Detailed information for compound 1095239

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 342.349 | Formula: C17H18N4O4
  • H donors: 4 H acceptors: 5 LogP: 0.63 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1OC([C@@H]([C@@H]1O)O)n1cnc2c1ccnc2Nc1ccccc1
  • InChi: 1S/C17H18N4O4/c22-8-12-14(23)15(24)17(25-12)21-9-19-13-11(21)6-7-18-16(13)20-10-4-2-1-3-5-10/h1-7,9,12,14-15,17,22-24H,8H2,(H,18,20)/t12-,14-,15-,17?/m1/s1
  • InChiKey: KPNMTRMMPYUFBM-UBEPTHPKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0031 0.0532 0.6069
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0532 0.0404
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.025
Onchocerca volvulus 0.0014 0.0134 0.341
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0314 0.1126
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0314 0.1429
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0541 0.1973
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0332 0.0961
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.007 0.0317
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0314 0.1429
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0314 0.1429
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0314 0.1429
Trypanosoma cruzi hexose transporter 0.0032 0.0541 0.8107
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0314 0.1126
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.025
Brugia malayi ecdysone receptor 0.001 0.004 0.0145
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0332 0.3046
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0532 0.0617
Brugia malayi steroid hormone receptor 0.0022 0.0314 0.1126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.004 0.0184
Onchocerca volvulus 0.0014 0.0134 0.341
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.004 0.0145
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0517 0.235
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0314 0.1429
Brugia malayi major facilitator superfamily protein 0.0014 0.0134 0.0479
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.22 1
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0134 0.0479
Onchocerca volvulus 0.0014 0.0134 0.341
Schistosoma mansoni sugar transporter 0.0014 0.0134 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0314 0.1126
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0314 0.1126
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0532 0.2418
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0332 0.1511
Echinococcus granulosus General substrate transporter 0.0088 0.1862 0.8463
Loa Loa (eye worm) hypothetical protein 0.0031 0.0532 0.1905
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0203 0.1383
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0314 0.1126
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.007 0.0317
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0517 0.235
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0517 0.1855
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0532 0.7919
Onchocerca volvulus 0.0014 0.0134 0.341
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0541 0.1973
Loa Loa (eye worm) hypothetical protein 0.0031 0.0517 0.1852
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.004 0.0184
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0532 0.0404
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0517 0.5615
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.004 0.0184
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.004 0.0184
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Echinococcus multilocularis solute carrier family 22 0.0014 0.0134 0.0608
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.22 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.004 0.0184
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0314 0.1429
Schistosoma mansoni zinc finger protein 0.001 0.004 0.0184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0314 0.1429
Brugia malayi tailless protein 0.001 0.004 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0314 0.1126
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Loa Loa (eye worm) sugar transporter 0.0014 0.0134 0.0479
Loa Loa (eye worm) DR-78 0.001 0.004 0.0145
Onchocerca volvulus 0.0014 0.0134 0.341
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0314 0.1126
Onchocerca volvulus 0.0014 0.0134 0.341
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3681 0.3595
Onchocerca volvulus 0.0014 0.0134 0.341
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0134 0.0608
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0314 0.1429
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Brugia malayi hypothetical protein 0.0014 0.0134 0.0479
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.22 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.004 0.0184
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0332 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0532 0.0404
Brugia malayi nuclear receptor NHR-88 0.0022 0.0314 0.1126
Plasmodium vivax CDK-related protein kinase 6, putative 0.0436 1 1
Echinococcus multilocularis General substrate transporter 0.0088 0.1862 0.8463
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0314 0.1429
Onchocerca volvulus 0.0014 0.0134 0.341
Mycobacterium ulcerans sugar transporter 0.0014 0.0134 0.2954
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0134 0.2954
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.22 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.007 0.0317
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0314 0.1429
Plasmodium vivax hexose transporter 0.0103 0.22 0.2094
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0541 0.1973
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0266 0.0641
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0314 0.1126
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0532 0.2418
Entamoeba histolytica hypothetical protein 0.0037 0.0661 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0134 0.0479
Brugia malayi Sugar transporter family protein 0.0014 0.0134 0.0479
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0332 0.1511
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0486 0.2211
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.004 0.0145
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0661 0.3006
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0541 0.8107
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0332 0.395
Brugia malayi hypothetical protein 0.0037 0.0661 0.2368
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.007 0.025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.22 1
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.004 0.0184
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0314 0.1429
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Schistosoma mansoni sugar transporter 0.0014 0.0134 0.0608
