TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 686.496 | Formula: C39H32Cl4N2O
H donors: 1 H acceptors: 0 LogP: 10.78 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(cc1)C1CC(c2ccc(cc2)Cl)C2/C(=N\OCc3ccccc3)/C1C(NC2c1ccc(cc1)Cl)c1ccc(cc1)Cl
InChi: 1S/C39H32Cl4N2O/c40-29-14-6-25(7-15-29)33-22-34(26-8-16-30(41)17-9-26)36-38(28-12-20-32(43)21-13-28)44-37(27-10-18-31(42)19-11-27)35(33)39(36)45-46-23-24-4-2-1-3-5-24/h1-21,33-38,44H,22-23H2
InChiKey: JFBIIOCVBRHFGD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0018	0.0161	0.0236
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.0614	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Entamoeba histolytica	hypothetical protein	0.0025	0.0317	0.4552
Onchocerca volvulus		0.0015	0.0084	0.0029
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0484	0.0404
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0018	0.0161	0.0216
Onchocerca volvulus		0.0015	0.0084	0.0029
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0019	0.0162	0.1715
Onchocerca volvulus		0.0015	0.0084	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Leishmania major	alpha glucosidase II subunit, putative	0.0039	0.0614	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0018	0.0161	0.17
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0333	0.0688
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.0614	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.8009
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0039	0.0614	0.1166
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0283	0.0557
Echinococcus granulosus	muscleblind protein	0.0153	0.3189	0.8667
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Schistosoma mansoni	glucose transport protein	0.0107	0.216	0.5819
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0589	0.9534
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0463	0.1058
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0484	0.0404
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0469	0.0855
Brugia malayi	hypothetical protein	0.0015	0.0084	0.0033
Onchocerca volvulus		0.0032	0.0463	0.0733
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0019	0.0162	0.1715
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0283	0.5182
Schistosoma mansoni	hypothetical protein	0.0038	0.061	0.1476
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0039	0.0614	0.1118
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.8009
Onchocerca volvulus		0.0015	0.0084	0.0029
Trypanosoma cruzi	target of rapamycin kinase 3	0.0018	0.0161	0.17
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.3938
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.3938
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1117
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.216	0.5795
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0018	0.0161	0.0217
Leishmania major	hypothetical protein, conserved	0.0015	0.0084	0.0284
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.216	0.5795
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0084	0.0284
Leishmania major	glucose transporter, lmgt3	0.0033	0.0493	0.7783
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0493	0.7783
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0084	0.0143
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0018	0.0161	0.17
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1117
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0283	0.3046
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0042	0.0075
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0018	0.0161	0.2548
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0463	0.0696
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.216	0.5795
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0161	0.17
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0469	0.1075
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0084	0.0284
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0614	0.1118
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0018	0.0161	0.17
Loa Loa (eye worm)	sugar transporter	0.0015	0.0084	0.0163
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0589	0.9534
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0589	0.051
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0173	0.3649	0.5548
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0469	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0018	0.0161	0.2548
Entamoeba histolytica	hypothetical protein	0.0024	0.0283	0.3938
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0469	0.1075
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0484	0.0404
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0283	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1117
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0068	0.0114
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1117
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0084	0.2954
Schistosoma mansoni	protein kinase	0.0033	0.0484	0.1121
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0025	0.0317	0.0531
Leishmania major	glucose transporter, lmgt2	0.0033	0.0493	0.7783
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0493	0.0895
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0018	0.0161	0.2548
Entamoeba histolytica	protein kinase, putative	0.0033	0.0484	0.761
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0018	0.0161	0.17
Onchocerca volvulus		0.0015	0.0084	0.0029
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0484	0.0728
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0484	0.0887
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0493	0.7783
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0084	0.0143
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0084	0.0118
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0493	0.8009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0018	0.0161	0.2548
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0463	0.0962
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0463	0.1058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.061	0.1469
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0084	0.0284
Schistosoma mansoni	hypothetical protein	0.0173	0.3652	1
Entamoeba histolytica	hypothetical protein	0.0038	0.061	0.9923
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0614	0.1118
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0469	0.0855
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0161	0.17
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0493	0.0895
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0014	0.0068	0.0114
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0614	0.1118
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0614	0.1118
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0283	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0484	0.0404
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0493	0.8009
Echinococcus granulosus	geminin	0.0173	0.3652	0.9959
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Brugia malayi	Sugar transporter family protein	0.0107	0.216	0.4464
