Detailed information for compound 1103880

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 337.416 | Formula: C11H19N3O5S2
  • H donors: 4 H acceptors: 5 LogP: -1.28 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCC[C@@H](C(=O)N[C@H](C(=O)N)CC(=O)O)NC(=O)CS
  • InChi: 1S/C11H19N3O5S2/c1-21-3-2-6(13-8(15)5-20)11(19)14-7(10(12)18)4-9(16)17/h6-7,20H,2-5H2,1H3,(H2,12,18)(H,13,15)(H,14,19)(H,16,17)/t6-,7-/m0/s1
  • InChiKey: UJOWAJHFKPNLAW-BQBZGAKWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) Pseudolysin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax importin-beta 2, putative 0.0028 0.0076 0.0746
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0011 0.0009
Trichomonas vaginalis bromodomain-containing protein, putative 0.0085 0.0424 0.3923
Loa Loa (eye worm) acetyltransferase 0.0289 0.1682 0.9459
Mycobacterium tuberculosis Possible exported protein 0.0612 0.3677 0.5232
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0085 0.0424 0.4177
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0052 0.1357
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0125 0.1233
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0092 0.0546
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0181 0.1015 0.5706
Onchocerca volvulus 0.0181 0.1015 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0293 0.1499
Plasmodium falciparum importin beta, putative 0.0028 0.0076 0.1991
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0076 0.0746
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0293 0.1499
Mycobacterium leprae Probable lipase LipE 0.0181 0.1015 1
Trichomonas vaginalis esterase, putative 0.0181 0.1015 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0092 0.0321
Brugia malayi jmjC domain containing protein 0.0061 0.0276 0.1639
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0042 0.0418
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0181 0.1015 0.1439
Onchocerca volvulus 0.0181 0.1015 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0049 0.0375
Brugia malayi RNA binding protein 0.0064 0.0293 0.174
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0125 0.0851
Schistosoma mansoni hypothetical protein 0.0037 0.0127 0.065
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0131 0.091
Mycobacterium ulcerans hypothetical protein 0.0024 0.0049 0.0375
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0181 0.1015 0.1439
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0293 0.1499
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.1015 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.0734 0.4128
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0131 0.091
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0131 0.129
Plasmodium vivax hypothetical protein, conserved 0.0181 0.1015 1
Brugia malayi TAR-binding protein 0.0064 0.0293 0.174
Brugia malayi MH2 domain containing protein 0.0121 0.065 0.3864
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0062
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0274
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0049 0.0479
Brugia malayi hypothetical protein 0.0025 0.0052 0.0307
Schistosoma mansoni importin beta-1 0.0028 0.0076 0.0388
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0062
Entamoeba histolytica hypothetical protein 0.0037 0.0127 0.2504
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0125 0.1137
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0049 0.0289
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0181 0.1015 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0734 0.3759
Schistosoma mansoni hypothetical protein 0.0031 0.0092 0.047
Brugia malayi hypothetical protein 0.0037 0.0127 0.0755
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0049 0.0375
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0276 0.1412
Echinococcus granulosus geminin 0.0332 0.1953 0.6837
Brugia malayi Inositol-1 0.0036 0.0125 0.0744
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0049 0.0375
Echinococcus multilocularis geminin 0.0332 0.1953 0.1953
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0125 0.0438
Leishmania major hypothetical protein, conserved 0.0025 0.0052 0.0508
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0181 0.1015 0.5196
Mycobacterium tuberculosis Probable hydrolase 0.0181 0.1015 0.1439
Loa Loa (eye worm) hypothetical protein 0.0146 0.0802 0.4507
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.0942 0.5596
Echinococcus multilocularis beta LACTamase domain containing family member 0.0181 0.1015 0.1015
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0049 0.0375
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0276 0.0276
Mycobacterium tuberculosis Conserved protein 0.0181 0.1015 0.1439
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0276 0.1551
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0102 0.0138
Onchocerca volvulus 0.0146 0.0802 0.7792
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0052 0.1357
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0507 0.3012
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0131 0.091
Mycobacterium ulcerans hypothetical protein 0.0181 0.1015 1
Echinococcus multilocularis neuropeptide receptor A26 0.0479 0.2857 0.2857
Toxoplasma gondii ABC1 family protein 0.0181 0.1015 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0052 0.0508
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0092 0.0092
