Detailed information for compound 1082899

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.54 | Formula: C26H29N5O3
  • H donors: 2 H acceptors: 3 LogP: 1.33 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCOc1cncc(c1)c1ncc2c(c1)c1[nH]c3c(c1CC2)C(=O)NCC13CN(C1)C
  • InChi: 1S/C26H29N5O3/c1-31-14-26(15-31)13-29-25(32)22-19-5-4-16-11-28-21(9-20(16)23(19)30-24(22)26)17-8-18(12-27-10-17)34-7-3-6-33-2/h8-12,30H,3-7,13-15H2,1-2H3,(H,29,32)
  • InChiKey: GSLSEAKPERDTFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase-activated protein kinase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Echinococcus multilocularis MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Echinococcus granulosus MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Brugia malayi map kinase activated protein kinase protein 2 Get druggable targets OG5_131483 All targets in OG5_131483
Schistosoma japonicum ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative Get druggable targets OG5_131483 All targets in OG5_131483
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase-activated protein kinase 2 370 aa 303 aa 26.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni intermediate filament proteins 0.0054 0.0397 0.0397
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0109 0.1247 0.2798
Echinococcus granulosus lysosomal alpha glucosidase 0.032 0.4531 0.4531
Echinococcus granulosus intermediate filament protein 0.0054 0.0397 0.0397
Trichomonas vaginalis sucrase-isomaltase, putative 0.0071 0.0663 0.1322
Toxoplasma gondii ABC1 family protein 0.0073 0.0698 0.1566
Schistosoma mansoni microtubule-associated protein tau 0.0672 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0491 0.0491
Leishmania major alpha glucosidase II subunit, putative 0.0071 0.0663 0.8336
Echinococcus multilocularis lamin 0.0054 0.0397 0.0397
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1685 0.1685
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1 0.1
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0584 0.0584
Brugia malayi beta-lactamase 0.0073 0.0698 0.154
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0397 0.0876
Mycobacterium tuberculosis Conserved protein 0.0073 0.0698 0.0327
Echinococcus multilocularis peptidase Clp (S14 family) 0.0207 0.277 0.277
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0698 0.0327
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0305 0.0305
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0008 0.0018
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0217 0.2936 0.6481
Loa Loa (eye worm) hypothetical protein 0.0048 0.0305 0.0672
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0315 0.4456 1
Echinococcus granulosus tumor protein p63 0.0329 0.4672 0.4672
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0308 0.0308
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0207 0.277 0.3596
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0397 0.0876
Brugia malayi beta-lactamase family protein 0.0073 0.0698 0.154
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0203 0.0203
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0203 0.0456
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0698 0.1421
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1746 0.1746
Schistosoma mansoni hypothetical protein 0.0048 0.0305 0.0305
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0109 0.1247 0.2798
Loa Loa (eye worm) hypothetical protein 0.0073 0.0698 0.154
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0584 0.129
Echinococcus granulosus tar DNA binding protein 0.0066 0.0584 0.0584
Brugia malayi Pre-SET motif family protein 0.0029 0.0012 0.0026
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0315 0.4456 1
Leishmania major hypothetical protein, conserved 0.0073 0.0698 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0663 0.1322
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0012 0.0027
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0026
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0172 0.0172
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0071 0.0663 0.1464
Loa Loa (eye worm) hypothetical protein 0.0073 0.0698 0.154
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0093 0.0093
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0698 1
Loa Loa (eye worm) glutaminase 0.0266 0.3683 0.8129
Trichomonas vaginalis glutaminase, putative 0.0266 0.3683 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0111 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0698 1
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0008 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0012 0.0012
Onchocerca volvulus 0.0073 0.0698 0.222
Schistosoma mansoni peptidase Clp (S14 family) 0.0315 0.4456 0.4456
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0305 0.0305
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0172 0.0172
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0111 0.0111
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0315 0.4456 0.5
Echinococcus multilocularis lysosomal alpha glucosidase 0.032 0.4531 0.4531
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.032 0.4531 1
Echinococcus multilocularis GPCR, family 2 0.0048 0.0305 0.0305
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0071 0.0663 0.1322
