Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0058 | 0.1993 | 0.5169 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0099 | 0.3855 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0099 | 0.3855 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0019 | 0.0238 | 0.0616 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0051 | 0.1678 | 0.3981 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0099 | 0.3855 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0019 | 0.0238 | 0.0616 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0099 | 0.3855 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0099 | 0.3855 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0058 | 0.1993 | 0.4851 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0099 | 0.3855 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0058 | 0.1993 | 0.5169 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0019 | 0.0238 | 0.5 |
Mycobacterium ulcerans | putative regulatory protein | 0.0038 | 0.108 | 1 |
Brugia malayi | hypothetical protein | 0.0171 | 0.7092 | 0.7021 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0058 | 0.1993 | 0.183 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0037 | 0.1058 | 0.2745 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0099 | 0.3855 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0037 | 0.1058 | 0.0876 |
Brugia malayi | MAP kinase sur-1 | 0.0058 | 0.1993 | 0.1798 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0019 | 0.0238 | 0.0616 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.1058 | 0.0841 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0099 | 0.3855 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0019 | 0.0238 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0099 | 0.3855 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0099 | 0.3855 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0058 | 0.1993 | 0.4851 |
Leishmania major | cytochrome p450-like protein | 0.0019 | 0.0238 | 0.0616 |
Leishmania major | cytochrome p450-like protein | 0.0037 | 0.1058 | 0.2745 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0058 | 0.1993 | 0.4851 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0099 | 0.3855 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0082 | 0.308 | 0.2912 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.1058 | 0.0876 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0058 | 0.1993 | 0.4851 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0037 | 0.1058 | 0.2745 |
Trypanosoma brucei | protein kinase, putative | 0.0058 | 0.1993 | 0.4851 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0058 | 0.1993 | 0.5169 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0099 | 0.3855 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0058 | 0.1993 | 0.4851 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0058 | 0.1993 | 0.5169 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0157 | 0.6494 | 0.6423 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0099 | 0.3855 | 0.3111 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0058 | 0.1993 | 0.5169 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0058 | 0.1993 | 0.4851 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0019 | 0.0238 | 0.0616 |
Trypanosoma brucei | cytochrome P450, putative | 0.0037 | 0.1058 | 0.2268 |
Loa Loa (eye worm) | cytochrome P450 | 0.0019 | 0.0238 | 0.0039 |
Brugia malayi | hypoxia-induced factor 1 | 0.0157 | 0.6494 | 0.6409 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.1058 | 0.0841 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.1058 | 0.0876 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0099 | 0.3855 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.7092 | 0.7032 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0082 | 0.308 | 0.294 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0099 | 0.3855 | 1 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0038 | 0.108 | 0.2329 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0099 | 0.3855 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0099 | 0.3855 | 1 |
Echinococcus granulosus | single minded 2 | 0.0038 | 0.108 | 0.2329 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0099 | 0.3855 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0099 | 0.3855 | 0.5 |
Brugia malayi | bHLH-PAS transcription factor | 0.0038 | 0.108 | 0.0863 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0099 | 0.3855 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0037 | 0.1058 | 0.9737 |
Leishmania major | cytochrome p450-like protein | 0.0019 | 0.0238 | 0.0616 |
Schistosoma mansoni | single-minded | 0.0051 | 0.1678 | 0.3981 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0058 | 0.1993 | 0.5169 |
Brugia malayi | PAS domain containing protein | 0.0051 | 0.1678 | 0.1475 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0058 | 0.1993 | 0.4851 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0099 | 0.3855 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.3855 | 0.373 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0099 | 0.3855 | 0.5 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0099 | 0.3855 | 0.3706 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of bovine liver DHFR assessed as NADPH consumption during conversion of dihydrofolic acid to tetrahydrofolic acid | ChEMBL. | 19716698 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.