Detailed information for compound 1082524

Basic information

Technical information
  • TDR Targets ID: 1082524
  • Name: [7-(trifluoromethyl)-9H-carbazol-2-yl]urea
  • MW: 293.244 | Formula: C14H10F3N3O
  • H donors: 3 H acceptors: 1 LogP: 2.87 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)Nc1ccc2c(c1)[nH]c1c2ccc(c1)C(F)(F)F
  • InChi: 1S/C14H10F3N3O/c15-14(16,17)7-1-3-9-10-4-2-8(19-13(18)21)6-12(10)20-11(9)5-7/h1-6,20H,(H3,18,19,21)
  • InChiKey: JWEBYTUDKRLSAX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinesin family member 11 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium berghei kinesin-5, putative Get druggable targets OG5_128460 All targets in OG5_128460
Brugia malayi Kinesin motor domain containing protein Get druggable targets OG5_128460 All targets in OG5_128460
Neospora caninum hypothetical protein Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium knowlesi kinesin-5, putative Get druggable targets OG5_128460 All targets in OG5_128460
Toxoplasma gondii kinesin motor domain-containing protein Get druggable targets OG5_128460 All targets in OG5_128460
Cryptosporidium parvum kinesin-like boursin, putative Get druggable targets OG5_128460 All targets in OG5_128460
Schistosoma japonicum ko:K10398 kinesin family member 11, putative Get druggable targets OG5_128460 All targets in OG5_128460
Echinococcus multilocularis kinesin family 1 Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium yoelii Kinesin motor domain, putative Get druggable targets OG5_128460 All targets in OG5_128460
Schistosoma mansoni kinesin eg-5 Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium vivax kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Giardia lamblia Kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Loa Loa (eye worm) kinesin-like protein KLP2 Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium falciparum kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Candida albicans kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein Get druggable targets OG5_128460 All targets in OG5_128460
Entamoeba histolytica kinesin, putative Get druggable targets OG5_128460 All targets in OG5_128460
Echinococcus granulosus kinesin family 1 Get druggable targets OG5_128460 All targets in OG5_128460
Cryptosporidium hominis kinesin-like boursin Get druggable targets OG5_128460 All targets in OG5_128460
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0036 0.0518 0.0793
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0223 0.0284
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.2254
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0143 0.0491
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0518 0.0793
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0518 0.2144
Onchocerca volvulus 0.0036 0.0518 1
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0223 0.0104
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0371 0.1613
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.253
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0968
Loa Loa (eye worm) hypothetical protein 0.0026 0.0275 0.1198
Plasmodium falciparum flap endonuclease 1 0.003 0.0371 0.8136
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0223 0.084
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0223 0.0223
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0223 0.0104
Loa Loa (eye worm) TAR-binding protein 0.0073 0.1319 0.5738
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0223 0.084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0223 0.0968
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0968
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0143 0.253
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.054 0.069
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0518 0.9588
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0117 0.2299 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0143 0.0624
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0223 0.0104
Schistosoma mansoni intermediate filament proteins 0.0027 0.0312 0.0221
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1319 0.1531
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1319 0.1531
Loa Loa (eye worm) hypothetical protein 0.0027 0.0312 0.1359
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.054 1
Schistosoma mansoni hypothetical protein 0.0365 0.7827 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0223 0.0284
Schistosoma mansoni ap endonuclease 0.002 0.0143 0.0001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.1319 0.5738
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0143 0.0021
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0143 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0518 0.0489
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.054 0.0517
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.1319 0.5678
Toxoplasma gondii ABC1 family protein 0.0036 0.0518 0.338
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0223 0.0223
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0371 0.205
Brugia malayi intermediate filament protein 0.0027 0.0312 0.1236
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0223 0.084
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0275 0.3522
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0371 0.5739
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0223 0.0284
Echinococcus multilocularis flap endonuclease 1 0.003 0.0371 0.0474
Echinococcus granulosus dna polymerase eta 0.002 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.2254
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0518 0.0793
Trypanosoma brucei unspecified product 0.002 0.0143 0.253
Echinococcus granulosus intermediate filament protein 0.0027 0.0312 0.0312
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0143 0.253
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0223 0.084
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.054 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0223 0.084
Mycobacterium ulcerans lipase LipD 0.0036 0.0518 0.3384
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.253
Brugia malayi Flap endonuclease-1 0.003 0.0371 0.1494
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0518 0.9448
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0371 0.6066
Schistosoma mansoni lamin 0.0027 0.0312 0.0221
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0518 0.3384