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.004 0.0145
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0532 0.2418
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0134 0.0479
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0332 0.0201
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0541 0.1973
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3681 0.3595
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0532 0.0404
Trypanosoma brucei glucose transporter 2A 0.0032 0.0541 0.8107
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0637 0.0779
Onchocerca volvulus 0.0022 0.0314 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.004 0.0184
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0314 0.1126
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0134 0.0479
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0532 0.0404
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.004 0.0145
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0637 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0314 0.1429
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0314 0.1126
Onchocerca volvulus 0.0014 0.0134 0.341
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.004 0.0184
Entamoeba histolytica protein kinase, putative 0.0031 0.0532 0.6069
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.004 0.0184
Plasmodium falciparum protein kinase 7 0.029 0.6589 0.6542
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0532 0.1905
Entamoeba histolytica hypothetical protein 0.0037 0.0661 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3681 0.5495
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.007 0.025
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0541 0.1973
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0134 0.0608
Schistosoma mansoni coup transcription factor 0.0022 0.0314 0.1429
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.22 0.3201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0314 0.1126
Brugia malayi nuclear receptor NHR-88 0.001 0.004 0.0145
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0314 0.1126
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0314 0.1126
Schistosoma mansoni glucose transport protein 0.0103 0.22 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0314 0.1126
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0332 0.1511
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0332 0.395
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0314 1
Brugia malayi Nuclear hormone receptor E75 0.001 0.004 0.0145
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0314 0.1429
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.22 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0314 0.1126
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.025
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0532 0.2418
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0517 1
Loa Loa (eye worm) sugar transporter 0.0103 0.22 0.7878
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0134 0.0608
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0314 0.1126
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0051 0.5
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0532 0.2418
Brugia malayi nuclear receptor RXR 0.0012 0.007 0.025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0314 0.1429
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0314 0.1429
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0314 0.1429
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0314 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0314 0.1429
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Echinococcus granulosus solute carrier family 22 0.0014 0.0134 0.0608
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0532 0.1927
Brugia malayi hypothetical protein 0.001 0.004 0.0145
Brugia malayi Nuclear hormone receptor E75 0.001 0.004 0.0145
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0314 0.1126
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0134 0.2954
Leishmania major glucose transporter, lmgt2 0.0032 0.0541 0.8107
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0637 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Brugia malayi Sugar transporter family protein 0.0014 0.0134 0.0479
Brugia malayi nuclear hormone receptor 0.001 0.004 0.0145
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0332 0.119
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.004 0.0184
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0532 0.0404
Onchocerca volvulus 0.0014 0.0134 0.341
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0134 0.2954
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0332 0.395
Loa Loa (eye worm) hypothetical protein 0.0025 0.0382 0.1367
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0314 0.1429
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0532 0.1905
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.025
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0517 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0332 0.119
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0517 0.1852
Schistosoma mansoni glucose transport protein 0.0103 0.22 1
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0637 0.051
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.004 0.0184
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0532 0.0617
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0314 0.1126
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0314 0.1429
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0332 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0314 0.1429
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0532 0.2418
Onchocerca volvulus 0.0014 0.0134 0.341
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0314 0.1126
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0314 0.1429
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Brugia malayi hypothetical protein 0.0014 0.0134 0.0479
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0134 0.0608
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0332 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0134 0.0608
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0541 0.8107
Brugia malayi nuclear hormone receptor 0.0022 0.0314 0.1126
Echinococcus multilocularis solute carrier family 22 0.0014 0.0134 0.0608
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.004 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0314 0.1126
Brugia malayi hypothetical protein 0.0012 0.007 0.025
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0134 0.0608
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Schistosoma mansoni hypothetical protein 0.0037 0.0661 0.3006
Schistosoma mansoni sugar transporter 0.0014 0.0134 0.0608
