Detailed information for compound 1086526

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 519.672 | Formula: C32H41NO5
  • H donors: 1 H acceptors: 4 LogP: 8.72 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCc1ccc(cc1)OCC(=O)Cn1cc(c2c1ccc(c2)C(=O)O)C(=O)CCCCC
  • InChi: 1S/C32H41NO5/c1-3-5-7-8-9-11-12-24-14-17-27(18-15-24)38-23-26(34)21-33-22-29(31(35)13-10-6-4-2)28-20-25(32(36)37)16-19-30(28)33/h14-20,22H,3-13,21,23H2,1-2H3,(H,36,37)
  • InChiKey: XCMKIPBGIUPMSH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus thymidylate synthase 0.0107 0.2476 0.292
Trypanosoma cruzi metacaspase, putative 0.0032 0.0434 0.1185
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.1173 0.1384
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.1106 0.3023
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0818 0.0818
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0105 0.0286
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0128 0.307 0.8837
Schistosoma mansoni jumonji domain containing protein 0.0059 0.1173 0.2629
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0818 0.1832
Echinococcus granulosus geminin 0.0169 0.4183 0.4933
Schistosoma mansoni caspase-7 (C14 family) 0.0118 0.2792 0.6256
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0118 0.2792 0.3292
Echinococcus multilocularis lamin 0.0032 0.0448 0.0528
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0105 0.0208
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.015 0.366 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.1106 0.1305
Brugia malayi glutathione reductase 0.0056 0.1106 0.1106
Trypanosoma cruzi metacaspase, putative 0.0032 0.0434 0.1185
Echinococcus multilocularis geminin 0.0169 0.4183 0.4933
Echinococcus multilocularis lamin dm0 0.0032 0.0448 0.0528
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0434 0.0461
Trypanosoma cruzi metacaspase, putative 0.0032 0.0434 0.1185
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0434 0.0461
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.1503 0.5895
Brugia malayi Muscleblind-like protein 0.0327 0.848 0.848
Echinococcus multilocularis muscleblind protein 1 0.0327 0.848 1
Mycobacterium tuberculosis Probable reductase 0.0128 0.307 0.8837
Echinococcus multilocularis musashi 0.0032 0.0448 0.0528
Echinococcus granulosus hypothetical protein 0.0032 0.0455 0.0537
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0079 0.1714 0.5
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0079 0.1714 0.2021
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0105 0.0217
Mycobacterium ulcerans thymidylate synthase 0.0107 0.2476 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0071 0.1503 0.4166
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0434 0.0461
Trypanosoma brucei calpain-like protein, putative 0.0133 0.3202 0.6637
Brugia malayi Pre-SET motif family protein 0.0248 0.6321 0.6321
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0133 0.3202 0.8747
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0107 0.2476 0.7067
Schistosoma mansoni lamin 0.0032 0.0448 0.1003
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0051 0.0954 0.2608
Leishmania major trypanothione reductase 0.0056 0.1106 0.2204
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.1503 0.5895
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.1542 0.4283
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0541 0.0638
Echinococcus multilocularis thymidylate synthase 0.0107 0.2476 0.292
Echinococcus multilocularis muscleblind protein 0.0327 0.848 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0434 0.0461
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0133 0.3202 0.8747
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0434 0.1185
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0133 0.3202 0.6637
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0128 0.307 0.8837
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0072 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0032 0.0434 0.0434
Brugia malayi Temporarily assigned gene name protein 44 0.0032 0.0456 0.0456
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0434 0.0461
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0071 0.1503 0.3368
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0818 0.1832
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0133 0.3202 0.6379
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.1542 0.606
Echinococcus granulosus intermediate filament protein 0.0032 0.0448 0.0528
Trichomonas vaginalis set domain proteins, putative 0.0282 0.7253 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0133 0.3202 0.6379
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0042 0.0042
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0434 0.1185
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0105 0.0286
Brugia malayi jmjC domain containing protein 0.0059 0.1173 0.1173
Trypanosoma brucei metacaspase 0.0032 0.0434 0.0899
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0818 0.0964
Brugia malayi Cell death protein 3 precursor 0.0032 0.0434 0.0434
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0105 0.0123
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0434 0.0461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0818 0.1832
Loa Loa (eye worm) dihydrofolate reductase 0.0043 0.0757 0.0757
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0105 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0434 0.0461
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0105 0.0286
Brugia malayi Thioredoxin reductase 0.0056 0.1106 0.1106
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0818 0.0818
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0105 0.0286
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0143 0.3461 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.1173 0.2629