Onchocerca volvulus 0.0036 0.0518 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0143 0.0182
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0143 0.2546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0223 0.0968
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0968
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.054 0.2241
Giardia lamblia Kinesin-5 0.0032 0.0423 0.7049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0223 0.0968
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0223 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1319 0.1531
Toxoplasma gondii kinesin motor domain-containing protein 0.0032 0.0423 0.2519
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.054 1
Mycobacterium leprae Probable lipase LipE 0.0036 0.0518 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0143 0.0487
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0968
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.253
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0143 0.253
Leishmania major hypothetical protein, conserved 0.0036 0.0518 0.3384
Leishmania major hypothetical protein, conserved 0.0026 0.0275 0.1197
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0223 0.0104
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.054 0.054
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0223 0.084
Mycobacterium ulcerans hypothetical protein 0.0036 0.0518 0.3384
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.253
Loa Loa (eye worm) beta-lactamase 0.0036 0.0518 0.2254
Onchocerca volvulus 0.0027 0.0312 0.3038
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0223 0.0284
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0223 0.084
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0518 0.0489
Onchocerca volvulus 0.0027 0.0312 0.3038
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.1252 1
Entamoeba histolytica kinesin, putative 0.0032 0.0423 0.7049
Echinococcus granulosus flap endonuclease 1 0.003 0.0371 0.0371
Brugia malayi hypothetical protein 0.0026 0.0275 0.1073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0223 0.0968
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0223 0.0104
Brugia malayi Kinesin motor domain containing protein 0.0032 0.0423 0.1724
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0275 0.119
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0143 0.0021
Echinococcus multilocularis FTZ F1 alpha 0.0117 0.2299 0.2937
Loa Loa (eye worm) hypothetical protein 0.0027 0.0301 0.1311
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0223 0.0968
Loa Loa (eye worm) hypothetical protein 0.0117 0.2299 1
Echinococcus granulosus lamin dm0 0.0027 0.0312 0.0312
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0223 0.0104
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.054 0.069
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0223 0.0968
Plasmodium falciparum kinesin-5 0.0032 0.0423 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0117 0.2299 0.2937
Brugia malayi nuclear receptor NHR-88 0.0023 0.0223 0.084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0968
Brugia malayi hypothetical protein 0.0016 0.0075 0.0187
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0518 0.0518
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.1252 0.1252
Plasmodium vivax kinesin-5 0.0032 0.0423 0.7455
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0518 0.9448
Brugia malayi TAR-binding protein 0.0073 0.1319 0.5678
Trichomonas vaginalis esterase, putative 0.0036 0.0518 0.9448
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0117 0.2299 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0143 0.0007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.054 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0223 0.084
Schistosoma mansoni coup transcription factor 0.0023 0.0223 0.0104
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0223 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0223 0.084
Loa Loa (eye worm) kinesin-like protein KLP2 0.0032 0.0423 0.1839
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.1252 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0968
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.054 0.054
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.1252 1
Loa Loa (eye worm) RNA binding protein 0.0073 0.1319 0.5738
Echinococcus multilocularis geminin 0.0365 0.7827 1
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0518 0.0793
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.054 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.1252 0.16
Echinococcus granulosus kinesin family 1 0.0247 0.5206 0.5206
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.253
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0117 0.2299 0.2299
Brugia malayi beta-lactamase 0.0036 0.0518 0.2144
Echinococcus multilocularis dna polymerase kappa 0.002 0.0143 0.0182
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0143 0.253
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0312 0.1236
Schistosoma mansoni hypothetical protein 0.0093 0.1785 0.2138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0223 0.0968
Echinococcus granulosus geminin 0.0365 0.7827 0.7827
Brugia malayi beta-lactamase family protein 0.0036 0.0518 0.2144
Schistosoma mansoni hypothetical protein 0.0365 0.7827 1
Schistosoma mansoni hypothetical protein 0.0215 0.4492 0.566
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0143 0.0143
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0223 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.253
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0371 0.6817
Entamoeba histolytica Flap nuclease, putative 0.003 0.0371 0.5739
Loa Loa (eye worm) hypothetical protein 0.0023 0.0223 0.0968
Echinococcus multilocularis dna polymerase eta 0.002 0.0143 0.0182
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0223 0.084
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0223 0.084
Loa Loa (eye worm) hypothetical protein 0.002 0.0143 0.062
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0143 0.0143
Echinococcus multilocularis tar DNA binding protein 0.0073 0.1319 0.1685
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0143 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0223 0.0968
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0518 0.0793
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0223 0.0284