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0468 0.1033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0012 0.0012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0698 0.154
Brugia malayi intermediate filament protein 0.0054 0.0397 0.0876
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0698 0.0327
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0305 0.0672
Brugia malayi jmjC domain containing protein 0.0093 0.1 0.2208
Schistosoma mansoni hypothetical protein 0.0104 0.1168 0.1168
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0012 0.0012
Echinococcus multilocularis tumor protein p63 0.0329 0.4672 0.4672
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0305 0.0672
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0698 0.1421
Echinococcus multilocularis lysosomal alpha glucosidase 0.032 0.4531 0.4531
Brugia malayi Probable ClpP-like protease 0.0315 0.4456 0.9835
Loa Loa (eye worm) hypothetical protein 0.0104 0.1168 0.2578
Plasmodium vivax SET domain protein, putative 0.0029 0.0012 0.0027
Loa Loa (eye worm) hypothetical protein 0.0073 0.0698 0.154
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0093 0.0093
Onchocerca volvulus 0.0048 0.0308 0.0981
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0698 0.0698
Trichomonas vaginalis esterase, putative 0.0073 0.0698 0.1421
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0698 0.0698
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.015 0.0336
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0071 0.0663 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.032 0.4531 1
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0397 0.0876
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0698 0.1421
Onchocerca volvulus 0.0054 0.0397 0.1262
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0315 0.4456 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0207 0.277 0.5512
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0663 0.1322
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0584 0.0584
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0491 0.0491
Loa Loa (eye worm) hypothetical protein 0.0048 0.0308 0.0681
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0305 0.0672
Schistosoma mansoni alpha-glucosidase 0.0276 0.3839 0.3839
Schistosoma mansoni alpha-glucosidase 0.0276 0.3839 0.3839
Echinococcus granulosus lamin 0.0054 0.0397 0.0397
Schistosoma mansoni glutaminase 0.0266 0.3683 0.3683
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0111 0.0111
Echinococcus granulosus peptidase Clp S14 family 0.0207 0.277 0.277
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0698 0.154
Brugia malayi Pre-SET motif family protein 0.0203 0.2709 0.5978
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0584 0.0584
Echinococcus granulosus GPCR family 2 0.0048 0.0305 0.0305
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0663 0.1322
Onchocerca volvulus 0.0185 0.2435 0.7746
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0305 0.0305
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.1912 0.4221
Onchocerca volvulus 0.0073 0.0698 0.222
Echinococcus multilocularis neuropeptide s receptor 0.0456 0.6645 0.6645
Toxoplasma gondii hypothetical protein 0.0109 0.1247 0.2798
Echinococcus multilocularis musashi 0.0054 0.0397 0.0397
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0315 0.4456 1
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0698 0.0523
Schistosoma mansoni alpha glucosidase 0.0071 0.0663 0.0663
Mycobacterium tuberculosis Conserved protein 0.0073 0.0698 0.0327
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0315 0.4456 0.5
Echinococcus granulosus neutral alpha glucosidase AB 0.0071 0.0663 0.0663
Echinococcus granulosus peregrin 0.0032 0.0054 0.0054
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2709 0.5978
Loa Loa (eye worm) glutaminase 2 0.0266 0.3683 0.8129
Loa Loa (eye worm) acetyltransferase 0.0141 0.1746 0.3854
Loa Loa (eye worm) hypothetical protein 0.0152 0.1912 0.4221
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.1168 0.2578
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0093 0.0093
Echinococcus multilocularis microtubule associated protein 2 0.0672 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0698 0.154
Trichomonas vaginalis maltase-glucoamylase, putative 0.0071 0.0663 0.1322
Brugia malayi Bromodomain containing protein 0.0032 0.0054 0.0118
Echinococcus multilocularis lamin dm0 0.0054 0.0397 0.0397
Loa Loa (eye worm) beta-lactamase 0.0073 0.0698 0.154
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0315 0.4456 0.4456
Brugia malayi TAR-binding protein 0.0066 0.0584 0.129
Mycobacterium ulcerans glutaminase 0.0266 0.3683 0.805
Mycobacterium ulcerans lipase LipD 0.0073 0.0698 0.0523
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0491 0.0491
Onchocerca volvulus 0.0073 0.0698 0.222
Brugia malayi map kinase activated protein kinase protein 2 0.0217 0.2936 0.6481
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0093 0.0204
Mycobacterium tuberculosis Conserved protein 0.0073 0.0698 0.0327
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0698 0.0327
Brugia malayi Glycosyl hydrolases family 31 protein 0.0071 0.0663 0.1464
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0049 0.0314 0.0693
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0012 0.0012
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0203 0.0456
Onchocerca volvulus 0.0231 0.3144 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0584 0.0584
