TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 360.324 | Formula: C16H13N2O4PS
H donors: 2 H acceptors: 5 LogP: 1.48 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OP(=O)(COc1ccc(c2c1c1ncsc1C2)c1ccccn1)O
InChi: 1S/C16H13N2O4PS/c19-23(20,21)9-22-13-5-4-10(12-3-1-2-6-17-12)11-7-14-16(15(11)13)18-8-24-14/h1-6,8H,7,9H2,(H2,19,20,21)
InChiKey: OARGGSAUIUELQS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fructose-1,6-bisphosphatase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	Fructose-1 6-biphosphatase, related	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Candida albicans	similar to S. cerevisiae FBP1 (YLR377C) Fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Schistosoma japonicum	ko:K03841 fructose-1,6-bisphosphatase I, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania donovani	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Echinococcus granulosus	fructose 16 bisphosphatase 1	Get druggable targets OG5_127400	All targets in OG5_127400
Brugia malayi	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania braziliensis	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Toxoplasma gondii	fructose-bisphospatase II	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania mexicana	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma brucei gambiense	fructose-1,6-bisphosphate, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma congolense	fructose-1,6-bisphosphate, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Schistosoma mansoni	fructose-16-bisphosphatase-related	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania infantum	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania major		Get druggable targets OG5_127400	All targets in OG5_127400
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma brucei	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	fructose-bisphospatase I	fructose-1,6-bisphosphatase 1	338 aa	326 aa	31.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.004	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0049	0.048	0.0639
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0032	0.022	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0093	0.0123
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.004	0.0019
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0026	0.0134	0.0113
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0049	0.048	0.0639
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0093	0.0072
Echinococcus multilocularis	nuclear receptor nhr 48	0.0023	0.0093	0.0072
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0519	0.7513	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0049	0.048	0.0639
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0049	0.048	0.046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0049	0.048	0.0639
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0049	0.048	0.046
Schistosoma mansoni	zinc finger protein	0.0023	0.0093	0.0072
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0049	0.048	0.046
Loa Loa (eye worm)	hypothetical protein	0.0519	0.7513	1
Toxoplasma gondii	fructose-bisphospatase I	0.007	0.0798	0.2992
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0049	0.048	0.046
Onchocerca volvulus	Protein ultraspiracle homolog	0.0049	0.048	0.0522
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0426	0.0567
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0093	0.0123
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0093	0.0072
Schistosoma mansoni	nuclear receptor nhr-48	0.0023	0.0093	0.0072
Brugia malayi	nuclear hormone receptor	0.0023	0.0093	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0093	0.0123
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.007	0.0798	0.2992
Echinococcus multilocularis	FTZ F1 alpha	0.0049	0.048	0.046
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0426	0.0406
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.0189	0.2574	0.2558
Brugia malayi	hypothetical protein	0.0023	0.0093	0.0123
Brugia malayi	Steroid receptor seven-up type 2	0.0049	0.048	0.0639
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.004	0.0019
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0426	0.0406
Echinococcus granulosus	ecdysone induced protein 78C	0.0049	0.048	0.046
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0023	0.0093	0.0123
Brugia malayi	Intermediate filament tail domain containing protein	0.0032	0.022	0.0292
Brugia malayi	hypothetical protein	0.0023	0.0093	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0134	0.0179
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0023	0.0093	0.0072
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.004	0.5
Schistosoma mansoni	ap endonuclease	0.002	0.004	0.0019
Loa Loa (eye worm)	steroid hormone receptor	0.0049	0.048	0.0639
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0049	0.048	0.0639
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0049	0.048	0.0639
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.004	0.0053
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0049	0.048	0.046
Loa Loa (eye worm)	hypothetical protein	0.0049	0.048	0.0639
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0023	0.0093	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0049	0.048	0.0639
Leishmania major		0.0189	0.2574	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0049	0.048	0.046
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0049	0.048	0.046
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0049	0.048	0.046
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0426	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0032	0.022	0.0292
Onchocerca volvulus		0.0032	0.022	0.0171
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0023	0.0093	0.0072
Brugia malayi	hypothetical protein	0.0519	0.7513	1
Echinococcus multilocularis	Protein lozenge	0.0065	0.0721	0.0701
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.004	1
Schistosoma mansoni	nuclear receptor	0.0023	0.0093	0.0072
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0049	0.048	0.046
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.0189	0.2574	0.2558
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.007	0.0798	0.2992
Echinococcus multilocularis	lamin	0.0032	0.022	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0049	0.048	0.0639
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0049	0.048	0.0639
Schistosoma mansoni	lamin	0.0032	0.022	0.0199
Schistosoma mansoni	lamin	0.0032	0.022	0.0199
Brugia malayi	Nuclear hormone receptor E75	0.0023	0.0093	0.0123
Toxoplasma gondii	fructose-bisphospatase II	0.0189	0.2574	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.048	0.0639
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0049	0.048	0.0639
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0093	0.0123
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0189	0.2574	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.004	0.5
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0023	0.0093	0.0072
Loa Loa (eye worm)	runx1	0.0065	0.0721	0.096
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0026	0.0134	0.0113
Schistosoma mansoni	nuclear hormone receptor	0.0049	0.048	0.046
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0026	0.0134	0.0113
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.007	0.0798	0.2992
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0049	0.048	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0093	0.0123
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0049	0.048	0.0522
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0426	0.0406
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0482	0.0642
Brugia malayi	nuclear receptor RXR	0.0026	0.0134	0.0179
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0049	0.048	0.046
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0023	0.0093	0.0072