Leishmania major	protein kinase, putative	0.0033	0.0484	0.761
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0025	0.0317	0.0653
Brugia malayi	major facilitator superfamily protein	0.0015	0.0084	0.0033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0173	0.3649	0.3595
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0493	0.8009
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0084	0.0143
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0039	0.0614	0.1481
Giardia lamblia	GTOR	0.0018	0.0161	0.2008
Onchocerca volvulus		0.0101	0.2013	0.3615
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0084	0.5
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0614	0.1118
Echinococcus multilocularis	General substrate transporter	0.0092	0.1821	0.4847
Toxoplasma gondii	protein kinase, putative	0.0303	0.6571	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0174	0.3667	0.7708
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0485
Brugia malayi	major facilitator superfamily protein	0.0015	0.0084	0.0033
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.0509
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0018	0.0161	0.0216
Toxoplasma gondii	facilitative glucose transporter GT1	0.0107	0.216	0.3281
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0283	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Echinococcus multilocularis	muscleblind protein	0.0153	0.3189	0.8667
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0174	0.3667	1
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0084	0.0118
Trichomonas vaginalis	conserved hypothetical protein	0.0107	0.216	0.3959
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0039	0.0614	0.0927
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0018	0.0161	0.17
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.0033
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.216	0.5795
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0039	0.0614	0.1281
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0589	0.0888
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.8009
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.8009
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0484	0.1006
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0068	0.0114
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0484	0.1006
Leishmania major	glucose transporter, lmgt1	0.0033	0.0493	0.7783
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0084	0.0118
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1117
Entamoeba histolytica	protein kinase, putative	0.0033	0.0484	0.761
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0068	0.0114
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Echinococcus multilocularis	muscleblind protein 1	0.0153	0.3189	0.8667
Entamoeba histolytica	hypothetical protein	0.0038	0.061	0.9923
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0084	0.0118
Echinococcus granulosus	serine protein kinase ATM	0.0025	0.0317	0.0651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0484	0.0404
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Loa Loa (eye worm)	sugar transporter	0.0107	0.216	0.4536
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Onchocerca volvulus		0.0015	0.0084	0.0029
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0018	0.0161	0.17
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0025	0.0317	0.4552
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.0033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0068	0.0114
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0484	0.1121
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0484	0.0404
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0493	0.8009
Echinococcus granulosus	neutral alpha glucosidase AB	0.0039	0.0614	0.1481
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0469	0.0975
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0084	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0153	0.3189	0.6702
Onchocerca volvulus		0.0015	0.0084	0.0029
Onchocerca volvulus		0.0015	0.0084	0.0029
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Echinococcus multilocularis	geminin	0.0173	0.3652	0.9959
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Schistosoma mansoni	protein kinase	0.0033	0.0484	0.1121
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Plasmodium vivax	hexose transporter	0.0107	0.216	0.2094
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0222	0.4755	1
Onchocerca volvulus		0.0015	0.0084	0.0029
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0161	0.0198
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0436	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Brugia malayi	Sugar transporter family protein	0.0015	0.0084	0.0033
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0018	0.0161	0.2548
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0283	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0469	0.0975
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0469	0.7335
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0084	0.0143
Brugia malayi	Pre-SET motif family protein	0.0222	0.4755	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0161	0.0326
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.0163
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.8009
Entamoeba histolytica	hypothetical protein	0.0038	0.061	0.9923
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0084	0.1276
Onchocerca volvulus		0.0015	0.0084	0.0029
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0463	0.1062
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0014	0.0068	0.1021
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0614	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0161	0.0198
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0589	0.9534
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0493	0.0895
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0173	0.3649	0.3595
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Echinococcus multilocularis	serine protein kinase ATM	0.0025	0.0317	0.0651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Echinococcus granulosus	lysosomal alpha glucosidase	0.0174	0.3667	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0084	0.2954
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0455	1	1
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0438	0.0989
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0161	0.0326
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0202	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.216	0.5795
Loa Loa (eye worm)	hypothetical protein	0.0153	0.3189	0.6702
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0614	0.1118
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0283	0.0422
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0174	0.3667	0.7678
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0202	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.0161	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0018	0.0161	0.17
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0	0.5
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0484	0.1117
