TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 367.312 | Formula: C16H19FN3O4P
H donors: 3 H acceptors: 4 LogP: 1.75 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCC(n1c(nc2c1ccc(c2N)F)c1ccc(o1)P(=O)(O)O)CC
InChi: 1S/C16H19FN3O4P/c1-3-9(4-2)20-11-6-5-10(17)14(18)15(11)19-16(20)12-7-8-13(24-12)25(21,22)23/h5-9H,3-4,18H2,1-2H3,(H2,21,22,23)
InChiKey: ZFKDVPHSRBHRBJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fructose-1,6-bisphosphatase 1	Starlite/ChEMBL	References
Rattus norvegicus	Fructose-1,6-bisphosphatase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Schistosoma japonicum	ko:K03841 fructose-1,6-bisphosphatase I, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Echinococcus granulosus	fructose 16 bisphosphatase 1	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania braziliensis	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma congolense	fructose-1,6-bisphosphate, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania infantum	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Toxoplasma gondii	fructose-bisphospatase II	Get druggable targets OG5_127400	All targets in OG5_127400
Neospora caninum	Fructose-1 6-biphosphatase, related	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma brucei	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania mexicana	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Schistosoma mansoni	fructose-16-bisphosphatase-related	Get druggable targets OG5_127400	All targets in OG5_127400
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma brucei gambiense	fructose-1,6-bisphosphate, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Candida albicans	similar to S. cerevisiae FBP1 (YLR377C) Fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania major		Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania donovani	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	Get druggable targets OG5_127400	All targets in OG5_127400

