TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 403.878 | Formula: C21H23ClFN3O2
H donors: 1 H acceptors: 2 LogP: 6.42 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCOc1cc2c(ncnc2cc1OC)Nc1ccc(c(c1)Cl)F
InChi: 1S/C21H23ClFN3O2/c1-3-4-5-6-9-28-20-11-15-18(12-19(20)27-2)24-13-25-21(15)26-14-7-8-17(23)16(22)10-14/h7-8,10-13H,3-6,9H2,1-2H3,(H,24,25,26)
InChiKey: DFYLUEWHTLNPPA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0025	0.0426	0.0682
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0049	0.0049
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1444	0.1474
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.167	0.167
Loa Loa (eye worm)	hypothetical protein	0.001	0.0049	0.0079
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0513	0.0823
Leishmania major	basic transcription factor 3a, putative	0.0034	0.0669	0.0352
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0097	0.2266	0.2266
Schistosoma mansoni	cpg binding protein	0.003	0.0554	0.0554
Loa Loa (eye worm)	TK/INSR protein kinase	0.0058	0.1265	0.2027
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0049	0.0049
Echinococcus granulosus	epidermal growth factor receptor	0.0097	0.2266	0.2266
Echinococcus multilocularis	cpg binding protein	0.003	0.0554	0.0554
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.2153	1
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.1444	0.1444
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0049	0.0049
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0049	0.0049
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0856	0.0624
Echinococcus multilocularis	tar DNA binding protein	0.0073	0.167	0.167
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0049	0.0079
Giardia lamblia	Kinase, PLK	0.0092	0.2153	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0049	0.0079
Echinococcus granulosus	epidermal growth factor receptor	0.018	0.4391	0.4391
Loa Loa (eye worm)	RNA binding protein	0.0073	0.167	0.2676
Schistosoma mansoni	tyrosine kinase	0.018	0.4391	0.4391
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.2153	0.2502
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.04	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.167	0.167
Echinococcus multilocularis	epidermal growth factor receptor	0.018	0.4391	0.4391
Brugia malayi	Furin-like cysteine rich region family protein	0.018	0.4391	0.7036
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0049	0.0049
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.2153	1
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0092	0.2153	0.2153
Brugia malayi	RNA recognition motif domain containing protein	0.0073	0.167	0.2676
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0295	0.7331	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0049	0.0079
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0079	0.0079
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0049	0.0079
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0049	0.0049
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0049	0.0079
Echinococcus granulosus	tar DNA binding protein	0.0073	0.167	0.167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0426	0.0682
Loa Loa (eye worm)	TAR-binding protein	0.0073	0.167	0.2676
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.167	0.167
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.167	0.167
Schistosoma mansoni	coup transcription factor	0.001	0.0049	0.0049
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.3362	0.4253
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.2153	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0049	0.0079
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0049	0.0079
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0049	0.0049
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0964	0.1983
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.001	0.0049	0.0079
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0049	0.0049
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0513	0.0823
Schistosoma mansoni	hypothetical protein	0.0011	0.0079	0.0079
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0049	0.0049
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.1154	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.018	0.4391	0.7036
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0092	0.2153	1
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.1444	0.1474
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0049	0.0079
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.2775	0.4446
Treponema pallidum	hypothetical protein	0.0279	0.6915	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0196	0.4808	0.4808
Brugia malayi	nuclear hormone receptor	0.001	0.0049	0.0079
Echinococcus granulosus	insulin receptor	0.0058	0.1265	0.1265
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.2153	1
Leishmania major	mitochondrial DNA polymerase beta	0.0295	0.7331	1
Schistosoma mansoni	tyrosine kinase	0.0096	0.224	0.224
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.075	0.075
Brugia malayi	TAR-binding protein	0.0073	0.167	0.2676
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0049	0.0049
Schistosoma mansoni	tyrosine kinase	0.0097	0.2266	0.2266
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0049	0.0079
Schistosoma mansoni	tyrosine kinase	0.0058	0.1265	0.1265
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0073	0.167	0.2676
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0049	0.0079
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.2153	0.2502
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0295	0.7331	1
Echinococcus multilocularis		0.0056	0.1219	0.1219
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.014	0.3362	0.4253
Schistosoma mansoni	tyrosine kinase	0.0096	0.224	0.224
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0295	0.7331	1
Brugia malayi	nuclear receptor NHR-88	0.001	0.0049	0.0079
Brugia malayi	RNA binding protein	0.0073	0.167	0.2676
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0279	0.6915	1
Echinococcus multilocularis	dnaJ subfamily B	0.04	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0049	0.0079
Echinococcus granulosus	cpg binding protein	0.003	0.0554	0.0554
Echinococcus granulosus	transcription factor btf3	0.0034	0.0669	0.0669
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0279	0.6915	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0049	0.0079
Schistosoma mansoni	cpg binding protein	0.0028	0.0513	0.0513
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0049	0.0079
Echinococcus multilocularis	geminin	0.0196	0.4808	0.4808