Mycobacterium tuberculosis Probable dehydrogenase 0.0128 0.307 0.8837
Echinococcus granulosus protein quaking 0.0032 0.0455 0.0537
Loa Loa (eye worm) tumor suppressor 0.0383 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0541 0.1213
Echinococcus granulosus lamin dm0 0.0032 0.0448 0.0528
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0128 0.307 0.8837
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0818 0.0964
Plasmodium falciparum glutathione reductase 0.0056 0.1106 0.3023
Trypanosoma brucei metacaspase MCA2 0.0032 0.0434 0.0899
Onchocerca volvulus 0.0032 0.0448 0.002
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.1714 0.4682
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0818 0.0964
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0133 0.3202 0.8747
Brugia malayi jmjC domain containing protein 0.0059 0.1173 0.1173
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.015 0.366 1
Onchocerca volvulus 0.0032 0.0448 0.002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.1106 0.2985
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0434 0.1185
Plasmodium falciparum metacaspase 1 0.0032 0.0434 0.1185
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0133 0.3202 0.6637
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0105 0.5
Brugia malayi intermediate filament protein 0.0032 0.0448 0.0448
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0079 0.1714 0.3414
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0448 0.0448
Brugia malayi hypothetical protein 0.0032 0.0456 0.0456
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.1503 0.1772
Echinococcus multilocularis caspase 8 0.0032 0.0434 0.0512
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.1542 0.606
Onchocerca volvulus 0.0282 0.7253 1
Schistosoma mansoni hypothetical protein 0.0169 0.4183 0.9374
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.1503 0.1772
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0541 0.0638
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0071 0.1503 0.2994
Echinococcus granulosus caspase 8 0.0032 0.0434 0.0512
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0105 0.5
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0105 0.0105
Echinococcus granulosus caspase 2 0.0032 0.0434 0.0512
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0434 0.1185
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0105 0.0208
Trypanosoma cruzi metacaspase, putative 0.0032 0.0434 0.1185
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.015 0.366 0.7587
Onchocerca volvulus 0.0107 0.2476 0.2995
Trypanosoma brucei hypothetical protein 0.0133 0.3202 0.6637
Echinococcus granulosus caspase 3 0.0087 0.1931 0.2277
Schistosoma mansoni dihydrofolate reductase 0.0043 0.0757 0.1697
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.1714 0.4682
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0105 0.0286
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0434 0.0972
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.1106 0.1106
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0105 0.0286
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0105 0.0208
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0032 0.0434 0.0972
Echinococcus multilocularis caspase 2 0.0032 0.0434 0.0512
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0434 0.1185
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0105 0.0286
Leishmania major metacaspase, putative 0.0032 0.0434 0.0864
Plasmodium falciparum glutathione reductase 0.002 0.0105 0.0286
Schistosoma mansoni intermediate filament proteins 0.0032 0.0448 0.1003
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.1173 0.1384
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.1542 0.3455
Schistosoma mansoni lamin 0.0032 0.0448 0.1003
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0105 0.0123
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0812 0.0958
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0105 0.5
Loa Loa (eye worm) glutathione reductase 0.0056 0.1106 0.1106
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0105 0.0286
Plasmodium falciparum thioredoxin reductase 0.002 0.0105 0.0286
Plasmodium falciparum metacaspase-like protein 0.0032 0.0434 0.1185
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0541 0.0638
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0434 0.1185
Loa Loa (eye worm) hypothetical protein 0.0032 0.0456 0.0456
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.1542 0.1818
Onchocerca volvulus 0.0036 0.0541 0.0157
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0105 0.0286
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0128 0.307 0.8837
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0105 0.0217
Plasmodium falciparum thioredoxin reductase 0.0056 0.1106 0.3023
Trypanosoma brucei Metacaspase-4 0.0032 0.0434 0.0899
Trypanosoma brucei trypanothione reductase 0.0056 0.1106 0.2293
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0105 0.0286
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0133 0.3202 0.6637
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.1542 0.4213
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.1542 0.606
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.015 0.366 1
Brugia malayi hypothetical protein 0.0051 0.0954 0.0954
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.1542 0.3072
Toxoplasma gondii thioredoxin reductase 0.0056 0.1106 0.3023
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0434 0.0461
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1173 0.1173
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0079 0.1714 0.1714
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0133 0.3202 0.6637
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0079 0.1714 0.384
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0079 0.1714 0.1714
