TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 315.364 | Formula: C18H21NO4
H donors: 1 H acceptors: 2 LogP: 2.38 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CO/C(=C\1/C(=NC(=C(C1c1ccccc1C)C(=O)OC)C)C)/O
InChi: 1S/C18H21NO4/c1-10-8-6-7-9-13(10)16-14(17(20)22-4)11(2)19-12(3)15(16)18(21)23-5/h6-9,16,20H,1-5H3/b17-14-
InChiKey: WDOQDXYCILWETQ-VKAVYKQESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0036	0.0122	0.0122
Brugia malayi	hypothetical protein	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1091	0.1091
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0036	0.0122	0.0122
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0446	0.4055	1
Onchocerca volvulus		0.0036	0.0122	0.0301
Echinococcus granulosus	acetylcholinesterase	0.0137	0.1091	0.1091
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0036	0.0122	0.0122
Echinococcus multilocularis	carboxylesterase 5A	0.0137	0.1091	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Echinococcus granulosus	expressed protein	0.0142	0.1138	0.1138
Schistosoma mansoni	pcd6 interacting protein-related	0.0036	0.0122	0.0122
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0036	0.0122	0.0122
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0036	0.0122	0.0122
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0036	0.0122	0.0122
Schistosoma mansoni	hypothetical protein	0.0106	0.0792	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0036	0.0122	0.0122
Entamoeba histolytica	glycogen phosphorylase, putative	0.0446	0.4055	1
Onchocerca volvulus		0.0036	0.0122	0.0301
Schistosoma mansoni	glycogen phosphorylase	0.0193	0.1627	0.1627
Trichomonas vaginalis	rotamase, putative	0.0142	0.1138	0.2806
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Schistosoma mansoni	protein tyrosine phosphatase	0.0036	0.0122	0.0122
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0036	0.0122	0.0122
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0043	0.0192	0.0706
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0446	0.4055	0.4055
Brugia malayi	hypothetical protein	0.0036	0.0122	0.0122
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0036	0.0122	0.0122
Echinococcus granulosus	glycogen phosphorylase	0.0446	0.4055	0.4055
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0036	0.0122	0.0122
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1065	1	1
Brugia malayi	hypothetical protein	0.0036	0.0122	0.0122
Wolbachia endosymbiont of Brugia malayi	parvulin-like peptidyl-prolyl isomerase, PPID	0.0043	0.0192	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0036	0.0122	0.0122
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0036	0.0122	0.0122
Echinococcus granulosus	Glycosyl transferase family 35	0.0446	0.4055	0.4055
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Echinococcus multilocularis	hypothetical protein	0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0193	0.1627	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Echinococcus multilocularis	glycogen phosphorylase	0.0446	0.4055	0.4055
Brugia malayi	Protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0036	0.0122	0.0122
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0137	0.1091	0.1091
Echinococcus multilocularis	acetylcholinesterase	0.0137	0.1091	0.1091
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0193	0.1627	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0036	0.0122	0.0122
Echinococcus granulosus	glycogen phosphorylase	0.0446	0.4055	0.4055
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0036	0.0122	0.0122
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0036	0.0122	0.0122
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0036	0.0122	0.0122
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0138	0.1106	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0138	0.1106	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0036	0.0122	0.0122
Entamoeba histolytica	glycogen phosphorylase, putative	0.0446	0.4055	1
Brugia malayi	Protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Echinococcus granulosus	acetylcholinesterase	0.0137	0.1091	0.1091
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0043	0.0192	0.0706
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0036	0.0122	0.0122
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0036	0.0122	0.0122
Schistosoma mansoni	protein tyrosine phosphatase	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1091	0.1091
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0036	0.0122	0.0122
Brugia malayi	hypothetical protein	0.0036	0.0122	0.0122
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0446	0.4055	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0036	0.0122	0.0122
Schistosoma mansoni	glycogen phosphorylase	0.0446	0.4055	0.4055
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0036	0.0122	0.0122
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0036	0.0122	0.0122
Chlamydia trachomatis	glycogen phosphorylase	0.0446	0.4055	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0036	0.0122	0.0122
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0036	0.0122	0.0122
Echinococcus multilocularis	acetylcholinesterase	0.0137	0.1091	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0036	0.0122	0.0122
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.0043	0.0192	0.0706
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0036	0.0122	0.0122
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0036	0.0122	0.0122
