Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Mus musculus | fructose bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose bisphosphatase 1 | 338 aa | 326 aa | 29.4 % |
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0083 | 0.0083 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0083 | 0.004 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0419 | 0.0419 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0083 | 0.0083 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.3197 | 0.3167 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0282 | 0.737 | 1 |
Echinococcus granulosus | lamin | 0.0029 | 0.0419 | 0.0419 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0633 | 0.0555 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.1721 | 0.1652 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.1107 | 0.1069 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0419 | 0.0419 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0077 | 0.1721 | 0.1652 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0083 | 0.0083 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0282 | 0.737 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0633 | 0.0593 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0185 | 0.4701 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0419 | 0.0419 |
Brugia malayi | hypothetical protein | 0.0077 | 0.1721 | 0.1685 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0077 | 0.1721 | 0.1721 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0419 | 0.0419 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0043 | 0.0043 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0083 | 0.0083 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0419 | 0.0419 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0984 | 0.0984 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0984 | 0.0945 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.3197 | 0.3197 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1107 | 0.1107 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.3197 | 0.3197 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0984 | 0.0908 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.1721 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0984 | 0.0984 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0195 | 0.4975 | 0.1027 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.1721 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0419 | 0.0378 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0282 | 0.737 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0282 | 0.737 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0282 | 0.737 | 0.737 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0984 | 0.0984 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.1107 | 0.1069 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0282 | 0.737 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0419 | 0.0419 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0083 | 0.0083 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0984 | 0.0908 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0633 | 0.0633 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0083 | 0.004 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0282 | 0.737 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0984 | 0.0908 |
Schistosoma mansoni | lamin | 0.0029 | 0.0419 | 0.0339 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.1721 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0195 | 0.4975 | 0.1027 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0984 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0404 | 0.0404 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0077 | 0.1721 | 0.1721 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0419 | 0.0378 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0419 | 0.0419 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0419 | 0.0419 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0984 | 0.0984 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0419 | 0.0339 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.1721 | 0.5 |
Schistosoma mansoni | lamin | 0.0029 | 0.0419 | 0.0339 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0282 | 0.737 | 0.7359 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.1107 | 0.1107 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.