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0293 0.1646
Leishmania major importin beta-1 subunit, putative 0.0023 0.0042 0.0418
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0276 0.0965
Loa Loa (eye worm) hypothetical protein 0.0181 0.1015 0.5706
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0062
Loa Loa (eye worm) hypothetical protein 0.0181 0.1015 0.5706
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0315 0.1871
Loa Loa (eye worm) RNA binding protein 0.0064 0.0293 0.1646
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0131 0.091
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0276 0.1412
Brugia malayi RNA, U transporter 1 0.0081 0.04 0.2379
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0734 0.257
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.065 0.3655
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0131 0.2618
Mycobacterium tuberculosis Probable esterase LipL 0.0181 0.1015 0.1439
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0131 0.2618
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0125 0.1233
Loa Loa (eye worm) hypothetical protein 0.0181 0.1015 0.5706
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0011 0.5
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0125 0.1233
Brugia malayi hypothetical protein 0.0146 0.0802 0.4764
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0181 0.1015 0.5196
Schistosoma mansoni hypothetical protein 0.0031 0.0092 0.047
Mycobacterium ulcerans beta-lactamase 0.0181 0.1015 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0085 0.0424 0.4177
Echinococcus granulosus histone acetyltransferase KAT2B 0.0085 0.0424 0.1484
Loa Loa (eye worm) hypothetical protein 0.0181 0.1015 0.5706
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0049 0.0375
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0942 0.0942
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0052 0.0508
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0131 0.129
Mycobacterium tuberculosis Conserved protein 0.0181 0.1015 0.1439
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0052 0.0508
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0181 0.1015 0.5706
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0274
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0125 0.1233
Trichomonas vaginalis penicillin-binding protein, putative 0.0181 0.1015 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0127 0.065
Echinococcus multilocularis snurportin 1 0.0304 0.1779 0.1779
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0092 0.0546
Schistosoma mansoni hypothetical protein 0.0067 0.0315 0.1611
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0131 0.129
Schistosoma mansoni inositol monophosphatase 0.0036 0.0125 0.0641
Echinococcus granulosus GPCR family 2 0.0031 0.0092 0.0321
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0049 0.0289
Echinococcus granulosus beta LACTamase domain containing family member 0.0181 0.1015 0.3553
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0181 0.1015 0.5706
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0049 0.0184
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.065 0.3655
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0011 0.0289
Loa Loa (eye worm) inositol-1 0.0036 0.0125 0.0704
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0085 0.0424 0.4177
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0131 0.091
Schistosoma mansoni hypothetical protein 0.0031 0.0092 0.047
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.1015 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0507 0.285
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0289 0.1682 0.1682
Giardia lamblia Histone acetyltransferase GCN5 0.0078 0.038 0.5
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0289 0.1682 0.8614
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1153 0.7024 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0293 0.174
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0125 0.1233
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.0942 0.5294
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0304 0.1779 0.9107
Trypanosoma brucei hypothetical protein, conserved 0.0181 0.1015 1
Brugia malayi jmjC domain containing protein 0.0061 0.0276 0.1639
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0049 0.0479
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0276 0.1412
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0127 0.0445
Entamoeba histolytica acetyltransferase, GNAT family 0.0078 0.038 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0085 0.0424 0.3923
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.1779 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0131 0.0131
Leishmania major hypothetical protein, conserved 0.0181 0.1015 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0049 0.0062
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.1015 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0734 0.3759
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0131 0.091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0734 0.0734
Onchocerca volvulus 0.0098 0.0502 0.4695
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0011 0.0108
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0131 0.091
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0025 0.0052 0.029