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Schistosoma mansoni	glycogen phosphorylase	0.0446	0.4055	0.4055
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0036	0.0122	0.0122
Trypanosoma brucei	RNA helicase, putative	0.0106	0.0792	0.6811
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0036	0.0122	0.0122
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Echinococcus multilocularis	expressed protein	0.0142	0.1138	0.1138
Brugia malayi	Protein-tyrosine phosphatase 1	0.0036	0.0122	0.0122
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0138	0.1106	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0036	0.0122	0.0122
Giardia lamblia	Glycogen phosphorylase	0.0446	0.4055	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1065	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0036	0.0122	0.0122
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0036	0.0122	0.0122
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1065	1	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.0193	0.1627	0.3827
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1065	1	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0036	0.0122	0.0122
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0446	0.4055	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0036	0.0122	0.0122
Echinococcus granulosus	carboxylesterase 5A	0.0137	0.1091	0.1091
Entamoeba histolytica	glycogen phosphorylase, putative	0.0193	0.1627	0.3827
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0138	0.1106	0.2501
Onchocerca volvulus		0.0036	0.0122	0.0301
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Echinococcus multilocularis	glycogen phosphorylase	0.0446	0.4055	0.4055
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0036	0.0122	0.0122
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0036	0.0122	0.0122
Brugia malayi	Carboxylesterase family protein	0.0137	0.1091	0.1091
Loa Loa (eye worm)	glycogen phosphorylase	0.0446	0.4055	0.4055
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0036	0.0122	0.0122
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0036	0.0122	0.0122
Brugia malayi	hypothetical protein	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0142	0.1138	0.1138
Brugia malayi	carbohydrate phosphorylase	0.0446	0.4055	0.4055
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Loa Loa (eye worm)	acetylcholinesterase 1	0.0137	0.1091	0.1091
Onchocerca volvulus		0.0036	0.0122	0.0301
Schistosoma mansoni	rotamase	0.0142	0.1138	0.1138
Onchocerca volvulus		0.0036	0.0122	0.0301
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0036	0.0122	0.0122
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0043	0.0192	0.0706
Onchocerca volvulus		0.0036	0.0122	0.0301
Trichomonas vaginalis	rotamase, putative	0.0138	0.1106	0.2727
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0036	0.0122	0.0122
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0036	0.0122	0.0122
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0036	0.0122	0.0122
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0036	0.0122	0.0122
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0036	0.0122	0.0122
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.1138	0.2806
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0036	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Entamoeba histolytica	glycogenphosphorylase, putative	0.0193	0.1627	0.3827
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0142	0.1138	0.1138
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0036	0.0122	0.0122
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Onchocerca volvulus	4.1 G protein, putative homolog	0.0036	0.0122	0.0301
Onchocerca volvulus		0.0036	0.0122	0.0301
Echinococcus multilocularis		0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Onchocerca volvulus		0.0036	0.0122	0.0301
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0036	0.0122	0.0122
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Loa Loa (eye worm)	carboxylesterase	0.0137	0.1091	0.1091
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0036	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0122	0.0301
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0036	0.0122	0.0122
Brugia malayi	Carboxylesterase family protein	0.0137	0.1091	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Toxoplasma gondii	peptidylprolyl isomerase	0.0138	0.1106	1
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0138	0.1106	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0122	0.0122
Trichomonas vaginalis	pten, drome, putative	0.0036	0.0122	0.0301

Activities

Activity type	Activity value	Assay description	Source	Reference
Binding energy (binding)	= -11.88 kCal M-1	Evaluated for the free energies of binding (delta G) (in the resting state (rs) of voltage-gated L-type [Ca2+] channel (VGCCs))	ChEMBL.	10377225
Binding energy (binding)	= -11.88 kCal M-1	Evaluated for the free energies of binding (delta G) (in the resting state (rs) of voltage-gated L-type [Ca2+] channel (VGCCs))	ChEMBL.	10377225
Delta Gsolv (ADMET)	= -7.993 kCal mol-1	Solvation energy	ChEMBL.	10377225
Log 1/EC50 (functional)	= 8.22	Effective concentration required to produce mechanical response determined in muscle strips of guinea pig	ChEMBL.	2846838
Log 1/IC50 (functional)	= 8.71	Compound was tested for its antagonist activity against calcium channel	ChEMBL.	2846838

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL63764

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 107876