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0093 0.0093
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0315 0.4456 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0012 0.0012
Brugia malayi beta-lactamase family protein 0.0073 0.0698 0.154
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0315 0.4456 1
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0698 0.1421
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.015 1
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.2936 0.2936
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0698 0.0698
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0663 0.1322
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0698 0.1421
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0698 0.0327
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0315 0.4456 1
Schistosoma mansoni hypothetical protein 0.0036 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0048 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0073 0.0698 0.154
Schistosoma mansoni hypothetical protein 0.0048 0.0305 0.0305
Schistosoma mansoni hypothetical protein 0.0048 0.0305 0.0305
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0584 0.129
Loa Loa (eye worm) hypothetical protein 0.0315 0.4456 0.9835
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0698 1
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0217 0.2936 0.2936
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0071 0.0663 0.1488
Brugia malayi hypothetical protein 0.0036 0.0111 0.0246
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1746 0.1746
Mycobacterium ulcerans hypothetical protein 0.0073 0.0698 0.0523
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0203 0.0456
Loa Loa (eye worm) hypothetical protein 0.0073 0.0698 0.154
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0315 0.4456 0.4456
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0217 0.2936 0.2936
Loa Loa (eye worm) RNA binding protein 0.0066 0.0584 0.129
Echinococcus multilocularis neutral alpha glucosidase AB 0.0071 0.0663 0.0663
Echinococcus granulosus neuropeptide s receptor 0.0456 0.6645 0.6645
Echinococcus granulosus lamin dm0 0.0054 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0053 0.0381 0.0842
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0704 0.0704
Onchocerca volvulus 0.0054 0.0397 0.1262
Mycobacterium ulcerans beta-lactamase 0.0073 0.0698 0.0523
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0698 0.0698
Schistosoma mansoni lamin 0.0054 0.0397 0.0397
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0698 0.0327
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0584 0.0584
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0207 0.277 0.3596
Loa Loa (eye worm) hypothetical protein 0.0054 0.0397 0.0876
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0315 0.4456 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0315 0.4456 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0305 0.0305
Onchocerca volvulus 0.0029 0.0012 0.0038
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0491 0.0491
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0584 0.129
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0584 0.0584
Echinococcus granulosus neuropeptide receptor A26 0.0456 0.6645 0.6645
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.1912 0.4221
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0071 0.0663 0.1322
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0468 0.6827 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0071 0.0663 1
Echinococcus multilocularis neuropeptide receptor A26 0.0456 0.6645 0.6645
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0698 0.0523
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0663 0.1322
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.1912 0.4221
Brugia malayi jmjC domain containing protein 0.0034 0.0093 0.0204
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1746 0.3854
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0698 0.0327
Echinococcus multilocularis peregrin 0.0032 0.0054 0.0054
Schistosoma mansoni lamin 0.0054 0.0397 0.0397
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0491 0.1101
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0698 0.1566
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1 0.1
Brugia malayi glutaminase DH11.1 0.0266 0.3683 0.8129
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0698 0.0327
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0012 0.0012
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0109 0.1247 0.1462
Brugia malayi RNA binding protein 0.0066 0.0584 0.129
Trichomonas vaginalis set domain proteins, putative 0.0231 0.3144 0.845
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.015 0.0691

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) < 0.003 uM Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis ChEMBL. 20591669
IC50 (functional) = 0.7 uM Inhibition of LPS-induced TNFalpha production in human PBMC preincubated for 30 mins measured after 3 hrs of LPS stimulation ChEMBL. 20591669
IC50 (binding) = 1.4 uM Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis ChEMBL. 20591669

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20591669

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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