Entamoeba histolytica hypothetical protein 0.0037 0.0127 0.2504
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0049 0.0062
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.0734 0.4364
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0131 0.0736
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0049 0.0184
Onchocerca volvulus 0.0181 0.1015 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0293 0.1499
Loa Loa (eye worm) hypothetical protein 0.0067 0.0315 0.177
Entamoeba histolytica hypothetical protein 0.0037 0.0127 0.2504
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0181 0.1015 0.1439
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0131 0.091
Echinococcus granulosus histone acetyltransferase KAT2B 0.028 0.1632 0.5714
Schistosoma mansoni inositol monophosphatase 0.0036 0.0125 0.0641
Loa Loa (eye worm) beta-lactamase 0.0181 0.1015 0.5706
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0942 0.0942
Brugia malayi beta-lactamase family protein 0.0181 0.1015 0.6032
Schistosoma mansoni hypothetical protein 0.0031 0.0092 0.047
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0125 0.2449
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0274
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0734 0.0734
Mycobacterium ulcerans esterase/lipase LipP 0.0181 0.1015 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0131 0.129
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.285
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0125 0.0851
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0125 0.0125
Echinococcus granulosus neuropeptide receptor A26 0.0479 0.2857 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0131 0.091
Loa Loa (eye worm) hypothetical protein 0.0028 0.0076 0.0426
Echinococcus multilocularis neuropeptide s receptor 0.0479 0.2857 0.2857
Loa Loa (eye worm) hypothetical protein 0.0031 0.0092 0.0516
Echinococcus granulosus snurportin 1 0.0304 0.1779 0.6226
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0734 0.3759
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0049 0.0375
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0049 0.0375
Brugia malayi beta-lactamase family protein 0.0181 0.1015 0.6032
Mycobacterium tuberculosis Probable lipase LipD 0.0181 0.1015 0.1439
Schistosoma mansoni alpha-glucosidase 0.0145 0.0796 0.4078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0062
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.0942 0.3296
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.1015 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0125 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0049 0.0479
Brugia malayi beta-lactamase 0.0181 0.1015 0.6032
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0102 0.0547
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0507 0.3012
Schistosoma mansoni alpha glucosidase 0.0037 0.0131 0.067
Echinococcus granulosus importin subunit beta 1 0.0028 0.0076 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.1015 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0092 0.0092
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0049 0.0184
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0734 0.257
Schistosoma mansoni alpha-glucosidase 0.0145 0.0796 0.4078
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0052 0.0508
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0131 0.0458
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0181 0.1015 0.6032
Mycobacterium ulcerans lipase LipD 0.0181 0.1015 1
Schistosoma mansoni hypothetical protein 0.0332 0.1953 1
Schistosoma mansoni hypothetical protein 0.0332 0.1953 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0076 0.0746
Trichomonas vaginalis penicillin-binding protein, putative 0.0181 0.1015 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0076 0.0746
Entamoeba histolytica hypothetical protein 0.0037 0.0127 0.2504
Trypanosoma brucei glucosidase, putative 0.0037 0.0131 0.129
Brugia malayi acetyltransferase, GNAT family protein 0.0289 0.1682 1
Echinococcus granulosus neuropeptide s receptor 0.0479 0.2857 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0092 0.0321
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0293 0.1646
Mycobacterium tuberculosis Probable lipase LipE 0.0181 0.1015 0.1439
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0049 0.0289
Echinococcus multilocularis GPCR, family 2 0.0031 0.0092 0.0092
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0131 0.0778
Mycobacterium tuberculosis Conserved protein 0.0181 0.1015 0.1439
Echinococcus granulosus tar DNA binding protein 0.0064 0.0293 0.1025
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0052 0.0508
Mycobacterium leprae conserved hypothetical protein 0.0181 0.1015 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0276 0.0965
Plasmodium falciparum histone acetyltransferase GCN5 0.0078 0.038 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0293 0.1499
Brugia malayi Importin beta-1 subunit 0.0028 0.0076 0.045
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0092 0.0516
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0125 0.0851

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 7 uM Inhibition of Pseudomonas aeruginosa LasB by fluorimetric assay in buffer of pH 7.2 ChEMBL. 19773163

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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