Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0135 | 0.0428 | 0.1997 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.0128 | 0.0363 | 0.059 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0805 | 0.599 | 1 |
Treponema pallidum | NAD synthetase | 0.0084 | 0 | 0.5 |
Trypanosoma brucei | glucosidase, putative | 0.0135 | 0.0428 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0805 | 0.599 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0176 | 0.0762 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.0068 | 0.0119 |
Mycobacterium ulcerans | arylamine N-acetyltransferase Nat | 0.1287 | 1 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0135 | 0.0428 | 0.1997 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0363 | 0.059 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0779 | 0.5773 | 0.9615 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0176 | 0.0762 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0085 | 0.001 | 0.0047 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0135 | 0.0428 | 0.0115 |
Toxoplasma gondii | Amylo-alpha-1,6-glucosidase | 0.0128 | 0.0363 | 0.8485 |
Schistosoma mansoni | alpha-glucosidase | 0.0755 | 0.5572 | 0.9652 |
Leishmania major | glycosyl hydrolase-like protein | 0.0085 | 0.001 | 0.0236 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0085 | 0.001 | 0.0047 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0135 | 0.0428 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0135 | 0.0428 | 0.1997 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0135 | 0.0428 | 0.1997 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0135 | 0.0428 | 0.0115 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0085 | 0.001 | 0.0236 |
Giardia lamblia | 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase | 0.0128 | 0.0363 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0085 | 0.001 | 0.0047 |
Plasmodium falciparum | glutamine-dependent NAD(+) synthetase, putative | 0.0084 | 0 | 0.5 |
Onchocerca volvulus | 0.0596 | 0.4253 | 1 | |
Entamoeba histolytica | glycogen debranching enzyme, putative | 0.0128 | 0.0363 | 0.8485 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0135 | 0.0428 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0342 | 0.2141 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0805 | 0.599 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0085 | 0.001 | 0.0047 |
Brugia malayi | dihydrofolate reductase family protein | 0.0176 | 0.0762 | 0.1257 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0176 | 0.0762 | 0.0709 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0085 | 0.001 | 0.0236 |
Schistosoma mansoni | alpha glucosidase | 0.0135 | 0.0428 | 0.0741 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0135 | 0.0428 | 0.1997 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0135 | 0.0428 | 1 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0128 | 0.0363 | 0.1694 |
Schistosoma mansoni | alpha-glucosidase | 0.0755 | 0.5572 | 0.9652 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0176 | 0.0762 | 0.1257 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0135 | 0.0428 | 0.1997 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0666 | 0.1153 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0779 | 0.5773 | 0.9615 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0135 | 0.0428 | 0.0698 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0085 | 0.001 | 0.0236 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0085 | 0.001 | 0.0047 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0805 | 0.599 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0135 | 0.0428 | 0.0698 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0135 | 0.0428 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0135 | 0.0428 | 0.1997 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0779 | 0.5773 | 0.9638 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0176 | 0.0762 | 0.0762 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0779 | 0.5773 | 0.9638 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0085 | 0.001 | 0.0047 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0135 | 0.0428 | 0.1997 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0135 | 0.0428 | 0.1997 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0085 | 0.001 | 0.0047 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0085 | 0.001 | 0.0047 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0176 | 0.0762 | 0.0762 |
Echinococcus granulosus | dihydrofolate reductase | 0.0176 | 0.0762 | 0.0709 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0085 | 0.001 | 0.0236 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0342 | 0.2141 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0176 | 0.0762 | 0.1257 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0135 | 0.0428 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0135 | 0.0428 | 1 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0779 | 0.5773 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0779 | 0.5773 | 0.5773 |
Schistosoma mansoni | dihydrofolate reductase | 0.0176 | 0.0762 | 0.132 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0128 | 0.0363 | 0.1694 |
Plasmodium vivax | glutamine-dependent NAD(+) synthetase, putative | 0.0084 | 0 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0805 | 0.599 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.