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0484	0.0728
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0614	0.1118
Onchocerca volvulus		0.0015	0.0084	0.0029
Echinococcus granulosus	General substrate transporter	0.0092	0.1821	0.4847
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0463	0.1062
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0283	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0484	0.0404
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0283	0.0559
Trypanosoma brucei	glucosidase, putative	0.0039	0.0614	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0068	0.0114
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.8009
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0283	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0084	0.0143
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0493	0.7783
Onchocerca volvulus		0.0015	0.0084	0.0029
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0484	0.0878
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0493	0.0895
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0039	0.0614	0.1118
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0484	0.0404
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0463	0.1062
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0283	0.0584
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0018	0.0161	0.17
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0493	0.0895
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1117
Schistosoma mansoni	protein kinase	0.0033	0.0484	0.1121
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.8009
Mycobacterium ulcerans	sugar transporter	0.0015	0.0084	0.2954
Toxoplasma gondii	FATC domain-containing protein	0.0025	0.0317	0.0473
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0317	0.0571
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0469	0.1079
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0589	0.9534
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0283	1
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0493	0.0895
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0084	0.0143
Onchocerca volvulus		0.0015	0.0084	0.0029
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Schistosoma mansoni	alpha-glucosidase	0.015	0.3121	0.8511
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0484	0.0728
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.216	0.5795
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.4557
Brugia malayi	Cam kinase protein 1	0.0033	0.0484	0.0887
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0154	0.1564
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.216	0.5795
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.0033
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0589	0.051
Plasmodium falciparum	protein kinase 7	0.0303	0.6571	0.6542
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Brugia malayi	hypothetical protein	0.0015	0.0084	0.0033
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.061	0.1476
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0438	0.0989
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0068	0.0131
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0493	0.7783
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0217	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0469	1
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0484	0.7854
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0014	0.0068	0.0114
Onchocerca volvulus		0.0015	0.0084	0.0029
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.0237	0.3083
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Brugia malayi	Muscleblind-like protein	0.0153	0.3189	0.6659
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0084	0.0143
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.8009
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0283	0.0559
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0484	0.1006
Onchocerca volvulus		0.0253	0.5448	1
Entamoeba histolytica	hypothetical protein	0.0038	0.061	0.9923
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0163
Plasmodium falciparum	hexose transporter	0.0107	0.216	0.2094
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0174	0.3667	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0025	0.0317	0.5108
Schistosoma mansoni	alpha-glucosidase	0.015	0.3121	0.8511
Plasmodium vivax	SET domain protein, putative	0.0032	0.0463	0.0382
Brugia malayi	Pre-SET motif family protein	0.0032	0.0463	0.0842
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0084	0.0284
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1117
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0493	0.8009
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Schistosoma mansoni	hypothetical protein	0.0107	0.216	0.5819
Trypanosoma cruzi	hexose transporter	0.0033	0.0493	0.7783
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0084	0.2954
Schistosoma mansoni	alpha glucosidase	0.0039	0.0614	0.1487
Schistosoma mansoni	glucose transport protein	0.0107	0.216	0.5819
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0463	0.1062
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0469	0.1079
Onchocerca volvulus		0.0015	0.0084	0.0029
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0107	0.216	0.5795
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.0161	0.0216
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0493	0.0895
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0463	0.1058
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.061	0.1469
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0014	0.0068	0.0114
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.0161	0.0217
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0484	0.0404
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0161	0.0285
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0614	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0589	0.9582
Schistosoma mansoni	glucose transport protein	0.0107	0.216	0.5819
Trichomonas vaginalis	set domain proteins, putative	0.0253	0.5448	1
Brugia malayi	hypothetical protein	0.0015	0.0084	0.0033
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0469	0.0851
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0143
Schistosoma mansoni	hypothetical protein	0.0173	0.3652	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.0163
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0084	0.1276
Brugia malayi	hypothetical protein	0.0038	0.061	0.1157
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0018	0.0161	0.17
Onchocerca volvulus		0.0015	0.0084	0.0029
Brugia malayi	Sugar transporter family protein	0.0015	0.0084	0.0033
Onchocerca volvulus	Putative transporter	0.0015	0.0084	0.0029

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 12.5 ug ml-1	Antifungal activity against Candida albicans by twofold serial dilution method	ChEMBL.	19879756
MIC (functional)	= 50 ug ml-1	Antibacterial activity against Escherichia coli by twofold serial dilution method	ChEMBL.	19879756

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1075900

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1120097