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0332 0.5182
Brugia malayi hypothetical protein 0.001 0.004 0.0145
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0332 0.0201
Brugia malayi hypothetical protein 0.0012 0.007 0.025
Echinococcus granulosus solute carrier family 22 0.0014 0.0134 0.0608
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0532 0.0617
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0314 0.1429
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0541 0.8107
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0517 0.1852
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0637 0.051
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0314 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0314 0.1429
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Onchocerca volvulus 0.0014 0.0134 0.341
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Echinococcus multilocularis solute carrier family 22 0.0014 0.0134 0.0608
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0541 0.1973
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.22 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0532 0.2418
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.004 0.0184
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0532 0.2418
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.007 0.025
Brugia malayi conserved hypotetical protein 0.001 0.004 0.0145
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0252 1
Entamoeba histolytica hypothetical protein 0.0037 0.0661 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0134 0.0608
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0314 0.1429
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Leishmania major glucose transporter, lmgt1 0.0032 0.0541 0.8107
Entamoeba histolytica hypothetical protein 0.0037 0.0661 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0532 0.0404
Schistosoma mansoni protein kinase 0.0031 0.0532 0.2418
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0517 0.235
Schistosoma mansoni nuclear receptor 0.001 0.004 0.0184
Loa Loa (eye worm) hypothetical protein 0.0031 0.0517 0.1852
Brugia malayi Cam kinase protein 1 0.0031 0.0532 0.1905
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0517 0.235
Brugia malayi nuclear receptor NHR-67 0.001 0.004 0.0145
Schistosoma mansoni protein kinase 0.0031 0.0532 0.2418
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.2793 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0637 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0486 0.2211
Leishmania major protein kinase, putative 0.0031 0.0532 0.7919
Onchocerca volvulus 0.0014 0.0134 0.341
Brugia malayi hypothetical protein 0.0014 0.0134 0.0479
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0314 0.1429
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.004 0.0184
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.22 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.025
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0092 0.0329
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.004 0.0145
Plasmodium falciparum hexose transporter 0.0103 0.22 0.2094
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0541 0.8107
Brugia malayi ecdysteroid receptor 0.0022 0.0314 0.1126
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0532 0.1905
Schistosoma mansoni nuclear receptor 0.001 0.004 0.0184
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0532 0.2418
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0541 0.8107
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0314 0.1429
Echinococcus granulosus solute carrier family 22 0.0014 0.0134 0.0608
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0314 0.1429
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.22 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0332 0.1511
Onchocerca volvulus 0.0014 0.0134 0.341
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0314 0.1126
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0541 0.1973
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0314 0.1126
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0252 1
Schistosoma mansoni protein kinase 0.0031 0.0532 0.2418
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.007 0.0317
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0532 0.0404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0314 0.1126
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0134 0.5
Onchocerca volvulus 0.0014 0.0134 0.341
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Schistosoma mansoni hypothetical protein 0.0103 0.22 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0541 0.8107
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0314 0.1429
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0314 0.1429
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0637 1
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.2793 1
Toxoplasma gondii protein kinase, putative 0.029 0.6589 1
Trypanosoma brucei glucose transporter 1E 0.0032 0.0541 0.8107
Schistosoma mansoni glucose transporter 0.0014 0.0134 0.0608
Brugia malayi nuclear receptor RXR 0.001 0.004 0.0145
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.004 0.0184
Schistosoma mansoni nuclear hormone receptor 0.001 0.004 0.0184
Brugia malayi major facilitator superfamily protein 0.0014 0.0134 0.0479
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0661 0.3006
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0314 0.1429
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.004 0.0145
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0637 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0541 0.8107
Brugia malayi MH2 domain containing protein 0.0128 0.2793 1
Schistosoma mansoni glucose transport protein 0.0103 0.22 1
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0314 0.1126
Onchocerca volvulus 0.0014 0.0134 0.341
Schistosoma mansoni sugar transporter 0.0014 0.0134 0.0608
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0332 0.0308
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0661 0.3006
Onchocerca volvulus Putative transporter 0.0014 0.0134 0.341
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0532 0.0404
Brugia malayi Sugar transporter family protein 0.0103 0.22 0.7878
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.004 0.0184
Leishmania major glucose transporter, lmgt3 0.0032 0.0541 0.8107

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 10 % Inhibition of lymphocyte-mediated cytolysis at a concentratioon of 100 uM in [51Cr]- labelled EL4 leukemia cells ChEMBL. 3941408
Inhibition (functional) = 18 % Compound was tested for inhibition of mouse connective tissue cell (L) growth at a concentration of 100 uM ChEMBL. 3941408

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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