Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | phosphofructokinase, putative | 0.0121 | 0.2863 | 1 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0061 | 0.0721 | 0.1206 |
Loa Loa (eye worm) | MBCTL1 | 0.0061 | 0.0721 | 0.0649 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0053 | 0.0462 | 0.0771 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0053 | 0.0462 | 0.0771 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0061 | 0.0721 | 0.1206 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0167 | 0.4465 | 0.7461 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.021 | 0.5984 | 1 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0121 | 0.2863 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0061 | 0.0721 | 0.1206 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0104 | 0.2255 | 0.5 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0061 | 0.0721 | 0.1206 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0053 | 0.0462 | 0.0462 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0113 | 0.2582 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0113 | 0.2582 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0121 | 0.2863 | 0.6413 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.2863 | 1 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0104 | 0.2255 | 0.678 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0974 | 0.0974 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0121 | 0.2863 | 1 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0104 | 0.2255 | 0.505 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0068 | 0.0981 | 0.0045 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0121 | 0.2863 | 0.2863 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.0974 | 0.1628 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.2863 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.2863 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.4465 | 1 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0121 | 0.2863 | 0.4784 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0121 | 0.2863 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0974 | 0.0974 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.0462 | 0.0462 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.0462 | 0.1034 |
Echinococcus granulosus | muscleblind protein | 0.0167 | 0.4465 | 0.7461 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0104 | 0.2255 | 0.678 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0121 | 0.2863 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0721 | 0.0649 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0121 | 0.2863 | 0.5999 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0121 | 0.2863 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0053 | 0.0462 | 0.0771 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0113 | 0.2582 | 0.5 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0121 | 0.2863 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0121 | 0.2863 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0121 | 0.2863 | 0.2863 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0061 | 0.0721 | 0.1616 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0121 | 0.2863 | 0.5999 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0121 | 0.2863 | 0.5 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.0462 | 0.0462 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.0462 | 0.1034 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0104 | 0.2255 | 0.3768 |
Onchocerca volvulus | 0.0053 | 0.0462 | 0.5 | |
Brugia malayi | 6-phosphofructokinase | 0.0121 | 0.2863 | 0.6413 |
Brugia malayi | Muscleblind-like protein | 0.0167 | 0.4465 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0068 | 0.0981 | 0.0038 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0113 | 0.2582 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.021 | 0.5984 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.2863 | 1 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0121 | 0.2863 | 1 |
Loa Loa (eye worm) | phosphofructokinase | 0.0121 | 0.2863 | 0.5999 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.4465 | 1 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0104 | 0.2255 | 0.2255 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0053 | 0.0462 | 0.0771 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0053 | 0.0462 | 0.5 |
Brugia malayi | phosphofructokinase | 0.0121 | 0.2863 | 0.6413 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0104 | 0.2255 | 0.448 |
Echinococcus multilocularis | muscleblind protein | 0.0167 | 0.4465 | 0.7461 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0121 | 0.2863 | 0.4784 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0104 | 0.2255 | 0.3768 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.0974 | 0.1628 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0061 | 0.0721 | 0.0721 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.