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0023	0.0093	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0049	0.048	0.0639
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0482	0.0642
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0023	0.0093	0.0072
Brugia malayi	nuclear receptor RXR	0.0023	0.0093	0.0123
Echinococcus granulosus	lamin dm0	0.0032	0.022	0.0199
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0093	0.0123
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0093	0.0072
Echinococcus multilocularis	microtubule associated protein 2	0.0685	1	1
Onchocerca volvulus		0.0519	0.7513	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0049	0.048	0.046
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0049	0.048	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0093	0.0123
Schistosoma mansoni	thyroid hormone receptor	0.0049	0.048	0.046
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0134	0.0179
Schistosoma mansoni	lozenge	0.0065	0.0721	0.0701
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0026	0.0134	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0049	0.048	0.0639
Brugia malayi	ecdysteroid receptor	0.0049	0.048	0.0639
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0049	0.048	0.046
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0049	0.048	0.046
Echinococcus granulosus	thyroid hormone receptor alpha	0.0023	0.0093	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0093	0.0123
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0093	0.0072
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0189	0.2574	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0249	0.0229
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.004	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0049	0.048	0.0639
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0249	0.0332
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0049	0.048	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0093	0.0123
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0049	0.048	0.0639
Brugia malayi	intermediate filament protein	0.0032	0.022	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0249	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0134	0.0179
Schistosoma mansoni	coup transcription factor	0.0049	0.048	0.046
Brugia malayi	Nuclear hormone receptor-like 1	0.0049	0.048	0.0639
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0049	0.048	0.046
Brugia malayi	fructose-1,6-bisphosphatase	0.0189	0.2574	0.3426
Schistosoma mansoni	microtubule-associated protein tau	0.0685	1	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0049	0.048	0.046
Echinococcus granulosus	nuclear receptor nhr 48	0.0023	0.0093	0.0072
Brugia malayi	nuclear hormone receptor family member odr-7	0.0023	0.0093	0.0123
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0426	0.0567
Loa Loa (eye worm)	intermediate filament protein	0.0032	0.022	0.0292
Echinococcus granulosus	lamin	0.0032	0.022	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0049	0.048	0.0639
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0023	0.0093	0.0123
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0049	0.048	0.0639
Brugia malayi	hypothetical protein	0.0026	0.0134	0.0179
Brugia malayi	photoreceptor-specific nuclear receptor	0.0049	0.048	0.0639
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0049	0.048	0.046
Brugia malayi	nuclear receptor NHR-67	0.0023	0.0093	0.0123
Onchocerca volvulus		0.0032	0.022	0.0171
Brugia malayi	Nuclear hormone receptor E75	0.0023	0.0093	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0093	0.0123
Schistosoma mansoni	nuclear receptor	0.0023	0.0093	0.0072
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0023	0.0093	0.0072
Loa Loa (eye worm)	nuclear hormone receptor	0.0023	0.0093	0.0123
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.004	1
Brugia malayi	conserved hypotetical protein	0.0023	0.0093	0.0123
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0049	0.048	0.0639
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0023	0.0093	0.0123
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0049	0.048	0.046
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.0189	0.2574	0.3426
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0049	0.048	0.0639
Loa Loa (eye worm)	DR-78	0.0023	0.0093	0.0123
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.0189	0.2574	0.2558
Onchocerca volvulus	Bile acid receptor homolog	0.0049	0.048	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0093	0.0123
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0482	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0093	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0093	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0211	0.0281
Brugia malayi	ecdysone receptor	0.0023	0.0093	0.0123
Schistosoma mansoni	retinoic acid receptor RXR	0.0049	0.048	0.046
Echinococcus multilocularis	ecdysone induced protein 78C	0.0049	0.048	0.046
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0049	0.048	0.0639
Schistosoma mansoni	intermediate filament proteins	0.0032	0.022	0.0199
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0049	0.048	0.046
Brugia malayi	Nuclear hormone receptor-like 1	0.0026	0.0134	0.0179
Onchocerca volvulus		0.0049	0.048	0.0522
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.004	0.0053
Brugia malayi	tailless protein	0.0023	0.0093	0.0123
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0426	0.0406
Brugia malayi	Nuclear hormone receptor-like 1	0.0026	0.0134	0.0179
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.007	0.0798	0.2992
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0426	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0134	0.0179
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0049	0.048	0.046
Brugia malayi	nuclear hormone receptor	0.0049	0.048	0.0639
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.004	1
Schistosoma mansoni	ap endonuclease	0.002	0.004	0.0019
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0049	0.048	0.0639
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.0189	0.2574	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0049	0.048	0.0639
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0049	0.048	0.046
Echinococcus granulosus	intermediate filament protein	0.0032	0.022	0.0199
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0426	0.0406
Brugia malayi	hypothetical protein	0.0026	0.0134	0.0179
Echinococcus multilocularis	musashi	0.0032	0.022	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0482	0.0642
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0049	0.048	0.046
Brugia malayi	nuclear receptor NHR-88	0.0049	0.048	0.0639
Brugia malayi	steroid hormone receptor	0.0049	0.048	0.0639
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0049	0.048	0.0639
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0023	0.0093	0.0072
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0026	0.0134	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0093	0.0123
Schistosoma mansoni	RAR-like nuclear receptor	0.0049	0.048	0.046
Echinococcus multilocularis	lamin dm0	0.0032	0.022	0.0199
Echinococcus granulosus	FTZ F1 alpha	0.0049	0.048	0.046
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0023	0.0093	0.0072
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0049	0.048	0.0639
Brugia malayi	orphan nuclear receptor NR2E1	0.0023	0.0093	0.0123
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0018	0.0021	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0134	0.0179
Schistosoma mansoni	thyroid hormone receptor	0.0049	0.048	0.046

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 40 nM	Inhibition of human liver recombinant FBPase	ChEMBL.	20045638

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL603871

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1098533