Mycobacterium tuberculosis Hypothetical protein 0.0051 0.0954 0.2532
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0133 0.3202 0.6637
Leishmania major pteridine reductase 1 0.02 0.5019 1
Schistosoma mansoni caspase-3 (C14 family) 0.0118 0.2792 0.6256
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.0032 0.0448 0.0448
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0541 0.1213
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0133 0.3202 0.8747
Trypanosoma brucei metacaspase 5, putative 0.0032 0.0434 0.0899
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0071 0.1503 0.1503
Plasmodium vivax SET domain protein, putative 0.0036 0.0541 0.1479
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0954 0.1189
Echinococcus granulosus dihydrofolate reductase 0.0043 0.0757 0.0893
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0118 0.2792 0.3292
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0107 0.2476 0.636
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.1173 0.2629
Loa Loa (eye worm) hypothetical protein 0.0032 0.0434 0.0434
Trypanosoma brucei pteridine reductase 1 0.0193 0.4824 1
Echinococcus multilocularis dihydrofolate reductase 0.0043 0.0757 0.0893
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0434 0.0461
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0105 0.0286
Echinococcus multilocularis protein quaking 0.0032 0.0455 0.0537
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0032 0.0434 0.0434
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0105 0.0217
Plasmodium vivax glutathione reductase, putative 0.0056 0.1106 0.3023
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0042 0.0042
Echinococcus granulosus muscleblind protein 0.0327 0.848 1
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.1542 0.3455
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0133 0.3202 0.6637
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0448 0.0448
Trypanosoma brucei metacaspase MCA3 0.0032 0.0434 0.0899
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0105 0.0286
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0133 0.3202 0.6379
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0105 0.0286
Plasmodium vivax metacaspase 1, putative 0.0032 0.0434 0.1185
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0541 0.1213
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0434 0.0461
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.015 0.366 1
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.1106 0.3023
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.1173 0.1384
Loa Loa (eye worm) thymidylate synthase 0.0107 0.2476 0.2476
Mycobacterium tuberculosis Probable oxidoreductase 0.0143 0.3461 1
Brugia malayi Dihydrofolate reductase 0.0043 0.0757 0.0757
Schistosoma mansoni hypothetical protein 0.0032 0.0455 0.102
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0434 0.0461
Brugia malayi thymidylate synthase 0.0107 0.2476 0.2476
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0105 0.0208
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.1173 0.1384
Leishmania major dihydrofolate reductase-thymidylate synthase 0.015 0.366 0.7293
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.1106 0.1305
Echinococcus granulosus caspase 0.0118 0.2792 0.3292
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0541 0.1213
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0133 0.3202 0.8747
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0434 0.0461
Loa Loa (eye worm) hypothetical protein 0.0327 0.848 0.848
Loa Loa (eye worm) hypothetical protein 0.0327 0.848 0.848
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0434 0.0461
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0812 0.0958
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0248 0.6321 0.6321
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0818 0.0964
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.1542 0.1818
Chlamydia trachomatis dihydrofolate reductase 0.0043 0.0757 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0506 0.0596
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0434 0.0461
Echinococcus multilocularis caspase 3 0.0087 0.1931 0.2277
Echinococcus granulosus lamin 0.0032 0.0448 0.0528
Loa Loa (eye worm) hypothetical protein 0.0032 0.0432 0.0432
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0105 0.0217
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0434 0.0461
Brugia malayi dihydrofolate reductase family protein 0.0043 0.0757 0.0757
Trypanosoma brucei calpain, putative 0.0133 0.3202 0.6637
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0043 0.0757 0.2751
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0133 0.3202 0.6637
Treponema pallidum NADH oxidase 0.002 0.0105 0.5
Echinococcus multilocularis caspase 0.0118 0.2792 0.3292
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0128 0.307 0.8557
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0541 0.1479
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0107 0.2476 0.555
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0043 0.0757 0.1944
Loa Loa (eye worm) hypothetical protein 0.0036 0.0541 0.0541
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0143 0.3461 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0105 0.0234
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.1714 0.3552
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0143 0.3461 1
Schistosoma mansoni hypothetical protein 0.0032 0.0455 0.102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0105 0.0286
Schistosoma mansoni hypothetical protein 0.0169 0.4183 0.9374
Brugia malayi Pre-SET motif family protein 0.0036 0.0541 0.0541
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0079 0.1714 0.2021

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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