TDR Targets

Basic information

Technical information

TDR Targets ID: 112271
Name: phosphono [(2E,4E,6E,8E)-3,7,11-trimethyldode ca-2,4,6,8,10-pentaenyl] hydrogen phosphate
MW: 378.294 | Formula: C15H24O7P2
H donors: 3 H acceptors: 5 LogP: 2.67 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: C/C(=C\COP(=O)(OP(=O)(O)O)O)/C=C/C=C(/C=C/C=C(C)C)\C
InChi: 1S/C15H24O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h5-11H,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b8-5+,10-6+,14-9+,15-11+
InChiKey: HGSJQRJNWSBKOL-BZCYSDSTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Saccharomyces cerevisiae	bifunctional protein farnesyltransferase/protein geranylgeranyltransferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Giardia lamblia	Rab geranylgeranyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium falciparum	protein farnesyltransferase subunit alpha	Get druggable targets OG5_128459	All targets in OG5_128459
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium knowlesi	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium parvum	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Theileria parva	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Babesia bovis	protein prenyltransferase alpha subunit repeat domain containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus granulosus	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium vivax	prenyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium hominis	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma mansoni	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium berghei	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	acetylcholinesterase	0.0138	0.2057	0.2021
Brugia malayi	Inositol-1	0.0036	0.0179	0.0074
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0163	0.2515	0.2435
Trypanosoma brucei	glucosidase, putative	0.0036	0.0183	0.2328
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4893	0.48
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0183	0.0005
Brugia malayi	Probable ClpP-like protease	0.0076	0.0916	0.0819
Schistosoma mansoni	hypothetical protein	0.0164	0.2547	0.2468
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.005	0.044	1
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.044	1
Echinococcus multilocularis	snurportin 1	0.034	0.5784	0.5879
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.3074	0.2948
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0183	0.0081
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0183	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1211	0.1117
Schistosoma mansoni	sex comb on midleg homolog	0.0117	0.168	0.1591
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.041	0.0308
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0916	0.5
Plasmodium falciparum	importin beta, putative	0.0032	0.0105	0.0343
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.044	1
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.005	0.044	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.2057	0.1973
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.041	0.0308
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.3074	0.2948
Brugia malayi	Carboxylesterase family protein	0.0138	0.2057	0.1973
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0183	0.0005
Onchocerca volvulus		0.0092	0.1211	0.6216
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0179	0.0074
Onchocerca volvulus		0.0117	0.168	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0916	0.0819
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0183	0.0079
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0163	0.2515	0.2435
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0179	0.0076
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0916	0.0751
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0556	0.9764	1
Echinococcus granulosus	snurportin 1	0.034	0.5784	0.5879
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0916	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0163	0.2515	0.2494
Echinococcus granulosus	carboxylesterase 5A	0.0138	0.2057	0.2021
Echinococcus granulosus	geminin	0.0164	0.2547	0.2528
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0435	0.0341
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.0916	0.298
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4893	0.48
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0179	0.0074
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0097	0.1305	0.6978
Loa Loa (eye worm)	mbt repeat family protein	0.0097	0.1305	0.1213
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0916	0.1872
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0193	0.3074	0.3073
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0092	0.1211	0.1117
Loa Loa (eye worm)	inositol-1	0.0036	0.0179	0.0074
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.005	0.044	0.0347
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0386	0.6636	0.6762
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0179	0.0076
Plasmodium vivax	importin-beta 2, putative	0.0032	0.0105	0.0343
Toxoplasma gondii	hypothetical protein	0.005	0.044	0.2046
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0183	0.0005
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.044	1
Echinococcus granulosus	neuropeptide s receptor	0.0458	0.7969	0.8142
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0916	0.5
Schistosoma mansoni	hypothetical protein	0.0033	0.0128	0.0023
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.005	0.044	0.1432
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0183	0.0175
Schistosoma mansoni	sex comb on midleg homolog	0.0117	0.168	0.1591
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0292	0.4893	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0183	0.0005
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0097	0.1305	0.1213
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0163	0.2515	0.2494
Trypanosoma brucei	hypothetical protein, conserved	0.005	0.044	1
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0193	0.3074	0.3073
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.0916	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0048	0.041	0.0308
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0183	0.0175
Brugia malayi	hypothetical protein	0.0036	0.018	0.0076
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.0916	0.0839
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0183	0.0081
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0143	0.2152	0.2009
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.018	0.0076
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0128	0.0023
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.0183	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0138	0.2057	0.1973
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.0916	0.4273
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.005	0.044	0.0347
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0386	0.6636	0.6762
Brugia malayi	RNA, U transporter 1	0.0091	0.1187	0.1094
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4893	0.48
