0.3227
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0073	0.001
Brugia malayi	Bromodomain containing protein	0.0033	0.0173	0.0111
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.6388	0.8709
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0249	0.0188
Brugia malayi	RNA, U transporter 1	0.0098	0.2027	0.1977
Giardia lamblia	Fructose-bisphosphate aldolase	0.0284	0.733	1
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0333	0.0412
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0037	0.029	0.0259
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0073	0.001
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3929	0.5339
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0428	0.0215
Echinococcus granulosus	peregrin	0.0033	0.0173	0.0141
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0141	0.3249	0.3098
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0096	0.1977	0.1951
Echinococcus multilocularis	importin subunit beta 1	0.0034	0.0218	0.0156
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0139	0.3191	0.3169
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.029	0.0354
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.6388	0.8709
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1453	0.341
Loa Loa (eye worm)	hypothetical protein	0.0033	0.018	0.0118
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0285	0.0346
Brugia malayi	hypothetical protein	0.0149	0.3478	0.3437
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0249	0.0188
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0285	0.0223
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0401	0.037
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.018	0.0118
Schistosoma mansoni	ap endonuclease	0.0037	0.029	0.0229
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0285	0.0254
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0073	0.0073
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.6388	0.8709
Echinococcus multilocularis	peregrin	0.0033	0.0173	0.0111
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0285	0.0346
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3929	0.5339
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.1453	0.1453
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0096	0.1977	0.1927
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3929	0.5339
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.1453	0.1453
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0037	0.0285	0.0223
Entamoeba histolytica	hypothetical protein	0.0071	0.1253	0.1673
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0073	0.0041
Treponema pallidum	fructose-bisphosphate aldolase	0.0284	0.733	1
Brugia malayi	PHD-finger family protein	0.0029	0.0073	0.001
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0617	0.0557
Toxoplasma gondii	exonuclease III APE	0.0037	0.029	0.029
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0298	0.7714	0.7707
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0285	0.0346
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0141	0.3239	0.3217

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.85 uM	Inhibition of human liver FBPase 1	ChEMBL.	20055427
IC50 (binding)	= 2.5 uM	Inhibition of rat liver FBPase 1	ChEMBL.	20055427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL571840

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1071713