Schistosoma mansoni	tyrosine kinase	0.0097	0.2266	0.2266
Plasmodium falciparum	basic transcription factor 3b, putative	0.0034	0.0669	0.0375
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0856	0.0624
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0079	0.0079
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0253	0.6242	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0856	0.0624
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.3362	0.4253
Brugia malayi	Protein kinase domain containing protein	0.0058	0.1265	0.2027
Schistosoma mansoni	kinase	0.0047	0.0995	0.0995
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0279	0.6915	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0049	0.0049
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0058	0.1265	0.1265
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0016	0.0025
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.167	0.167
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0049	0.0049
Schistosoma mansoni	transcription factor btf3	0.0034	0.0669	0.0669
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.001	0.0049	0.0079
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.1444	0.2313
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.2153	1
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0049	0.0049
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0049	0.0079
Brugia malayi	ecdysteroid receptor	0.001	0.0049	0.0079
Loa Loa (eye worm)	hypothetical protein	0.001	0.0049	0.0079
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0019	0.003
Schistosoma mansoni	cpg binding protein	0.003	0.0554	0.0554
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0049	0.0079
Onchocerca volvulus		0.0028	0.0513	0.2207
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0279	0.6915	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0049	0.0049
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0669	0.0352
Brugia malayi	hypothetical protein	0.0016	0.0203	0.0325
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.2153	0.2153
Loa Loa (eye worm)	hypothetical protein	0.001	0.0049	0.0079
Loa Loa (eye worm)	ICD-1 protein	0.0034	0.0669	0.1072
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0049	0.0079
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.1444	0.1444
Loa Loa (eye worm)	hypothetical protein	0.001	0.0049	0.0079
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0049	0.0079
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.2775	0.4446
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0058	0.1265	0.1265
Brugia malayi	serine/threonine-protein kinase plk-2	0.0092	0.2153	0.345
Schistosoma mansoni	tyrosine kinase	0.0058	0.1265	0.1265
Plasmodium vivax	basic transcription factor 3b, putative	0.0034	0.0669	0.0375
Brugia malayi	follicle stimulating hormone receptor	0.0253	0.6242	1
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0049	0.0079
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0049	0.0049
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0049	0.0049
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.2153	1
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0964	0.1983
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0049	0.0079
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.075	0.075
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0279	0.6915	1
Echinococcus granulosus	geminin	0.0196	0.4808	0.4808
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0856	0.0624
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0049	0.0079
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0092	0.2153	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0049	0.0079
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0049	0.0049
Toxoplasma gondii	NAC domain-containing protein	0.0034	0.0669	0.3341
Echinococcus multilocularis	epidermal growth factor receptor	0.0097	0.2266	0.2266
Brugia malayi	steroid hormone receptor	0.001	0.0049	0.0079
Echinococcus multilocularis	insulin receptor	0.0058	0.1265	0.1265
Trypanosoma brucei	polo-like protein kinase	0.0092	0.2153	0.2502
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.1444	0.5219
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0019	0.0019
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0092	0.2153	0.2502
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0092	0.2153	0.345
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1444	0.1474
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0049	0.0049
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0049	0.0079
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0049	0.0079
Toxoplasma gondii	hypothetical protein	0.0048	0.1012	0.8049
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0049	0.0079
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0669	0.0352
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.1317	0.1317
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.1088	0.0959
Schistosoma mansoni	tyrosine kinase	0.0096	0.224	0.224
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0049	0.0079
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0049	0.0049
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0049	0.0079
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0049	0.0049
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.1444	0.1444
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1444	0.1474
Brugia malayi	beta-NAC-like protein	0.0034	0.0669	0.1072
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0049	0.0049
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0049	0.0049
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0049	0.0049
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0092	0.2153	0.2153
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.1444	0.2313
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0049	0.0049
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.2153	1
Echinococcus multilocularis	transcription factor btf3	0.0034	0.0669	0.0669
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0196	0.4808	0.4808
Brugia malayi	MH2 domain containing protein	0.0117	0.2775	0.4446
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0049	0.0049
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0049	0.0049
Trypanosoma brucei	transcription factor BTF3, putative	0.0034	0.0669	0.0352

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 106 nM	Inhibition of recombinant EGFR by ELISA	ChEMBL.	19969465

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL608860

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1114336