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0916	0.298
Treponema pallidum	fructose-bisphosphate aldolase	0.0292	0.4893	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0142	0.2144	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0097	0.1305	0.1242
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0092	0.1211	0.1117
Echinococcus multilocularis	neuropeptide s receptor	0.0458	0.7969	0.8142
Schistosoma mansoni	hypothetical protein	0.0036	0.018	0.0076
Echinococcus granulosus	SAM and MBT domain containing protein	0.0097	0.1305	0.1242
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0435	0.0341
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.0183	0.0005
Schistosoma mansoni	alpha-glucosidase	0.014	0.2097	0.2013
Schistosoma mansoni	glutaminase	0.0569	1	1
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.0183	0.0852
Schistosoma mansoni	hypothetical protein	0.0483	0.8423	0.8406
Trichomonas vaginalis	glutaminase, putative	0.0569	1	1
Schistosoma mansoni	hypothetical protein	0.034	0.5784	0.5739
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0179	0.0831
Echinococcus granulosus	neuropeptide receptor A26	0.0458	0.7969	0.8142
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.0916	0.0819
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.044	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.0435	0.2027
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0916	0.0751
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0138	0.2057	0.1973
Toxoplasma gondii	HEAT repeat-containing protein	0.0032	0.0105	0.049
Brugia malayi	mbt repeat family protein	0.0097	0.1305	0.1213
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0193	0.3074	0.3
Loa Loa (eye worm)	glutaminase 2	0.0569	1	1
Giardia lamblia	Rab geranylgeranyltransferase	0.0193	0.3074	0.5914
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3074	0.3
Loa Loa (eye worm)	glutaminase	0.0569	1	1
Onchocerca volvulus		0.0094	0.1251	0.6544
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4893	0.48
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0193	0.3074	0.3
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0183	0.0005
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4893	0.48
Brugia malayi	mbt repeat family protein	0.0097	0.1305	0.1213
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0142	0.2144	0.2001
Entamoeba histolytica	hypothetical protein	0.0036	0.018	0.0003
Echinococcus granulosus	polycomb protein SCMH1	0.0117	0.168	0.163
Schistosoma mansoni	hypothetical protein	0.0164	0.2547	0.2468
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.044	1
Entamoeba histolytica	hypothetical protein	0.0036	0.018	0.0003
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0092	0.1211	0.1144
Echinococcus multilocularis	tumor suppressor p53 binding protein 1	0.032	0.542	0.5502
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0183	0.0079
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.034	0.5784	0.5739
Echinococcus multilocularis	neuropeptide receptor A26	0.0458	0.7969	0.8142
Giardia lamblia	Fructose-bisphosphate aldolase	0.0292	0.4893	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.005	0.044	0.0266
Echinococcus granulosus	L aminoadipate semialdehyde	0.0092	0.1211	0.1144
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0292	0.4893	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0163	0.2515	0.2494
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0179	0.2191
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.018	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0128	0.0023
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.005	0.044	0.0338
Schistosoma mansoni	alpha glucosidase	0.0036	0.0183	0.0079
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.0435	0.1597
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.018	0.0077
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.0435	0.1597
Entamoeba histolytica	hypothetical protein	0.0036	0.018	0.0003
Echinococcus granulosus	tm gpcr rhodopsin	0.0556	0.9764	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.005	0.044	0.0338
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.005	0.044	0.0347
Toxoplasma gondii	hypothetical protein	0.0143	0.2152	1
Echinococcus granulosus	acetylcholinesterase	0.0138	0.2057	0.2021
Schistosoma mansoni	alpha-glucosidase	0.014	0.2097	0.2013
Loa Loa (eye worm)	acetylcholinesterase 1	0.0138	0.2057	0.1973
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.005	0.044	0.1432
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0193	0.3074	0.3
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0183	0.001
Schistosoma mansoni	hypothetical protein	0.032	0.542	0.5371
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0183	0.0005
Echinococcus multilocularis	acetylcholinesterase	0.0138	0.2057	0.2021
Echinococcus multilocularis	geminin	0.0164	0.2547	0.2528
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4893	0.48
Echinococcus multilocularis	acetylcholinesterase	0.0138	0.2057	0.2021
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.041	0.0308
Echinococcus granulosus	tumor suppressor p53 binding protein 1	0.032	0.542	0.5502
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4893	0.48
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0193	0.3074	1
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0193	0.3074	0.614
Echinococcus multilocularis	carboxylesterase 5A	0.0138	0.2057	0.2021
Entamoeba histolytica	hypothetical protein	0.0036	0.018	0.0003
Mycobacterium ulcerans	glutaminase	0.0569	1	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0142	0.2144	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.1305	0.1213
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.0183	0.0005
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4893	0.48
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.005	0.044	0.0347
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.044	1
Brugia malayi	Carboxylesterase family protein	0.0138	0.2057	0.1973
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.011	0.0511
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0916	0.4257
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0193	0.3074	1
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.044	1
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.005	0.044	0.0555
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0183	0.001
Echinococcus multilocularis	polycomb protein SCMH1	0.0117	0.168	0.163
Loa Loa (eye worm)	carboxylesterase	0.0138	0.2057	0.1973
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0193	0.3074	0.2948
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.005	0.044	0.0338
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0916	0.4257

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 8.8 uM	Dissociation constant against yeast farnesyltransferase	ChEMBL.	15080995
Ki (binding)	= 8.8 uM	Dissociation constant against yeast farnesyltransferase	ChEMBL.	15080995

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10249049

Bibliographic References

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Detailed information for compound 112271