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0518 0.0662
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.253
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.054 0.054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0223 0.0104
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.054 0.069
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1319 0.1531
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0312 0.1359
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.2254
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.1252 0.2342
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0518 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0275 0.3341
Echinococcus granulosus tar DNA binding protein 0.0073 0.1319 0.1319
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0143 0.0183
Loa Loa (eye worm) hypothetical protein 0.0037 0.054 0.2349
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0223 0.0284
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0371 0.2056
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.054 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0518 0.3384
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.2254
Echinococcus multilocularis kinesin family 1 0.0247 0.5206 0.6651
Echinococcus granulosus dna polymerase kappa 0.002 0.0143 0.0143
Echinococcus multilocularis lamin dm0 0.0027 0.0312 0.0399
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0143 0.0021
Brugia malayi beta-lactamase family protein 0.0036 0.0518 0.2144
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0032 0.0139
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.1252 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0143 0.0021
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0143 0.0487
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0223 0.0104
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0518 0.9448
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0143 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.1252 0.1444
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0223 0.0284
Echinococcus granulosus lamin 0.0027 0.0312 0.0312
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0518 0.2254
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0223 0.0104
Schistosoma mansoni lamin 0.0027 0.0312 0.0221
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0143 0.0007
Mycobacterium tuberculosis Conserved protein 0.0036 0.0518 0.0793
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.1252 1
Echinococcus multilocularis lamin 0.0027 0.0312 0.0399
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0117 0.2299 0.2806
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0223 0.084
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0275 0.5026
Schistosoma mansoni kinesin eg-5 0.0032 0.0423 0.0365
Echinococcus multilocularis musashi 0.0027 0.0312 0.0399
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0143 0.0021
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.1252 0.1444
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0143 0.062
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.054 0.3582
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.2254
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.4881 1
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0223 0.0223
Brugia malayi steroid hormone receptor 0.0023 0.0223 0.084
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1319 0.1531
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.253
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.054 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0223 0.084
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.253
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0275 0.4725
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0518 0.0793
Mycobacterium ulcerans beta-lactamase 0.0036 0.0518 0.3384
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0518 0.9448
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.054 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0312 0.1359
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0275 0.3341
Brugia malayi RNA binding protein 0.0073 0.1319 0.5678
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0518 0.0793
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0518 0.9448
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0223 0.0223
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.054 1
Brugia malayi nuclear hormone receptor 0.0023 0.0223 0.084
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0371 0.5739
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.2254
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0143 0.253
Onchocerca volvulus 0.0036 0.0518 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0518 0.9448
Mycobacterium tuberculosis Conserved protein 0.0036 0.0518 0.0793
Schistosoma mansoni ap endonuclease 0.002 0.0143 0.0001
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0518 0.0793
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0518 0.9448
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0223 0.084
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0371 0.5739
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0518 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0275 0.4725
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0223 0.0223
Schistosoma mansoni flap endonuclease-1 0.0027 0.0307 0.0214
Brugia malayi ecdysteroid receptor 0.0023 0.0223 0.084
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0143 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.085 uM Inhibition of C-terminally His6-tagged microtubule-activated KSP motor domain ATPase activity after 15 mins by luciferase-derived luminescence assay ChEMBL. 21599002
IC50 (functional) = 0.38 uM Cytotoxicity against human HeLa cells after 72 hrs by MTS assay ChEMBL. 21599002
Inhibition (binding) Inhibition of Kid ATPase activity at 20 uM ChEMBL. 21599002
Inhibition (binding) Inhibition of MKLP-1 ATPase activity at 20 uM ChEMBL. 21599002
MI50 (functional) = 1.3 uM Antimitotic activity in human HeLa cells assessed as cell cycle arrest after 24 hrs using DAPI staining by fluorescent microscopic analysis ChEMBL. 21599002

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 21599002

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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