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus	CES-1 homolog	Fructose-1,6-bisphosphatase	363 aa	319 aa	60.5 %
Toxoplasma gondii	fructose-bisphospatase I	Fructose-1,6-bisphosphatase	363 aa	326 aa	31.3 %
Toxoplasma gondii	fructose-bisphospatase I	fructose-1,6-bisphosphatase 1	338 aa	326 aa	31.0 %
Neospora caninum	fructose-1,6-bisphosphatase, putative	Fructose-1,6-bisphosphatase	363 aa	298 aa	32.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0428	0.0398
Schistosoma mansoni	jumonji domain containing protein	0.0076	0.1414	0.136
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0073	0.0073
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Schistosoma mansoni	ap endonuclease	0.0037	0.029	0.0229
Echinococcus multilocularis	peregrin	0.0033	0.0173	0.0111
Plasmodium falciparum	importin beta, putative	0.0034	0.0218	0.1496
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3929	0.5339
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0689	0.0659
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0433	0.0433
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0073	0.0503
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0285	0.0223
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.733	1
Toxoplasma gondii	hypothetical protein	0.0048	0.0603	0.0603
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0037	0.029	0.0259
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0333	0.229
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0037	0.029	0.0074
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0037	0.029	0.0229
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0037	0.029	0.0396
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3929	0.5339
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0428	0.0398
Schistosoma mansoni	hypothetical protein	0.0071	0.1253	0.1197
Toxoplasma gondii	fructose-bisphospatase I	0.0141	0.3239	0.3239
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.029	0.0354
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0249	0.0188
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.6388	0.8709
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0078	0.1453	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0433	0.0402
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0037	0.029	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0073	0.001
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0063	0.0031
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.1453	0.1453
Brugia malayi	Bromodomain containing protein	0.0033	0.0173	0.0111
Schistosoma mansoni	hypothetical protein	0.0029	0.0073	0.001
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0037	0.0285	0.0292
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.3249	0.3227
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0428	0.0398
Brugia malayi	Pre-SET motif family protein	0.0202	0.5	0.4968
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.069	0.1171
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.6388	0.8709
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0285	0.0223
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.069	0.0631
Echinococcus granulosus	peregrin	0.0033	0.0173	0.0141
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.1453	0.4556
Entamoeba histolytica	hypothetical protein	0.0071	0.1253	0.1673
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.1253	0.1197
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0139	0.319	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0285	0.0346
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0141	0.3239	0.3217
Loa Loa (eye worm)	hypothetical protein	0.0033	0.018	0.0118
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1453	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0433	0.2976
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0143	0.3305	0.3263
Brugia malayi	exodeoxyribonuclease III family protein	0.0037	0.029	0.0229
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Plasmodium vivax	SET domain protein, putative	0.0029	0.0063	0.0432
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0433	0.0433
Schistosoma mansoni	importin beta-1	0.0034	0.0218	0.0156
Onchocerca volvulus		0.023	0.5796	1
Brugia malayi	hypothetical protein	0.0071	0.1253	0.1197
Schistosoma mansoni	hypothetical protein	0.0033	0.018	0.0118
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0249	0.0188
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3929	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1453	0.14
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0037	0.029	0.0229
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0037	0.029	0.0259
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.1453	0.1453
Brugia malayi	PHD-finger family protein	0.0029	0.0073	0.001
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0617	0.0557
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0037	0.0285	0.0223
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.1453	0.1426
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0073	0.001
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3929	0.5339
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0037	0.029	0.0259
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0617	0.0557
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1453	0.5
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.1253	0.1224
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0249	0.0188
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0037	0.0285	0.0223
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.069	0.2162
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.069	0.0659
Leishmania major	mitochondrial DNA polymerase beta	0.0298	0.7714	0.7707
Onchocerca volvulus	Alhambra homolog	0.0029	0.0073	0.0018
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.0141	0.3239	0.3239
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0037	0.0285	0.0346
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.4181	0.5686
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0285	0.0069
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1453	0.341
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0037	0.0285	0.0223
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0433	0.0549
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0141	0.3239	0.3217
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1453	1
Loa Loa (eye worm)	acetyltransferase	0.0143	0.3305	0.3263
Echinococcus multilocularis	ubiquitin specific protease 41	0.0037	0.0285	0.0223
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0285	0.0346
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0298	0.7714	0.7707
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0037	0.0285	0.0254
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0285	0.0223
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0073	0.0503
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0285	0.0254
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0096	0.1977	0.1927
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0139	0.3191	0.3169
Brugia malayi	RNA, U transporter 1	0.0098	0.2027	0.1977
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0141	0.3249	0.3098
Brugia malayi	jmjC domain containing protein	0.0096	0.1977	0.1927
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0251	0.6388	0.6365
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1453	0.1983
Onchocerca volvulus		0.0149	0.3478	0.5957
Loa Loa (eye worm)	hypothetical protein	0.0149	0.3478	0.3437
Echinococcus granulosus	importin subunit beta 1	0.0034	0.0218	0.0186
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.029	0.0354
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.0141	0.3239	0.3089
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0037	0.029	0.0299
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0368	0.9714	0.9712
Onchocerca volvulus	Glucosylceramidase homolog	0.0165	0.3929	0.6743
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0096	0.1977	0.1951
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0251	0.6388	0.6365
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3929	0.5339
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.029	0.1996
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.6388	0.8709
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0433	0.0549
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.018	0.0118
Trichomonas vaginalis	set domain proteins, putative	0.023	0.5796	0.7898
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0428	0.0215
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1453	0.341
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0157	0.3702	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.069	0.1171
Schistosoma mansoni	peptidase Clp (S14 family)	0.0078	0.1453	0.14
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0063	0.0063
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.1453	0.14
Brugia malayi	Probable ClpP-like protease	0.0078	0.1453	0.14
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0285	0.0253
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0285	0.0253
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.029	0.1996
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0617	0.0557
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0333	0.0412
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.4181	0.5686
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0298	0.7714	0.7664
Echinococcus granulosus	snurportin 1	0.0368	0.9714	0.9713
Schistosoma mansoni	hypothetical protein	0.0368	0.9714	0.9712
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0139	0.319	0.85
Plasmodium vivax	importin-beta 2, putative	0.0034	0.0218	0.1496
Schistosoma mansoni	ap endonuclease	0.0037	0.029	0.0229
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0401	0.034
Toxoplasma gondii	exonuclease III APE	0.0037	0.029	0.029
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0333	0.0358
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0617	0.0557
Brugia malayi	Importin beta-1 subunit	0.0034	0.0218	0.0156
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.733	1
Brugia malayi	hypothetical protein	0.0149	0.3478	0.3437
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0298	0.7714	0.7707
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3929	0.5339
Entamoeba histolytica	hypothetical protein	0.0071	0.1253	0.1673
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.005	0.0671	0.0612
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0139	0.319	0.85
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0249	0.0188
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.3249	0.3227
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0218	0.0156
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.5	0.4968
Entamoeba histolytica	hypothetical protein	0.0071	0.1253	0.1673
Echinococcus multilocularis	snurportin 1	0.0368	0.9714	0.9712
Entamoeba histolytica	hypothetical protein	0.0071	0.1253	0.1673
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3929	0.5339
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.6388	0.8709
Mycobacterium ulcerans	hypothetical protein	0.0157	0.3702	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.1253	0.1197
Echinococcus granulosus	ubiquitin specific protease 41	0.0037	0.0285	0.0253
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.733	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1453	0.5
Brugia malayi	acetyltransferase, GNAT family protein	0.0143	0.3305	0.3263
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0037	0.029	0.0259
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0285	0.0254
Treponema pallidum	fructose-bisphosphate aldolase	0.0284	0.733	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.6388	0.8709
Echinococcus multilocularis	importin subunit beta 1	0.0034	0.0218	0.0156
Giardia lamblia	Fructose-bisphosphate aldolase	0.0284	0.733	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0143	0.3305	0.3263
Brugia malayi	jmjC domain containing protein	0.0036	0.0249	0.0188
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.0249	0.0218
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.6388	0.8709
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0073	0.001
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0964	0.0907
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0073	0.001
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0401	0.037
Toxoplasma gondii	HEAT repeat-containing protein	0.0034	0.0218	0.0218
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0285	0.0346
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0073	0.0041

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.85 uM	Inhibition of human liver FBPase 1	ChEMBL.	20055427
IC50 (binding)	= 2.5 uM	Inhibition of rat liver FBPase 1	ChEMBL.	20055427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL571840

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1071713